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Science 22 December 1995:
Vol. 270. no. 5244, pp. 1995 - 1999
DOI: 10.1126/science.270.5244.1995
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Reports

A Subclass of bHLH Proteins Required for Cardiac Morphogenesis

Deepak Srivastava (1),  Peter Cserjesi (2),  Eric N. Olson (3)

Skeletal muscle development is controlled by a family of muscle-specific basic helix-loop-helix (bHLH) transcription factors. Two bHLH genes, dHAND and eHAND, have now been isolated that are expressed in the bilateral heart primordia and subsequently throughout the primitive tubular heart and its derivatives during chick and mouse embryogenesis. Incubation of stage 8 chick embryos with dHAND and eHAND antisense oligonucleotides revealed that either oligonucleotide alone had no effect on embryonic development, whereas together they arrested development at the looping heart tube stage. Thus, dHAND and eHAND may play redundant roles in the regulation of the morphogenetic events of vertebrate heart development.


Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
(1) Present address: Departments of Pediatrics (Division of Cardiology) and Molecular Biology and Oncology, The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
(2) Present address: Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA.
(3) Present address: Department of Molecular Biology and Oncology, The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.


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Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis..
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Genes & Dev. 11, 1061-1072
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Control of Vertebrate Left-Right Asymmetry by a Snail-Related Zinc Finger Gene.
A. Isaac, M. G. Sargent, and J. Cooke (1997)
Science 275, 1301-1304
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Cardiomyocyte differentiation by GATA-4-deficient embryonic stem cells.
N Narita, M Bielinska, and D. Wilson (1997)
Development 124, 3755-3764
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Fashioning the vertebrate heart: earliest embryonic decisions.
M. Fishman and K. Chien (1997)
Development 124, 2099-2117
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Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor.
C Grepin, G Nemer, and M Nemer (1997)
Development 124, 2387-2395
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