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Science 8 December 1995:
Vol. 270. no. 5242, pp. 1595 - 1601
DOI: 10.1126/science.270.5242.1595
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Special

Chromosomal Control of Meiotic Cell Division

Kim S. McKim and R. Scott Hawley (1)

Chromosomes have multiple roles both in controlling the cell assembly and structure of the spindle and in determining chromosomal position on the spindle in many meiotic cells and in some types of mitotic cells. Moreover, functionally significant chromosome-microtubule interactions are not limited to the kinetochore but are also mediated by proteins localized along the arms of chromosomes. Finally, chromosomes also play a crucial role in control of the cell cycle.


The authors are in the Department of Genetics, Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA.
(1) To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Wac: a new Augmin subunit required for chromosome alignment but not for acentrosomal microtubule assembly in female meiosis.
A. M. Meireles, K. H. Fisher, N. Colombie, J. G. Wakefield, and H. Ohkura (2009)
J. Cell Biol. 184, 777-784
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Kinesin-14 Family Proteins HSET/XCTK2 Control Spindle Length by Cross-Linking and Sliding Microtubules.
S. Cai, L. N. Weaver, S. C. Ems-McClung, and C. E. Walczak (2009)
Mol. Biol. Cell 20, 1348-1359
   Abstract »    Full Text »    PDF »
Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis.
N. Colombie, C. F. Cullen, A. L. Brittle, J. K. Jang, W. C. Earnshaw, M. Carmena, K. McKim, and H. Ohkura (2008)
Development 135, 3239-3246
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mei-38 Is Required for Chromosome Segregation During Meiosis in Drosophila Females.
C. Wu, V. Singaram, and K. S. McKim (2008)
Genetics 180, 61-72
   Abstract »    Full Text »    PDF »
Aurora A Phosphorylates MCAK to Control Ran-dependent Spindle Bipolarity.
X. Zhang, S. C. Ems-McClung, and C. E. Walczak (2008)
Mol. Biol. Cell 19, 2752-2765
   Abstract »    Full Text »    PDF »
Spindle assembly in the absence of chromosomes in mouse oocytes.
J.-W. Yang, Z.-L. Lei, Y.-L. Miao, J.-C. Huang, L.-H. Shi, Y.-C. OuYang, Q.-Y. Sun, and D.-Y. Chen (2007)
Reproduction 134, 731-738
   Abstract »    Full Text »    PDF »
Kinesin 6 family member Subito participates in mitotic spindle assembly and interacts with mitotic regulators.
J. M. Cesario, J. K. Jang, B. Redding, N. Shah, T. Rahman, and K. S. McKim (2006)
J. Cell Sci. 119, 4770-4780
   Abstract »    Full Text »    PDF »
The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster.
C. F. Cullen, A. L. Brittle, T. Ito, and H. Ohkura (2005)
J. Cell Biol. 171, 593-602
   Abstract »    Full Text »    PDF »
The Kinesinlike Protein Subito Contributes to Central Spindle Assembly and Organization of the Meiotic Spindle in Drosophila Oocytes.
J. K. Jang, T. Rahman, and K. S. McKim (2005)
Mol. Biol. Cell 16, 4684-4694
   Abstract »    Full Text »    PDF »
The meiotic spindle of the Drosophila oocyte: the role of Centrosomin and the central aster.
M. G. Riparbelli and G. Callaini (2005)
J. Cell Sci. 118, 2827-2836
   Abstract »    Full Text »    PDF »
Nuclear Origin of Aging-Associated Meiotic Defects in Senescence-Accelerated Mice.
L. Liu and D. L. Keefe (2004)
Biol Reprod 71, 1724-1729
   Abstract »    Full Text »    PDF »
The mechanism of spindle assembly: functions of Ran and its target TPX2.
O. J. Gruss and I. Vernos (2004)
J. Cell Biol. 166, 949-955
   Abstract »    Full Text »    PDF »
Microtubule composition: Cryptography of dynamic polymers.
K. Bloom (2004)
PNAS 101, 6839-6840
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KLP-18, a Klp2 Kinesin, Is Required for Assembly of Acentrosomal Meiotic Spindles in Caenorhabditis elegans.
C. Segbert, R. Barkus, J. Powers, S. Strome, W. M. Saxton, and O. Bossinger (2003)
Mol. Biol. Cell 14, 4458-4469
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Telomere-independent homologue pairing and checkpoint escape of accessory ring chromosomes in male mouse meiosis.
T. Voet, B. Liebe, C. Labaere, P. Marynen, and H. Scherthan (2003)
J. Cell Biol. 162, 795-808
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A perfect funeral with no corpse.
W. C. Earnshaw and M. Carmena (2003)
J. Cell Biol. 160, 989-990
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Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs.
B. J. Tunquist and J. L. Maller (2003)
Genes & Dev. 17, 683-710
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subito Encodes a Kinesin-like Protein Required for Meiotic Spindle Pole Formation in Drosophila melanogaster.
K. L. Giunta, J. K. Jang, E. A. Manheim, G. Subramanian, and K. S. McKim (2002)
Genetics 160, 1489-1501
   Abstract »    Full Text »    PDF »
The centrosome is a dynamic structure that ejects PCM flares.
T. L. Megraw, S. Kilaru, F. R. Turner, and T. C. Kaufman (2002)
J. Cell Sci. 115, 4707-4718
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Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts.
P. P. Budde, A. Kumagai, W. G. Dunphy, and R. Heald (2001)
J. Cell Biol. 153, 149-158
   Abstract »    Full Text »    PDF »
Dis1/TOG universal microtubule adaptors - one MAP for all?.
H. Ohkura, M. A. Garcia, and T. Toda (2001)
J. Cell Sci. 114, 3805-3812
   Abstract »    Full Text »    PDF »
The Drosophila wispy Gene Is Required for RNA Localization and Other Microtubule-Based Events of Meiosis and Early Embryogenesis.
A. E. Brent, A. MacQueen, and T. Hazelrigg (2000)
Genetics 154, 1649-1662
   Abstract »    Full Text »
Linker Histones Play a Role in Male Meiosis and the Development of Pollen Grains in Tobacco.
M. Prymakowska-Bosak, M. R. Przewloka, J. lusarczyk, M. Kura, J. Lichota, B. Kiliaczyk, and A. Jerzmanowski (1999)
PLANT CELL 11, 2317-2330
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The Kinesin-Related Protein, Hset, Opposes the Activity of Eg5 and Cross-Links Microtubules in the Mammalian Mitotic Spindle.
V. Mountain, C. Simerly, L. Howard, A. Ando, G. Schatten, and D. A. Compton (1999)
J. Cell Biol. 147, 351-366
   Abstract »    Full Text »    PDF »
mini spindles: A Gene Encoding a Conserved Microtubule-Associated Protein Required for the Integrity of the Mitotic Spindle in Drosophila.
C. F. Cullen, P. Deak, D. M. Glover, and H. Ohkura (1999)
J. Cell Biol. 146, 1005-1018
   Abstract »    Full Text »    PDF »
Nuclear Organization and Chromosome Segregation.
A. E. Franklin and W. Z. Cande (1999)
PLANT CELL 11, 523-534
   Full Text »
The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila.
T. Megraw, K Li, L. Kao, and T. Kaufman (1999)
Development 126, 2829-2839
   Abstract »    PDF »
Dynein is required for spindle assembly in cytoplasmic extracts of Spisula solidissima oocytes.
R. Palazzo, E. Vaisberg, D. Weiss, S. Kuznetsov, and W Steffen (1999)
J. Cell Sci. 112, 1291-1302
   Abstract »    PDF »
CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint.
D. Stuart and C. Wittenberg (1998)
Genes & Dev. 12, 2698-2710
   Abstract »    Full Text »
Spindle Self-organization and Cytokinesis During Male Meiosis in asterless Mutants of Drosophila melanogaster.
S. Bonaccorsi, M. G. Giansanti, and M. Gatti (1998)
J. Cell Biol. 142, 751-761
   Abstract »    Full Text »    PDF »
Spindle Assembly and Mitosis without Centrosomes in Parthenogenetic Sciara Embryos.
B. de Saint Phalle and W. Sullivan (1998)
J. Cell Biol. 141, 1383-1391
   Abstract »    Full Text »    PDF »
Maize meiotic spindles assemble around chromatin and do not require paired chromosomes.
A Chan and W. Cande (1998)
J. Cell Sci. 111, 3507-3515
   Abstract »    PDF »
Focusing on spindle poles.
D. Compton (1998)
J. Cell Sci. 111, 1477-1481
   Abstract »    PDF »
Lack of Checkpoint Control at the Metaphase/Anaphase Transition: A Mechanism of Meiotic Nondisjunction in Mammalian Females.
R. LeMaire-Adkins, K. Radke, and P. A. Hunt (1997)
J. Cell Biol. 139, 1611-1619
   Abstract »    Full Text »    PDF »
The Yeast Motor Protein, Kar3p, Is Essential for Meiosis I.
C. A. Bascom-Slack and D. S. Dawson (1997)
J. Cell Biol. 139, 459-467
   Abstract »    Full Text »    PDF »
Mitotic Spindle Poles are Organized by Structural and Motor Proteins in Addition to Centrosomes.
T. Gaglio, M. A. Dionne, and D. A. Compton (1997)
J. Cell Biol. 138, 1055-1066
   Abstract »    Full Text »    PDF »
Spindle Assembly in Xenopus Egg Extracts: Respective Roles of Centrosomes and Microtubule Self-Organization.
R. Heald, R. Tournebize, A. Habermann, E. Karsenti, and A. Hyman (1997)
J. Cell Biol. 138, 615-628
   Abstract »    Full Text »    PDF »
Role of microtubules and microtubule organizing centers on meiotic chromosome elimination in Sciara ocellaris.
M. Esteban, M. Campos, A. Perondini, and C Goday (1997)
J. Cell Sci. 110, 721-730
   Abstract »    PDF »
Incomplete sister chromatid separation is the mechanism of programmed chromosome elimination during early Sciara coprophila embryogenesis.
B de Saint Phalle and W Sullivan (1996)
Development 122, 3775-3784
   Abstract »    PDF »
Meiotic spindle organization in fertilized Drosophila oocyte: presence of centrosomal components in the meiotic apparatus.
M. Riparbelli and G Callaini (1996)
J. Cell Sci. 109, 911-918
   Abstract »    PDF »


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