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Science 22 September 1995:
Vol. 269. no. 5231, pp. 1692 - 1696
DOI: 10.1126/science.7569895
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Articles

Science, Vol 269, Issue 5231, 1692-1696
Copyright © 1995 by American Association for the Advancement of Science

articles

Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors

DS McGehee, MJ Heath, S Gelber, P Devay, and LW Role

Department of Cell Biology and Anatomy, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.

The behavioral and cognitive effects of nicotine suggest that nicotinic acetylcholine receptors (nAChRs) participate in central nervous system (CNS) function. Although nAChR subunit messenger RNA (mRNA) and nicotine binding sites are common in the brain, there is little evidence for synapses mediated by nAChRs in the CNS. To test whether, CNS nAChRs might modify rather than mediate transmission, the regulation of excitatory synaptic transmission by these receptors was examined. Nanomolar concentrations of nicotine enhanced both glutamatergic and cholinergic synaptic transmission by activation of presynaptic nAChRs that increased presynaptic [Ca2]i. Pharmacological and subunit deletion experiments reveal that these presynaptic nAChRs include the alpha 7 subunit. These findings reveal that CNS nAChRs enhance fast excitatory transmission, providing a likely mechanism for the complex behavioral effects of nicotine.


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R. C. Drisdel and W. N. Green (2000)
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J. Neurosci. 19, 3007-3022
   Abstract »    Full Text »    PDF »
Spatiotemporal Patterns of Activity in an Intact Mammalian Network with Single-Cell Resolution: Optical Studies of Nicotinic Activity in an Enteric Plexus.
A. L. Obaid, T. Koyano, J. Lindstrom, T. Sakai, and B. M. Salzberg (1999)
J. Neurosci. 19, 3073-3093
   Abstract »    Full Text »    PDF »
Choline and Selective Antagonists Identify Two Subtypes of Nicotinic Acetylcholine Receptors that Modulate GABA Release from CA1 Interneurons in Rat Hippocampal Slices.
M. Alkondon, E. F. R. Pereira, H. M. Eisenberg, and E. X. Albuquerque (1999)
J. Neurosci. 19, 2693-2705
   Abstract »    Full Text »    PDF »
Synaptic transmission at nicotinic acetylcholine receptors in rat hippocampal organotypic cultures and slices.
S. Hefft, S. Hulo, D. Bertrand, and D. Muller (1999)
J. Physiol. 515, 769-776
   Abstract »    Full Text »    PDF »
Light-Induced Calcium Influx Into Retinal Axons Is Regulated by Presynaptic Nicotinic Acetylcholine Receptor Activity In Vivo.
J. A. Edwards and H. T. Cline (1999)
J Neurophysiol 81, 895-907
   Abstract »    Full Text »    PDF »
Nicotinic acetylcholine currents of cultured Kenyon cells from the mushroom bodies of the honey bee Apis mellifera.
F. Goldberg, B. Grunewald, H. Rosenboom, and R. Menzel (1999)
J. Physiol. 514, 759-768
   Abstract »    Full Text »    PDF »
Cross-Modulation of Synaptic Plasticity by beta -Adrenergic and 5-HT1A Receptors in the Rat Basolateral Amygdala.
S.-J. Wang, L.-L. Cheng, and P.-W. Gean (1999)
J. Neurosci. 19, 570-577
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Neuronal Acetylcholine Receptors with alpha 7 Subunits Are Concentrated on Somatic Spines for Synaptic Signaling in Embryonic Chick Ciliary Ganglia.
R. D. Shoop, M. E. Martone, N. Yamada, M. H. Ellisman, and D. K. Berg (1999)
J. Neurosci. 19, 692-704
   Abstract »    Full Text »    PDF »


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