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Science 17 November 1995:
Vol. 270. no. 5239, pp. 1189 - 1192
DOI: 10.1126/science.270.5239.1189
Prev | Table of Contents | Next

Reports

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

Thomas S. Griffith,  Thomas Brunner,  Sharon M. Fletcher,  Douglas R. Green,  Thomas A. Ferguson (1)

The eye is a privileged site that cannot tolerate destructive inflammatory responses. Inflammatory cells entering the anterior chamber of the eye in response to viral infection underwent apoptosis that was dependent on Fas (CD95)-Fas ligand (FasL) and produced no tissue damage. In contrast, viral infection in gld mice, which lack functional FasL, resulted in an inflammation and invasion of ocular tissue without apoptosis. Fas-positive but not Fas-negative tumor cells were killed by apoptosis when placed within isolated anterior segments of the eyes of normal but not FasL-negative mice. FasL messenger RNA and protein were detectable in the eye. Thus, Fas-FasL interactions appear to be an important mechanism for the maintenance of immune privilege.


T. S. Griffith and S. M. Fletcher, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.
T. Brunner and D. R. Green, Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
T. A. Ferguson, Departments of Ophthalmology and Visual Sciences and Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
(1) To whom correspondence should be addressed.


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J. Immunol. 172, 2118-2125
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   Abstract »    Full Text »    PDF »
Characterization of Daunorubicin-Induced Apoptosis in Retinal Pigment Epithelial Cells: Modulation by CD95L.
A. Hueber, M. Weller, G. Welsandt, N. Kociok, B. Kirchhof, and P. Esser (2003)
Invest. Ophthalmol. Vis. Sci. 44, 2851-2857
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Increased Retinal Neovascularization in Fas Ligand-Deficient Mice.
M. H. Davies, J. P. Eubanks, and M. R. Powers (2003)
Invest. Ophthalmol. Vis. Sci. 44, 3202-3210
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Hr44 Secreted with Exosomes: Loss from Ciliary Epithelium in Response to Inflammation.
N. M. McKechnie, D. Copland, and G. Braun (2003)
Invest. Ophthalmol. Vis. Sci. 44, 2650-2656
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Visualization of Cell Death In Vivo during Murine Endotoxin-Induced Uveitis.
P. Yang, J. R. Smith, K. S. Damodar, S. R. Planck, and J. T. Rosenbaum (2003)
Invest. Ophthalmol. Vis. Sci. 44, 1993-1997
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Endothelial Cell Overexpression of Fas Ligand Attenuates Ischemia-Reperfusion Injury in the Heart.
J. Yang, S. P. Jones, T. Suhara, J. J. M. Greer, P. D. Ware, N. P. Nguyen, H. Perlman, D. P. Nelson, D. J. Lefer, and K. Walsh (2003)
J. Biol. Chem. 278, 15185-15191
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Concentrations of Soluble Fas in Maternal Serum and Amniotic Fluid During Uncomplicated Pregnancies.