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Science 24 November 1995:
Vol. 270. no. 5240, pp. 1354 - 1357
DOI: 10.1126/science.270.5240.1354
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Reports

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

Sergio A. Oñate,  Sophia Y. Tsai,  Ming-Jer Tsai,  Bert W. O'Malley (1)

A yeast two-hybrid system was used to identify a protein that interacts with and enhances the human progesterone receptor (hPR) transcriptional activity without altering the basal activity of the promoter. Because the protein stimulated transactivation of all the steroid receptors tested, it has been termed steroid receptor coactivator-1 (SRC-1). Coexpression of SRC-1 reversed the ability of the estrogen receptor to squelch activation by hPR. Also, the amino terminal truncated form of SRC-1 acted as a dominant-negative repressor. Together, these results indicate that SRC-1 encodes a coactivator that is required for full transcriptional activity of the steroid receptor superfamily.


Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.
(1) To whom correspondence should be addressed.


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F. Molnar, M. Perakyla, and C. Carlberg (2006)
J. Biol. Chem. 281, 10516-10526
   Abstract »    Full Text »    PDF »
Identification and characterization of RanBPM, a novel coactivator of thyroid hormone receptors..
M.-B. Poirier, L. Laflamme, and M.-F. Langlois (2006)
J. Mol. Endocrinol. 36, 313-325
   Abstract »    Full Text »    PDF »
MED14 and MED1 Differentially Regulate Target-Specific Gene Activation by the Glucocorticoid Receptor.
W. Chen, I. Rogatsky, and M. J. Garabedian (2006)
Mol. Endocrinol. 20, 560-572
   Abstract »    Full Text »    PDF »
Thyroid Hormone-Regulated Target Genes Have Distinct Patterns of Coactivator Recruitment and Histone Acetylation.
Y. Liu, X. Xia, J. D. Fondell, and P. M. Yen (2006)
Mol. Endocrinol. 20, 483-490
   Abstract »    Full Text »    PDF »
The Interaction of TR{beta}1-N Terminus with Steroid Receptor Coactivator-1 (SRC-1) Serves a Full Transcriptional Activation Function of SRC-1.
T. Iwasaki, A. Takeshita, W. Miyazaki, W. W. Chin, and N. Koibuchi (2006)
Endocrinology 147, 1452-1457
   Abstract »    Full Text »    PDF »
Differential Recruitment of p160 Coactivators by Glucocorticoid Receptor between Schwann Cells and Astrocytes.
J. Grenier, A. Trousson, A. Chauchereau, J. Cartaud, M. Schumacher, and C. Massaad (2006)
Mol. Endocrinol. 20, 254-267
   Abstract »    Full Text »    PDF »
An hGCN5/TRRAP Histone Acetyltransferase Complex Co-activates BRCA1 Transactivation Function through Histone Modification.
H. Oishi, H. Kitagawa, O. Wada, S. Takezawa, L. Tora, M. Kouzu-Fujita, I. Takada, T. Yano, J. Yanagisawa, and S. Kato (2006)
J. Biol. Chem. 281, 20-26
   Abstract »    Full Text »    PDF »
Mechanism of Action of Hic-5/Androgen Receptor Activator 55, a LIM Domain-Containing Nuclear Receptor Coactivator.
M. D Heitzer and D. B. DeFranco (2006)
Mol. Endocrinol. 20, 56-64
   Abstract »    Full Text »    PDF »
Adrenocorticotropic Hormone-Mediated Signaling Cascades Coordinate a Cyclic Pattern of Steroidogenic Factor 1-Dependent Transcriptional Activation.
J. N. Winnay and G. D. Hammer (2006)
Mol. Endocrinol. 20, 147-166
   Abstract »    Full Text »    PDF »
Discovery of Small Molecule Inhibitors of the Interaction of the Thyroid Hormone Receptor with Transcriptional Coregulators.
L. A. Arnold, E. Estebanez-Perpina, M. Togashi, N. Jouravel, A. Shelat, A. C. McReynolds, E. Mar, P. Nguyen, J. D. Baxter, R. J. Fletterick, et al. (2005)
J. Biol. Chem. 280, 43048-43055
   Abstract »    Full Text »    PDF »
Role of aspartate 351 in transactivation and active conformation of estrogen receptor {alpha}.
J. H. Kim, M. H. Lee, B. J. Kim, J. H. Kim, S. J. Han, H. Y. Kim, and M. R Stallcup (2005)
J. Mol. Endocrinol. 35, 449-464
   Abstract »    Full Text »    PDF »
Coregulators in Nuclear Estrogen Receptor Action: From Concept to Therapeutic Targeting.
J. M. Hall and D. P. McDonnell (2005)
Mol. Interv. 5, 343-357
   Abstract »    Full Text »    PDF »
The Nuclear Xenobiotic Receptor Pregnane X Receptor: Recent Insights and New Challenges.
J. Orans, D. G. Teotico, and M. R. Redinbo (2005)
Mol. Endocrinol. 19, 2891-2900
   Abstract »    Full Text »    PDF »
Repressive domain of unliganded human estrogen receptor {alpha} associates with Hsc70.
S. Ogawa, H. Oishi, Y. Mezaki, M. Kouzu-Fujita, R. Matsuyama, M. Nakagomi, E. Mori, E. Murayama, H. Nagasawa, H. Kitagawa, et al. (2005)
Genes Cells 10, 1095-1102
   Abstract »    Full Text »    PDF »
Peptidyl-Prolyl Isomerase 1 (Pin1) Serves as a Coactivator of Steroid Receptor by Regulating the Activity of Phosphorylated Steroid Receptor Coactivator 3 (SRC-3/AIB1).
P. Yi, R.-C. Wu, J. Sandquist, J. Wong, S. Y. Tsai, M.-J. Tsai, A. R. Means, and B. W. O'Malley (2005)
Mol. Cell. Biol. 25, 9687-9699
   Abstract »    Full Text »    PDF »
Effects of 2,4-D and DCP on the DHT-Induced Androgenic Action in Human Prostate Cancer Cells.
H.-J. Kim, Y. I. Park, and M.-S. Dong (2005)
Toxicol. Sci. 88, 52-59
   Abstract »    Full Text »    PDF »
Suppression of Death Receptor-mediated Apoptosis by 1,25-Dihydroxyvitamin D3 Revealed by Microarray Analysis.
X. Zhang, P. Li, J. Bao, S. V. Nicosia, H. Wang, S. A. Enkemann, and W. Bai (2005)
J. Biol. Chem. 280, 35458-35468
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Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis.
J. Igarashi-Migitaka, A. Takeshita, N. Koibuchi, S. Yamada, R. Ohtani-Kaneko, and K. Hirata (2005)
Eur. J. Endocrinol. 153, 595-604
   Abstract »    Full Text »    PDF »
Development of Peptide Antagonists for the Androgen Receptor Using Combinatorial Peptide Phage Display.
C.-y. Chang, J. Abdo, T. Hartney, and D. P. McDonnell (2005)
Mol. Endocrinol. 19, 2478-2490
   Abstract »    Full Text »    PDF »
Proteomic Analysis of Steady-State Nuclear Hormone Receptor Coactivator Complexes.
S. Y. Jung, A. Malovannaya, J. Wei, B. W. O'Malley, and J. Qin (2005)
Mol. Endocrinol. 19, 2451-2465
   Abstract »    Full Text »    PDF »
Dynamic Cell Type Specificity of SRC-1 Coactivator in Modulating Uterine Progesterone Receptor Function in Mice.
S. J. Han, J. Jeong, F. J. DeMayo, J. Xu, S. Y. Tsai, M.-J. Tsai, and B. W. O'Malley (2005)
Mol. Cell. Biol. 25, 8150-8165
   Abstract »    Full Text »    PDF »


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