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Science 24 November 1995:
Vol. 270. no. 5240, pp. 1319 - 1325
DOI: 10.1126/science.270.5240.1319
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Articles

Origin of Bilaterian Body Plans: Evolution of Developmental Regulatory Mechanisms

Eric H. Davidson,  Kevin J. Peterson,  R. Andrew Cameron

An argument is proposed to explain the origin of large metazoans, based on the regulatory processes that underlie the morphogenetic organization of pattern in modern animals. Genetic regulatory systems similar to those used in modern, indirectly developing marine invertebrates are considered to indicate the Precambrian regulatory platform on which were erected innovations that underlie the development of macroscopic body plans. Those systems are genetic regulatory programs that produce groups of unspecified ``set-aside cells'' and hierarchical regulatory programs that initially define regions of morphogenetic space in terms of domains of transcription factor expression. These ideas affect interpretation of the development of arthropods and chordates as well as interpretation of the role of the genes of the homeotic complex in embryogenesis.


E. H. Davidson and R. A. Cameron are at the Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. K. J. Peterson is at the Department of Earth and Space Sciences, University of California, Los Angeles, CA 90095-1567, USA.


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