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Science 29 September 1995:
Vol. 269. no. 5232, pp. 1835 - 1842
DOI: 10.1126/science.7569920
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Articles

Science, Vol 269, Issue 5232, 1835-1842
Copyright © 1995 by American Association for the Advancement of Science

articles

From molecular diversity to catalysis: lessons from the immune system

PG Schultz and RA Lerner

Howard Hughes Medical Institute, Department of Chemistry, University of California, Berkeley 94720, USA.

By combining the enormous molecular diversity of the immune system with basic mechanistic principles of chemistry, one can produce catalytic antibodies that allow control of reactions in ways heretofore not possible. Mechanistic and structural studies of these antibodies are also providing insights into important aspects of enzymatic catalysis and the evolution of catalytic function. Moreover, the ability to rationally direct the immune response to generate selective catalysts for reactions ranging from pericyclic and redox reactions to cationic rearrangement reactions underscores the chemical potential of this and other large combinatorial libraries.


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Immunological Origins of Binding and Catalysis in a Diels-Alderase Antibody.
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An Antibody exo Diels-Alderase Inhibitor Complex at 1.95 Angstrom Resolution.
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Phage display of a catalytic antibody to optimize affinity for transition-state analog binding.
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Analysis of highly disfavored processes through pathway-specific correlated fluorescence.
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