Science 15 September 1995: Vol. 269. no. 5230, pp. 1585 - 1588 DOI: 10.1126/science.7545313

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Articles

The role of heat shock proteins in gastrointestinal diseases.

V Dudeja, S M Vickers, and A K Saluja (2009)
Gut 58, 1000-1009
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CD40-Independent Engagement of Mammalian hsp70 by Antigen-Presenting Cells.

R. J. Binder (2009)
J. Immunol. 182, 6844-6850
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Differential Pathways Govern CD4+CD28- T Cell Proinflammatory and Effector Responses in Patients with Coronary Artery Disease.

B. Zal, J. C. Kaski, J. P. Akiyu, D. Cole, G. Arno, J. Poloniecki, A. Madrigal, A. Dodi, and C. Baboonian (2008)
J. Immunol. 181, 5233-5241
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Phylogenetic Conservation of Glycoprotein 96 Ability to Interact with CD91 and Facilitate Antigen Cross-Presentation.

J. Robert, T. Ramanayake, G. D. Maniero, H. Morales, and A. S. Chida (2008)
J. Immunol. 180, 3176-3182
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Heat-shock protein 90 associates with N-terminal extended peptides and is required for direct and indirect antigen presentation.

M. K. Callahan, M. Garg, and P. K. Srivastava (2008)
PNAS 105, 1662-1667
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Specific Immunogenicity of Heat Shock Protein gp96 Derives from Chaperoned Antigenic Peptides and Not from Contaminating Proteins.

R. J. Binder, J. B. Kelly III, R. E. Vatner, and P. K. Srivastava (2007)
J. Immunol. 179, 7254-7261
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Structure and Function: Heat Shock Proteins and Adaptive Immunity.

B. Javid, P. A. MacAry, and P. J. Lehner (2007)
J. Immunol. 179, 2035-2040
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Molecular and Cellular Requirements for Enhanced Antigen Cross-Presentation to CD8 Cytotoxic T Lymphocytes.

S. Oizumi, N. Strbo, S. Pahwa, V. Deyev, and E. R. Podack (2007)
J. Immunol. 179, 2310-2317
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Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy.

E. Schmitt, M. Gehrmann, M. Brunet, G. Multhoff, and C. Garrido (2007)
J. Leukoc. Biol. 81, 15-27
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TLR4 Up-Regulation at Protein or Gene Level Is Pathogenic for Lupus-Like Autoimmune Disease.

B. Liu, Y. Yang, J. Dai, R. Medzhitov, M. A. Freudenberg, P. L. Zhang, and Z. Li (2006)
J. Immunol. 177, 6880-6888
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The N-terminal fragment of GRP94 is sufficient for peptide presentation via professional antigen-presenting cells.

C. Biswas, U. Sriram, B. Ciric, O. Ostrovsky, S. Gallucci, and Y. Argon (2006)
Int. Immunol. 18, 1147-1157
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IL-2 Is Required for the Activation of Memory CD8+ T Cells via Antigen Cross-Presentation..

N. E. Blachere, H. K. Morris, D. Braun, H. Saklani, J. P. Di Santo, R. B. Darnell, and M. L. Albert (2006)
J. Immunol. 176, 7288-7300
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Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72.

J. D. Johnson and M. Fleshner (2006)
J. Leukoc. Biol. 79, 425-434
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Brain-Derived Heat Shock Protein 70-Peptide Complexes Induce NK Cell-Dependent Tolerance to Experimental Autoimmune Encephalomyelitis.

G. Galazka, M. Stasiolek, A. Walczak, A. Jurewicz, A. Zylicz, C. F. Brosnan, C. S. Raine, and K. W. Selmaj (2006)
J. Immunol. 176, 1588-1599
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Chaperoning Function of Stress Protein grp170, a Member of the hsp70 Superfamily, Is Responsible for its Immunoadjuvant Activity.

J.-E. Park, J. Facciponte, X. Chen, I. MacDonald, E. A. Repasky, M. H. Manjili, X.-Y. Wang, and J. R. Subjeck (2006)
Cancer Res. 66, 1161-1168
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New Targeted Approaches in Chronic Myeloid Leukemia.

J. Cortes and H. Kantarjian (2005)
J. Clin. Oncol. 23, 6316-6324
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Differences in Glycosylation Patterns of Heat Shock Protein, gp96: Implications for Prostate Cancer Prevention.

R. Suriano, S. K. Ghosh, B. T. Ashok, A. Mittelman, Y. Chen, A. Banerjee, and R. K. Tiwari (2005)
Cancer Res. 65, 6466-6475
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Mycobacterium Tuberculosis Heat Shock Proteins Use Diverse Toll-like Receptor Pathways to Activate Pro-inflammatory Signals.

Y. Bulut, K. S. Michelsen, L. Hayrapetian, Y. Naiki, R. Spallek, M. Singh, and M. Arditi (2005)
J. Biol. Chem. 280, 20961-20967
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Heat Shock Protein 90 Expression in Epstein-Barr Virus-Infected B Cells Promotes {gamma}{delta} T-Cell Proliferation In Vitro.

M. Kotsiopriftis, J. E. Tanner, and C. Alfieri (2005)
J. Virol. 79, 7255-7261
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Mycobacterium tuberculosis Heat Shock Fusion Protein Enhances Class I MHC Cross-Processing and -Presentation by B Lymphocytes.

A. A. R. Tobian, C. V. Harding, and D. H. Canaday (2005)
J. Immunol. 174, 5209-5214
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Induction of BCR-ABL-specific immunity following vaccination with chaperone-rich cell lysates derived from BCR-ABL+ tumor cells.

Y. Zeng, M. W. Graner, S. Thompson, M. Marron, and E. Katsanis (2005)
Blood 105, 2016-2022
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Generation of Murine CTL by a Hepatitis B Virus-Specific Peptide and Evaluation of the Adjuvant Effect of Heat Shock Protein Glycoprotein 96 and Its Terminal Fragments.

H. Li, M. Zhou, J. Han, X. Zhu, T. Dong, G. F. Gao, and P. Tien (2005)
J. Immunol. 174, 195-204
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Heat Shock Proteins and Their Use as Anticancer Vaccines.

G. Parmiani, A. Testori, M. Maio, C. Castelli, L. Rivoltini, L. Pilla, F. Belli, V. Mazzaferro, J. Coppa, R. Patuzzo, et al. (2004)
Clin. Cancer Res. 10, 8142-8146
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SREC-I, a Type F Scavenger Receptor, Is an Endocytic Receptor for Calreticulin.

B. Berwin, Y. Delneste, R. V. Lovingood, S. R. Post, and S. V. Pizzo (2004)
J. Biol. Chem. 279, 51250-51257
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Cutting Edge: Cross-Presentation of Cell-Associated Antigens to MHC Class I Molecule Is Regulated by a Major Transcription Factor for Heat Shock Proteins.

H. Zheng and Z. Li (2004)
J. Immunol. 173, 5929-5933
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Hsc70 and Hsp70 interact with phosphatidylserine on the surface of PC12 cells resulting in a decrease of viability.

N. ARISPE, M. DOH, O. SIMAKOVA, B. KURGANOV, and A. DE MAIO (2004)
FASEB J 18, 1636-1645
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Bacterial Heat Shock Proteins Enhance Class II MHC Antigen Processing and Presentation of Chaperoned Peptides to CD4+ T Cells.

A. A. R. Tobian, D. H. Canaday, and C. V. Harding (2004)
J. Immunol. 173, 5130-5137
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Heat Shock Protein-Mediated Cross-Presentation of Exogenous HIV Antigen on HLA Class I and Class II.

D. SenGupta, P. J. Norris, T. J. Suscovich, M. Hassan-Zahraee, H. F. Moffett, A. Trocha, R. Draenert, P. J. R. Goulder, R. J. Binder, D. L. Levey, et al. (2004)
J. Immunol. 173, 1987-1993
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Treatment of Colon and Lung Cancer Patients with ex Vivo Heat Shock Protein 70-Peptide-Activated, Autologous Natural Killer Cells: A Clinical Phase I Trial.

S. W. Krause, R. Gastpar, R. Andreesen, C. Gross, H. Ullrich, G. Thonigs, K. Pfister, and G. Multhoff (2004)
Clin. Cancer Res. 10, 3699-3707
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Bacterial Heat Shock Proteins Promote CD91-Dependent Class I MHC Cross-Presentation of Chaperoned Peptide to CD8+ T Cells by Cytosolic Mechanisms in Dendritic Cells versus Vacuolar Mechanisms in Macrophages.

A. A. R. Tobian, D. H. Canaday, W. H. Boom, and C. V. Harding (2004)
J. Immunol. 172, 5277-5286
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Essential role of CD91 in re-presentation of gp96-chaperoned peptides.

R. J. Binder and P. K. Srivastava (2004)
PNAS 101, 6128-6133
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Identification of the N-terminal Peptide Binding Site of Glucose-regulated Protein 94.

T. Gidalevitz, C. Biswas, H. Ding, D. Schneidman-Duhovny, H. J. Wolfson, F. Stevens, S. Radford, and Y. Argon (2004)
J. Biol. Chem. 279, 16543-16552
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DNA vaccination with gp96-peptide fusion proteins induces protection against an intracellular bacterial pathogen.

U. K. Rapp and S. H. Kaufmann (2004)
Int. Immunol. 16, 597-605
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Immune modulation with high-dose heat-shock protein gp96: therapy of murine autoimmune diabetes and encephalomyelitis.

R. Y. Chandawarkar, M. S. Wagh, J. T. Kovalchin, and P. Srivastava (2004)
Int. Immunol. 16, 615-624
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Glucose-Regulated Protein 94/Glycoprotein 96 Elicits Bystander Activation of CD4+ T Cell Th1 Cytokine Production In Vivo.

J. C. Baker-LePain, M. Sarzotti, and C. V. Nicchitta (2004)
J. Immunol. 172, 4195-4203
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Cellular protein is the source of cross-priming antigen in vivo.

L. Shen and K. L. Rock (2004)
PNAS 101, 3035-3040
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T cell recognition of a highly conserved epitope in heat shock protein 60: self-tolerance maintained by TCR distinguishing between asparagine and aspartic acid.

M. S. Lillicrap, R. C. Duggleby, J. C. Goodall, and J. S. H. Gaston (2004)
Int. Immunol. 16, 405-414
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Interferon-{gamma}: an overview of signals, mechanisms and functions.

K. Schroder, P. J. Hertzog, T. Ravasi, and D. A. Hume (2004)
J. Leukoc. Biol. 75, 163-189
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Melanoma-Reactive Class I-Restricted Cytotoxic T Cell Clones Are Stimulated by Dendritic Cells Loaded with Synthetic Peptides, but Fail to Respond to Dendritic Cells Pulsed with Melanoma-Derived Heat Shock Proteins In Vitro.

K. Fleischer, B. Schmidt, W. Kastenmuller, D. H. Busch, I. Drexler, G. Sutter, M. Heike, C. Peschel, and H. Bernhard (2004)
J. Immunol. 172, 162-169
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Cell Surface-bound Heat Shock Protein 70 (Hsp70) Mediates Perforin-independent Apoptosis by Specific Binding and Uptake of Granzyme B.

C. Gross, W. Koelch, A. DeMaio, N. Arispe, and G. Multhoff (2003)
J. Biol. Chem. 278, 41173-41181
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GRP94/gp96 Elicits ERK Activation in Murine Macrophages: A ROLE FOR ENDOTOXIN CONTAMINATION IN NF-{kappa}B ACTIVATION AND NITRIC OXIDE PRODUCTION.

R. C. Reed, B. Berwin, J. P. Baker, and C. V. Nicchitta (2003)
J. Biol. Chem. 278, 31853-31860
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Toll-like receptor ligand links innate and adaptive immune responses by the production of heat-shock proteins.

U. Kumaraguru, C. D. Pack, and B. T. Rouse (2003)
J. Leukoc. Biol. 73, 574-583
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Chronic Lymphocytic Leukemia-reactive T Cells during Disease Progression and after Autologous Tumor Cell Vaccines.

E. Gitelson, C. Hammond, J. Mena, M. Lorenzo, R. Buckstein, N. L. Berinstein, K. Imrie, and D. E. Spaner (2003)
Clin. Cancer Res. 9, 1656-1665
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Heat shock protein 70 associations with myelin basic protein and proteolipid protein in multiple sclerosis brains.

H. Cwiklinska, M. P. Mycko, O. Luvsannorov, B. Walkowiak, C. F. Brosnan, C. S. Raine, and K. W. Selmaj (2003)
Int. Immunol. 15, 241-249
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Macrophages and Dendritic Cells Use the Cytosolic Pathway to Rapidly Cross-Present Antigen from Live, Vaccinia-Infected Cells.

M. C. Ramirez and L. J. Sigal (2002)
J. Immunol. 169, 6733-6742
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GRP94 (gp96) and GRP94 N-Terminal Geldanamycin Binding Domain Elicit Tissue Nonrestricted Tumor Suppression.

J. C. Baker-LePain, M. Sarzotti, T. A. Fields, C.-Y. Li, and C. V. Nicchitta (2002)
J. Exp. Med. 196, 1447-1459
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Tumor-Derived Heat Shock Protein 70 Peptide Complexes Are Cross-Presented by Human Dendritic Cells.

E. Noessner, R. Gastpar, V. Milani, A. Brandl, P. J. S. Hutzler, M. C. Kuppner, M. Roos, E. Kremmer, A. Asea, S. K. Calderwood, et al. (2002)
J. Immunol. 169, 5424-5432
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Lack of Effector Cell Function and Altered Tetramer Binding of Tumor-Infiltrating Lymphocytes.

U. Blohm, E. Roth, K. Brommer, T. Dumrese, F. M. Rosenthal, and H. Pircher (2002)
J. Immunol. 169, 5522-5530
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The Adjuvant Effects of Mycobacterium tuberculosis Heat Shock Protein 70 Result from the Rapid and Prolonged Activation of Antigen-Specific CD8+ T Cells In Vivo.

L. A. E. Harmala, E. G. Ingulli, J. M. Curtsinger, M. M. Lucido, C. S. Schmidt, B. J. Weigel, B. R. Blazar, M. F. Mescher, and C. A. Pennell (2002)
J. Immunol. 169, 5622-5629
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Molecular Cloning of a Novel Chaperone-like Protein Induced by Rhabdovirus Infection with Sequence Similarity to the Bacterial Extracellular Solute-binding Protein Family 5.

W. J. Cho, W. J. Yoon, C. H. Moon, S. J. Cha, H. Song, H. R. Cho, S. J. Jang, D. K. Chung, C. S. Jeong, and J. W. Park (2002)
J. Biol. Chem. 277, 41489-41496
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Radicicol-sensitive Peptide Binding to the N-terminal Portion of GRP94.

S. Vogen, T. Gidalevitz, C. Biswas, B. B. Simen, E. Stein, F. Gulmen, and Y. Argon (2002)
J. Biol. Chem. 277, 40742-40750
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Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays.

G. R. Stewart, L. Wernisch, R. Stabler, J. A. Mangan, J. Hinds, K. G. Laing, D. B. Young, and P. D. Butcher (2002)
Microbiology 148, 3129-3138
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Enhancing the Efficacy of a Weak Allogeneic Melanoma Vaccine by Viral Fusogenic Membrane Glycoprotein-mediated Tumor Cell-Tumor Cell Fusion.

E. Linardakis, A. Bateman, V. Phan, A. Ahmed, M. Gough, K. Olivier, R. Kennedy, F. Errington, K. J. Harrington, A. Melcher, et al. (2002)
Cancer Res. 62, 5495-5504
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Evidence That Glycoprotein 96 (B2), a Stress Protein, Functions as a Th2-Specific Costimulatory Molecule.

P. P. Banerjee, D. S. Vinay, A. Mathew, M. Raje, V. Parekh, D. V. R. Prasad, A. Kumar, D. Mitra, and G. C. Mishra (2002)
J. Immunol. 169, 3507-3518
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Peripheral Blood Mononuclear Cell Proliferation to Heat Shock Protein-70 Derived from Autologous Lung Carcinoma.

A. Michils, D. Dutry, V. Z. de Beyl, M. Remmelink, V. de Maertelaer, and P. Rocmans (2002)
Am. J. Respir. Crit. Care Med. 166, 749-753
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GRP94-associated Enzymatic Activities. RESOLUTION BY CHROMATOGRAPHIC FRACTIONATION.

R. C. Reed, T. Zheng, and C. V. Nicchitta (2002)
J. Biol. Chem. 277, 25082-25089
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The Endoplasmic Reticulum-resident Heat Shock Protein Gp96 Activates Dendritic Cells via the Toll-like Receptor 2/4 Pathway.

R. M. Vabulas, S. Braedel, N. Hilf, H. Singh-Jasuja, S. Herter, P. Ahmad-Nejad, C. J. Kirschning, C. da Costa, H.-G. Rammensee, H. Wagner, et al. (2002)
J. Biol. Chem. 277, 20847-20853
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CD91-Independent Cross-Presentation of GRP94(gp96)-Associated Peptides.

B. Berwin, J. P. Hart, S. V. Pizzo, and C. V. Nicchitta (2002)
J. Immunol. 168, 4282-4286
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Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility.

M M de Jong, I M Nolte, G J te Meerman, W T A van der Graaf, J C Oosterwijk, J H Kleibeuker, M Schaapveld, and E G E de Vries (2002)
J. Med. Genet. 39, 225-242
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Critical Role for Activation of Antigen-Presenting Cells in Priming of Cytotoxic T Cell Responses After Vaccination with Virus-Like Particles.

T. Storni, F. Lechner, I. Erdmann, T. Bachi, A. Jegerlehner, T. Dumrese, T. M. Kundig, C. Ruedl, and M. F. Bachmann (2002)
J. Immunol. 168, 2880-2886
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Heat Shock Proteins gp96 and hsp70 Activate the Release of Nitric Oxide by APCs.

N. N. Panjwani, L. Popova, and P. K. Srivastava (2002)
J. Immunol. 168, 2997-3003
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Minor Histocompatibility Antigen-Specific MHC-Restricted CD8 T Cell Responses Elicited by Heat Shock Proteins.

J. Robert, J. Gantress, L. Rau, A. Bell, and N. Cohen (2002)
J. Immunol. 168, 1697-1703
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Immunization with Chaperone-Peptide Complex Induces Low-Avidity Cytotoxic T Lymphocytes Providing Transient Protection against Herpes Simplex Virus Infection.

U. Kumaraguru, M. Gierynska, S. Norman, B. D. Bruce, and B. T. Rouse (2002)
J. Virol. 76, 136-141
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Tolerance or Immunity to a Tumor Antigen Expressed in Somatic Cells Can Be Determined by Systemic Proinflammatory Signals at the Time of First Antigen Exposure.

I. H. Frazer, R. D. Kluyver, G. R. Leggatt, H. Yang Guo, L. Dunn, O. White, C. Harris, A. Liem, and P. Lambert (2001)
J. Immunol. 167, 6180-6187
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Immunization with gp96 from Listeria monocytogenes-Infected Mice Is Due to N-Formylated Listerial Peptides.

A.-M. Sponaas, U. Zuegel, S. Weber, R. Hurwitz, R. Winter, S. Lamer, P. R. Jungblut, and S. H. E. Kaufmann (2001)
J. Immunol. 167, 6480-6486
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Generation of cytotoxic T lymphocytes by MHC class I ligands fused to heat shock cognate protein 70.

H. Udono, T. Yamano, Y. Kawabata, M. Ueda, and K. Yui (2001)
Int. Immunol. 13, 1233-1242
 |  Abstract »  |  Full Text »  |  PDF »

Local Costimulation Reinvigorates Tumor-Specific Cytolytic T Lymphocytes for Experimental Therapy in Mice with Large Tumor Burdens.

X.-F. Bai, J. Bender, J. Liu, H. Zhang, Y. Wang, O. Li, P. Du, P. Zheng, and Y. Liu (2001)
J. Immunol. 167, 3936-3943
 |  Abstract »  |  Full Text »  |  PDF »

DNA Fusion Vaccine Designed to Induce Cytotoxic T Cell Responses Against Defined Peptide Motifs: Implications for Cancer Vaccines.

J. Rice, T. Elliott, S. Buchan, and F. K. Stevenson (2001)
J. Immunol. 167, 1558-1565
 |  Abstract »  |  Full Text »  |  PDF »

gp96-Peptide Vaccination of Mice against Intracellular Bacteria.

U. Zugel, A.-M. Sponaas, J. Neckermann, B. Schoel, and S. H. E. Kaufmann (2001)
Infect. Immun. 69, 4164-4167
 |  Abstract »  |  Full Text »  |  PDF »

Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Linkage of Mycobacterium tuberculosis Heat Shock Protein 70 Gene to an Antigen Gene.

W.-F. Cheng, C.-F. Hung, C.-Y. Chai, K.-F. Hsu, L. He, C. M. Rice, M. Ling, and T.-C. Wu (2001)
J. Immunol. 166, 6218-6226
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Adjuvanticity of {{alpha}}2-Macroglobulin, an Independent Ligand for the Heat Shock Protein Receptor CD91.

R. J. Binder, D. Karimeddini, and P. K. Srivastava (2001)
J. Immunol. 166, 4968-4972
 |  Abstract »  |  Full Text »  |  PDF »

CD8+ T Cells Have an Essential Role in Pulmonary Clearance of Nontypeable Haemophilus influenzae following Mucosal Immunization.

A. R. Foxwell, J. M. Kyd, G. Karupiah, and A. W. Cripps (2001)
Infect. Immun. 69, 2636-2642
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Antigen-Specific Processing Pathways for Activating Naive CD8+ T Cells In Vivo.

C. C. Norbury, M. F. Princiotta, I. Bacik, R. R. Brutkiewicz, P. Wood, T. Elliott, J. R. Bennink, and J. W. Yewdell (2001)
J. Immunol. 166, 4355-4362
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Human Heat Shock Protein 70 Peptide Complexes Specifically Activate Antimelanoma T Cells.

C. Castelli, A.-M. T. Ciupitu, F. Rini, L. Rivoltini, A. Mazzocchi, R. Kiessling, and G. Parmiani (2001)
Cancer Res. 61, 222-227
 |  Abstract »  |  Full Text »

Characterization of Heat Shock Protein 110 and Glucose-Regulated Protein 170 as Cancer Vaccines and the Effect of Fever-Range Hyperthermia on Vaccine Activity.

X.-Y. Wang, L. Kazim, E. A. Repasky, and J. R. Subjeck (2001)
J. Immunol. 166, 490-497
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HSP70 from Trypanosoma cruzi is endowed with specific cell proliferation potential leading to apoptosis.

C. Maranon, L. Planelles, C. Alonso, and M. C. Lopez (2000)
Int. Immunol. 12, 1685-1693
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Heat Shock Protein gp96 Induces Maturation and Migration of CD11c+ Cells In Vivo.

R. J. Binder, K. M. Anderson, S. Basu, and P. K. Srivastava (2000)
J. Immunol. 165, 6029-6035
 |  Abstract »  |  Full Text »  |  PDF »

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-{kappa}B pathway.

S. Basu, R. J. Binder, R. Suto, K. M. Anderson, and P. K. Srivastava (2000)
Int. Immunol. 12, 1539-1546
 |  Abstract »  |  Full Text »  |  PDF »

Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death.

C. Jolly and R. I. Morimoto (2000)
J Natl Cancer Inst 92, 1564-1572
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Prevention and Antitumor Immunity with Heat Shock Protein 70 Induced by 15-Deoxy-{{Delta}}12,14-prostaglandin J2 in Transgenic Adenocarcinoma of Mouse Prostate Cells.

D. K. Vanaja, M. E. Grossmann, E. Celis, and C. Y. F. Young (2000)
Cancer Res. 60, 4714-4718
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Saturation, Competition, and Specificity in Interaction of Heat Shock Proteins (hsp) gp96, hsp90, and hsp70 with CD11b+ Cells.

R. J. Binder, M. L. Harris, A. Menoret, and P. K. Srivastava (2000)
J. Immunol. 165, 2582-2587
 |  Abstract »  |  Full Text »  |  PDF »

Cationic Lipid:Bacterial DNA Complexes Elicit Adaptive Cellular Immunity in Murine Intraperitoneal Tumor Models.

M. Lanuti, S. Rudginsky, S. D. Force, E. S. Lambright, W. M. Siders, M. Y. Chang, K. M. Amin, L. R. Kaiser, R. K. Scheule, and S. M. Albelda (2000)
Cancer Res. 60, 2955-2963
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Immunoprotective Activities of Multiple Chaperone Proteins Isolated from Murine B-Cell Leukemia/Lymphoma.

M. Graner, A. Raymond, D. Romney, L. He, L. Whitesell, and E. Katsanis (2000)
Clin. Cancer Res. 6, 909-915
 |  Abstract »  |  Full Text »

Heat Shock Protein 70 Is Able to Prevent Heat Shock-Induced Resistance of Target Cells to CTL.

R. Dressel, L. Elsner, T. Quentin, L. Walter, and E. Gunther (2000)
J. Immunol. 164, 2362-2371
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Identification of the Peptide-binding Site in the Heat Shock Chaperone/Tumor Rejection Antigen gp96 (Grp94).

N. A. Linderoth, A. Popowicz, and S. Sastry (2000)
J. Biol. Chem. 275, 5472-5477
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Recognition of a Sequestered Self Peptide by Influenza Virus-Specific CD8+ Cytolytic T Lymphocytes.

R. Fan, S. S. Tykodi, and T. J. Braciale (2000)
J. Immunol. 164, 1669-1680
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Consequences of Cell Death: Exposure to Necrotic Tumor Cells, but Not Primary Tissue Cells or Apoptotic Cells, Induces the Maturation of Immunostimulatory Dendritic Cells.

B. Sauter, M. L. Albert, L. Francisco, M. Larsson, S. Somersan, and N. Bhardwaj (2000)
J. Exp. Med. 191, 423-434
 |  Abstract »  |  Full Text »  |  PDF »

Enhancement of DNA Vaccine Potency by Linkage of Antigen Gene to an HSP70 Gene.

C.-H. Chen, T.-L. Wang, C.-F. Hung, Y. Yang, R. A. Young, D. M. Pardoll, and T-C. Wu (2000)
Cancer Res. 60, 1035-1042
 |  Abstract »  |  Full Text »

Induction of CTL Responses by Simultaneous Administration of Liposomal Peptide Vaccine with Anti-CD40 and Anti-CTLA-4 mAb.

D. Ito, K. Ogasawara, K. Iwabuchi, Y. Inuyama, and K. Onoe (2000)
J. Immunol. 164, 1230-1235
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Cytotoxic T Lymphocyte Elicitation by Mycobacterial Heat Shock Protein 70 Fusion Proteins Maps to a Discrete Domain and Is CD4+ T Cell Independent.

Q. Huang, J. F.L. Richmond, K. Suzue, H. N. Eisen, and R. A. Young (2000)
J. Exp. Med. 191, 403-408
 |  Abstract »  |  Full Text »  |  PDF »

Percutaneous peptide immunization via corneum barrier-disrupted murine skin for experimental tumor immunoprophylaxis.

N. Seo, Y. Tokura, T. Nishijima, H. Hashizume, F. Furukawa, and M. Takigawa (2000)
PNAS 97, 371-376
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Tumor Secreted Heat Shock-Fusion Protein Elicits CD8 Cells for Rejection.

K. Yamazaki, T. Nguyen, and E. R. Podack (1999)
J. Immunol. 163, 5178-5182
 |  Abstract »  |  Full Text »  |  PDF »

Hyperthermia enhances cytomegalovirus regulation of HIV-1 and TNF-alpha gene expression.

G. K. Iwamoto, A. M. Ainsworth, and P. L. Moseley (1999)
Am J Physiol Lung Cell Mol Physiol 277, L1051-L1056
 |  Abstract »  |  Full Text »  |  PDF »

Cell Surface Expression of the Endoplasmic Reticular Heat Shock Protein gp96 Is Phylogenetically Conserved.

J. Robert, A. Menoret, and N. Cohen (1999)
J. Immunol. 163, 4133-4139
 |  Abstract »  |  Full Text »  |  PDF »

Immunogenicity of DNA Vaccines Expressing Tuberculosis Proteins Fused to Tissue Plasminogen Activator Signal Sequences.

Z. Li, A. Howard, C. Kelley, G. Delogu, F. Collins, and S. Morris (1999)
Infect. Immun. 67, 4780-4786
 |  Abstract »  |  Full Text »  |  PDF »

Follicle cell proteasome activity and acid extract from the egg vitelline coat prompt the onset of self-sterility in Ciona intestinalis oocytes.

R. Marino, R. De Santis, P. Giuliano, and M. R. Pinto (1999)
PNAS 96, 9633-9636
 |  Abstract »  |  Full Text »  |  PDF »

Heat Shock Protein 70 Induced During Tumor Cell Killing Induces Th1 Cytokines and Targets Immature Dendritic Cell Precursors to Enhance Antigen Uptake.

S. Todryk, A. A. Melcher, N. Hardwick, E. Linardakis, A. Bateman, M. P. Colombo, A. Stoppacciaro, and R. G. Vile (1999)
J. Immunol. 163, 1398-1408
 |  Abstract »  |  Full Text »  |  PDF »

Sialoadhesin-Positive Host Macrophages Play an Essential Role in Graft-Versus-Leukemia Reactivity in Mice.

S. Muerkoster, M. Rocha, P. R. Crocker, V. Schirrmacher, and V. Umansky (1999)
Blood 93, 4375-4386
 |  Abstract »  |  Full Text »  |  PDF »

Receptor-mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways.

F. Castellino, P. E. Boucher, K. Eichelberg, M. Mayhew, J. E. Rothman, A. N. Houghton, and R. N. Germain (1999)
J. Exp. Med. 191, 1957-1964
 |  Abstract »  |  Full Text »  |  PDF »

Cross-Presentation of Glycoprotein 96-associated Antigens on Major Histocompatibility Complex Class I Molecules Requires Receptor-mediated Endocytosis.

H. Singh-Jasuja, R. E.M. Toes, P. Spee, C. Munz, N. Hilf, S. P. Schoenberger, P. Ricciardi-Castagnoli, J. Neefjes, H.-G. Rammensee, D. Arnold-Schild, et al. (1999)
J. Exp. Med. 191, 1965-1974
 |  Abstract »  |  Full Text »  |  PDF »

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