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Science 13 October 1995:
Vol. 270. no. 5234, pp. 296 - 299
DOI: 10.1126/science.270.5234.296
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Reports

Requirement for Generation of HO for Platelet-Derived Growth Factor Signal Transduction

Maitrayee Sundaresan,  Zu-Xi Yu,  Victor J. Ferrans,  Kaikobad Irani,  Toren Finkel (1)

Stimulation of rat vascular smooth muscle cells (VSMCs) by platelet-derived growth factor (PDGF) transiently increased the intracellular concentration of hydrogen peroxide (H(2)O(2)). This increase could be blunted by increasing the intracellular concentration of the scavenging enzyme catalase or by the chemical antioxidant N-acetylcysteine. The response of VSMCs to PDGF, which includes tyrosine phosphorylation, mitogen-activated protein kinase stimulation, DNA synthesis, and chemotaxis, was inhibited when the growth factor-stimulated rise in H(2)O(2) concentration was blocked. These results suggest that H(2)O(2) may act as a signal-transducing molecule, and they suggest a potential mechanism for the cardioprotective effects of antioxidants.

M. Sundaresan, K. Irani, T. Finkel, Cardiology Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892-1650, USA.  Z.-X. Yu and V. J. Ferrans, Pathology Section, NHLBI, NIH, Bethesda, MD 20892-1518, USA.  
(1) To whom correspondence should be addressed 


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Critical Role of Phospholipase C{gamma}1 in the Generation of H2O2-evoked [Ca2+]i Oscillations in Cultured Rat Cortical Astrocytes.
J. H. Hong, S. J. Moon, H. M. Byun, M. S. Kim, H. Jo, Y. S. Bae, S.-I. Lee, M. D. Bootman, H. L. Roderick, D. M. Shin, et al. (2006)
J. Biol. Chem. 281, 13057-13067
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Molecular Cloning and Functional Characterization of a Cell-permeable Superoxide Dismutase Targeted to Lung Adenocarcinoma Cells: INHIBITION CELL PROLIFERATION THROUGH THE Akt/p27kip1 PATHWAY.
M. Lu, X. Gong, Y. Lu, J. Guo, C. Wang, and Y. Pan (2006)
J. Biol. Chem. 281, 13620-13627
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Mitochondrial localization of catalase provides optimal protection from H2O2-induced cell death in lung epithelial cells.
Y. Arita, S. H. Harkness, J. A. Kazzaz, H.-c. Koo, A. Joseph, J.A. Melendez, J. M. Davis, A. Chander, and Y. Li (2006)
Am J Physiol Lung Cell Mol Physiol 290, L978-L986
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Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging.
B. J. Wu, K. Kathir, P. K. Witting, K. Beck, K. Choy, C. Li, K. D. Croft, T. A. Mori, D. Tanous, M. R. Adams, et al. (2006)
J. Exp. Med. 203, 1117-1127
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Antioxidants Inhibit the Ability of Lysophosphatidylcholine to Regulate Proteoglycan Synthesis.
M. Y. Chang, C.-Y. Han, T. N. Wight, and A. Chait (2006)
Arterioscler Thromb Vasc Biol 26, 494-500
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Redox-Sensitive Proteins Are Potential Targets of Garlic-Derived Mercaptocysteine Derivatives.
J. T. Pinto, B. F. Krasnikov, and A. J. L. Cooper (2006)
J. Nutr. 136, 835S-841S
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Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir..
J. Alexandre, C. Nicco, C. Chereau, A. Laurent, B. Weill, F. Goldwasser, and F. Batteux (2006)
J Natl Cancer Inst 98, 236-244
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Nox2 and Rac1 Regulate H2O2-Dependent Recruitment of TRAF6 to Endosomal Interleukin-1 Receptor Complexes.
Q. Li, M. M. Harraz, W. Zhou, L. N. Zhang, W. Ding, Y. Zhang, T. Eggleston, C. Yeaman, B. Banfi, and J. F. Engelhardt (2006)
Mol. Cell. Biol. 26, 140-154
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Platelet-Derived Growth Factor-Induced p42/44 Mitogen-Activated Protein Kinase Activation and Cellular Growth Is Mediated by Reactive Oxygen Species in the Absence of TSC2/Tuberin.
G. A. Finlay, V. J. Thannickal, B. L. Fanburg, and D. J. Kwiatkowski (2005)
Cancer Res. 65, 10881-10890
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Impaired Generation of Reactive Oxygen Species in Leprechaunism Through Downregulation of Nox4.
H. S. Park, D. K. Jin, S. M. Shin, M. K. Jang, N. Longo, J. W. Park, D. S. Bae, and Y. S. Bae (2005)
Diabetes 54, 3175-3181
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A Prodrug of Cysteine, L-2-Oxothiazolidine-4-carboxylic Acid, Regulates Vascular Permeability by Reducing Vascular Endothelial Growth Factor Expression in Asthma.
K. S. Lee, H. S. Park, S. J. Park, S. R. Kim, K. H. Min, S. M. Jin, K.-H. Park, U.-H. Kim, C. Y. Kim, and Y. C. Lee (2005)
Mol. Pharmacol. 68, 1281-1290
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Oxidative Stress and the Vascular Wall: NADPH Oxidases Take Center Stage.
J. F. Keaney Jr (2005)
Circulation 112, 2585-2588
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Novel Roles for Nox Oxidases in Cardiac Arrhythmia and Oxidized Glutathione Export in Endothelial Function.
M. S. Wolin and S. A. Gupte (2005)
Circ. Res. 97, 612-614
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Gene expression profiling reveals a signaling role of glutathione in redox regulation.
M. Fratelli, L. O. Goodwin, U. A. Orom, S. Lombardi, R. Tonelli, M. Mengozzi, and P. Ghezzi (2005)
PNAS 102, 13998-14003
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Redox Equilibrium in Mucosal T Cells Tunes the Intestinal TCR Signaling Threshold.
B. M. R. Reyes, S. Danese, M. Sans, C. Fiocchi, and A. D. Levine (2005)
J. Immunol. 175, 2158-2166
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A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.
N. K. Lee, Y. G. Choi, J. Y. Baik, S. Y. Han, D.-w. Jeong, Y. S. Bae, N. Kim, and S. Y. Lee (2005)
Blood 106, 852-859
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Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor.
K. Matsushita, C. N. Morrell, R. J.A. Mason, M. Yamakuchi, F. A. Khanday, K. Irani, and C. J. Lowenstein (2005)
J. Cell Biol. 170, 73-79
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