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Science 22 September 1995: Vol. 269. no. 5231, pp. 1737 - 1740 DOI: 10.1126/science.7569905
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Articles
Science, Vol 269, Issue 5231, 1737-1740
Copyright © 1995 by American Association for the Advancement of Science
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
HC Kornau,
LT Schenker,
MB Kennedy,
and
PH Seeburg
Center for Molecular Biology (ZMBH), University of Heidelberg, Germany.
The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission and plasticity in central neurons. The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent postsynaptic density protein PSD-95. The second PDZ domain in PSD-95 binds to the seven-amino acid, COOH-terminal domain containing the terminal tSXV motif (where S is serine, X is any amino acid, and V is valine) common to NR2 subunits and certain NR1 splice forms. Transcripts encoding PSD-95 are expressed in a pattern similar to that of NMDA receptors, and the NR2B subunit co-localizes with PSD-95 in cultured rat hippocampal neurons. The interaction of these proteins may affect the plasticity of excitatory synapses.
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- Regulation of the NMDA Receptor Complex and Trafficking by Activity-Dependent Phosphorylation of the NR2B Subunit PDZ Ligand.
- H. J. Chung, Y. H. Huang, L.-F. Lau, and R. L. Huganir (2004)
J. Neurosci.
24, 10248-10259
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- PSD-95 and Lin-7b Interact with Acid-sensing Ion Channel-3 and Have Opposite Effects on H+-gated Current.
- A. M. Hruska-Hageman, C. J. Benson, A. S. Leonard, M. P. Price, and M. J. Welsh (2004)
J. Biol. Chem.
279, 46962-46968
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- Synaptic Changes in Alzheimer's Disease: Increased Amyloid-{beta} and Gliosis in Surviving Terminals Is Accompanied by Decreased PSD-95 Fluorescence.
- K. H. Gylys, J. A. Fein, F. Yang, D. J. Wiley, C. A. Miller, and G. M. Cole (2004)
Am. J. Pathol.
165, 1809-1817
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- The C-terminal Tail of Presenilin Regulates Omi/HtrA2 Protease Activity.
- S. Gupta, R. Singh, P. Datta, Z. Zhang, C. Orr, Z. Lu, G. DuBois, A. S. Zervos, M. H. Meisler, S. M. Srinivasula, et al. (2004)
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279, 45844-45854
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- Regulation of Brain Proteolytic Activity Is Necessary for the In Vivo Function of NMDA Receptors.
- M. Kvajo, H. Albrecht, M. Meins, U. Hengst, E. Troncoso, S. Lefort, J. Z. Kiss, C. C. H. Petersen, and D. Monard (2004)
J. Neurosci.
24, 9734-9743
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- Excessive Expression of Acetylcholinesterase Impairs Glutamatergic Synaptogenesis in Hippocampal Neurons.
- H. Dong, Y.-Y. Xiang, N. Farchi, W. Ju, Y. Wu, L. Chen, Y. Wang, B. Hochner, B. Yang, H. Soreq, et al. (2004)
J. Neurosci.
24, 8950-8960
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- Vulnerability of Central Neurons to Secondary Insults after In Vitro Mechanical Stretch.
- M. Arundine, M. Aarts, A. Lau, and M. Tymianski (2004)
J. Neurosci.
24, 8106-8123
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- NMDA Receptor GluR{epsilon}/NR2 Subunits Are Essential for Postsynaptic Localization and Protein Stability of GluR{zeta}1/NR1 Subunit.
- M. Abe, M. Fukaya, T. Yagi, M. Mishina, M. Watanabe, and K. Sakimura (2004)
J. Neurosci.
24, 7292-7304
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- Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol.
- D. Ron (2004)
Neuroscientist
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- Subunit-Specific Regulation of NMDA Receptor Endocytosis.
- G. Lavezzari, J. McCallum, C. M. Dewey, and K. W. Roche (2004)
J. Neurosci.
24, 6383-6391
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- Two Discontinuous Segments in the Carboxyl Terminus Are Required for Membrane Targeting of the Rat {gamma}-Aminobutyric Acid Transporter-1 (GAT1).
- H. Farhan, V. M. Korkhov, V. Paulitschke, M. M. Dorostkar, P. Scholze, O. Kudlacek, M. Freissmuth, and H. H. Sitte (2004)
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279, 28553-28563
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- Nitric Oxide in Health and Disease of the Respiratory System.
- F. L. M. Ricciardolo, P. J. Sterk, B. Gaston, and G. Folkerts (2004)
Physiol Rev
84, 731-765
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- Molecular Structure and Physiological Functions of GABAB Receptors.
- B. Bettler, K. Kaupmann, J. Mosbacher, and M. Gassmann (2004)
Physiol Rev
84, 835-867
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- Abnormal Ca2+-Calmodulin-Dependent Protein Kinase II Function Mediates Synaptic and Motor Deficits in Experimental Parkinsonism.
- B. Picconi, F. Gardoni, D. Centonze, D. Mauceri, M. A. Cenci, G. Bernardi, P. Calabresi, and M. Di Luca (2004)
J. Neurosci.
24, 5283-5291
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- Semiquantitative Proteomic Analysis of Rat Forebrain Postsynaptic Density Fractions by Mass Spectrometry.
- J. Peng, M. J. Kim, D. Cheng, D. M. Duong, S. P. Gygi, and M. Sheng (2004)
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279, 21003-21011
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- Formation of Molecular Complexes by N-Methyl-D-aspartate Receptor Subunit NR2B and Ryanodine Receptor 2 in Neonatal Rat Myocard.
- S. Seeber, A. Humeny, M. Herkert, T. Rau, T. Eschenhagen, and C.-M. Becker (2004)
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279, 21062-21068
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- A Multiprotein Trafficking Complex Composed of SAP97, CASK, Veli, and Mint1 Is Associated with Inward Rectifier Kir2 Potassium Channels.
- D. Leonoudakis, L. R. Conti, C. M. Radeke, L. M. M. McGuire, and C. A. Vandenberg (2004)
J. Biol. Chem.
279, 19051-19063
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- Regulation of the Neuron-specific Ras GTPase-activating Protein, synGAP, by Ca2+/Calmodulin-dependent Protein Kinase II.
- J. S. Oh, P. Manzerra, and M. B. Kennedy (2004)
J. Biol. Chem.
279, 17980-17988
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- Bidirectional Regulation of Neuronal Nitric-oxide Synthase Phosphorylation at Serine 847 by the N-Methyl-D-aspartate Receptor.
- G. A. Rameau, L.-Y. Chiu, and E. B. Ziff (2004)
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- Functions of lipoprotein receptors in neurons.
- U. Beffert, P. C. Stolt, and J. Herz (2004)
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45, 403-409
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- Postsynaptic Density Assembly Is Fundamentally Different from Presynaptic Active Zone Assembly.
- T. Bresler, M. Shapira, T. Boeckers, T. Dresbach, M. Futter, C. C. Garner, K. Rosenblum, E. D. Gundelfinger, and N. E. Ziv (2004)
J. Neurosci.
24, 1507-1520
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- Cyclin-Dependent Kinase 5 Phosphorylates the N-Terminal Domain of the Postsynaptic Density Protein PSD-95 in Neurons.
- M. A. Morabito, M. Sheng, and L.-H. Tsai (2004)
J. Neurosci.
24, 865-876
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- Postsynaptic Density 95 controls AMPA Receptor Incorporation during Long-Term Potentiation and Experience-Driven Synaptic Plasticity.
- I. Ehrlich and R. Malinow (2004)
J. Neurosci.
24, 916-927
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- Developmental Decrease in NMDA Receptor Desensitization Associated with Shift to Synapse and Interaction with Postsynaptic Density-95.
- B. Li, Y. Otsu, T. H. Murphy, and L. A. Raymond (2003)
J. Neurosci.
23, 11244-11254
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- Distribution of Postsynaptic Density (PSD)-95 and Ca2+/Calmodulin-Dependent Protein Kinase II at the PSD.
- J. D. Petersen, X. Chen, L. Vinade, A. Dosemeci, J. E. Lisman, and T. S. Reese (2003)
J. Neurosci.
23, 11270-11278
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