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Science 29 September 1995:
Vol. 269. no. 5232, pp. 1872 - 1875
DOI: 10.1126/science.7569928

Articles

Science, Vol 269, Issue 5232, 1872-1875
Copyright © 1995 by American Association for the Advancement of Science


articles

Interaction of tyrosine-based sorting signals with clathrin-associated proteins

H Ohno, J Stewart, MC Fournier, H Bosshart, I Rhee, S Miyatake, T Saito, A Gallusser, T Kirchhausen, and JS Bonifacino

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Tyrosine-based signals within the cytoplasmic domain of integral membrane proteins mediate clathrin-dependent protein sorting in the endocytic and secretory pathways. A yeast two-hybrid system was used to identify proteins that bind to tyrosine-based signals. The medium chains (mu 1 and mu 2) of two clathrin-associated protein complexes (AP-1 and AP-2, respectively) specifically interacted with tyrosine-based signals of several integral membrane proteins. The interaction was confirmed by in vitro binding assays. Thus, it is likely that the medium chains serve as signal-binding components of the clathrin-dependent sorting machinery.


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O. Vincent, L. Rainbow, J. Tilburn, H. N. Arst Jr., and M. A. Penalva (2003)
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   Abstract »    Full Text »    PDF »
Changing directions: clathrin-mediated transport between the Golgi and endosomes.
I. Hinners and S. A. Tooze (2003)
J. Cell Sci. 116, 763-771
   Abstract »    Full Text »    PDF »
AP-1 in Toxoplasma gondii Mediates Biogenesis of the Rhoptry Secretory Organelle from a Post-Golgi Compartment.
H. M. Ngo, M. Yang, K. Paprotka, M. Pypaert, H. Hoppe, and K. A. Joiner (2003)
J. Biol. Chem. 278, 5343-5352
   Abstract »    Full Text »    PDF »
Alternative Splicing Regulates the Subcellular Localization of Divalent Metal Transporter 1 Isoforms.
M. Tabuchi, N. Tanaka, J. Nishida-Kitayama, H. Ohno, and F. Kishi (2002)
Mol. Biol. Cell 13, 4371-4387
   Abstract »    Full Text »    PDF »
Neuronal Leucine-rich Repeat Protein-3 Amplifies MAPK Activation by Epidermal Growth Factor through a Carboxyl-terminal Region Containing Endocytosis Motifs.
K. Fukamachi, Y. Matsuoka, H. Ohno, T. Hamaguchi, and H. Tsuda (2002)
J. Biol. Chem. 277, 43549-43552
   Abstract »    Full Text »    PDF »
Role of Two Dileucine-like Motifs in Insulin Receptor Anchoring to Microvilli.
S. Shackleton, I. Hamer, M. Foti, N. Zumwald, C. Maeder, and J.-L. Carpentier (2002)
J. Biol. Chem. 277, 43631-43637
   Abstract »    Full Text »    PDF »
Transforming Growth Factor-beta Receptors Interact with AP2 by Direct Binding to beta 2 Subunit.
D. Yao, M. Ehrlich, Y. I. Henis, and E. B. Leof (2002)
Mol. Biol. Cell 13, 4001-4012
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Adenovirus RID{beta} Subunit Contains a Tyrosine Residue That Is Critical for RID-Mediated Receptor Internalization and Inhibition of Fas- and TRAIL-Induced Apoptosis.
D. L. Lichtenstein, P. Krajcsi, D. J. Esteban, A. E. Tollefson, and W. S. M. Wold (2002)
J. Virol. 76, 11329-11342
   Abstract »    Full Text »    PDF »
ARF1{middle dot}GTP, Tyrosine-based Signals, and Phosphatidylinositol 4,5-Bisphosphate Constitute a Minimal Machinery to Recruit the AP-1 Clathrin Adaptor to Membranes.
P. Crottet, D. M. Meyer, J. Rohrer, and M. Spiess (2002)
Mol. Biol. Cell 13, 3672-3682
   Abstract »    Full Text »    PDF »
Identification of a Non-canonical Tyrosine-based Endocytic Motif in an Ionotropic Receptor.
S. J. Royle, L. K. Bobanovic', and R. D. Murrell-Lagnado (2002)
J. Biol. Chem. 277, 35378-35385
   Abstract »    Full Text »    PDF »
Subunit H of the V-ATPase Binds to the Medium Chain of Adaptor Protein Complex 2 and Connects Nef to the Endocytic Machinery.
M. Geyer, H. Yu, R. Mandic, T. Linnemann, Y.-H. Zheng, O. T. Fackler, and B. M. Peterlin (2002)
J. Biol. Chem. 277, 28521-28529
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Delta/Notch-like Epidermal Growth Factor (EGF)-related Receptor, a Novel EGF-like Repeat-containing Protein Targeted to Dendrites of Developing and Adult Central Nervous System Neurons.
M. Eiraku, Y. Hirata, H. Takeshima, T. Hirano, and M. Kengaku (2002)
J. Biol. Chem. 277, 25400-25407
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Differential Recognition of Tyrosine-based Basolateral Signals by AP-1B Subunit {micro}1B in Polarized Epithelial Cells.
H. Sugimoto, M. Sugahara, H. Folsch, Y. Koide, F. Nakatsu, N. Tanaka, T. Nishimura, M. Furukawa, C. Mullins, N. Nakamura, et al. (2002)
Mol. Biol. Cell 13, 2374-2382
   Abstract »    Full Text »    PDF »
Subunit H of the V-ATPase Involved in Endocytosis Shows Homology to beta -Adaptins.
M. Geyer, O. T. Fackler, and B. M. Peterlin (2002)
Mol. Biol. Cell 13, 2045-2056
   Abstract »    Full Text »    PDF »
Tyrosine 537 within the Na+,K+-ATPase alpha -Subunit Is Essential for AP-2 Binding and Clathrin-dependent Endocytosis.
S. C. Done, I. B. Leibiger, R. Efendiev, A. I. Katz, B. Leibiger, P.-O. Berggren, C. H. Pedemonte, and A. M. Bertorello (2002)
J. Biol. Chem. 277, 17108-17111
   Abstract »    Full Text »    PDF »



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