Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 27 October 1995:
Vol. 270. no. 5236, pp. 593 - 598
DOI: 10.1126/science.270.5236.593
Prev | Table of Contents | Next

Articles

Neurotrophins and Neuronal Plasticity

Hans Thoenen

There is increasing evidence that neurotrophins (NTs) are involved in processes of neuronal plasticity besides their well-established actions in regulating the survival, differentiation, and maintenance of functions of specific populations of neurons. Nerve growth factor, brain-derived neurotrophic factor, NT-4/5, and corresponding antibodies dramatically modify the development of the visual cortex. Although the neuronal elements involved have not yet been identified, complementary studies of other systems have demonstrated that NT synthesis is rapidly regulated by neuronal activity and that NTs are released in an activity-dependent manner from neuronal dendrites. These data, together with the observation that NTs enhance transmitter release from neurons that express the corresponding signal-transducing Trk receptors, suggest a role for NTs as selective retrograde messengers that regulate synaptic efficacy.


The author is in the Department of Neurochemistry, Max Planck Institute for Psychiatry, Am Klopferspitz 18A, D-82152 Martinsried, Germany.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-{gamma} signaling for glutamate release via a glutamate transporter.
T. Numakawa, E. Kumamaru, N. Adachi, Y. Yagasaki, A. Izumi, and H. Kunugi (2009)
PNAS 106, 647-652
   Abstract »    Full Text »    PDF »
BDNF-TrkB signaling interacts with the GABAergic system to inhibit rhythmic swallowing in the rat.
B. Bariohay, C. Tardivel, J. Pio, A. Jean, and B. Felix (2008)
Am J Physiol Regulatory Integrative Comp Physiol 295, R1050-R1059
   Abstract »    Full Text »    PDF »
Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection.
J. A. Lieberman, F. P. Bymaster, H. Y. Meltzer, A. Y. Deutch, G. E. Duncan, C. E. Marx, J. R. Aprille, D. S. Dwyer, X.-M. Li, S. P. Mahadik, et al. (2008)
Pharmacol. Rev. 60, 358-403
   Abstract »    Full Text »    PDF »
Alterations of Serum Brain-Derived Neurotrophic Factor Levels in Early Alcohol Withdrawal.
M.-C. Huang, C.-H. Chen, C.-H. Chen, S.-C. Liu, C.-J. Ho, W. W Shen, and S.-J. Leu (2008)
Alcohol Alcohol.
   Abstract »    Full Text »    PDF »
Effector Immediate-Early Gene Arc in the Amygdala Plays a Critical Role in Alcoholism.
S. C. Pandey, H. Zhang, R. Ugale, A. Prakash, T. Xu, and K. Misra (2008)
J. Neurosci. 28, 2589-2600
   Abstract »    Full Text »    PDF »
BHLHB2 Controls Bdnf Promoter 4 Activity and Neuronal Excitability.
X. Jiang, F. Tian, Y. Du, N. G. Copeland, N. A. Jenkins, L. Tessarollo, X. Wu, H. Pan, X.-Z. Hu, K. Xu, et al. (2008)
J. Neurosci. 28, 1118-1130
   Abstract »    Full Text »    PDF »
Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor.
F. Angelucci, V. Ricci, M. Pomponi, G. Conte, A. A. Mathe, P. Attilio Tonali, and P. Bria (2007)
J Psychopharmacol 21, 820-825
   Abstract »    PDF »
Impaired Cerebellar Development and Function in Mice Lacking CAPS2, a Protein Involved in Neurotrophin Release.
T. Sadakata, W. Kakegawa, A. Mizoguchi, M. Washida, R. Katoh-Semba, F. Shutoh, T. Okamoto, H. Nakashima, K. Kimura, M. Tanaka, et al. (2007)
J. Neurosci. 27, 2472-2482
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor Regulates the Maturation of Layer 4 Fast-Spiking Cells after the Second Postnatal Week in the Developing Barrel Cortex.
C. Itami, F. Kimura, and S. Nakamura (2007)
J. Neurosci. 27, 2241-2252
   Abstract »    Full Text »    PDF »
Dissociation between CA3-CA1 Synaptic Plasticity and Associative Learning in TgNTRK3 Transgenic Mice.
I. Sahun, J. M. Delgado-Garcia, A. Amador-Arjona, A. Giralt, J. Alberch, M. Dierssen, and A. Gruart (2007)
J. Neurosci. 27, 2253-2260
   Abstract »    Full Text »    PDF »
Immunohistochemical Distribution of NGF, BDNF, NT-3, and NT-4 in Adult Rhesus Monkey Brains.
H.-T. Zhang, L.-Y. Li, X.-L. Zou, X.-B. Song, Y.-L. Hu, Z.-T. Feng, and T. T.-H. Wang (2007)
J. Histochem. Cytochem. 55, 1-19
   Abstract »    Full Text »    PDF »
Amphetamine-Induced Place Preference and Conditioned Motor Sensitization Requires Activation of Tyrosine Kinase Receptors in the Hippocampus.
F. Shen, G. E. Meredith, and T. C. Napier (2006)
J. Neurosci. 26, 11041-11051
   Abstract »    Full Text »    PDF »
Serum Brain-Derived Neurotrophic Factor Concentrations in Lean and Overweight Children and Adolescents.
A. H. El-Gharbawy, D. C. Adler-Wailes, M. C. Mirch, K. R. Theim, L. Ranzenhofer, M. Tanofsky-Kraff, and J. A. Yanovski (2006)
J. Clin. Endocrinol. Metab. 91, 3548-3552
   Abstract »    Full Text »    PDF »
Enhancement of Antidepressant-Like Effects but Not Brain-Derived Neurotrophic Factor mRNA Expression by the Novel N-Methyl-D-aspartate Receptor Antagonist Neramexane in Mice.
T. Kos, B. Legutko, W. Danysz, G. Samoriski, and P. Popik (2006)
J. Pharmacol. Exp. Ther. 318, 1128-1136
   Abstract »    Full Text »    PDF »
Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors..
S. C. Pandey, H. Zhang, A. Roy, and K. Misra (2006)
J. Neurosci. 26, 8320-8331
   Abstract »    Full Text »    PDF »
Consensus document on European brain research.
J. Olesen, M. G Baker, T. Freund, M. di Luca, J. Mendlewicz, I. Ragan, and M. Westphal (2006)
J. Neurol. Neurosurg. Psychiatry 77, i1-i49
   Abstract »    Full Text »    PDF »
Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF.
K. Furutani, Y. Okubo, S. Kakizawa, and M. Iino (2006)
PNAS 103, 8528-8533
   Abstract »    Full Text »    PDF »
Chronic Antidepressants Potentiate via Sigma-1 Receptors the Brain-derived Neurotrophic Factor-induced Signaling for Glutamate Release.
Y. Yagasaki, T. Numakawa, E. Kumamaru, T. Hayashi, T.-P. Su, and H. Kunugi (2006)
J. Biol. Chem. 281, 12941-12949
   Abstract »    Full Text »    PDF »
Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade.
M. A. Bruno and A. C. Cuello (2006)
PNAS 103, 6735-6740
   Abstract »    Full Text »    PDF »
Neurologic links between epilepsy and depression in women: Is hippocampal neuroplasticity the key?.
T. Hajszan and N. J. MacLusky (2006)
Neurology 66, S13-S22
   Abstract »    Full Text »
Postnatal Expression Profile of OBCAM Implies its Involvement in Visual Cortex Development and Plasticity.
P. Li, S.S. Prasad, D.E. Mitchell, A. Hachisuka, J.-I. Sawada, A.M. Al-Housseini, and Q. Gu (2006)
Cereb Cortex 16, 291-299
   Abstract »    Full Text »    PDF »
Age-dependent Spontaneous Hyperexcitability and Impairment of GABAergic Function in the Hippocampus of Mice Lacking trkB.
M. A. Carmona, E. Pozas, A. Martinez, J. F. Espinosa-Parrilla, E. Soriano, and F. Aguado (2006)
Cereb Cortex 16, 47-63
   Abstract »    Full Text »    PDF »
Deltamethrin, a Pyrethroid Insecticide, Is a Potent Inducer for the Activity-Dependent Gene Expression of Brain-Derived Neurotrophic Factor in Neurons.
L. Imamura, M. Yasuda, K. Kuramitsu, D. Hara, A. Tabuchi, and M. Tsuda (2006)
J. Pharmacol. Exp. Ther. 316, 136-143
   Abstract »    Full Text »    PDF »
Axonal metabolic recovery and potential neuroprotective effect of glatiramer acetate in relapsing-remitting multiple sclerosis.
O. Khan, Y. Shen, C. Caon, F e. Bao, W. Ching, M. Reznar, A. Buccheister, J. Hu, Z. Latif, A. Tselis, et al. (2005)
Multiple Sclerosis 11, 646-651
   Abstract »    PDF »
PolyADP-Ribosylation Is Involved in Neurotrophic Activity.
L. Visochek, R. A. Steingart, I. Vulih-Shultzman, R. Klein, E. Priel, I. Gozes, and M. Cohen-Armon (2005)
J. Neurosci. 25, 7420-7428
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor in Amygdala-Dependent Learning.
L. M. Rattiner, M. Davis, and K. J. Ressler (2005)
Neuroscientist 11, 323-333
   Abstract »    PDF »
Programmed and Induced Phenotype of the Hippocampal Granule Cells.
G. Gomez-Lira, M. Lamas, H. Romo-Parra, and R. Gutierrez (2005)
J. Neurosci. 25, 6939-6946
   Abstract »    Full Text »    PDF »
Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle Cells.
W. J. Moody and M. M. Bosma (2005)
Physiol Rev 85, 883-941
   Abstract »    Full Text »    PDF »
Nerve Growth Factor Rapidly Increases Muscarinic Tone in Mouse Medial Septum/Diagonal Band of Broca.
C.-w. K. Wu and H. H. Yeh (2005)
J. Neurosci. 25, 4232-4242
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus.
M. Sairanen, G. Lucas, P. Ernfors, M. Castren, and E. Castren (2005)
J. Neurosci. 25, 1089-1094
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor Induces Mammalian Target of Rapamycin-Dependent Local Activation of Translation Machinery and Protein Synthesis in Neuronal Dendrites.
N. Takei, N. Inamura, M. Kawamura, H. Namba, K. Hara, K. Yonezawa, and H. Nawa (2004)
J. Neurosci. 24, 9760-9769
   Abstract »    Full Text »    PDF »
Neuronal Roles of the Integrin-associated Protein (IAP/CD47) in Developing Cortical Neurons.
T. Numakawa, T. Ishimoto, S. Suzuki, Y. Numakawa, N. Adachi, T. Matsumoto, D. Yokomaku, H. Koshimizu, K. E. Fujimori, R. Hashimoto, et al. (2004)
J. Biol. Chem. 279, 43245-43253
   Abstract »    Full Text »    PDF »
Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications.
R. Arnon and R. Aharoni (2004)
PNAS 101, 14593-14598
   Abstract »    Full Text »    PDF »
Expression of Brain-Derived Neurotrophic Factor and Its Receptors in the Median Eminence Cells with Sensitivity to Stress.
L. Givalois, S. Arancibia, G. Alonso, and L. Tapia-Arancibia (2004)
Endocrinology 145, 4737-4747
   Abstract »    Full Text »    PDF »
Long-Lasting Rescue of Age-Associated Deficits in Cognition and the CNS Cholinergic Phenotype by a Partial Agonist Peptidomimetic Ligand of TrkA.
M. A. Bruno, P. B. S. Clarke, A. Seltzer, R. Quirion, K. Burgess, A. C. Cuello, and H. U. Saragovi (2004)
J. Neurosci. 24, 8009-8018
   Abstract »    Full Text »    PDF »
Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations.
M. Ribases, M. Gratacos, F. Fernandez-Aranda, L. Bellodi, C. Boni, M. Anderluh, M. C. Cavallini, E. Cellini, D. Di Bella, S. Erzegovesi, et al. (2004)
Hum. Mol. Genet. 13, 1205-1212
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B Involvement in Amygdala-Dependent Fear Conditioning.
L. M. Rattiner, M. Davis, C. T. French, and K. J. Ressler (2004)
J. Neurosci. 24, 4796-4806
   Abstract »    Full Text »    PDF »
Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2.
C. Rivera, J. Voipio, J. Thomas-Crusells, H. Li, Z. Emri, S. Sipila, J. A. Payne, L. Minichiello, M. Saarma, and K. Kaila (2004)
J. Neurosci. 24, 4683-4691
   Abstract »    Full Text »    PDF »
Regulations of Methamphetamine Reward by Extracellular Signal-Regulated Kinase 1/2/ets-Like Gene-1 Signaling Pathway via the Activation of Dopamine Receptors.
H. Mizoguchi, K. Yamada, M. Mizuno, T. Mizuno, A. Nitta, Y. Noda, and T. Nabeshima (2004)
Mol. Pharmacol. 65, 1293-1301
   Abstract »    Full Text »
Galectin-1 induces astrocyte differentiation, which leads to production of brain-derived neurotrophic factor.
T. Sasaki, J. Hirabayashi, H. Manya, K.-i. Kasai, and T. Endo (2004)
Glycobiology 14, 357-363
   Abstract »    Full Text »    PDF »
Life Stress, Genes, and Depression: Multiple Pathways Lead to Increased Risk and New Opportunities for Intervention.
D. S. Charney and H. K. Manji (2004)
Sci. STKE 2004, re5
   Abstract »    Full Text »    PDF »
Timing of brain-derived neurotrophic factor exposure affects life expectancy of new neurons.
B. Alvarez-Borda, B. Haripal, and F. Nottebohm (2004)
PNAS 101, 3957-3961
   Abstract »    Full Text »    PDF »
Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling.
S. Kawa, J. Fujimoto, T. Tezuka, T. Nakazawa, and T. Yamamoto (2004)
Genes Cells 9, 219-232
   Abstract »    Full Text »    PDF »
A Single Infusion of Brain-Derived Neurotrophic Factor into the Ventral Tegmental Area Induces Long-Lasting Potentiation of Cocaine Seeking after Withdrawal.
L. Lu, J. Dempsey, S. Y. Liu, J. M. Bossert, and Y. Shaham (2004)
J. Neurosci. 24, 1604-1611
   Abstract »    Full Text »    PDF »
Glatiramer acetate-specific T cells in the brain express T helper 2/3 cytokines and brain-derived neurotrophic factor in situ.
R. Aharoni, B. Kayhan, R. Eilam, M. Sela, and R. Arnon (2003)
PNAS 100, 14157-14162
   Abstract »    Full Text »    PDF »
Voltage-gated Na+ channel activation induces both action potentials in utricular hair cells and brain-derived neurotrophic factor release in the rat utricle during a restricted period of development.
C. Chabbert, I. Mechaly, V. Sieso, P. Giraud, A. Brugeaud, J. Lehouelleur, F. Couraud, J. Valmier, and A. Sans (2003)
J. Physiol. 553, 113-123
   Abstract »    Full Text »    PDF »
A Rapid Increase in the Total Number of Cell Surface Functional GABAA Receptors Induced by Brain-derived Neurotrophic Factor in Rat Visual Cortex.
Y. Mizoguchi, T. Kanematsu, M. Hirata, and J. Nabekura (2003)
J. Biol. Chem. 278, 44097-44102
   Abstract »    Full Text »    PDF »
Brain-derived neurotrophic factor-dependent unmasking of """silent""" synapses in the developing mouse barrel cortex.
C. Itami, F. Kimura, T. Kohno, M. Matsuoka, M. Ichikawa, T. Tsumoto, and S. Nakamura (2003)
PNAS 100, 13069-13074
   Abstract »    Full Text »    PDF »
Nerve Growth Factor-induced Glutamate Release Is via p75 Receptor, Ceramide, and Ca2+ from Ryanodine Receptor in Developing Cerebellar Neurons.
T. Numakawa, H. Nakayama, S. Suzuki, T. Kubo, F. Nara, Y. Numakawa, D. Yokomaku, T. Araki, T. Ishimoto, A. Ogura, et al. (2003)
J. Biol. Chem. 278, 41259-41269
   Abstract »    Full Text »    PDF »
In Vivo Expression of Neurotrophins and Neurotrophin Receptors Is Conserved in Adult Porcine Retina In Vitro.
M. Garcia, V. Forster, D. Hicks, and E. Vecino (2003)
Invest. Ophthalmol. Vis. Sci. 44, 4532-4541
   Abstract »    Full Text »    PDF »
Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens.
B. Kolb, G. Gorny, Y. Li, A.-N. Samaha, and T. E. Robinson (2003)
PNAS 100, 10523-10528
   Abstract »    Full Text »    PDF »
The Neurotrophins Nerve Growth Factor, Brain-derived Neurotrophic Factor, Neurotrophin-3, and Neurotrophin-4 Are Survival and Activation Factors for Eosinophils in Patients with Allergic Bronchial Asthma.
C. Nassenstein, A. Braun, V. J. Erpenbeck, M. Lommatzsch, S. Schmidt, N. Krug, W. Luttmann, H. Renz, and J. C. Virchow Jr. (2003)
J. Exp. Med. 198, 455-467
   Abstract »    Full Text »    PDF »
Presence and Localization of Neurotrophins and Neurotrophin Receptors in Rat Lacrimal Gland.
E. Ghinelli, J. Johansson, J. D. Rios, L.-L. Chen, D. Zoukhri, R. R. Hodges, and D. A. Dartt (2003)
Invest. Ophthalmol. Vis. Sci. 44, 3352-3357
   Abstract »    Full Text »    PDF »
Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects.
Y. Dwivedi, H. S. Rizavi, R. R. Conley, R. C. Roberts, C. A. Tamminga, and G. N. Pandey (2003)
Arch Gen Psychiatry 60, 804-815
   Abstract »    Full Text »    PDF »
Transcriptional Activation of the Human Brain-derived Neurotrophic Factor Gene Promoter III by Dopamine Signaling in NT2/N Neurons.
H. Fang, J. Chartier, C. Sodja, A. Desbois, M. Ribecco-Lutkiewicz, P. R. Walker, and M. Sikorska (2003)
J. Biol. Chem. 278, 26401-26409
   Abstract »    Full Text »    PDF »
Inhibitory But Not Excitatory Cortical Neurons Require Presynaptic Brain-Derived Neurotrophic Factor for Dendritic Development, as Revealed by Chimera Cell Culture.
K. Kohara, A. Kitamura, N. Adachi, M. Nishida, C. Itami, S. Nakamura, and T. Tsumoto (2003)
J. Neurosci. 23, 6123-6131
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor Mediates Activity-Dependent Dendritic Growth in Nonpyramidal Neocortical Interneurons in Developing Organotypic Cultures.
X. Jin, H. Hu, P. H. Mathers, and A. Agmon (2003)
J. Neurosci. 23, 5662-5673
   Abstract »    Full Text »    PDF »
BDNF is Upregulated by Postnatal Development and Visual Experience: Quantitative and Immunohistochemical Analyses of BDNF in the Rat Retina.
M. Seki, H. Nawa, T. Fukuchi, H. Abe, and N. Takei (2003)
Invest. Ophthalmol. Vis. Sci. 44, 3211-3218
   Abstract »    Full Text »    PDF »
Neurotrophin 4/5 is required for the normal development of the slow muscle fiber phenotype in the rat soleus.
D. I. Carrasco and A. W. English (2003)
J. Exp. Biol. 206, 2191-2200
   Abstract »    Full Text »    PDF »
Individual and Combined Effects of TrkA and p75NTR Nerve Growth Factor Receptors: A ROLE FOR THE HIGH AFFINITY RECEPTOR SITE.
S. P. Lad, D. A. Peterson, R. A. Bradshaw, and K. E. Neet (2003)
J. Biol. Chem. 278, 24808-24817
   Abstract »    Full Text »    PDF »
Differential Effects of Neurotrophins and Schwann Cell-Derived Signals on Neuronal Survival/Growth and Synaptogenesis.
H. B. Peng, J.-F. Yang, Z. Dai, C. W. Lee, H. W. Hung, Z. H. Feng, and C.-P. Ko (2003)
J. Neurosci. 23, 5050-5060
   Abstract »    Full Text »    PDF »
The action of BDNF on GABAA currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons.
Y. Mizoguchi, H. Ishibashi, and J. Nabekura (2003)
J. Physiol. 548, 703-709
   Abstract »    Full Text »    PDF »
Pituitary Adenylate Cyclase-activating Polypeptide (PACAP(1-38)) Enhances N-Methyl-D-aspartate Receptor Function and Brain-derived Neurotrophic Factor Expression via RACK1.
R. Yaka, D.-Y. He, K. Phamluong, and D. Ron (2003)
J. Biol. Chem. 278, 9630-9638
   Abstract »    Full Text »    PDF »
BDNF and Activity-Dependent Synaptic Modulation.
B. Lu (2003)
Learn. Mem. 10, 86-98
   Abstract »    Full Text »    PDF »
Time-Dependent Increases in Brain-Derived Neurotrophic Factor Protein Levels within the Mesolimbic Dopamine System after Withdrawal from Cocaine: Implications for Incubation of Cocaine Craving.
J. W. Grimm, L. Lu, T. Hayashi, B. T. Hope, T.-P. Su, and Y. Shaham (2003)
J. Neurosci. 23, 742-747
   Abstract »    Full Text »    PDF »
Plasticity in Respiratory Motor Control: Invited Review: Neuroplasticity in respiratory motor control.
G. S. Mitchell and S. M. Johnson (2003)
J Appl Physiol 94, 358-374
   Abstract »    Full Text »    PDF »
Telomerase Mediates the Cell Survival-Promoting Actions of Brain-Derived Neurotrophic Factor and Secreted Amyloid Precursor Protein in Developing Hippocampal Neurons.
W. Fu, C. Lu, and M. P. Mattson (2002)
J. Neurosci. 22, 10710-10719
   Abstract »    Full Text »    PDF »
Reconsidering Punitive and Harsh Discipline.
W. K. Mohr and J. A. Anderson (2002)
The Journal of School Nursing 18, 346-352
   Abstract »    Full Text »    PDF »
Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy.
T. Ziemssen, T. Kumpfel, W. E. F. Klinkert, O. Neuhaus, and R. Hohlfeld (2002)
Brain 125, 2381-2391
   Abstract »    Full Text »    PDF »
Regulation of TRKB Surface Expression by Brain-derived Neurotrophic Factor and Truncated TRKB Isoforms.
A. Haapasalo, I. Sipola, K. Larsson, K. E. O. Akerman, P. Stoilov, S. Stamm, G. Wong, and E. Castren (2002)
J. Biol. Chem. 277, 43160-43167
   Abstract »    Full Text »    PDF »
Effects of rearing temperature on sympathoadrenal activity in young adult rats.
J. B. Young, J. Weiss, and N. Boufath (2002)
Am J Physiol Regulatory Integrative Comp Physiol 283, R1198-R1209
   Abstract »    Full Text »    PDF »
NEUROSCIENCE: New Insights into Neuron-Glia Communication.
R. D. Fields and B. Stevens-Graham (2002)
Science 298, 556-562
   Abstract »    Full Text »    PDF »
Involvement of an Upstream Stimulatory Factor as Well as cAMP-responsive Element-binding Protein in the Activation of Brain-derived Neurotrophic Factor Gene Promoter I.
A. Tabuchi, H. Sakaya, T. Kisukeda, H. Fushiki, and M. Tsuda (2002)
J. Biol. Chem. 277, 35920-35931
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor Triggers Transcription-Dependent, Late Phase Long-Term Potentiation In Vivo.
E. Messaoudi, S.-W. Ying, T. Kanhema, S. D. Croll, and C. R. Bramham (2002)
J. Neurosci. 22, 7453-7461
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor Promotes the Maturation of GABAergic Mechanisms in Cultured Hippocampal Neurons.
M. K. Yamada, K. Nakanishi, S. Ohba, T. Nakamura, Y. Ikegaya, N. Nishiyama, and N. Matsuki (2002)
J. Neurosci. 22, 7580-7585
   Abstract »    Full Text »    PDF »
Plastic Changes in the Central Auditory System After Hearing Loss, Restoration of Function, and During Learning.
J. Syka (2002)
Physiol Rev 82, 601-636
   Abstract »    Full Text »    PDF »
Effects of Infantile/Prepubertal Chronic Estrogen Treatment and Chemical Sympathectomy with Guanethidine on Developing Cholinergic Nerves of the Rat Uterus.
A. Richeri, L. Viettro, R. Chavez-Genaro, G. Burnstock, T. Cowen, and M. M. Brauer (2002)
J. Histochem. Cytochem. 50, 839-850
   Abstract »    Full Text »    PDF »
Late-Stage Immature Neocortical Neurons Reconstruct Interhemispheric Connections and Form Synaptic Contacts with Increased Efficiency in Adult Mouse Cortex Undergoing Targeted Neurodegeneration.
R. A. Fricker-Gates, J. J. Shin, C. C. Tai, L. A. Catapano, and J. D. Macklis (2002)
J. Neurosci. 22, 4045-4056
   Abstract »    Full Text »    PDF »
Neurotrophin secretion from hippocampal neurons evoked by long-term-potentiation-inducing electrical stimulation patterns.
A. Gartner and V. Staiger (2002)
PNAS 99, 6386-6391
   Abstract »    Full Text »    PDF »
Estrogen Regulates the Development of Brain-Derived Neurotrophic Factor mRNA and Protein in the Rat Hippocampus.
D. T. Solum and R. J. Handa (2002)
J. Neurosci. 22, 2650-2659
   Abstract »    Full Text »    PDF »
Effects of litter size on sympathetic activity in young adult rats.
J. B. Young (2002)
Am J Physiol Regulatory Integrative Comp Physiol 282, R1113-R1121
   Abstract »    Full Text »    PDF »
Postsynaptic Induction of BDNF-Mediated Long-Term Potentiation.
Y. Kovalchuk, E. Hanse, K. W. Kafitz, and A. Konnerth (2002)
Science 295, 1729-1734
   Abstract »    Full Text »    PDF »
Nitric oxide down-regulates brain-derived neurotrophic factor secretion in cultured hippocampal neurons.
M. Canossa, E. Giordano, S. Cappello, C. Guarnieri, and S. Ferri (2002)
PNAS
   Abstract »    Full Text »    PDF »
Brain-derived Neurotrophic Factor-induced Potentiation of Ca2+ Oscillations in Developing Cortical Neurons.
T. Numakawa, S. Yamagishi, N. Adachi, T. Matsumoto, D. Yokomaku, M. Yamada, and H. Hatanaka (2002)
J. Biol. Chem. 277, 6520-6529
   Abstract »    Full Text »    PDF »
Book Review: Neurotrophins and Plasticity in the Visual Cortex.
M. Caleo and L. Maffei (2002)
Neuroscientist 8, 52-61
   Abstract »    PDF »
Delphilin: a Novel PDZ and Formin Homology Domain-Containing Protein that Synaptically Colocalizes and Interacts with Glutamate Receptor delta 2 Subunit.
Y. Miyagi, T. Yamashita, M. Fukaya, T. Sonoda, T. Okuno, K. Yamada, M. Watanabe, Y. Nagashima, I. Aoki, K. Okuda, et al. (2002)
J. Neurosci. 22, 803-814
   Abstract »    Full Text »    PDF »
Expression of the Nerve Growth Factor Receptors TrkA and p75NTR in the Visual Cortex of the Rat: Development and Regulation by the Cholinergic Input.
F. M. Rossi, R. Sala, and L. Maffei (2002)
J. Neurosci. 22, 912-919
   Abstract »    Full Text »    PDF »
Mechanisms of the Release of Anterogradely Transported Neurotrophin-3 from Axon Terminals.
X. Wang, R. Butowt, M. R. Vasko, and C. S. von Bartheld (2002)
J. Neurosci. 22, 931-945
   Abstract »    Full Text »    PDF »
A caged Ab reveals an immediate/instructive effect of BDNF during hippocampal synaptic potentiation.
A. H. Kossel, S. B. Cambridge, U. Wagner, and T. Bonhoeffer (2001)
PNAS
   Abstract »    Full Text »    PDF »
An Activity-Dependent Neurotrophin-3 Autocrine Loop Regulates the Phenotype of Developing Hippocampal Pyramidal Neurons before Target Contact.
H. Boukhaddaoui, V. Sieso, F. Scamps, and J. Valmier (2001)
J. Neurosci. 21, 8789-8797
   Abstract »    Full Text »    PDF »
Neurotrophins are key mediators of the myelination program in the peripheral nervous system.
J. R. Chan, J. M. Cosgaya, Y. J. Wu, and E. M. Shooter (2001)
PNAS
   Abstract »    Full Text »    PDF »
Brain-derived Neurotrophic Factor Enhances Neuronal Translation by Activating Multiple Initiation Processes. COMPARISON WITH THE EFFECTS OF INSULIN.
N. Takei, M. Kawamura, K. Hara, K. Yonezawa, and H. Nawa (2001)
J. Biol. Chem. 276, 42818-42825
   Abstract »    Full Text »    PDF »
Retrograde signaling at central synapses.
H. W. Tao and M.-m. Poo (2001)
PNAS 98, 11009-11015
   Abstract »    Full Text »    PDF »
BDNF Enhances Quantal Neurotransmitter Release and Increases the Number of Docked Vesicles at the Active Zones of Hippocampal Excitatory Synapses.
W. J. Tyler and L. D. Pozzo-Miller (2001)
J. Neurosci. 21, 4249-4258
   Abstract »    Full Text »    PDF »
Effects of Early Visual Experience and Diurnal Rhythms on BDNF mRNA and Protein Levels in the Visual System, Hippocampus, and Cerebellum.
G. S. Pollock, E. Vernon, M. E. Forbes, Q. Yan, Y.-T. Ma, T. Hsieh, R. Robichon, D. O. Frost, and J. E. Johnson (2001)
J. Neurosci. 21, 3923-3931
   Abstract »    Full Text »    PDF »
Nerve Growth Factor Rapidly Induces Prolonged Acetylcholine Release from Cultured Basal Forebrain Neurons: Differentiation between Neuromodulatory and Neurotrophic Influences.
D. S. Auld, F. Mennicken, and R. Quirion (2001)
J. Neurosci. 21, 3375-3382
   Abstract »    Full Text »    PDF »
Spatiotemporal Dynamics of Brain-Derived Neurotrophic Factor mRNA Induction in the Vestibulo-Olivary Network during Vestibular Compensation.
Y. X. Li, T. Hashimoto, W. Tokuyama, Y. Miyashita, and H. Okuno (2001)
J. Neurosci. 21, 2738-2748
   Abstract »    Full Text »    PDF »
Mechanism for Increased Hippocampal Synaptic Strength Following Differential Experience.
T. C. Foster and T. C. Dumas (2001)
J Neurophysiol 85, 1377-1383
   Abstract »    Full Text »    PDF »
Multiple Distinct Signal Pathways, Including an Autocrine Neurotrophic Mechanism, Contribute to the Survival-Promoting Effect of Depolarization on Spiral Ganglion Neurons In Vitro.
M. R. Hansen, X.-M. Zha, J. Bok, and S. H. Green (2001)
J. Neurosci. 21, 2256-2267
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)