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Science 22 September 1995:
Vol. 269. no. 5231, pp. 1737 - 1740
DOI: 10.1126/science.7569905

Articles

Science, Vol 269, Issue 5231, 1737-1740
Copyright © 1995 by American Association for the Advancement of Science


articles

Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

HC Kornau, LT Schenker, MB Kennedy, and PH Seeburg

Center for Molecular Biology (ZMBH), University of Heidelberg, Germany.

The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission and plasticity in central neurons. The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent postsynaptic density protein PSD-95. The second PDZ domain in PSD-95 binds to the seven-amino acid, COOH-terminal domain containing the terminal tSXV motif (where S is serine, X is any amino acid, and V is valine) common to NR2 subunits and certain NR1 splice forms. Transcripts encoding PSD-95 are expressed in a pattern similar to that of NMDA receptors, and the NR2B subunit co-localizes with PSD-95 in cultured rat hippocampal neurons. The interaction of these proteins may affect the plasticity of excitatory synapses.


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J. Neurosci. 24, 9734-9743
   Abstract »    Full Text »    PDF »
Excessive Expression of Acetylcholinesterase Impairs Glutamatergic Synaptogenesis in Hippocampal Neurons.
H. Dong, Y.-Y. Xiang, N. Farchi, W. Ju, Y. Wu, L. Chen, Y. Wang, B. Hochner, B. Yang, H. Soreq, et al. (2004)
J. Neurosci. 24, 8950-8960
   Abstract »    Full Text »    PDF »
Vulnerability of Central Neurons to Secondary Insults after In Vitro Mechanical Stretch.
M. Arundine, M. Aarts, A. Lau, and M. Tymianski (2004)
J. Neurosci. 24, 8106-8123
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NMDA Receptor GluR{epsilon}/NR2 Subunits Are Essential for Postsynaptic Localization and Protein Stability of GluR{zeta}1/NR1 Subunit.
M. Abe, M. Fukaya, T. Yagi, M. Mishina, M. Watanabe, and K. Sakimura (2004)
J. Neurosci. 24, 7292-7304
   Abstract »    Full Text »    PDF »
Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol.
D. Ron (2004)
Neuroscientist 10, 325-336
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Subunit-Specific Regulation of NMDA Receptor Endocytosis.
G. Lavezzari, J. McCallum, C. M. Dewey, and K. W. Roche (2004)
J. Neurosci. 24, 6383-6391
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Two Discontinuous Segments in the Carboxyl Terminus Are Required for Membrane Targeting of the Rat {gamma}-Aminobutyric Acid Transporter-1 (GAT1).
H. Farhan, V. M. Korkhov, V. Paulitschke, M. M. Dorostkar, P. Scholze, O. Kudlacek, M. Freissmuth, and H. H. Sitte (2004)
J. Biol. Chem. 279, 28553-28563
   Abstract »    Full Text »    PDF »
Nitric Oxide in Health and Disease of the Respiratory System.
F. L. M. Ricciardolo, P. J. Sterk, B. Gaston, and G. Folkerts (2004)
Physiol Rev 84, 731-765
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Molecular Structure and Physiological Functions of GABAB Receptors.
B. Bettler, K. Kaupmann, J. Mosbacher, and M. Gassmann (2004)
Physiol Rev 84, 835-867
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Abnormal Ca2+-Calmodulin-Dependent Protein Kinase II Function Mediates Synaptic and Motor Deficits in Experimental Parkinsonism.
B. Picconi, F. Gardoni, D. Centonze, D. Mauceri, M. A. Cenci, G. Bernardi, P. Calabresi, and M. Di Luca (2004)
J. Neurosci. 24, 5283-5291
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Semiquantitative Proteomic Analysis of Rat Forebrain Postsynaptic Density Fractions by Mass Spectrometry.
J. Peng, M. J. Kim, D. Cheng, D. M. Duong, S. P. Gygi, and M. Sheng (2004)
J. Biol. Chem. 279, 21003-21011
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Formation of Molecular Complexes by N-Methyl-D-aspartate Receptor Subunit NR2B and Ryanodine Receptor 2 in Neonatal Rat Myocard.
S. Seeber, A. Humeny, M. Herkert, T. Rau, T. Eschenhagen, and C.-M. Becker (2004)
J. Biol. Chem. 279, 21062-21068
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A Multiprotein Trafficking Complex Composed of SAP97, CASK, Veli, and Mint1 Is Associated with Inward Rectifier Kir2 Potassium Channels.
D. Leonoudakis, L. R. Conti, C. M. Radeke, L. M. M. McGuire, and C. A. Vandenberg (2004)
J. Biol. Chem. 279, 19051-19063
   Abstract »    Full Text »    PDF »
Regulation of the Neuron-specific Ras GTPase-activating Protein, synGAP, by Ca2+/Calmodulin-dependent Protein Kinase II.
J. S. Oh, P. Manzerra, and M. B. Kennedy (2004)
J. Biol. Chem. 279, 17980-17988
   Abstract »    Full Text »    PDF »
Bidirectional Regulation of Neuronal Nitric-oxide Synthase Phosphorylation at Serine 847 by the N-Methyl-D-aspartate Receptor.
G. A. Rameau, L.-Y. Chiu, and E. B. Ziff (2004)
J. Biol. Chem. 279, 14307-14314
   Abstract »    Full Text »    PDF »
Functions of lipoprotein receptors in neurons.
U. Beffert, P. C. Stolt, and J. Herz (2004)
J. Lipid Res. 45, 403-409
   Abstract »    Full Text »    PDF »
Postsynaptic Density Assembly Is Fundamentally Different from Presynaptic Active Zone Assembly.
T. Bresler, M. Shapira, T. Boeckers, T. Dresbach, M. Futter, C. C. Garner, K. Rosenblum, E. D. Gundelfinger, and N. E. Ziv (2004)
J. Neurosci. 24, 1507-1520
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Cyclin-Dependent Kinase 5 Phosphorylates the N-Terminal Domain of the Postsynaptic Density Protein PSD-95 in Neurons.
M. A. Morabito, M. Sheng, and L.-H. Tsai (2004)
J. Neurosci. 24, 865-876
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Postsynaptic Density 95 controls AMPA Receptor Incorporation during Long-Term Potentiation and Experience-Driven Synaptic Plasticity.
I. Ehrlich and R. Malinow (2004)
J. Neurosci. 24, 916-927
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Developmental Decrease in NMDA Receptor Desensitization Associated with Shift to Synapse and Interaction with Postsynaptic Density-95.
B. Li, Y. Otsu, T. H. Murphy, and L. A. Raymond (2003)
J. Neurosci. 23, 11244-11254
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Distribution of Postsynaptic Density (PSD)-95 and Ca2+/Calmodulin-Dependent Protein Kinase II at the PSD.
J. D. Petersen, X. Chen, L. Vinade, A. Dosemeci, J. E. Lisman, and T. S. Reese (2003)
J. Neurosci. 23, 11270-11278
   Abstract »    Full Text »    PDF »



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