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Science 27 October 1995:
Vol. 270. no. 5236, pp. 610 - 614
DOI: 10.1126/science.270.5236.610
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Reports

Nanoscale Complexity of Phospholipid Monolayers Investigated by Near-Field Scanning Optical Microscopy

Jeeseong Hwang (1),  Lukas K. Tamm,  Christine Böhm,  Tirunelveli S. Ramalingam,  Eric Betzig (2),  Michael Edidin

Near-field scanning optical microscopy of phospholipid monolayers doped with fluorescent lipid analogs reveals previously undescribed features in various phases, including a concentration gradient at the liquid-expanded/liquid-condensed domain boundary and weblike structures in the solid-condensed phase. Presumably, the web structures are grain boundaries between crystalline solid lipid. These structures are strongly modulated by the addition of low concentrations of cholesterol and ganglioside G in the monolayer.


J. Hwang, T. S. Ramalingam, M. Edidin, Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
L. K. Tamm and C. Böhm, Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.
E. Betzig, AT&T Bell Laboratories, Murray Hill, NJ 07974, USA.
(1) To whom correspondence should be addressed.
(2) Present address: NSOM Enterprises, Berkeley Heights, NJ 07922, USA.


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