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Science 19 January 1996:
Vol. 271. no. 5247, pp. 360 - 362
DOI: 10.1126/science.271.5247.360
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Reports

Bone Morphogenetic Protein-1: The Type I Procollagen C-Proteinase

Efrat Kessler,  Kazuhiko Takahara,  Luba Biniaminov,  Marina Brusel,  Daniel S. Greenspan

Bone morphogenetic proteins (BMPs) are bone-derived factors capable of inducing ectopic bone formation. Unlike other BMPs, BMP-1 is not like transforming growth factor-beta (TGF-beta), but it is the prototype of a family of putative proteases implicated in pattern formation during development in diverse organisms. Although some members of this group, such as Drosophila tolloid (TLD), are postulated to activate TGF-beta-like proteins, actual substrates are unknown. Procollagen C-proteinase (PCP) cleaves the COOH-propeptides of procollagens I, II, and III to yield the major fibrous components of vertebrate extracellular matrix. Here it is shown that BMP-1 and PCP are identical. This demonstration of enzymatic activity for a BMP-1/TLD-like protein links an enzyme involved in matrix deposition to genes involved in pattern formation.


E. Kessler, L. Biniaminov, M. Brusel, Maurice and Gabriela Goldschleger Eye Research Institute, Tel Aviv University Sackler Faculty of Medicine, Sheba Medical Center, Tel Hashomer, 52621 Israel.
K. Takahara and D. S. Greenspan, Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53706, USA.


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A Developmental Gene (Tolloid/BMP-1) Is Regulated in Aplysia Neurons by Treatments that Induce Long-Term Sensitization.
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Instructional Course Lectures, The American Academy of Orthopaedic Surgeons - Growth Factors as Therapeutic Agents*{{dagger}}.
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Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid.
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   Abstract »    Full Text »    PDF »
Lysyl Oxidase-like Protein from Bovine Aorta. ISOLATION AND MATURATION TO AN ACTIVE FORM BY BONE MORPHOGENETIC PROTEIN-1.
A. Borel, D. Eichenberger, J. Farjanel, E. Kessler, C. Gleyzal, D. J. S. Hulmes, P. Sommer, and B. Font (2001)
J. Biol. Chem. 276, 48944-48949
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Science. ISSN 0036-8075 (print), 1095-9203 (online)