Science 29 September 1995: Vol. 269. no. 5232, pp. 1875 - 1877 DOI: 10.1126/science.7569929

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Articles

Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function.

D. Trageser, I. Iacobucci, R. Nahar, C. Duy, G. von Levetzow, L. Klemm, E. Park, W. Schuh, T. Gruber, S. Herzog, et al. (2009)
J. Exp. Med. 206, 1739-1753
 |  Abstract »  |  Full Text »  |  PDF »

Butein Suppresses Constitutive and Inducible Signal Transducer and Activator of Transcription (STAT) 3 Activation and STAT3-Regulated Gene Products through the Induction of a Protein Tyrosine Phosphatase SHP-1.

M. K. Pandey, B. Sung, K. S. Ahn, and B. B. Aggarwal (2009)
Mol. Pharmacol. 75, 525-533
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive nuclear import of latent and activated STAT5a by its coiled coil domain.

J. Iyer and N. C. Reich (2008)
FASEB J 22, 391-400
 |  Abstract »  |  Full Text »  |  PDF »

Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells.

A. K. Pathak, M. Bhutani, A. S. Nair, K. S. Ahn, A. Chakraborty, H. Kadara, S. Guha, G. Sethi, and B. B. Aggarwal (2007)
Mol. Cancer Res. 5, 943-955
 |  Abstract »  |  Full Text »  |  PDF »

Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-{kappa}B-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.

A. Bhardwaj, G. Sethi, S. Vadhan-Raj,, C. Bueso-Ramos, Y. Takada, U. Gaur, A. S. Nair, S. Shishodia, and B. B. Aggarwal (2007)
Blood 109, 2293-2302
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome-dependent down-regulation of activated Stat5A in the nucleus.

Y. Chen, X. Dai, A. L. Haas, R. Wen, and D. Wang (2006)
Blood 108, 566-574
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive tyrosine and serine phosphorylation of STAT4 in T-cells transformed with HTLV-I.

T. Higashi, J. Tsukada, Y. Yoshida, T. Mizobe, F. Mouri, Y. Minami, H. Morimoto, and Y. Tanaka (2005)
Genes Cells 10, 1153-1162
 |  Abstract »  |  Full Text »  |  PDF »

Management of Central Nervous System Lymphomas Using Monoclonal Antibodies: Challenges and Opportunities.

E. T. Wong (2005)
Clin. Cancer Res. 11, 7151s-7157s
 |  Abstract »  |  Full Text »  |  PDF »

Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog.

T. J. Boggon, Y. Li, P. W. Manley, and M. J. Eck (2005)
Blood 106, 996-1002
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: IL-4 Induces Suppressor of Cytokine Signaling-3 Expression in B Cells by a Mechanism Dependent on Activation of p38 MAPK.

S. Canfield, Y. Lee, A. Schroder, and P. Rothman (2005)
J. Immunol. 174, 2494-2498
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel Conserved Motif in the STAT Family That Is Required for Tyrosine Phosphorylation.

A. M. Gamero, S. Sakamoto, J. Montenegro, and A. C. Larner (2004)
J. Biol. Chem. 279, 12379-12385
 |  Abstract »  |  Full Text »  |  PDF »

Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.

J. L. Roberts, A. Lengi, S. M. Brown, M. Chen, Y.-J. Zhou, J. J. O'Shea, and R. H. Buckley (2004)
Blood 103, 2009-2018
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Signal Transducer and Activator of Transcription Factors in Leukemogenesis.

D. W. Sternberg and D. G. Gilliland (2004)
J. Clin. Oncol. 22, 361-371
 |  Abstract »  |  Full Text »  |  PDF »

Increased Expression of Bcl-xL and c-Myc Is Associated with Transformation by Abelson Murine Leukemia Virus.

E. J. Noronha, K. H. Sterling, and K. L. Calame (2003)
J. Biol. Chem. 278, 50915-50922
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Signal Transducer and Activator of Transcription 5 is Required for Progression of Autochthonous Prostate Cancer: Evidence from the Transgenic Adenocarcinoma of the Mouse Prostate System.

A. V. Kazansky, D. M. Spencer, and N. M. Greenberg (2003)
Cancer Res. 63, 8757-8762
 |  Abstract »  |  Full Text »  |  PDF »

Methylation-Mediated Silencing of SOCS-1 Gene in Hepatocellular Carcinoma Derived from Cirrhosis.

O. Okochi, K. Hibi, M. Sakai, S. Inoue, S. Takeda, T. Kaneko, and A. Nakao (2003)
Clin. Cancer Res. 9, 5295-5298
 |  Abstract »  |  Full Text »  |  PDF »

Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma.

J. A. Kelly, R. Spolski, P. E. Kovanen, T. Suzuki, J. Bollenbacher, C. A. Pise-Masison, M. F. Radonovich, S. Lee, N. A. Jenkins, N. G. Copeland, et al. (2003)
J. Exp. Med. 198, 79-89
 |  Abstract »  |  Full Text »  |  PDF »

Jak1 deficiency leads to enhanced Abelson-induced B-cell tumor formation.

V. Sexl, B. Kovacic, R. Piekorz, R. Moriggl, D. Stoiber, A. Hoffmeyer, R. Liebminger, O. Kudlacek, E. Weisz, K. Rothammer, et al. (2003)
Blood 101, 4937-4943
 |  Abstract »  |  Full Text »  |  PDF »

The Extreme Carboxyl Terminus of v-Abl Is Required for Lymphoid Cell Transformation by Abelson Virus.

D. Warren, D. S. Griffin, C. Mainville, and N. Rosenberg (2003)
J. Virol. 77, 4617-4625
 |  Abstract »  |  Full Text »  |  PDF »

Signal transducer and activator of transcription proteins in leukemias.

M. Benekli, M. R. Baer, H. Baumann, and M. Wetzler (2003)
Blood 101, 2940-2954
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Cellular Signaling Pathways: Prospects for Targeted Therapy in Hematological Malignancies.

F. Ravandi, M. Talpaz, and Z. Estrov (2003)
Clin. Cancer Res. 9, 535-550
 |  Abstract »  |  Full Text »  |  PDF »

JAK-STAT Signaling Mediates Gangliosides-induced Inflammatory Responses in Brain Microglial Cells.

O. S. Kim, E. J. Park, E.-h. Joe, and I. Jou (2002)
J. Biol. Chem. 277, 40594-40601
 |  Abstract »  |  Full Text »  |  PDF »

STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration.

W. Li, X. Liang, C. Kellendonk, V. Poli, and R. Taub (2002)
J. Biol. Chem. 277, 28411-28417
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B1 Can Inhibit v-Abl-Induced Lymphoid Transformation by Functioning as a Negative Regulator of Cyclin D1 Expression.

Y. Nakamura, R. J. Grumont, and S. Gerondakis (2002)
Mol. Cell. Biol. 22, 5563-5574
 |  Abstract »  |  Full Text »  |  PDF »

Functional involvement of Akt signaling downstream of Jak1 in v-Abl-induced activation of hematopoietic cells.

S. Oki, A. Limnander, N. N. Danial, and P. B. Rothman (2002)
Blood 100, 966-973
 |  Abstract »  |  Full Text »  |  PDF »

Suppressor of Cytokine Signaling 3 Inhibits Activation of NFATp.

A. Banerjee, A. S. Banks, M. C. Nawijn, X. P. Chen, and P. B. Rothman (2002)
J. Immunol. 168, 4277-4281
 |  Abstract »  |  Full Text »  |  PDF »

Activated STAT Signaling in Human Tumors Provides Novel Molecular Targets for Therapeutic Intervention.

R. Buettner, L. B. Mora, and R. Jove (2002)
Clin. Cancer Res. 8, 945-954
 |  Abstract »  |  Full Text »  |  PDF »

Pim serine/threonine kinases regulate the stability of Socs-1 protein.

X. P. Chen, J. A. Losman, S. Cowan, E. Donahue, S. Fay, B. Q. Vuong, M. C. Nawijn, D. Capece, V. L. Cohan, and P. Rothman (2002)
PNAS 99, 2175-2180
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: STAT6 Serves as a Positive and Negative Regulator of Gene Expression in IL-4-Stimulated B Lymphocytes.

A. J. Schroder, P. Pavlidis, A. Arimura, D. Capece, and P. B. Rothman (2002)
J. Immunol. 168, 996-1000
 |  Abstract »  |  Full Text »  |  PDF »

Immunoreceptor Tyrosine-Based Inhibitory Motif of the IL-4 Receptor Associates with SH2-Containing Phosphatases and Regulates IL-4-Induced Proliferation.

M. Kashiwada, C. C. Giallourakis, P.-Y. Pan, and P. B. Rothman (2001)
J. Immunol. 167, 6382-6387
 |  Abstract »  |  Full Text »  |  PDF »

The deubiquitinating enzyme DUB-2 prolongs cytokine-induced signal transducers and activators of transcription activation and suppresses apoptosis following cytokine withdrawal.

T.-S. Migone, M. Humbert, A. Rascle, D. Sanden, A. D'Andrea, and J. A. Johnston (2001)
Blood 98, 1935-1941
 |  Abstract »  |  Full Text »  |  PDF »

STAT3 is constitutively activated in Hodgkin cell lines.

D. Kube, U. Holtick, M. Vockerodt, T. Ahmadi, B. Haier, I. Behrmann, P. C. Heinrich, V. Diehl, and H. Tesch (2001)
Blood 98, 762-770
 |  Abstract »  |  Full Text »  |  PDF »

Rituximab Inactivates Signal Transducer and Activation of Transcription 3 (STAT3) Activity in B-Non-Hodgkin's Lymphoma through Inhibition of the Interleukin 10 Autocrine/Paracrine Loop and Results in Down-Regulation of Bcl-2 and Sensitization to Cytotoxic Drugs.

S. Alas and B. Bonavida (2001)
Cancer Res. 61, 5137-5144
 |  Abstract »  |  Full Text »  |  PDF »

Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neutrophils.

P. K. Epling-Burnette, B. Zhong, F. Bai, K. Jiang, R. D. Bailey, R. Garcia, R. Jove, J. Y. Djeu, T. P. Loughran Jr., and S. Wei (2001)
J. Immunol. 166, 7486-7495
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transducers and Activators of Transcription 5B Potentiates v-Src-mediated Transformation of NIH-3T3 Cells.

A. V. Kazansky and J. M. Rosen (2001)
Cell Growth Differ. 12, 1-7
 |  Abstract »  |  Full Text »

Cytokine-Stimulated T Lymphocyte Proliferation Is Regulated by p27Kip1 1.

S. Zhang, V. A. Lawless, and M. H. Kaplan (2000)
J. Immunol. 165, 6270-6277
 |  Abstract »  |  Full Text »  |  PDF »

The molecular biology of chronic myeloid leukemia.

M. W. N. Deininger, J. M. Goldman, and J. V. Melo (2000)
Blood 96, 3343-3356
 |  Full Text »  |  PDF »

Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6-independent phenotype by murine plasmacytomas and hybridomas.

R. Rawat, G. J. Rainey, C. D. Thompson, M. R. Frazier-Jessen, R. T. Brown, and R. P. Nordan (2000)
Blood 96, 3514-3521
 |  Abstract »  |  Full Text »  |  PDF »

Abl Interactor 1 Binds to Sos and Inhibits Epidermal Growth Factor- and v-Abl-Induced Activation of Extracellular Signal-Regulated Kinases.

P.-D. Fan and S. P. Goff (2000)
Mol. Cell. Biol. 20, 7591-7601
 |  Abstract »  |  Full Text »

Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of Stat5.

V. Sexl, R. Piekorz, R. Moriggl, J. Rohrer, M. P. Brown, K. D. Bunting, K. Rothammer, M. F. Roussel, and J. N. Ihle (2000)
Blood 96, 2277-2283
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6.

J.-J. Schuringa, A. T. J. Wierenga, W. Kruijer, and E. Vellenga (2000)
Blood 95, 3765-3770
 |  Abstract »  |  Full Text »  |  PDF »

The Carboxyl Terminus of v-Abl Protein Can Augment SH2 Domain Function.

D. Warren, A. J. Heilpern, K. Berg, and N. Rosenberg (2000)
J. Virol. 74, 4495-4504
 |  Abstract »  |  Full Text »

Activation of the IL-4 STAT Pathway in Rheumatoid Synovium.

U. Muller-Ladner, M. Judex, W. Ballhorn, F. Kullmann, O. Distler, K. Schlottmann, R. E. Gay, J. Scholmerich, and S. Gay (2000)
J. Immunol. 164, 3894-3901
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Constitutively Activated Stat3 Signaling Pathway Suppresses Growth of Prostate Cancer Cells.

Z. Ni, W. Lou, E. S. Leman, and A. C. Gao (2000)
Cancer Res. 60, 1225-1228
 |  Abstract »  |  Full Text »

Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains.

M. Chen, A. Cheng, F. Candotti, Y.-J. Zhou, A. Hymel, A. Fasth, L. D. Notarangelo, and J. J. O'Shea (2000)
Mol. Cell. Biol. 20, 947-956
 |  Abstract »  |  Full Text »

p53 Deficiency Increases Transformation by v-Abl and Rescues the Ability of a C-Terminally Truncated v-Abl Mutant To Induce Pre-B Lymphoma In Vivo.

X. Zou, F. Cong, M. Coutts, G. Cattoretti, S. P. Goff, and K. Calame (2000)
Mol. Cell. Biol. 20, 628-633
 |  Abstract »  |  Full Text »

Interferon-gamma Has Dual Potentials in Inhibiting or Promoting Cell Proliferation.

H. Asao and X.-Y. Fu (2000)
J. Biol. Chem. 275, 867-874
 |  Abstract »  |  Full Text »  |  PDF »

The Jak-Stat pathway in normal and perturbed hematopoiesis.

A. C. Ward, I. Touw, and A. Yoshimura (2000)
Blood 95, 19-29
 |  Full Text »  |  PDF »

Characterization of Insulin-Like Growth Factor-1-Induced Activation of the JAK/STAT Pathway in Rat Cardiomyocytes.

T. Takahashi, K. Fukuda, J. Pan, H. Kodama, M. Sano, S. Makino, T. Kato, T. Manabe, and S. Ogawa (1999)
Circ. Res. 85, 884-891
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein.

J. Turkson, T. Bowman, J. Adnane, Y. Zhang, J. Y. Djeu, M. Sekharam, D. A. Frank, L. B. Holzman, J. Wu, S. Sebti, et al. (1999)
Mol. Cell. Biol. 19, 7519-7528
 |  Abstract »  |  Full Text »  |  PDF »

A Thrombopoietin Receptor Mutant Deficient in Jak-STAT Activation Mediates Proliferation But Not Differentiation in UT-7 Cells.

M. Dorsch, N. N. Danial, P. B. Rothman, and S. P. Goff (1999)
Blood 94, 2676-2685
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transducer and Activator of Transcription 5a Influences Mammary Epithelial Cell Survival and Tumorigenesis.

R. C. Humphreys and L. Hennighausen (1999)
Cell Growth Differ. 10, 685-694
 |  Abstract »  |  Full Text »

Gene Therapy with Dominant-negative Stat3 Suppresses Growth of the Murine Melanoma B16 Tumor in Vivo.

G. Niu, R. Heller, R. Catlett-Falcone, D. Coppola, M. Jaroszeski, W. Dalton, R. Jove, and H. Yu (1999)
Cancer Res. 59, 5059-5063
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Epstein-Barr Virus-Like Virus, HVMNE, in a Macaca Nemestrina With Mycosis Fungoides.

E.D. Rivadeneira, M.G. Ferrari, R.F. Jarrett, A.A. Armstrong, P. Markham, T. Birkebak, S. Takemoto, C. Johnson-Delaney, J. Pecon-Slattery, E.A. Clark, et al. (1999)
Blood 94, 2090-2101
 |  Abstract »  |  Full Text »  |  PDF »

Differential Effects of Prolactin and src/abl Kinases on the Nuclear Translocation of STAT5B and STAT5A.

A. V. Kazansky, E. B. Kabotyanski, S. L. Wyszomierski, M. A. Mancini, and J. M. Rosen (1999)
J. Biol. Chem. 274, 22484-22492
 |  Abstract »  |  Full Text »  |  PDF »

STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells.

R. P. de Groot, J. A.M. Raaijmakers, J.-W. J. Lammers, R. Jove, and L. Koenderman (1999)
Blood 94, 1108-1112
 |  Abstract »  |  Full Text »  |  PDF »

Signaling Pathways Activated by Oncogenic Forms of Abl Tyrosine Kinase.

X. Zou and K. Calame (1999)
J. Biol. Chem. 274, 18141-18144
 |  Full Text »  |  PDF »

ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases.

M. A. Olayioye, I. Beuvink, K. Horsch, J. M. Daly, and N. E. Hynes (1999)
J. Biol. Chem. 274, 17209-17218
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase B (c-Akt), Phosphatidylinositol 3-Kinase, and STAT5 Are Activated by Erythropoietin (EPO) in HCD57 Erythroid Cells But Are Constitutively Active in an EPO-Independent, Apoptosis-Resistant Subclone (HCD57-SREI Cells).

H. Bao, S. M. Jacobs-Helber, A. E. Lawson, K. Penta, A. Wickrema, and S. T. Sawyer (1999)
Blood 93, 3757-3773
 |  Abstract »  |  Full Text »  |  PDF »

Mechanical Stretch Activates the JAK/STAT Pathway in Rat Cardiomyocytes.

J. Pan, K. Fukuda, M. Saito, J. Matsuzaki, H. Kodama, M. Sano, T. Takahashi, T. Kato, and S. Ogawa (1999)
Circ. Res. 84, 1127-1136
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis.

M. Nieborowska-Skorska, M. A. Wasik, A. Slupianek, P. Salomoni, T. Kitamura, B. Calabretta, and T. Skorski (1999)
J. Exp. Med. 189, 1229-1242
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: SOCS-1 Is a Potent Inhibitor of IL-4 Signal Transduction.

J. A. Losman, X. P. Chen, D. Hilton, and P. Rothman (1999)
J. Immunol. 162, 3770-3774
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Activation of the JAK2/STAT5 Signal Transduction Pathway Correlates With Growth Factor Independence of Megakaryocytic Leukemic Cell Lines.

R. Y. Liu, C. Fan, R. Garcia, R. Jove, and K. S. Zuckerman (1999)
Blood 93, 2369-2379
 |  Abstract »  |  Full Text »  |  PDF »

Sustained Receptor Activation and Hyperproliferation in Response to Granulocyte Colony-stimulating Factor (G-CSF) in Mice with a Severe Congenital Neutropenia/Acute Myeloid Leukemia-derived Mutation in the G-CSF Receptor Gene.

M. H.A. Hermans, C. Antonissen, A. C. Ward, A. E.M. Mayen, R. E. Ploemacher, and I. P. Touw (1999)
J. Exp. Med. 189, 683-692
 |  Abstract »  |  Full Text »  |  PDF »

A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation.

D. Besser, J. F. Bromberg, J. E. Darnell Jr., and H. Hanafusa (1999)
Mol. Cell. Biol. 19, 1401-1409
 |  Abstract »  |  Full Text »  |  PDF »

STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene.

N. Kiuchi, K. Nakajima, M. Ichiba, T. Fukada, M. Narimatsu, K. Mizuno, M. Hibi, and T. Hirano (1999)
J. Exp. Med. 189, 63-73
 |  Abstract »  |  Full Text »  |  PDF »

The PTK-STAT Signaling Pathway Has Essential Roles in T-cell Activation in Response to Antigen Stimulation.

T. WELTE, D. LEITENBERG, B.N. DITTEL, B.K. AL-RAMADI, W.R. HANSEN, B. XIE, C.A. JANEWAY, A.L.M. BOTHWELL, K. BOTTOMLY, and X.Y. FU (1999)
Cold Spring Harb Symp Quant Biol 64, 291-302
 |  Abstract »  |  PDF »

A Single Amino Acid in the DNA Binding Regions of STAT5A and STAT5B Confers Distinct DNA Binding Specificities.

C. Boucheron, S. Dumon, S. C. R. Santos, R. Moriggl, L. Hennighausen, S. Gisselbrecht, and F. Gouilleux (1998)
J. Biol. Chem. 273, 33936-33941
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Stat5 by Granulocyte Colony-Stimulating Factor (G-CSF) Is Modulated by Two Distinct Cytoplasmic Regions of the G-CSF Receptor.

F. Dong, X. Liu, J. P. de Koning, I. P. Touw, L. Henninghausen, A. Larner, and P. M. Grimley (1998)
J. Immunol. 161, 6503-6509
 |  Abstract »  |  Full Text »  |  PDF »

Direct Interaction of Jak1 and v-Abl Is Required for v-Abl-Induced Activation of STATs and Proliferation.

N. N. Danial, J. A. Losman, T. Lu, N. Yip, K. Krishnan, J. Krolewski, S. P. Goff, J. Y. J. Wang, and P. B. Rothman (1998)
Mol. Cell. Biol. 18, 6795-6804
 |  Abstract »  |  Full Text »

IL-7 Reconstitutes Multiple Aspects of v-Abl-Mediated Signaling.

A. Banerjee and P. Rothman (1998)
J. Immunol. 161, 4611-4617
 |  Abstract »  |  Full Text »  |  PDF »

HBx Protein of Hepatitis B Virus Activates Jak1-STAT Signaling.

Y.-H. Lee and Y. Yun (1998)
J. Biol. Chem. 273, 25510-25515
 |  Abstract »  |  Full Text »  |  PDF »

Differential Binding Activity of the Transcription Factor LIL-Stat in Immature and Differentiated Normal and Leukemic Myeloid Cells.

L. M.L. Tuyt, K. Bregman, C. Lummen, W. H.A. Dokter, and E. Vellenga (1998)
Blood 92, 1364-1373
 |  Abstract »  |  Full Text »  |  PDF »

Role of Tyrosine Kinases in Induction of the c-jun Proto-oncogene in Irradiated B-lineage Lymphoid Cells.

P. A. Goodman, L. B. Niehoff, and F. M. Uckun (1998)
J. Biol. Chem. 273, 17742-17748
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation.

M. Onishi, T. Nosaka, K. Misawa, A. L.-F. Mui, D. Gorman, M. McMahon, A. Miyajima, and T. Kitamura (1998)
Mol. Cell. Biol. 18, 3871-3879
 |  Abstract »  |  Full Text »

The Evolution of B Precursor Leukemia in the Eµ-ret Mouse.

R. Wasserman, X.-X. Zeng, and R. R. Hardy (1998)
Blood 92, 273-282
 |  Abstract »  |  Full Text »  |  PDF »

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation.

J. Turkson, T. Bowman, R. Garcia, E. Caldenhoven, R. P. De Groot, and R. Jove (1998)
Mol. Cell. Biol. 18, 2545-2552
 |  Abstract »  |  Full Text »

Stat Proteins Control Lymphocyte Proliferation by Regulating p27Kip1 Expression.

M. H. Kaplan, C. Daniel, U. Schindler, and M. J. Grusby (1998)
Mol. Cell. Biol. 18, 1996-2003
 |  Abstract »  |  Full Text »

Activation of STAT3 by the c-Fes Protein-tyrosine Kinase.

K. L. Nelson, J. A. Rogers, T. L. Bowman, R. Jove, and T. E. Smithgall (1998)
J. Biol. Chem. 273, 7072-7077
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Jak/STAT Signaling by Activation of the Type 1 TNF Receptor.

D. Guo, J. D. Dunbar, C. H. Yang, L. M. Pfeffer, and D. B. Donner (1998)
J. Immunol. 160, 2742-2750
 |  Abstract »  |  Full Text »  |  PDF »

Autoregulation of the Stat3 Gene through Cooperation with a cAMP-responsive Element-binding Protein.

M. Ichiba, K. Nakajima, Y. Yamanaka, N. Kiuchi, and T. Hirano (1998)
J. Biol. Chem. 273, 6132-6138
 |  Abstract »  |  Full Text »  |  PDF »

Erythropoietin and Friend Virus gp55 Activate Different JAK/STAT Pathways through the Erythropoietin Receptor in Erythroid Cells.

Y. Yamamura, H. Senda, Y. Kageyama, T. Matsuzaki, M. Noda, and Y. Ikawa (1998)
Mol. Cell. Biol. 18, 1172-1180
 |  Abstract »  |  Full Text »

Cutting Edge: Constitutive Activation of TCR Signaling Molecules in IL-2-Independent Herpesvirus saimiri-Transformed T Cells.

N. Noraz, K. Saha, F. Ottones, S. Smith, and N. Taylor (1998)
J. Immunol. 160, 2042-2045
 |  Abstract »  |  Full Text »  |  PDF »

The Thrombopoietin Receptor Can Mediate Proliferation without Activation of the Jak-STAT Pathway.

M. Dorsch, P.-D. Fan, N. N. Danial, P. B. Rothman, and S. P. Goff (1997)
J. Exp. Med. 186, 1947-1955
 |  Abstract »  |  Full Text »  |  PDF »

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins.

S. Takemoto, J. C. Mulloy, A. Cereseto, T.-S. Migone, B. K. R. Patel, M. Matsuoka, K. Yamaguchi, K. Takatsuki, S. Kamihira, J. D. White, et al. (1997)
PNAS 94, 13897-13902
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Inhibition by Stat5. DIFFERENTIAL ACTIVITIES AT GROWTH-RELATED VERSUS DIFFERENTIATION-SPECIFIC PROMOTERS.

G. Luo and L.-y. Yu-Lee (1997)
J. Biol. Chem. 272, 26841-26849
 |  Abstract »  |  Full Text »  |  PDF »

JAK2 and STAT5, but not JAK1 and STAT1, Are Required for Prolactin-Induced {beta}-Lactoglobulin Transcription.

Y. Han, D. Watling, N. C. Rogers, and G. R. Stark (1997)
Mol. Endocrinol. 11, 1180-1188
 |  Abstract »  |  Full Text »

Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines.

M. Nielsen, K. Kaltoft, M. Nordahl, C. Ropke, C. Geisler, T. Mustelin, P. Dobson, A. Svejgaard, and N. Odum (1997)
PNAS 94, 6764-6769
 |  Abstract »  |  Full Text »  |  PDF »

The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma  chain and confers the ability to transmit interleukin 2-mediated signals.

M. Chen, A. Cheng, Y.-Q. Chen, A. Hymel, E. P. Hanson, L. Kimmel, Y. Minami, T. Taniguchi, P. S. Changelian, and J. J. O'Shea (1997)
PNAS 94, 6910-6915
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Activation of JAK1 in Src-transformed Cells.

G. S. Campbell, C.-L. Yu, R. Jove, and C. Carter-Su (1997)
J. Biol. Chem. 272, 2591-2594
 |  Abstract »  |  Full Text »  |  PDF »

The mouse transcription factor Stat4 is expressed in haploid male germ cells and is present in the perinuclear theca of spermatozoa.

G Herrada and D. Wolgemuth (1997)
J. Cell Sci. 110, 1543-1553
 |  Abstract »  |  PDF »

P210 and P190BCR/ABL Induce the Tyrosine Phosphorylation and DNA Binding Activity of Multiple Specific STAT Family Members.

R. L. Ilaria Jr. and R. A. Van Etten (1996)
J. Biol. Chem. 271, 31704-31710
 |  Abstract »  |  Full Text »  |  PDF »

Stat6 and Jak1 Are Common Elements in Platelet-derived Growth Factor and Interleukin-4 Signal Transduction Pathways in NIH 3T3 Fibroblasts.

B. K.R. Patel, L.-M. Wang, C.-C. Lee, W. G. Taylor, J. H. Pierce, and W. J. LaRochelle (1996)
J. Biol. Chem. 271, 22175-22182
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Interferon (IFN)-inducible Gene Expression by Retinoic Acid.

V. Kolla, D. J. Lindner, X. Weihua, E. C. Borden, and D. V. Kalvakolanu (1996)
J. Biol. Chem. 271, 10508-10514
 |  Abstract »  |  Full Text »  |  PDF »

A Gain-of-function Mutation in STAT6.

C. Daniel, A. Salvekar, and U. Schindler (2000)
J. Biol. Chem. 275, 14255-14259
 |  Abstract »  |  Full Text »  |  PDF »

FER Kinase Activation of Stat3 Is Determined by the N-terminal Sequence.

S. Priel-Halachmi, I. Ben-Dor, S. Shpungin, T. Tennenbaum, H. Molavani, M. Bachrach, S. Salzberg, and U. Nir (2000)
J. Biol. Chem. 275, 28902-28910
 |  Abstract »  |  Full Text »  |  PDF »

v-Abl Protein-tyrosine Kinase Up-regulates p21WAF-1 in Cell Cycle Arrested and Proliferating Myeloid Cells.

S. J. Khanna, R. Brown, A. D. Whetton, K. L. Ball, and C. Dive (2001)
J. Biol. Chem. 276, 11143-11150
 |  Abstract »  |  Full Text »  |  PDF »

Co-operative Effect of c-Src Tyrosine Kinase and Stat3 in Activation of Hepatocyte Growth Factor Expression in Mammary Carcinoma Cells.

W. Hung and B. Elliott (2001)
J. Biol. Chem. 276, 12395-12403
 |  Abstract »  |  Full Text »  |  PDF »

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