Science 15 September 1995: Vol. 269. no. 5230, pp. 1575 - 1577 DOI: 10.1126/science.7667636

Prev | Table of Contents | Next

Articles

Stress-Activated Mitogen-Activated Protein Kinases c-Jun NH2-Terminal Kinase and p38 Target Cdc25B for Degradation.

S. Uchida, K. Yoshioka, R. Kizu, H. Nakagama, T. Matsunaga, Y. Ishizaka, R. Y.C. Poon, and K. Yamashita (2009)
Cancer Res. 69, 6438-6444
 |  Abstract »  |  Full Text »  |  PDF »

Inappropriate Activation of Cyclin-dependent Kinases by the Phosphatase Cdc25b Results in Premature Mitotic Entry and Triggers a p53-dependent Checkpoint.

S. Varmeh and J. J. Manfredi (2009)
J. Biol. Chem. 284, 9475-9488
 |  Abstract »  |  Full Text »  |  PDF »

CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells.

R.-q. Chen, Q.-k. Yang, B.-w. Lu, W. Yi, G. Cantin, Y.-l. Chen, C. Fearns, J. R. Yates III, and J.-D. Lee (2009)
Cancer Res. 69, 2663-2668
 |  Abstract »  |  Full Text »  |  PDF »

Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model.

A. Dhar, S. Mehta, G. Dhar, K. Dhar, S. Banerjee, P. Van Veldhuizen, D. R. Campbell, and S. K. Banerjee (2009)
Mol. Cancer Ther. 8, 315-323
 |  Abstract »  |  Full Text »  |  PDF »

Cdc25A Serine 123 Phosphorylation Couples Centrosome Duplication with DNA Replication and Regulates Tumorigenesis.

S. Shreeram, W. K. Hee, and D. V. Bulavin (2008)
Mol. Cell. Biol. 28, 7442-7450
 |  Abstract »  |  Full Text »  |  PDF »

Aberrant Polo-Like Kinase 1-Cdc25A Pathway in Metastatic Hepatocellular Carcinoma.

X. Q. Wang, Y. Q. Zhu, K. S. Lui, Q. Cai, P. Lu, and R. T. Poon (2008)
Clin. Cancer Res. 14, 6813-6820
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of CDC25B and LAMC2 mRNA and Protein in Esophageal Squamous Cell Carcinomas and Premalignant Lesions in Subjects from a High-Risk Population in China.

J.-Z. Shou, N. Hu, M. Takikita, M. J. Roth, L. L. Johnson, C. Giffen, Q.-H. Wang, C. Wang, Y. Wang, H. Su, et al. (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 1424-1435
 |  Abstract »  |  Full Text »  |  PDF »

CDC25A Phosphatase: a Rate-Limiting Oncogene That Determines Genomic Stability.

D. Ray and H. Kiyokawa (2008)
Cancer Res. 68, 1251-1253
 |  Abstract »  |  Full Text »  |  PDF »

Cell Division Cycle 25B Phosphatase Is Essential for Benzo(a)Pyrene-7,8-Diol-9,10-Epoxide Induced Neoplastic Transformation.

S. K. Srivastava, P. Bansal, T. Oguri, J. S. Lazo, and S. V. Singh (2007)
Cancer Res. 67, 9150-9157
 |  Abstract »  |  Full Text »  |  PDF »

The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells.

C. D. Johnson, A. Esquela-Kerscher, G. Stefani, M. Byrom, K. Kelnar, D. Ovcharenko, M. Wilson, X. Wang, J. Shelton, J. Shingara, et al. (2007)
Cancer Res. 67, 7713-7722
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Cdc25B Regulates Cell Cycle Resumption after Genotoxic Stress.

P. Bansal and J. S. Lazo (2007)
Cancer Res. 67, 3356-3363
 |  Abstract »  |  Full Text »  |  PDF »

RNA Interference Knockdown of hU2AF35 Impairs Cell Cycle Progression and Modulates Alternative Splicing of Cdc25 Transcripts.

T. R. Pacheco, L. F. Moita, A. Q. Gomes, N. Hacohen, and M. Carmo-Fonseca (2006)
Mol. Biol. Cell 17, 4187-4199
 |  Abstract »  |  Full Text »  |  PDF »

p27Kip1 Repression of ErbB2-Induced Mammary Tumor Growth in Transgenic Mice Involves Skp2 and Wnt/{beta}-Catenin Signaling..

J. Hulit, R. J. Lee, Z. Li, C. Wang, S. Katiyar, J. Yang, A. A. Quong, K. Wu, C. Albanese, R. Russell, et al. (2006)
Cancer Res. 66, 8529-8541
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis.

A. Noren-Muller, I. Reis-Correa Jr, H. Prinz, C. Rosenbaum, K. Saxena, H. J. Schwalbe, D. Vestweber, G. Cagna, S. Schunk, O. Schwarz, et al. (2006)
PNAS 103, 10606-10611
 |  Abstract »  |  Full Text »  |  PDF »

Prognostic significance of CDC25B expression in gliomas..

H Nakabayashi, M Hara, and K Shimizu (2006)
J. Clin. Pathol. 59, 725-728
 |  Abstract »  |  Full Text »  |  PDF »

PM-20, a novel inhibitor of Cdc25A, induces extracellular signal-regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo..

S. Kar, M. Wang, W. Yao, C. J. Michejda, and B. I. Carr (2006)
Mol. Cancer Ther. 5, 1511-1519
 |  Abstract »  |  Full Text »  |  PDF »

Direct Control of Cell Cycle Gene Expression by Proto-Oncogene Product ACTR, and Its Autoregulation Underlies Its Transforming Activity.

M. C. Louie, A. S. Revenko, J. X. Zou, J. Yao, and H.-W. Chen (2006)
Mol. Cell. Biol. 26, 3810-3823
 |  Abstract »  |  Full Text »  |  PDF »

Redox Regulation of Cdc25B by Cell-Active Quinolinediones.

M. Brisson, T. Nguyen, P. Wipf, B. Joo, B. W. Day, J. S. Skoko, E. M. Schreiber, C. Foster, P. Bansal, and J. S. Lazo (2005)
Mol. Pharmacol. 68, 1810-1820
 |  Abstract »  |  Full Text »  |  PDF »

Increased Expression and Activity of CDC25C Phosphatase and an Alternatively Spliced Variant in Prostate Cancer.

M. Ozen and M. Ittmann (2005)
Clin. Cancer Res. 11, 4701-4706
 |  Abstract »  |  Full Text »  |  PDF »

The STAT3 Transcription Factor Is a Target for the Myc and Riboblastoma Proteins on the Cdc25A Promoter.

B. Barre, A. Vigneron, and O. Coqueret (2005)
J. Biol. Chem. 280, 15673-15681
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor {beta} Facilitates {beta}-TrCP-Mediated Degradation of Cdc25A in a Smad3-Dependent Manner.

D. Ray, Y. Terao, D. Nimbalkar, L.-H. Chu, M. Donzelli, T. Tsutsui, X. Zou, A. K. Ghosh, J. Varga, G. F. Draetta, et al. (2005)
Mol. Cell. Biol. 25, 3338-3347
 |  Abstract »  |  Full Text »  |  PDF »

Discovery and Characterization of Novel Small Molecule Inhibitors of Human Cdc25B Dual Specificity Phosphatase.

M. Brisson, T. Nguyen, A. Vogt, J. Yalowich, A. Giorgianni, D. Tobi, I. Bahar, C. R. J. Stephenson, P. Wipf, and J. S. Lazo (2004)
Mol. Pharmacol. 66, 824-833
 |  Abstract »  |  Full Text »  |  PDF »

Binding of 14-3-3{beta} but not 14-3-3{sigma} controls the cytoplasmic localization of CDC25B: binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B.

S. Uchida, A. Kuma, M. Ohtsubo, M. Shimura, M. Hirata, H. Nakagama, T. Matsunaga, Y. Ishizaka, and K. Yamashita (2004)
J. Cell Sci. 117, 3011-3020
 |  Abstract »  |  Full Text »  |  PDF »

DNA damage responses triggered by a highly cytotoxic monofunctional DNA alkylator, hedamycin, a pluramycin antitumor antibiotic.

L. C. Tu, T. Melendy, and T. A. Beerman (2004)
Mol. Cancer Ther. 3, 577-586
 |  Abstract »  |  Full Text »  |  PDF »

Suramin Derivatives as Inhibitors and Activators of Protein-tyrosine Phosphatases.

D. F. McCain, L. Wu, P. Nickel, M. U. Kassack, A. Kreimeyer, A. Gagliardi, D. C. Collins, and Z.-Y. Zhang (2004)
J. Biol. Chem. 279, 14713-14725
 |  Abstract »  |  Full Text »  |  PDF »

G2 checkpoint abrogators as anticancer drugs.

T. Kawabe (2004)
Mol. Cancer Ther. 3, 513-519
 |  Abstract »  |  Full Text »  |  PDF »

Alteration of gene expression during radiation-induced resistance and tumorigenesis in NIH3T3 cells revealed by cDNA microarrays: involvement of MDM2 and CDC25B.

C.-M. Kang, H.-N. Cho, J.-M. Ahn, S.-S. Lee, D.-I. Jeoung, C.-K. Cho, S. Bae, S.-J. Lee, and Y.-S. Lee (2004)
Carcinogenesis 25, 123-132
 |  Abstract »  |  Full Text »  |  PDF »

Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding.

M.-S. Chen, C. E. Ryan, and H. Piwnica-Worms (2003)
Mol. Cell. Biol. 23, 7488-7497
 |  Abstract »  |  Full Text »  |  PDF »

Differential Contribution of Inhibitory Phosphorylation of CDC2 and CDK2 for Unperturbed Cell Cycle Control and DNA Integrity Checkpoints.

J. P. H. Chow, W. Y. Siu, H. T. B. Ho, K. H. T. Ma, C. C. Ho, and R. Y. C. Poon (2003)
J. Biol. Chem. 278, 40815-40828
 |  Abstract »  |  Full Text »  |  PDF »

Coordinate Expression of Cdc25B and ER-{alpha} Is Frequent in Low-Grade Endometrioid Endometrial Carcinoma but Uncommon in High-Grade Endometrioid and Nonendometrioid Carcinomas.

W. Wu, B. M. Slomovitz, J. Celestino, L. Chung, A. Thornton, and K. H. Lu (2003)
Cancer Res. 63, 6195-6199
 |  Abstract »  |  Full Text »  |  PDF »

Cdc25A-inhibitory properties and antineoplastic activity of bisperoxovanadium analogues.

P. J. Scrivens, M. A. Alaoui-Jamali, G. Giannini, T. Wang, M. Loignon, G. Batist, and V. A. Sandor (2003)
Mol. Cancer Ther. 2, 1053-1059
 |  Abstract »  |  Full Text »

Regulation of Cdc25A Half-life in Interphase by Cyclin-dependent Kinase 2 Activity.

A. P. Ducruet and J. S. Lazo (2003)
J. Biol. Chem. 278, 31838-31842
 |  Abstract »  |  Full Text »  |  PDF »

Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents.

Z. Xiao, Z. Chen, A. H. Gunasekera, T. J. Sowin, S. H. Rosenberg, S. Fesik, and H. Zhang (2003)
J. Biol. Chem. 278, 21767-21773
 |  Abstract »  |  Full Text »  |  PDF »

Distinctive Patterns of Gene Expression in Premalignant Gastric Mucosa and Gastric Cancer.

A. Boussioutas, H. Li, J. Liu, P. Waring, S. Lade, A. J. Holloway, D. Taupin, K. Gorringe, I. Haviv, P. V. Desmond, et al. (2003)
Cancer Res. 63, 2569-2577
 |  Abstract »  |  Full Text »  |  PDF »

Protein Tyrosine Phosphatase {varepsilon} Inhibits Signaling by Mitogen-Activated Protein Kinases.

H. Toledano-Katchalski, J. Kraut, T. Sines, S. Granot-Attas, G. Shohat, H. Gil-Henn, Y. Yung, and A. Elson (2003)
Mol. Cancer Res. 1, 541-550
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of CDC25A Phosphatase Is Associated with Hypergrowth Activity and Poor Prognosis of Human Hepatocellular Carcinomas.

X. Xu, H. Yamamoto, M. Sakon, M. Yasui, C. Y. Ngan, H. Fukunaga, T. Morita, M. Ogawa, H. Nagano, S. Nakamori, et al. (2003)
Clin. Cancer Res. 9, 1764-1772
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine Phosphatase-epsilon Activates Src and Supports the Transformed Phenotype of Neu-induced Mammary Tumor Cells.

H. Gil-Henn and A. Elson (2003)
J. Biol. Chem. 278, 15579-15586
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic Potential of a Dominant Negative Mutant of Interferon Regulatory Factor 3.

T. Y. Kim, K.-H. Lee, S. Chang, C. Chung, H.-W. Lee, J. Yim, and T. K. Kim (2003)
J. Biol. Chem. 278, 15272-15278
 |  Abstract »  |  Full Text »  |  PDF »

The Carcinogen (7R,8S)-Dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene Induces Cdc25B Expression in Human Bronchial and Lung Cancer Cells.

T. Oguri, S. V. Singh, K. Nemoto, and J. S. Lazo (2003)
Cancer Res. 63, 771-775
 |  Abstract »  |  Full Text »  |  PDF »

Dual G1 and G2 Phase Inhibition by a Novel, Selective Cdc25 Inhibitor 7-Chloro-6-(2-morpholin-4-ylethylamino)- quinoline-5,8-dione.

L. Pu, A. A. Amoscato, M. E. Bier, and J. S. Lazo (2002)
J. Biol. Chem. 277, 46877-46885
 |  Abstract »  |  Full Text »  |  PDF »

A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells.

E. Melkun, M. Pilione, and R. F. Paulson (2002)
Blood 100, 3804-3811
 |  Abstract »  |  Full Text »  |  PDF »

Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease.

D. A. Weinstein, C. N. Roy, M. D. Fleming, M. F. Loda, J. I. Wolfsdorf, and N. C. Andrews (2002)
Blood 100, 3776-3781
 |  Abstract »  |  Full Text »  |  PDF »

A Bioinformatics-Based Strategy Identifies c-Myc and Cdc25A as Candidates for the Apmt Mammary Tumor Latency Modifiers.

D. Cozma, L. Lukes, J. Rouse, T. H. Qiu, E. T. Liu, and K. W. Hunter (2002)
Genome Res. 12, 969-975
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Potent and Selective Pharmacophore for Cdc25 Dual Specificity Phosphatase Inhibitors..

J. S. Lazo, K. Nemoto, K. E. Pestell, K. Cooley, E. C. Southwick, D. A. Mitchell, W. Furey, R. Gussio, D. W. Zaharevitz, B. Joo, et al. (2002)
Mol. Pharmacol. 61, 720-728
 |  Abstract »  |  Full Text »  |  PDF »

Human Papillomavirus Type 16 E7 Maintains Elevated Levels of the cdc25A Tyrosine Phosphatase during Deregulation of Cell Cycle Arrest.

D. X. Nguyen, T. F. Westbrook, and D. J. McCance (2002)
J. Virol. 76, 619-632
 |  Abstract »  |  Full Text »  |  PDF »

Organ-specific cell division abnormalities caused by mutation in a general cell cycle regulator in C. elegans.

I. Kostic and R. Roy (2002)
Development 129, 2155-2165
 |  Abstract »  |  Full Text »  |  PDF »

Cdc25B Functions as a Novel Coactivator for the Steroid Receptors.

Z.-Q. Ma, Z. Liu, E. S. W. Ngan, and S. Y. Tsai (2001)
Mol. Cell. Biol. 21, 8056-8067
 |  Abstract »  |  Full Text »  |  PDF »

Expression of the cdc25B mRNA Correlated with that of N-myc in Neuroblastoma.

Y. Sato, H. Sasaki, S. Kondo, I. Fukai, M. Kiriyama, Y. Yamakawa, and Y. Fujii (2001)
Jpn. J. Clin. Oncol. 31, 428-431
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Differentially Expressed Genes in Esophageal Squamous Cell Carcinoma (ESCC) by cDNA Expression Array: Overexpression of Fra-1, Neogenin, Id-1, and CDC25B Genes in ESCC.

Y. C. Hu, K. Y. Lam, S. Law, J. Wong, and G. Srivastava (2001)
Clin. Cancer Res. 7, 2213-2221
 |  Abstract »  |  Full Text »  |  PDF »

The Cell Cycle-Regulatory CDC25A Phosphatase Inhibits Apoptosis Signal-Regulating Kinase 1.

X. Zou, T. Tsutsui, D. Ray, J. F. Blomquist, H. Ichijo, D. S. Ucker, and H. Kiyokawa (2001)
Mol. Cell. Biol. 21, 4818-4828
 |  Abstract »  |  Full Text »  |  PDF »

Absence of Apparent Phenotype in Mice Lacking Cdc25C Protein Phosphatase.

M.-S. Chen, J. Hurov, L. S. White, T. Woodford-Thomas, and H. Piwnica-Worms (2001)
Mol. Cell. Biol. 21, 3853-3861
 |  Abstract »  |  Full Text »

Overexpression of CDC25B Overrides Radiation-induced G2-M Arrest and Results in Increased Apoptosis in Esophageal Cancer Cells.

H. Miyata, Y. Doki, H. Yamamoto, K. Kishi, H. Takemoto, Y. Fujiwara, T. Yasuda, M. Yano, M. Inoue, H. Shiozaki, et al. (2001)
Cancer Res. 61, 3188-3193
 |  Abstract »  |  Full Text »

Multifaceted Regulation of Cell Cycle Progression by Estrogen: Regulation of Cdk Inhibitors and Cdc25A Independent of Cyclin D1-Cdk4 Function.

J. S. Foster, D. C. Henley, A. Bukovsky, P. Seth, and J. Wimalasena (2001)
Mol. Cell. Biol. 21, 794-810
 |  Abstract »  |  Full Text »

CDC25B and p53 Are Independently Implicated in Radiation Sensitivity for Human Esophageal Cancers.

H. Miyata, Y. Doki, H. Shiozaki, M. Inoue, M. Yano, Y. Fujiwara, H. Yamamoto, K. Nishioka, K. Kishi, and M. Monden (2000)
Clin. Cancer Res. 6, 4859-4865
 |  Abstract »  |  Full Text »

Tumor Induction by the c-Myc Target Genes rcl and Lactate Dehydrogenase A.

B. C. Lewis, J. E. Prescott, S. E. Campbell, H. Shim, R. Z. Orlowski, and C. V. Dang (2000)
Cancer Res. 60, 6178-6183
 |  Abstract »  |  Full Text »

HMG-I/Y, a New c-Myc Target Gene and Potential Oncogene.

L. J. Wood, M. Mukherjee, C. E. Dolde, Y. Xu, J. F. Maher, T. E. Bunton, J. B. Williams, and L. M. S. Resar (2000)
Mol. Cell. Biol. 20, 5490-5502
 |  Abstract »  |  Full Text »

Transforming Growth Factor-{beta}1 Recruits Histone Deacetylase 1 to a p130 Repressor Complex in Transgenic Mice in Vivo.

B. Bouzahzah, M. Fu, A. Iavarone, V. M. Factor, S. S. Thorgeirsson, and R. G. Pestell (2000)
Cancer Res. 60, 4531-4537
 |  Abstract »  |  Full Text »

Overexpression of CDC25B Phosphatase as a Novel Marker of Poor Prognosis of Human Colorectal Carcinoma.

I. Takemasa, H. Yamamoto, M. Sekimoto, M. Ohue, S. Noura, Y. Miyake, T. Matsumoto, T. Aihara, N. Tomita, Y. Tamaki, et al. (2000)
Cancer Res. 60, 3043-3050
 |  Abstract »  |  Full Text »  |  PDF »

Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis.

I.B. Weinstein (2000)
Carcinogenesis 21, 857-864
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Kinase-Associated Phosphatase (KAP) in Breast and Prostate Cancer and Inhibition of the Transformed Phenotype by Antisense KAP Expression.

S. W. Lee, C. L. Reimer, L. Fang, M. L. Iruela-Arispe, and S. A. Aaronson (2000)
Mol. Cell. Biol. 20, 1723-1732
 |  Abstract »  |  Full Text »

Cdc25 Inhibition and Cell Cycle Arrest by a Synthetic Thioalkyl Vitamin K Analogue.

K. Tamura, E. C. Southwick, J. Kerns, K. Rosi, B. I. Carr, C. Wilcox, and J. S. Lazo (2000)
Cancer Res. 60, 1317-1325
 |  Abstract »  |  Full Text »

Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis.

P. J. Greasley, C. Bonnard, and B. Amati (2000)
Nucleic Acids Res. 28, 446-453
 |  Abstract »  |  Full Text »  |  PDF »

Defects in transforming growth factor-beta signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes.

A. Glick, N. Popescu, V. Alexander, H. Ueno, E. Bottinger, and S. H. Yuspa (1999)
PNAS 96, 14949-14954
 |  Abstract »  |  Full Text »  |  PDF »

Ectopic Expression of Cdc25A Accelerates the G1/S Transition and Leads to Premature Activation of Cyclin E- and Cyclin A-Dependent Kinases.

I. Blomberg and I. Hoffmann (1999)
Mol. Cell. Biol. 19, 6183-6194
 |  Abstract »  |  Full Text »  |  PDF »

CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase.

E. Vigo, H. Muller, E. Prosperini, G. Hateboer, P. Cartwright, M. C. Moroni, and K. Helin (1999)
Mol. Cell. Biol. 19, 6379-6395
 |  Abstract »  |  Full Text »  |  PDF »

Serum-Induced Expression of the cdc25A Gene by Relief of E2F-Mediated Repression.

X. Chen and R. Prywes (1999)
Mol. Cell. Biol. 19, 4695-4702
 |  Abstract »  |  Full Text »  |  PDF »

Physical and Functional Interactions between Pim-1 Kinase and Cdc25A Phosphatase. IMPLICATIONS FOR THE Pim-1-MEDIATED ACTIVATION OF THE c-Myc SIGNALING PATHWAY.

T. Mochizuki, C. Kitanaka, K. Noguchi, T. Muramatsu, A. Asai, and Y. Kuchino (1999)
J. Biol. Chem. 274, 18659-18666
 |  Abstract »  |  Full Text »  |  PDF »

Bovine Papillomavirus E2 Protein Activates a Complex Growth-inhibitory Program in p53-negative HT-3 Cervical Carcinoma Cells that Includes Repression of Cyclin A and cdc25A Phosphatase Genes and Accumulation of Hypophosphorylated Retinoblastoma Protein.

L. K. Naeger, E. C. Goodwin, E.-S. Hwang, R. A. DeFilippis, H. Zhang, and D. DiMaio (1999)
Cell Growth Differ. 10, 413-422
 |  Abstract »  |  Full Text »

The Tmp Gene, Encoding a Membrane Protein, Is a c-Myc Target with a Tumorigenic Activity.

I. Ben-Porath, O. Yanuka, and N. Benvenisty (1999)
Mol. Cell. Biol. 19, 3529-3539
 |  Abstract »  |  Full Text »  |  PDF »

c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets.

A. Bush, M. Mateyak, K. Dugan, A. Obaya, S. Adachi, J. Sedivy, and M. Cole (1998)
Genes & Dev. 12, 3797-3802
 |  Abstract »  |  Full Text »

The cdc25B phosphatase is essential for the G2/M phase transition in human cells.

C Lammer, S Wagerer, R Saffrich, D Mertens, W Ansorge, and I Hoffmann (1998)
J. Cell Sci. 111, 2445-2453
 |  Abstract »  |  PDF »

Phosphorylation of Human CDC25B Phosphatase by CDK1-Cyclin A Triggers Its Proteasome-dependent Degradation.

V. Baldin, C. Cans, M. Knibiehler, and B. Ducommun (1997)
J. Biol. Chem. 272, 32731-32734
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design.

Y. A. Puius, Y. Zhao, M. Sullivan, D. S. Lawrence, S. C. Almo, and Z.-Y. Zhang (1997)
PNAS 94, 13420-13425
 |  Abstract »  |  Full Text »  |  PDF »

Myc represses transcription of the growth arrest gene gas1.

T. C. Lee, L. Li, L. Philipson, and E. B. Ziff (1997)
PNAS 94, 12886-12891
 |  Abstract »  |  Full Text »  |  PDF »

A Dual-Specificity Phosphatase Cdc25B Is an Unstable Protein and Triggers p34cdc2/Cyclin B Activation in Hamster BHK21 Cells Arrested with Hydroxyurea.

H. Nishijima, H. Nishitani, T. Seki, and T. Nishimoto (1997)
J. Cell Biol. 138, 1105-1116
 |  Abstract »  |  Full Text »  |  PDF »

Platelet-activating Factor (PAF) Induces Growth Stimulation, Inhibition, and Suppression of Oncogenic Transformation in NRK Cells Overexpressing the PAF Receptor.

K. Kume and T. Shimizu (1997)
J. Biol. Chem. 272, 22898-22904
 |  Abstract »  |  Full Text »  |  PDF »

Induction of c-myc transcription by the v-Abl tyrosine kinase requires Ras, Raf1, and cyclin-dependent kinases..

X Zou, S Rudchenko, K Wong, and K Calame (1997)
Genes & Dev. 11, 654-662
 |  Abstract »  |  PDF »

Cloning and Characterization of Islet Cell Antigen-related Protein-tyrosine Phosphatase (PTP), a Novel Receptor-like PTP and Autoantigen in Insulin-dependent Diabetes.

L. Cui, W.-P. Yu, H. J. DeAizpurua, R. S. Schmidli, and C. J. Pallen (1996)
J. Biol. Chem. 271, 24817-24823
 |  Abstract »  |  Full Text »  |  PDF »

14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region..

S S Chong, A Tanigami, A V Roschke, and D H Ledbetter (1996)
Genome Res. 6, 735-741
 |  Abstract »  |  PDF »

Paradoxical accumulation of the cyclin-dependent kinase inhibitor p27kip1 during the cAMP-dependent mitogenic stimulation of thyroid epithelial cells.

F Depoortere, J. Dumont, and P. Roger (1996)
J. Cell Sci. 109, 1759-1764
 |  Abstract »  |  PDF »

The Cyclin D1 Gene Is Transcriptionally Repressed by Caveolin-1.

J. Hulit, T. Bash, M. Fu, F. Galbiati, C. Albanese, D. R. Sage, A. Schlegel, J. Zhurinsky, M. Shtutman, A. Ben-Ze'ev, et al. (2000)
J. Biol. Chem. 275, 21203-21209
 |  Abstract »  |  Full Text »  |  PDF »

An Essential Phosphorylation-site Domain of Human cdc25C Interacts with Both 14-3-3 and Cyclins.

M. C. Morris, A. Heitz, J. Mery, F. Heitz, and G. Divita (2000)
J. Biol. Chem. 275, 28849-28857
 |  Abstract »  |  Full Text »  |  PDF »

Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway.

F. Chen, Z. Zhang, J. Bower, Y. Lu, S. S. Leonard, M. Ding, V. Castranova, H. Piwnica-Worms, and X. Shi (2002)
PNAS 99, 1990-1995
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products