Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 December 1995:
Vol. 270. no. 5241, pp. 1497 - 1499
DOI: 10.1126/science.270.5241.1497
Prev | Table of Contents | Next

Reports

A Population Genetic Test of Selection at the Molecular Level

M. F. J. Taylor (1),  Y. Shen,  M. E. Kreitman

The role of natural selection in molecular evolution has been inferred primarily by rejection of null hypotheses based on neutral theory, rather than by acceptance of specific predictions based on selection. In this report, a population genetic test of a specific prediction for selection on DNA polymorphism is presented. Pyrethroid insecticide use constitutes an experiment for which form of selection and molecular target (voltage-gated sodium channels) are both known. As predicted, differential pyrethroid selection on tobacco budworm populations generated significant geographic heterogeneity in sodium channel marker allele frequencies, compared with arbitrary loci.


M. F. J. Taylor and Y. Shen, Department of Entomology, Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA.
M. E. Kreitman, Department of Ecology and Evolution, University of Chicago, 1103 East 57th Street, Chicago, IL 60637, USA.
(1) To whom correspondence should be addressed. E-mail: Taylor{at}biosci.arizona.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Selective sweep mapping of genes with large phenotypic effects.
J. P. Pollinger, C. D. Bustamante, A. Fledel-Alon, S. Schmutz, M. M. Gray, and R. K. Wayne (2005)
Genome Res. 15, 1809-1819
   Abstract »    Full Text »    PDF »
Geographical Distribution of Selected and Putatively Neutral SNPs in Southeast Asian Malaria Parasites.
T. J. C. Anderson, S. Nair, D. Sudimack, J. T. Williams, M. Mayxay, P. N. Newton, J.-P. Guthmann, F. M. Smithuis, T. T. Hien, I. V.F. van den Broek, et al. (2005)
Mol. Biol. Evol. 22, 2362-2374
   Abstract »    Full Text »    PDF »
Population Genetic and Phylogenetic Evidence for Positive Selection on Regulatory Mutations at the Factor VII Locus in Humans.
M. W. Hahn, M. V. Rockman, N. Soranzo, D. B. Goldstein, and G. A. Wray (2004)
Genetics 167, 867-877
   Abstract »    Full Text »    PDF »
Haplotype Structure and Evidence for Positive Selection at the Human IL13 Locus.
G. Zhou, Y. Zhai, X. Dong, X. Zhang, F. He, K. Zhou, Y. Zhu, H. Wei, Z. Yao, S. Zhong, et al. (2004)
Mol. Biol. Evol. 21, 29-36
   Abstract »    Full Text »    PDF »
Locus-Specific Genetic Differentiation at Rw Among Warfarin-Resistant Rat (Rattus norvegicus) Populations.
M. H. Kohn, H.-J. Pelz, and R. K. Wayne (2003)
Genetics 164, 1055-1070
   Abstract »    Full Text »    PDF »
Natural selection mapping of the warfarin-resistance gene.
M. H. Kohn, H.-J. Pelz, and R. K. Wayne (2000)
PNAS 97, 7911-7915
   Abstract »    Full Text »    PDF »
Different Trajectories of Parallel Evolution During Viral Adaptation.
H. A. Wichman, M. R. Badgett, L. A. Scott, C. M. Boulianne, and J. J. Bull (1999)
Science 285, 422-424
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)