Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 22 September 1995:
Vol. 269. no. 5231, pp. 1727 - 1730
DOI: 10.1126/science.7569902
Prev | Table of Contents | Next

Articles

Science, Vol 269, Issue 5231, 1727-1730
Copyright © 1995 by American Association for the Advancement of Science

articles

Activation of dual T cell signaling pathways by the chemokine RANTES

KB Bacon, BA Premack, P Gardner, and TJ Schall

Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.

The chemokine RANTES induced biphasic mobilization of Ca2+ in T cells. The initial peak, a transient increase in cytosolic Ca2+ mediated by a heterotrimeric guanine nucleotide-binding protein (G protein)--coupled pathway, was associated predominantly with chemotaxis. The second peak, Ca2+ release and sustained influx dependent on protein tyrosine kinases, was associated with a spectrum of cellular responses--Ca2+ channel opening, interleukin-2 receptor expression, cytokine release, and T cell proliferation--characteristic of T cell receptor activation. Other chemokines did not produce these responses. Thus, in addition to inducing chemotaxis, RANTES can act as an antigen-independent activator of T cells in vitro.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Distinct contributions of CD4+ T cell subsets in hepatic ischemia/reperfusion injury.
S. Kuboki, N. Sakai, J. Tschop, M. J. Edwards, A. B. Lentsch, and C. C. Caldwell (2009)
Am J Physiol Gastrointest Liver Physiol 296, G1054-G1059
   Abstract »    Full Text »    PDF »
CXC Chemokine Ligand 12 Promotes CCR7-Dependent Naive T Cell Trafficking to Lymph Nodes and Peyer's Patches.
Z. Bai, H. Hayasaka, M. Kobayashi, W. Li, Z. Guo, M. H. Jang, A. Kondo, B.-i. Choi, Y. Iwakura, and M. Miyasaka (2009)
J. Immunol. 182, 1287-1295
   Abstract »    Full Text »    PDF »
CCR5 Expression Levels Influence NFAT Translocation, IL-2 Production, and Subsequent Signaling Events during T Lymphocyte Activation.
J. F. Camargo, M. P. Quinones, S. Mummidi, S. Srinivas, A. A. Gaitan, K. Begum, F. Jimenez, S. VanCompernolle, D. Unutmaz, S. S. Ahuja, et al. (2009)
J. Immunol. 182, 171-182
   Abstract »    Full Text »    PDF »
The Role of Chemokines in Transplant Graft Arterial Disease.
K. Shimizu and R. N. Mitchell (2008)
Arterioscler. Thromb. Vasc. Biol. 28, 1937-1949
   Abstract »    Full Text »    PDF »
XCL1 Enhances Regulatory Activities of CD4+CD25highCD127low/- T Cells in Human Allergic Asthma.
K. D. Nguyen, A. Fohner, J. D. Booker, C. Dong, A. M. Krensky, and K. C. Nadeau (2008)
J. Immunol. 181, 5386-5395
   Abstract »    Full Text »    PDF »
Blood Cell-Derived RANTES Mediates Cerebral Microvascular Dysfunction, Inflammation, and Tissue Injury After Focal Ischemia-Reperfusion.
S. Terao, G. Yilmaz, K. Y. Stokes, J. Russell, M. Ishikawa, T. Kawase, and D. N. Granger (2008)
Stroke 39, 2560-2570
   Abstract »    Full Text »    PDF »
CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1.
T. T. Murooka, R. Rahbar, L. C. Platanias, and E. N. Fish (2008)
Blood 111, 4892-4901
   Abstract »    Full Text »    PDF »
Human cytomegalovirus-derived protein UL18 alters the phenotype and function of monocyte-derived dendritic cells.
C. S. Wagner, L. Walther-Jallow, E. Buentke, H.-G. Ljunggren, A. Achour, and B. J. Chambers (2008)
J. Leukoc. Biol. 83, 56-63
   Abstract »    Full Text »    PDF »
Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes.
G. Shi, S. Partida-Sanchez, R. S. Misra, M. Tighe, M. T. Borchers, J. J. Lee, M. I. Simon, and F. E. Lund (2007)
J. Exp. Med. 204, 2705-2718
   Abstract »    Full Text »    PDF »
Lymphocyte function during hepatic ischemia/reperfusion injury.
C. C. Caldwell, J. Tschoep, and A. B. Lentsch (2007)
J. Leukoc. Biol. 82, 457-464
   Abstract »    Full Text »    PDF »
Requirements for T Lymphocyte Migration in Explanted Lymph Nodes.
J. H. Huang, L. I. Cardenas-Navia, C. C. Caldwell, T. J. Plumb, C. G. Radu, P. N. Rocha, T. Wilder, J. S. Bromberg, B. N. Cronstein, M. Sitkovsky, et al. (2007)
J. Immunol. 178, 7747-7755
   Abstract »    Full Text »    PDF »
Interaction of PRP4 with Kruppel-Like Factor 13 Regulates CCL5 Transcription.
B. Huang, Y.-T. Ahn, L. McPherson, C. Clayberger, and A. M. Krensky (2007)
J. Immunol. 178, 7081-7087
   Abstract »    Full Text »    PDF »
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NF{kappa}B.
J. Yang, X. Liao, M. K. Agarwal, L. Barnes, P. E. Auron, and G. R. Stark (2007)
Genes & Dev. 21, 1396-1408
   Abstract »    Full Text »    PDF »
Production of Specific mRNA Transcripts, Usage of an Alternate Promoter, and Octamer-Binding Transcription Factors Influence the Surface Expression Levels of the HIV Coreceptor CCR5 on Primary T Cells.
S. Mummidi, L. M. Adams, S. E. VanCompernolle, M. Kalkonde, J. F. Camargo, H. Kulkarni, A. S. Bellinger, G. Bonello, H. Tagoh, S. S. Ahuja, et al. (2007)
J. Immunol. 178, 5668-5681
   Abstract »    Full Text »    PDF »
RANTES Modulates TLR4-Induced Cytokine Secretion in Human Peripheral Blood Monocytes.
S. Shahrara, C. C. Park, V. Temkin, J. W. Jarvis, M. V. Volin, and R. M. Pope (2006)
J. Immunol. 177, 5077-5087
   Abstract »    Full Text »    PDF »
CCL5-CCR5-mediated Apoptosis in T Cells: REQUIREMENT FOR GLYCOSAMINOGLYCAN BINDING AND CCL5 AGGREGATION.
T. T. Murooka, M. M. Wong, R. Rahbar, B. Majchrzak-Kita, A. E. I. Proudfoot, and E. N. Fish (2006)
J. Biol. Chem. 281, 25184-25194
   Abstract »    Full Text »    PDF »
Human V{gamma}2V{delta}2 T cells contain cytoplasmic RANTES.
I Tikhonov, C. Deetz, R Paca, S Berg, V Lukyanenko, J. Lim, and C. Pauza (2006)
Int. Immunol. 18, 1243-1251
   Abstract »    Full Text »    PDF »
N-methyl-D-aspartate receptor type 2B is epigenetically inactivated and exhibits tumor-suppressive activity in human esophageal cancer..
M. S. Kim, K. Yamashita, J. H. Baek, H. L. Park, A. L. Carvalho, M. Osada, M. O. Hoque, S. Upadhyay, M. Mori, C. Moon, et al. (2006)
Cancer Res. 66, 3409-3418
   Abstract »    Full Text »    PDF »
Renal Ischemia-Reperfusion Injury and Adenosine 2A Receptor-Mediated Tissue Protection: The Role of CD4+ T Cells and IFN-{gamma}..
Y.-J. Day, L. Huang, H. Ye, L. Li, J. Linden, and M. D. Okusa (2006)
J. Immunol. 176, 3108-3114
   Abstract »    Full Text »    PDF »
CCL5 Modulates Pneumococcal Immunity and Carriage.
R. Palaniappan, S. Singh, U. P. Singh, R. Singh, E. W. Ades, D. E. Briles, S. K. Hollingshead, W. Royal III, J. S. Sampson, J. K. Stiles, et al. (2006)
J. Immunol. 176, 2346-2356
   Abstract »    Full Text »    PDF »
Generation of GPI-linked CCL5 based chemokine receptor antagonists for the suppression of acute vascular damage during allograft transplantation.
M. Notohamiprodjo, R. Djafarzadeh, A. Mojaat, I. von Luttichau, H.-J. Grone, and P. J. Nelson (2006)
Protein Eng. Des. Sel. 19, 27-35
   Abstract »    Full Text »    PDF »
Molecular Control of Physiological and Pathological T-Cell Recruitment after Mouse Spinal Cord Injury.
T. B. Jones, R. P. Hart, and P. G. Popovich (2005)
J. Neurosci. 25, 6576-6583
   Abstract »    Full Text »    PDF »
Absence of Recipient CCR5 Promotes Early and Increased Allospecific Antibody Responses to Cardiac Allografts.
H. Amano, A. Bickerstaff, C. G. Orosz, A. C. Novick, H. Toma, and R. L. Fairchild (2005)
J. Immunol. 174, 6499-6508
   Abstract »    Full Text »    PDF »
Transgenic expression of CCL2 in the central nervous system prevents experimental autoimmune encephalomyelitis.
A. Elhofy, J. Wang, M. Tani, B. T. Fife, K. J. Kennedy, J. Bennett, D. Huang, R. M. Ransohoff, and W. J. Karpus (2005)
J. Leukoc. Biol. 77, 229-237
   Abstract »    Full Text »    PDF »
Recombinant guinea pig CCL5 (RANTES) differentially modulates cytokine production in alveolar and peritoneal macrophages.
T. A. Skwor, H. Cho, C. Cassidy, T. Yoshimura, and D. N. McMurray (2004)
J. Leukoc. Biol. 76, 1229-1239
   Abstract »    Full Text »    PDF »
Granulocyte chemotactic protein-2 mediates adaptive immunity in part through IL-8R{beta} interactions.
U. P. Singh, S. Singh, P. N. Boyaka, J. R. McGhee, and J. W. Lillard Jr (2004)
J. Leukoc. Biol. 76, 1240-1247
   Abstract »    Full Text »    PDF »
Chemokine Monokine Induced by IFN-{gamma}/CXC Chemokine Ligand 9 Stimulates T Lymphocyte Proliferation and Effector Cytokine Production.
D. Whiting, G. Hsieh, J. J. Yun, A. Banerji, W. Yao, M. C. Fishbein, J. Belperio, R. M. Strieter, B. Bonavida, and A. Ardehali (2004)
J. Immunol. 172, 7417-7424
   Abstract »    Full Text »    PDF »
Migration of Antigen-Specific T Cells Away from CXCR4-Binding Human Immunodeficiency Virus Type 1 gp120.
D. M. Brainard, W. G. Tharp, E. Granado, N. Miller, A. K. Trocha, X.-H. Ren, B. Conrad, E. F. Terwilliger, R. Wyatt, B. D. Walker, et al. (2004)
J. Virol. 78, 5184-5193
   Abstract »    Full Text »    PDF »
Expression and Function of the Vascular Endothelial Growth Factor Receptor FLT-1 in Human Eosinophils.
C. Feistritzer, N. C. Kaneider, D. H. Sturn, B. A. Mosheimer, C. M. Kahler, and C. J. Wiedermann (2004)
Am. J. Respir. Cell Mol. Biol. 30, 729-735
   Abstract »    Full Text »    PDF »
Combined Blockade of the Chemokine Receptors CCR1 and CCR5 Attenuates Chronic Rejection.
J. J. Yun, D. Whiting, M. P. Fischbein, A. Banerji, Y. Irie, D. Stein, M. C. Fishbein, A. E.I. Proudfoot, H. Laks, J. A. Berliner, et al. (2004)
Circulation 109, 932-937
   Abstract »    Full Text »    PDF »
CXCR3 Is Involved in Tubulointerstitial Injury in Human Glomerulonephritis.
S. Segerer, B. Banas, M. Wornle, H. Schmid, C. D. Cohen, M. Kretzler, M. Mack, E. Kiss, P. J. Nelson, D. Schlondorff, et al. (2004)
Am. J. Pathol. 164, 635-649
   Abstract »    Full Text »    PDF »
Enhanced expression of inflammatory cytokines and activation markers in T-cells from patients with chronic heart failure.
A. Yndestad, A. M Holm, F. Muller, S. Simonsen, S. S Froland, L. Gullestad, and P. Aukrust (2003)
Cardiovasc Res 60, 141-146
   Abstract »    Full Text »    PDF »
RANTES (CCL5) uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement.
B. Roscic-Mrkic, M. Fischer, C. Leemann, A. Manrique, C. J. Gordon, J. P. Moore, A. E. I. Proudfoot, and A. Trkola (2003)
Blood 102, 1169-1177
   Abstract »    Full Text »    PDF »
Chemokine Receptor Expression in Human Endometrium.
N. Mulayim, S. F. Palter, U. A. Kayisli, L. Senturk, and A. Arici (2003)
Biol Reprod 68, 1491-1495
   Abstract »    Full Text »    PDF »
A Role for Stat5 in CD8+ T Cell Homeostasis.
J. Kelly, R. Spolski, K. Imada, J. Bollenbacher, S. Lee, and W. J. Leonard (2003)
J. Immunol. 170, 210-217
   Abstract »    Full Text »    PDF »
Platelet-Activating Factor Activates Two Distinct Effector Pathways in Human Eosinophils.
M. Kato, H. Kimura, Y. Motegi, A. Tachibana, H. Minakami, A. Morikawa, and H. Kita (2002)
J. Immunol. 169, 5252-5259
   Abstract »    Full Text »    PDF »
Polyethylene Glycol Reduces Early and Long-Term Cold Ischemia-Reperfusion and Renal Medulla Injury.
J. P. Faure, T. Hauet, Z. Han, J. M. Goujon, I. Petit, G. Mauco, M. Eugene, M. Carretier, and V. Papadopoulos (2002)
J. Pharmacol. Exp. Ther. 302, 861-870
   Abstract »    Full Text »    PDF »
Platelet Factor 4 Inhibits Proliferation and Cytokine Release of Activated Human T Cells.
J. Fleischer, E. Grage-Griebenow, B. Kasper, H. Heine, M. Ernst, E. Brandt, H.-D. Flad, and F. Petersen (2002)
J. Immunol. 169, 770-777
   Abstract »    Full Text »    PDF »
Activation of Group III Metabotropic Glutamate Receptors Inhibits the Production of RANTES in Glial Cell Cultures.
G. Besong, G. Battaglia, M. D'Onofrio, R. Di Marco, R. T. Ngomba, M. Storto, M. Castiglione, K. Mangano, C. L. Busceti, F. R. Nicoletti, et al. (2002)
J. Neurosci. 22, 5403-5411
   Abstract »    Full Text »    PDF »
The State of CD4+ T Cell Activation Is a Major Factor for Determining the Kinetics and Location of T Cell Responses to Oral Antigen.
H.-o. Lee, C. J. Cooper, J.-h. Choi, Z. Alnadjim, and T. A. Barrett (2002)
J. Immunol. 168, 3833-3838
   Abstract »    Full Text »    PDF »
Interaction of the CC-Chemokine RANTES with Glycosaminoglycans Activates a p44/p42 Mitogen-Activated Protein Kinase-Dependent Signaling Pathway and Enhances Human Immunodeficiency Virus Type 1 Infectivity.
T. L.-Y. Chang, C. J. Gordon, B. Roscic-Mrkic, C. Power, A. E. I. Proudfoot, J. P. Moore, and A. Trkola (2002)
J. Virol. 76, 2245-2254
   Abstract »    Full Text »    PDF »
Stimulant-Dependent Modulation of Cytokines and Chemokines by Airway Epithelial Cells: Cross Talk between Pulmonary Epithelial and Peripheral Blood Mononuclear Cells.
T. Krakauer (2002)
Clin. Vaccine Immunol. 9, 126-131
   Abstract »    Full Text »    PDF »
Immunity, Inflammation, and Remodeling in the Airway Epithelial Barrier: Epithelial-Viral-Allergic Paradigm.
M. J. Holtzman, J. D. Morton, L. P. Shornick, J. W. Tyner, M. P. O'Sullivan, A. Antao, M. Lo, M. Castro, and M. J. Walter (2002)
Physiol Rev 82, 19-46
   Abstract »    Full Text »    PDF »
Expression of the Chemokine Receptor CXCR3 and Its Ligand IP-10 During Human Cardiac Allograft Rejection.
M. Melter, A. Exeni, M. E.J. Reinders, J. C. Fang, G. McMahon, P. Ganz, W. W. Hancock, and D. M. Briscoe (2001)
Circulation 104, 2558-2564
   Abstract »    Full Text »    PDF »
Expression of CC Chemokines and Their Receptors in the Eye in Autoimmune Anterior Uveitis Associated with EAE.
G. Adamus, M. Manczak, and M. Machnicki (2001)
Invest. Ophthalmol. Vis. Sci. 42, 2894-2903
   Abstract »    Full Text »    PDF »
Chemokines Regulate IL-6 and IL-8 Production by Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis.
T. Nanki, K. Nagasaka, K. Hayashida, Y. Saita, and N. Miyasaka (2001)
J. Immunol. 167, 5381-5385
   Abstract »    Full Text »    PDF »
CCR1+/CCR5+ Mononuclear Phagocytes Accumulate in the Central Nervous System of Patients with Multiple Sclerosis.
C. Trebst, T. Lykke Sorensen, P. Kivisakk, M. K. Cathcart, J. Hesselgesser, R. Horuk, F. Sellebjerg, H. Lassmann, and R. M. Ransohoff (2001)
Am. J. Pathol. 159, 1701-1710
   Abstract »    Full Text »    PDF »
IL-9 Stimulates Release of Chemotactic Factors from Human Bronchial Epithelial Cells.
F. F. Little, W. W. Cruikshank, and D. M. Center (2001)
Am. J. Respir. Cell Mol. Biol. 25, 347-352
   Abstract »    Full Text »    PDF »
Negative Regulation of the NFAT1 Factor by CD45: Implication in HIV-1 Long Terminal Repeat Activation.
B. Barbeau, G. A. Robichaud, J.-F. Fortin, and M. J. Tremblay (2001)
J. Immunol. 167, 2700-2713
   Abstract »    Full Text »    PDF »
RANTES-Induced Chemokine Cascade in Dendritic Cells.
F. R. Fischer, Y. Luo, M. Luo, L. Santambrogio, and M. E. Dorf (2001)
J. Immunol. 167, 1637-1643
   Abstract »    Full Text »    PDF »
Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis.
W. Peters, H. M. Scott, H. F. Chambers, J. L. Flynn, I. F. Charo, and J. D. Ernst (2001)
PNAS 98, 7958-7963
   Abstract »    Full Text »    PDF »
Coregulation of CXC Chemokine Receptor and CD4 Expression on T Lymphocytes During Allogeneic Activation.
L. M. Ebert and S. R. McColl (2001)
J. Immunol. 166, 4870-4878
   Abstract »    Full Text »    PDF »
The C-class chemokine lymphotactin costimulates the apoptosis of human CD4+ T cells.
C. Cerdan, E. Devilard, L. Xerri, and D. Olive (2001)
Blood 97, 2205-2212
   Abstract »    Full Text »    PDF »
The Cutaneous Response in Humans to Treponema pallidum Lipoprotein Analogues Involves Cellular Elements of Both Innate and Adaptive Immunity.
T. J. Sellati, S. L. Waldrop, J. C. Salazar, P. R. Bergstresser, L. J. Picker, and J. D. Radolf (2001)
J. Immunol. 166, 4131-4140
   Abstract »    Full Text »    PDF »
Expression of the Th1 Chemokine IFN-{{gamma}}-Inducible Protein 10 in the Airway Alters Mucosal Allergic Sensitization in Mice.
R. E. Wiley, K. Palmer, B. U. Gajewska, M. R. Stampfli, D. Alvarez, A. J. Coyle, J.-C. Gutierrez-Ramos, and M. Jordana (2001)
J. Immunol. 166, 2750-2759
   Abstract »    Full Text »    PDF »
RANTES Potentiates Antigen-Specific Mucosal Immune Responses.
J. W. Lillard Jr., P. N. Boyaka, D. D. Taub, and J. R. McGhee (2001)
J. Immunol. 166, 162-169
   Abstract »    Full Text »    PDF »
A Mechanism for the Impaired IFN-{gamma} Production in C-C Chemokine Receptor 2 (CCR2) Knockout Mice: Role of CCR2 in Linking the Innate and Adaptive Immune Responses.
W. Peters, M. Dupuis, and I. F. Charo (2000)
J. Immunol. 165, 7072-7077
   Abstract »    Full Text »    PDF »
{micro}-Opioid Induction of Monocyte Chemoattractant Protein-1, RANTES, and IFN-{gamma}-Inducible Protein-10 Expression in Human Peripheral Blood Mononuclear Cells.
M. A. Wetzel, A. D. Steele, T. K. Eisenstein, M. W. Adler, E. E. Henderson, and T. J. Rogers (2000)
J. Immunol. 165, 6519-6524
   Abstract »    Full Text »    PDF »
Chemokines in the limbal form of vernal keratoconjunctivitis.
A. M A. El-Asrar, S. Struyf, S. A Al-Kharashi, L. Missotten, J. Van Damme, and K. Geboes (2000)
Br. J. Ophthalmol. 84, 1360-1366
   Abstract »    Full Text »
RANTES Plays an Important Role in the Evolution of Allograft Transplant-induced Fibrous Airway Obliteration.
M. SUGA, A. A. MACLEAN, S. KESHAVJEE, S. FISCHER, J. M. F. MOREIRA, and M. LIU (2000)
Am. J. Respir. Crit. Care Med. 162, 1940-1948
   Abstract »    Full Text »
Human recombinant histamine-releasing factor activates human eosinophils and the eosinophilic cell line, AML14-3D10.
R. Bheekha-Escura, D. W. MacGlashan Jr, J. M. Langdon, and S. M. MacDonald (2000)
Blood 96, 2191-2198
   Abstract »    Full Text »    PDF »
Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice.
H. Rabb, F. Daniels, M. O'Donnell, M. Haq, S. R. Saba, W. Keane, and W. W. Tang (2000)
Am J Physiol Renal Physiol 279, F525-F531
   Abstract »    Full Text »    PDF »
Trafficking of neutrophils across airway epithelium is dependent upon both thioredoxin- and pertussis toxin-sensitive signaling mechanisms.
L. A. Miller, J. Usachenko, R. J. McDonald, and D. M. Hyde (2000)
J. Leukoc. Biol. 68, 201-208
   Abstract »    Full Text »
RANTES activates antigen-specific cytotoxic T lymphocytes in a mitogen-like manner through cell surface aggregation.
V. Appay, P. R. Dunbar, V. Cerundolo, A. McMichael, L. Czaplewski, and S. Rowland-Jones (2000)
Int. Immunol. 12, 1173-1182
   Abstract »    Full Text »    PDF »
Signal Transduction by CXC Chemokine Receptor 4: Stromal Cell-derived Factor 1 Stimulates Prolonged Protein Kinase B and Extracellular Signal-regulated Kinase 2 Activation in T Lymphocytes.
B. Tilton, L. Ho, E. Oberlin, P. Loetscher, F. Baleux, I. Clark-Lewis, and M. Thelen (2000)
J. Exp. Med. 192, 313-324
   Abstract »    Full Text »    PDF »
The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4+ T cells.
C. Cerdan, E. Serfling, and D. Olive (2000)
Blood 96, 420-428
   Abstract »    Full Text »    PDF »
The Role of the CC Chemokine, RANTES, in Acute Lung Allograft Rejection.
J. A. Belperio, M. D. Burdick, M. P. Keane, Y. Y. Xue, J. P. Lynch III, B. L. Daugherty, S. L. Kunkel, and R. M. Strieter (2000)
J. Immunol. 165, 461-472
   Abstract »    Full Text »    PDF »
Postanoxic T Lymphocyte-Endothelial Cell Interactions Induce Tumor Necrosis Factor-{alpha} Production and Neutrophil Adhesion : Role of Very Late Antigen-4/Vascular Cell Adhesion Molecule-1.
S. Kokura, R. E. Wolf, T. Yoshikawa, D. N. Granger, and T. Y. Aw (2000)
Circ. Res. 86, 1237-1244
   Abstract »    Full Text »    PDF »
TNF-{alpha}-Induced Secretion of C-C Chemokines Modulates C-C Chemokine Receptor 5 Expression on Peripheral Blood Lymphocytes.
F. Hornung, G. Scala, and M. J. Lenardo (2000)
J. Immunol. 164, 6180-6187
   Abstract »    Full Text »    PDF »
Cutting Edge: Stromal Cell-Derived Factor-1 Is a Costimulator for CD4+ T Cell Activation.
T. Nanki and P. E. Lipsky (2000)
J. Immunol. 164, 5010-5014
   Abstract »    Full Text »    PDF »
Distinct Requirements for C-C Chemokine and IL-2 Production by Naive, Previously Activated, and Anergic T Cells.
C. G. Lerner, M. R. Horton, R. H. Schwartz, and J. D. Powell (2000)
J. Immunol. 164, 3996-4002
   Abstract »    Full Text »    PDF »
Distinct T Cell/Renal Tubular Epithelial Cell Interactions Define Differential Chemokine Production: Implications for Tubulointerstitial Injury in Chronic Glomerulonephritides.
T. Kuroiwa, R. Schlimgen, G. G. Illei, I. B. McInnes, and D. T. Boumpas (2000)
J. Immunol. 164, 3323-3329
   Abstract »    Full Text »    PDF »
Adenoviral-Mediated Overexpression of Monocyte Chemoattractant Protein-1 Differentially Alters the Development of Th1 and Th2 Type Responses In Vivo.
A. Matsukawa, N. W. Lukacs, T. J. Standiford, S. W. Chensue, and S. L. Kunkel (2000)
J. Immunol. 164, 1699-1704
   Abstract »    Full Text »    PDF »
Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis.
G X Zhang, C M Baker, D L Kolson, and A M Rostami (2000)
Multiple Sclerosis 6, 3-13
   Abstract »    PDF »
C-C chemokine profile of cord blood mononuclear cells: selective defect in RANTES production.
D. Hariharan, W. Ho, J. Cutilli, D. E. Campbell, and S. D. Douglas (2000)
Blood 95, 715-718
   Abstract »    Full Text »    PDF »
Chemokines, Chemokine Receptors, and Renal Disease: From Basic ScienceTo Pathophysiologic and Therapeutic Studies.
S. SEGERER, P. J. NELSON, and D. SCHLÖNDORFF (2000)
J. Am. Soc. Nephrol. 11, 152-176
   Abstract »    Full Text »
Chemokine and Chemokine Receptor Interactions Provide a Mechanism for Selective T Cell Recruitment to Specific Liver Compartments Within Hepatitis C-Infected Liver.
Philip. L. Shields, C. M. Morland, M. Salmon, S. Qin, S. G. Hubscher, and D. H. Adams (1999)
J. Immunol. 163, 6236-6243
   Abstract »    Full Text »    PDF »
Macrophage Inflammatory Protein-3{beta} Enhances IL-10 Production by Activated Human Peripheral Blood Monocytes and T Cells.
H. D. Byrnes, H. Kaminski, A. Mirza, G. Deno, D. Lundell, and J. S. Fine (1999)
J. Immunol. 163, 4715-4720
   Abstract »    Full Text »    PDF »
Regulation of T Cell Homeostasis by Heparan Sulfate-Bound IL-2.
L. E. Wrenshall and J. L. Platt (1999)
J. Immunol. 163, 3793-3800
   Abstract »    Full Text »    PDF »
Aggregation of RANTES Is Responsible for Its Inflammatory Properties. CHARACTERIZATION OF NONAGGREGATING, NONINFLAMMATORY RANTES MUTANTS.
V. Appay, A. Brown, S. Cribbes, E. Randle, and L. G. Czaplewski (1999)
J. Biol. Chem. 274, 27505-27512
   Abstract »    Full Text »    PDF »
Reciprocal Desensitization of CCR5 and CD4 Is Mediated by IL-16 and Macrophage-Inflammatory Protein-1{beta}, Respectively.
M. V. Mashikian, T. C. Ryan, A. Seman, W. Brazer, D. M. Center, and W. W. Cruikshank (1999)
J. Immunol. 163, 3123-3130
   Abstract »    Full Text »    PDF »
Selective Diapedesis of Th1 Cells Induced by Endothelial Cell RANTES.
T. Kawai, M. Seki, K. Hiromatsu, J. W. Eastcott, G. F. M. Watts, M. Sugai, D. J. Smith, S. A. Porcelli, and M. A. Taubman (1999)
J. Immunol. 163, 3269-3278
   Abstract »    Full Text »    PDF »
Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells.
A. B. H. Bakker, E. Baker, G. R. Sutherland, J. H. Phillips, and L. L. Lanier (1999)
PNAS 96, 9792-9796
   Abstract »    Full Text »    PDF »
The CC-Chemokine RANTES Increases the Attachment of Human Immunodeficiency Virus Type 1 to Target Cells via Glycosaminoglycans and Also Activates a Signal Transduction Pathway That Enhances Viral Infectivity.
A. Trkola, C. Gordon, J. Matthews, E. Maxwell, T. Ketas, L. Czaplewski, A. E. I. Proudfoot, and J. P. Moore (1999)
J. Virol. 73, 6370-6379
   Abstract »    Full Text »
Reduced Risk of AIDS Lymphoma in Individuals Heterozygous for the CCR5-{{Delta}}32 Mutation.
M. Dean, L. P. Jacobson, G. McFarlane, J. B. Margolick, F. J. Jenkins, O. M. Z. Howard, H.-F. Dong, J. J. Goedert, S. Buchbinder, E. Gomperts, et al. (1999)
Cancer Res. 59, 3561-3564
   Abstract »    Full Text »    PDF »
Characterization of Fractalkine in Rat Brain Cells: Migratory and Activation Signals for CX3CR-1-Expressing Microglia.
D. Maciejewski-Lenoir, S. Chen, L. Feng, R. Maki, and K. B. Bacon (1999)
J. Immunol. 163, 1628-1635
   Abstract »    Full Text »    PDF »
Gi Proteins Use a Novel beta gamma - and Ras-independent Pathway to Activate Extracellular Signal-regulated Kinase and Mobilize AP-1 Transcription Factors in Jurkat T Lymphocytes.
K. E. Hedin, M. P. Bell, C. J. Huntoon, L. M. Karnitz, and D. J. McKean (1999)
J. Biol. Chem. 274, 19992-20001
   Abstract »    Full Text »    PDF »
Induction of Phosphorylation and Intracellular Association of CC Chemokine Receptor 5 and Focal Adhesion Kinase in Primary Human CD4+ T Cells by Macrophage-Tropic HIV Envelope.
C. Cicala, J. Arthos, M. Ruiz, M. Vaccarezza, A. Rubbert, A. Riva, K. Wildt, O. Cohen, and A. S. Fauci (1999)
J. Immunol. 163, 420-426
   Abstract »    Full Text »    PDF »
Interleukin-18, Interferon-{gamma}, IP-10, and Mig Expression in Epstein-Barr Virus-Induced Infectious Mononucleosis and Posttransplant Lymphoproliferative Disease.
J. Setsuda, J. Teruya-Feldstein, N. L. Harris, J. A. Ferry, L. Sorbara, G. Gupta, E. S. Jaffe, and G. Tosato (1999)
Am. J. Pathol. 155, 257-265
   Abstract »    Full Text »    PDF »
Human Thymocytes Express CCR-3 and Are Activated by Eotaxin.
K. Franz-Bacon, D. J. Dairaghi, S. A. Boehme, S. K. Sullivan, T. J. Schall, P. J. Conlon, N. Taylor, and K. B. Bacon (1999)
Blood 93, 3233-3240
   Abstract »    Full Text »    PDF »
Virus-inducible expression of a host chemokine gene relies on replication-linked mRNA stabilization.
T. Koga, E. Sardina, R. M. Tidwell, M. Pelletier, D. C. Look, and M. J. Holtzman (1999)
PNAS 96, 5680-5685
   Abstract »    Full Text »    PDF »
Eotaxin Activates T Cells to Chemotaxis and Adhesion Only if Induced to Express CCR3 by IL-2 Together with IL-4.
T. Jinquan, S. Quan, G. Feili, C. G. Larsen, and K. Thestrup-Pedersen (1999)
J. Immunol. 162, 4285-4292
   Abstract »    Full Text »    PDF »
Distinct Biological Effects of Macrophage Inflammatory Protein-1{alpha} and Stroma-Derived Factor-1{alpha} on CD34+ Hemopoietic Cells.
J. Dürig, N. G. Testa, and C. M. Heyworth (1999)
Stem Cells 17, 62-71
   Abstract »    Full Text »
Similarities and Differences in RANTES- and (AOP)-RANTES-triggered Signals: Implications for Chemotaxis.
J. M. Rodriguez-Frade, A. J. Vila-Coro, A. Martin, M. Nieto, F. Sanchez-Madrid, A. E.I. Proudfoot, T. N.C. Wells, C. Martinez-A, and M. Mellado (1999)
J. Cell Biol. 144, 755-765
   Abstract »    Full Text »    PDF »
Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization.
M. D. Gunn, S. Kyuwa, C. Tam, T. Kakiuchi, A. Matsuzawa, L. T. Williams, and H. Nakano (1999)
J. Exp. Med. 189, 451-460
   Abstract »    Full Text »    PDF »
Eradication of Pre-Established Lymphoma Using Herpes Simplex Virus Amplicon Vectors.
M. Kutubuddin, H. J. Federoff, P. M. Challita-Eid, M. Halterman, B. Day, M. Atkinson, V. Planelles, and J. D. Rosenblatt (1999)
Blood 93, 643-654
   Abstract »    Full Text »    PDF »
Association of Rhinovirus Infections with Asthma.
J. E. Gern and W. W. Busse (1999)
Clin. Microbiol. Rev. 12, 9-18
   Abstract »    Full Text »    PDF »
Enhancement of Human Immunodeficiency Virus Type 1 Infection by the CC-Chemokine RANTES Is Independent of the Mechanism of Virus-Cell Fusion.
C. J. Gordon, M. A. Muesing, A. E. I. Proudfoot, C. A. Power, J. P. Moore, and A. Trkola (1999)
J. Virol. 73, 684-694
   Abstract »    Full Text »    PDF »
Degree of TCR Internalization and Ca2+ Flux Correlates with Thymocyte Selection.
S. Mariathasan, M. F. Bachmann, D. Bouchard, T. Ohteki, and P. S. Ohashi (1998)
J. Immunol. 161, 6030-6037
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)