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Science 15 December 1995:
Vol. 270. no. 5243, pp. 1828 - 1831
DOI: 10.1126/science.270.5243.1828
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Reports

Control of Cell Fate by a Deubiquitinating Enzyme Encoded by the fat facets Gene

Yongzhao Huang,  Rohan T. Baker,  Janice A. Fischer-Vize (1)

Ubiquitin is a highly conserved polypeptide found in all eukaryotes. The major function of ubiquitin is to target proteins for complete or partial degradation by a multisubunit protein complex called the proteasome. Here, the Drosophila fat facets gene, which is required for the appropriate determination of particular cells in the fly eye, was shown to encode a ubiquitin-specific protease (Ubp), an enzyme that cleaves ubiquitin from ubiquitin-protein conjugates. The Fat facets protein (FAF) acts as a regulatory Ubp that prevents degradation of its substrate by the proteasome. Flies bearing fat facets gene mutations were used to show that a Ubp is cell type- and substrate-specific and a regulator of cell fate decisions in a multicellular organism.


Y. Huang and J. A. Fischer-Vize, Department of Zoology, University of Texas, Austin, TX 78712, USA.
R. T. Baker, Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia.
(1) To whom correspondence should be addressed.


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