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Science 22 September 1995:
Vol. 269. no. 5231, pp. 1721 - 1723
DOI: 10.1126/science.7569900
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Articles

Science, Vol 269, Issue 5231, 1721-1723
Copyright © 1995 by American Association for the Advancement of Science

articles

Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins

M David, E Petricoin 3rd, C Benjamin, R Pine, MJ Weber, and AC Larner

Division of Cytokine Biology, Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA.

Activation of early response genes by interferons (IFNs) requires tyrosine phosphorylation of STAT (signal transducers and activators of transcription) proteins. It was found that the serine-threonine kinase mitogen-activated protein kinase (MAPK) [specifically, the 42-kilodalton MAPK or extracellular signal-regulated kinase 2 (ERK2)] interacted with the alpha subunit of IFN-alpha/beta receptor in vitro and in vivo. Treatment of cells with IFN-beta induced tyrosine phosphorylation and activation of MAPK and caused MAPK and Stat1 alpha to coimmunoprecipitate. Furthermore, expression of dominant negative MAPK inhibited IFN-beta-induced transcription. Therefore, MAPK appears to regulate IFN-alpha and IFN-beta activation of early response genes by modifying the Jak-STAT signaling cascade.


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Serine Phosphorylation and Negative Regulation of Stat3 by JNK.
C. P. Lim and X. Cao (1999)
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Activation of the p38 Mitogen-activated Protein Kinase by Type I Interferons.
S. Uddin, B. Majchrzak, J. Woodson, P. Arunkumar, Y. Alsayed, R. Pine, P. R. Young, E. N. Fish, and L. C. Platanias (1999)
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J. Biol. Chem. 274, 30222-30227
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Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells.
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J. Biol. Chem. 274, 10723-10730
   Abstract »    Full Text »    PDF »
Transforming Growth Factor beta 1 Rescues Serum Deprivation-induced Apoptosis via the Mitogen-activated Protein Kinase (MAPK) Pathway in Macrophages.
B. Y. Chin, I. Petrache, A. M. K. Choi, and M. E. Choi (1999)
J. Biol. Chem. 274, 11362-11368
   Abstract »    Full Text »    PDF »
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers.
H. J. Schaeffer and M. J. Weber (1999)
Mol. Cell. Biol. 19, 2435-2444
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Extracellular Signal-Regulated Kinase (ERK) Interacts with Signal Transducer and Activator of Transcription (STAT) 5a.
T. J. Pircher, H. Petersen, J.-A. Gustafsson, and L.-A. Haldosén (1999)
Mol. Endocrinol. 13, 555-565
   Abstract »    Full Text »
JAK3, STAT, and MAPK Signaling Pathways as Novel Molecular Targets for the Tyrphostin AG-490 Regulation of IL-2-Mediated T Cell Response.
L. H. Wang, R. A. Kirken, R. A. Erwin, C.-R. Yu, and W. L. Farrar (1999)
J. Immunol. 162, 3897-3904
   Abstract »    Full Text »    PDF »
Dissociation Between IFN-{alpha}-Induced Anti-Viral and Growth Signaling Pathways.
T. Arora, G. Floyd-Smith, M. J. Espy, and D. F. Jelinek (1999)
J. Immunol. 162, 3289-3297
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Activation of Signal Transducers and Activators of Transcription 1 and 3 by Leukemia Inhibitory Factor, Oncostatin-M, and Interferon-gamma in Adipocytes.
J. M. Stephens, S. J. Lumpkin, and J. B. Fishman (1998)
J. Biol. Chem. 273, 31408-31416
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Differential Control of the Phosphorylation State of Proline-juxtaposed Serine Residues Ser725 of Stat5a and Ser730 of Stat5b in Prolactin-sensitive Cells.
H. Yamashita, J. Xu, R. A. Erwin, W. L. Farrar, R. A. Kirken, and H. Rui (1998)
J. Biol. Chem. 273, 30218-30224
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Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases.
T. K. Sengupta, E. S. Talbot, P. A. Scherle, and L. B. Ivashkiv (1998)
PNAS 95, 11107-11112
   Abstract »    Full Text »    PDF »
IFN-{alpha} Is a Survival Factor for Human Myeloma Cells and Reduces Dexamethasone-Induced Apoptosis.
M. Ferlin-Bezombes, M. Jourdan, J. Liautard, J. Brochier, J.-F. Rossi, and B. Klein (1998)
J. Immunol. 161, 2692-2699
   Abstract »    Full Text »    PDF »
The mechanism of IL-5 signal transduction.
T. Adachi and R. Alam (1998)
Am J Physiol Cell Physiol 275, C623-C633
   Abstract »    Full Text »    PDF »
Activation of Raf-1 by Interferon gamma  and Oncostatin M Requires Expression of the Stat1 Transcription Factor.
L. F. Stancato, C.-R. Yu, E. F. Petricoin III, and A. C. Larner (1998)
J. Biol. Chem. 273, 18701-18704
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Control of Lytic Function by Mitogen-activated Protein Kinase/Extracellular Regulatory Kinase 2 (ERK2) in a Human Natural Killer Cell Line: Identification of Perforin and Granzyme B Mobilization by Functional ERK2.
S. Wei, A. M. Gamero, J. H. Liu, A. A. Daulton, N. I. Valkov, J. A. Trapani, A. C. Larner, M. J. Weber, and J. Y. Djeu (1998)
J. Exp. Med. 187, 1753-1765
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Activation of STAT Proteins and Cytokine Genes in Human Th1 and Th2 Cells Generated in the Absence of IL-12 and IL-4.
R. Moriggl, C. Kristofic, B. Kinzel, S. Volarevic, B. Groner, and V. Brinkmann1 (1998)
J. Immunol. 160, 3385-3392
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The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif.
S.-H. Yang, P. R. Yates, A. J. Whitmarsh, R. J. Davis, and A. D. Sharrocks (1998)
Mol. Cell. Biol. 18, 710-720
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Interferongamma Activation of Raf-1 Is Jak1-dependent and p21ras-independent.
M. Sakatsume, L. F. Stancato, M. David, O. Silvennoinen, P. Saharinen, J. Pierce, A. C. Larner, and D. S. Finbloom (1998)
J. Biol. Chem. 273, 3021-3026
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Inhibition of Interferon Regulatory Factor-1 Expression Results in Predominance of Cell Growth Stimulatory Effects of Interferon-gamma Due to Phosphorylation of Stat1 and Stat3.
T. Sato, C. Selleri, N. S. Young, and J. P. Maciejewski (1997)
Blood 90, 4749-4758
   Abstract »    Full Text »    PDF »
Immunologic Aspects of Neurologic and Neuromuscular Diseases.
D. R. Smith and H. L. Weiner (1997)
JAMA 278, 1956-1961
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Signal Transducer and Activator of Transcription-3 Serine Phosphorylation by Insulin Is Mediated by a Ras/Raf/MEK-Dependent Pathway.
B. P. Ceresa, C. M. Horvath, and J. E. Pessin (1997)
Endocrinology 138, 4131-4137
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Leukemia Inhibitory Factor-dependent Transcriptional Activation in Embryonic Stem Cells.
H. Boeuf, C. Hauss, F. D. Graeve, N. Baran, and C. Kedinger (1997)
J. Cell Biol. 138, 1207-1217
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Positive Effects of SH2 Domain-containing Tyrosine Phosphatase SHP-1 on Epidermal Growth Factor- and Interferon-gamma -stimulated Activation of STAT Transcription Factors in HeLa Cells.
M. You and Z. Zhao (1997)
J. Biol. Chem. 272, 23376-23381
   Abstract »    Full Text »    PDF »


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