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Science 27 October 1995:
Vol. 270. no. 5236, pp. 630 - 633
DOI: 10.1126/science.270.5236.630
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Reports

T Cell Awareness of Paternal Alloantigens During Pregnancy

Anna Tafuri,  Judith Alferink,  Peter Möller,  Günter J. Hämmerling,  Bernd Arnold (1)

During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2K^b was used to follow the fate of T cells reactive to paternal alloantigens. In contrast to syngeneic and third-party allogeneic pregnancies, mice bearing a K^b-positive conceptus had reduced numbers of K^b-reactive T cells and accepted K^b-positive tumor grafts. T cell phenotype and responsiveness were restored after delivery. Thus, during pregnancy maternal T cells acquire a transient state of tolerance specific for paternal alloantigens.


A. Tafuri, J. Alferink, G. J. Hämmerling, B. Arnold, Tumor Immunology Program, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
P. Möller, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany.
(1) To whom correspondence should be addressed.


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