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Science 24 November 1995:
Vol. 270. no. 5240, pp. 1351 - 1353
DOI: 10.1126/science.270.5240.1351
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Reports

Designer Cytokines: Targeting Actions to Cells of Choice

Aris N. Economides,  Jeffrey V. Ravetch,  George D. Yancopoulos (1),  Neil Stahl (1)

Some growth factors are therapeutically useful partly because restricted expression of their receptors limits their action to particular cell types. However, no unique stimulatory factor is known for many clinically relevant cell types, such as CD34 hematopoietic stem cells. Here, soluble alpha receptor (Ralpha) components for interleukin-6 (IL-6) and ciliary neurotrophic factor (CNTF) were targeted in an active form to cells expressing surface markers such as CD34 or CD45, thereby rendering those cells responsive to IL-6 or CNTF. The targeting of Ralpha components may provide the means to create ``designer'' cytokines that activate a desired cell type expressing a specific cell surface marker.


A. N. Economides, G. D. Yancopoulos, N. Stahl, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
J. V. Ravetch, Laboratory of Biochemical Genetics, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA.
(1) To whom correspondence should be addressed.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)