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Science 15 September 1995:
Vol. 269. no. 5230, pp. 1588 - 1590
DOI: 10.1126/science.7667640
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Articles

Science, Vol 269, Issue 5230, 1588-1590
Copyright © 1995 by American Association for the Advancement of Science

articles

Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein

W Wang, LR Meadows, JM den Haan, NE Sherman, Y Chen, E Blokland, J Shabanowitz, AI Agulnik, RC Hendrickson, CE Bishop, and al. et

Department of Microbiology, University of Virginia, Charlottesville 22908, USA.

H-Y is a transplantation antigen that can lead to rejection of male organ and bone marrow grafts by female recipients, even if the donor and recipient match at the major histocompatibility locus of humans, the HLA (human leukocyte antigen) locus. However, the origin and function of H-Y antigens has eluded researchers for 40 years. One human H-Y antigen presented by HLA-B7 was identified as an 11-residue peptide derived from SMCY, an evolutionarily conserved protein encoded on the Y chromosome. The protein from the homologous gene on the X chromosome, SMCX, differs by two amino acid residues in the same region. The identification of H-Y may aid in transplantation prognosis, prenatal diagnosis, and fertilization strategies.


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