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Science 29 September 1995: Vol. 269. no. 5232, pp. 1872 - 1875 DOI: 10.1126/science.7569928
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Articles
Science, Vol 269, Issue 5232, 1872-1875
Copyright © 1995 by American Association for the Advancement of Science
Interaction of tyrosine-based sorting signals with clathrin-associated proteins
H Ohno,
J Stewart,
MC Fournier,
H Bosshart,
I Rhee,
S Miyatake,
T Saito,
A Gallusser,
T Kirchhausen,
and
JS Bonifacino
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Tyrosine-based signals within the cytoplasmic domain of integral membrane proteins mediate clathrin-dependent protein sorting in the endocytic and secretory pathways. A yeast two-hybrid system was used to identify proteins that bind to tyrosine-based signals. The medium chains (mu 1 and mu 2) of two clathrin-associated protein complexes (AP-1 and AP-2, respectively) specifically interacted with tyrosine-based signals of several integral membrane proteins. The interaction was confirmed by in vitro binding assays. Thus, it is likely that the medium chains serve as signal-binding components of the clathrin-dependent sorting machinery.
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- Identification of an apical sorting determinant in the cytoplasmic tail of megalin.
- T. Takeda, H. Yamazaki, and M. G. Farquhar (2003)
Am J Physiol Cell Physiol
284, C1105-C1113
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- The AP-1 Clathrin-adaptor Is Required for Lysosomal Enzymes Sorting and Biogenesis of the Contractile Vacuole Complex in Dictyostelium Cells.
- Y. Lefkir, B. de Chassey, A. Dubois, A. Bogdanovic, R. J. Brady, O. Destaing, F. Bruckert, T. J. O'Halloran, P. Cosson, and F. Letourneur (2003)
Mol. Biol. Cell
14, 1835-1851
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- A Functional YNKI Motif in the Short Cytoplasmic Tail of Varicella-Zoster Virus Glycoprotein gH Mediates Clathrin-Dependent and Antibody-Independent Endocytosis.
- T. J. Pasieka, L. Maresova, and C. Grose (2003)
J. Virol.
77, 4191-4204
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- The B Cell Coreceptor CD22 Associates with AP50, a Clathrin-Coated Pit Adapter Protein, Via Tyrosine-Dependent Interaction.
- B. John, B. R. Herrin, C. Raman, Y.-n. Wang, K. R. Bobbitt, B. A. Brody, and L. B. Justement (2003)
J. Immunol.
170, 3534-3543
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- Tyrphostin A23 Inhibits Internalization of the Transferrin Receptor by Perturbing the Interaction between Tyrosine Motifs and the Medium Chain Subunit of the AP-2 Adaptor Complex.
- D. N. Banbury, J. D. Oakley, R. B. Sessions, and G. Banting (2003)
J. Biol. Chem.
278, 12022-12028
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- YPXL/I Is a Protein Interaction Motif Recognized by Aspergillus PalA and Its Human Homologue, AIP1/Alix.
- O. Vincent, L. Rainbow, J. Tilburn, H. N. Arst Jr., and M. A. Penalva (2003)
Mol. Cell. Biol.
23, 1647-1655
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- Changing directions: clathrin-mediated transport between the Golgi and endosomes.
- I. Hinners and S. A. Tooze (2003)
J. Cell Sci.
116, 763-771
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- AP-1 in Toxoplasma gondii Mediates Biogenesis of the Rhoptry Secretory Organelle from a Post-Golgi Compartment.
- H. M. Ngo, M. Yang, K. Paprotka, M. Pypaert, H. Hoppe, and K. A. Joiner (2003)
J. Biol. Chem.
278, 5343-5352
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- Alternative Splicing Regulates the Subcellular Localization of Divalent Metal Transporter 1 Isoforms.
- M. Tabuchi, N. Tanaka, J. Nishida-Kitayama, H. Ohno, and F. Kishi (2002)
Mol. Biol. Cell
13, 4371-4387
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- Neuronal Leucine-rich Repeat Protein-3 Amplifies MAPK Activation by Epidermal Growth Factor through a Carboxyl-terminal Region Containing Endocytosis Motifs.
- K. Fukamachi, Y. Matsuoka, H. Ohno, T. Hamaguchi, and H. Tsuda (2002)
J. Biol. Chem.
277, 43549-43552
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- Role of Two Dileucine-like Motifs in Insulin Receptor Anchoring to Microvilli.
- S. Shackleton, I. Hamer, M. Foti, N. Zumwald, C. Maeder, and J.-L. Carpentier (2002)
J. Biol. Chem.
277, 43631-43637
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- Transforming Growth Factor-beta Receptors Interact with AP2 by Direct Binding to beta 2 Subunit.
- D. Yao, M. Ehrlich, Y. I. Henis, and E. B. Leof (2002)
Mol. Biol. Cell
13, 4001-4012
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- Adenovirus RID{beta} Subunit Contains a Tyrosine Residue That Is Critical for RID-Mediated Receptor Internalization and Inhibition of Fas- and TRAIL-Induced Apoptosis.
- D. L. Lichtenstein, P. Krajcsi, D. J. Esteban, A. E. Tollefson, and W. S. M. Wold (2002)
J. Virol.
76, 11329-11342
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- ARF1{middle dot}GTP, Tyrosine-based Signals, and Phosphatidylinositol 4,5-Bisphosphate Constitute a Minimal Machinery to Recruit the AP-1 Clathrin Adaptor to Membranes.
- P. Crottet, D. M. Meyer, J. Rohrer, and M. Spiess (2002)
Mol. Biol. Cell
13, 3672-3682
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- Identification of a Non-canonical Tyrosine-based Endocytic Motif in an Ionotropic Receptor.
- S. J. Royle, L. K. Bobanovic', and R. D. Murrell-Lagnado (2002)
J. Biol. Chem.
277, 35378-35385
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- Subunit H of the V-ATPase Binds to the Medium Chain of Adaptor Protein Complex 2 and Connects Nef to the Endocytic Machinery.
- M. Geyer, H. Yu, R. Mandic, T. Linnemann, Y.-H. Zheng, O. T. Fackler, and B. M. Peterlin (2002)
J. Biol. Chem.
277, 28521-28529
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- Delta/Notch-like Epidermal Growth Factor (EGF)-related Receptor, a Novel EGF-like Repeat-containing Protein Targeted to Dendrites of Developing and Adult Central Nervous System Neurons.
- M. Eiraku, Y. Hirata, H. Takeshima, T. Hirano, and M. Kengaku (2002)
J. Biol. Chem.
277, 25400-25407
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- Differential Recognition of Tyrosine-based Basolateral Signals by AP-1B Subunit {micro}1B in Polarized Epithelial Cells.
- H. Sugimoto, M. Sugahara, H. Folsch, Y. Koide, F. Nakatsu, N. Tanaka, T. Nishimura, M. Furukawa, C. Mullins, N. Nakamura, et al. (2002)
Mol. Biol. Cell
13, 2374-2382
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- Subunit H of the V-ATPase Involved in Endocytosis Shows Homology to beta -Adaptins.
- M. Geyer, O. T. Fackler, and B. M. Peterlin (2002)
Mol. Biol. Cell
13, 2045-2056
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- Tyrosine 537 within the Na+,K+-ATPase alpha -Subunit Is Essential for AP-2 Binding and Clathrin-dependent Endocytosis.
- S. C. Done, I. B. Leibiger, R. Efendiev, A. I. Katz, B. Leibiger, P.-O. Berggren, C. H. Pedemonte, and A. M. Bertorello (2002)
J. Biol. Chem.
277, 17108-17111
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