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Science 1 December 1995:
Vol. 270. no. 5241, pp. 1497 - 1499
DOI: 10.1126/science.270.5241.1497
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Reports

A Population Genetic Test of Selection at the Molecular Level

M. F. J. Taylor (1),  Y. Shen,  M. E. Kreitman

The role of natural selection in molecular evolution has been inferred primarily by rejection of null hypotheses based on neutral theory, rather than by acceptance of specific predictions based on selection. In this report, a population genetic test of a specific prediction for selection on DNA polymorphism is presented. Pyrethroid insecticide use constitutes an experiment for which form of selection and molecular target (voltage-gated sodium channels) are both known. As predicted, differential pyrethroid selection on tobacco budworm populations generated significant geographic heterogeneity in sodium channel marker allele frequencies, compared with arbitrary loci.


M. F. J. Taylor and Y. Shen, Department of Entomology, Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA.
M. E. Kreitman, Department of Ecology and Evolution, University of Chicago, 1103 East 57th Street, Chicago, IL 60637, USA.
(1) To whom correspondence should be addressed. E-mail: Taylor{at}biosci.arizona.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Selective sweep mapping of genes with large phenotypic effects.
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Genome Res. 15, 1809-1819
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Geographical Distribution of Selected and Putatively Neutral SNPs in Southeast Asian Malaria Parasites.
T. J. C. Anderson, S. Nair, D. Sudimack, J. T. Williams, M. Mayxay, P. N. Newton, J.-P. Guthmann, F. M. Smithuis, T. T. Hien, I. V.F. van den Broek, et al. (2005)
Mol. Biol. Evol. 22, 2362-2374
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Population Genetic and Phylogenetic Evidence for Positive Selection on Regulatory Mutations at the Factor VII Locus in Humans.
M. W. Hahn, M. V. Rockman, N. Soranzo, D. B. Goldstein, and G. A. Wray (2004)
Genetics 167, 867-877
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Haplotype Structure and Evidence for Positive Selection at the Human IL13 Locus.
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Locus-Specific Genetic Differentiation at Rw Among Warfarin-Resistant Rat (Rattus norvegicus) Populations.
M. H. Kohn, H.-J. Pelz, and R. K. Wayne (2003)
Genetics 164, 1055-1070
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Natural selection mapping of the warfarin-resistance gene.
M. H. Kohn, H.-J. Pelz, and R. K. Wayne (2000)
PNAS 97, 7911-7915
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Different Trajectories of Parallel Evolution During Viral Adaptation.
H. A. Wichman, M. R. Badgett, L. A. Scott, C. M. Boulianne, and J. J. Bull (1999)
Science 285, 422-424
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