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Science 29 September 1995:
Vol. 269. no. 5232, pp. 1854 - 1857
DOI: 10.1126/science.7569924
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Articles

Science, Vol 269, Issue 5232, 1854-1857
Copyright © 1995 by American Association for the Advancement of Science

articles

Magnetic resonance elastography by direct visualization of propagating acoustic strain waves

R Muthupillai, DJ Lomas, PJ Rossman, JF Greenleaf, A Manduca, and RL Ehman

Mayo Clinic and Foundation, Rochester, MN 55905, USA.

A nuclear magnetic resonance imaging (MRI) method is presented for quantitatively mapping the physical response of a material to harmonic mechanical excitation. The resulting images allow calculation of regional mechanical properties. Measurements of shear modulus obtained with the MRI technique in gel materials correlate with independent measurements of static shear modulus. The results indicate that displacement patterns corresponding to cyclic displacements smaller than 200 nanometers can be measured. The findings suggest the feasibility of a medical imaging technique for delineating elasticity and other mechanical properties of tissue.


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