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Science 15 September 1995:
Vol. 269. no. 5230, pp. 1570 - 1572
DOI: 10.1126/science.7545312
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Articles

Science, Vol 269, Issue 5230, 1570-1572
Copyright © 1995 by American Association for the Advancement of Science

articles

Inhibition of cell cycle progression by the alternatively spliced integrin beta 1C

J Meredith Jr, Y Takada, M Fornaro, LR Languino, and MA Schwartz

Department of Vascular Biology, Scripps Research Institute, La Jolla, CA 92037, USA.

Integrins regulate cell growth, differentiation, and behavior in many systems. Integrin beta 1C (beta 1S) is an alternatively spliced variant of integrin beta 1 with a specific cytoplasmic domain and is expressed in several human tissues. Human beta 1c transiently expressed in mouse 10T1/2 fibroblasts showed a diffuse pattern of cell surface staining, whereas beta1 localized to focal adhesions. Moderate concentrations of beta 1C had no effect on actin stress fibers or focal adhesions, but markedly inhibited DNA synthesis. Inhibition by beta 1C mapped to the late G1 phase of the cell cycle, near the G1-S boundary. Thus, alternative splicing of beta1 results in transmission of distinct signals that may regulate growth in vivo.


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Cloning and Characterization of a Novel Integrin beta 3 Subunit.
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J. Biol. Chem. 272, 16390-16397
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Affinity Modulation of Platelet Integrin alpha IIbbeta 3 by beta 3-Endonexin, a Selective Binding Partner of the beta 3 Integrin Cytoplasmic Tail.
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J. Cell Biol. 137, 1433-1443
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M. Sattler, R. Salgia, G. Shrikhande, S. Verma, N. Uemura, S. F. Law, E. A. Golemis, and J. D. Griffin (1997)
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Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts.
T. H. Lin, A. E. Aplin, Y. Shen, Q. Chen, M. Schaller, L. Romer, I. Aukhil, and R.L. Juliano (1997)
J. Cell Biol. 136, 1385-1395
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Anchorage-dependent Cell Cycle Progression.
R. K. Assoian (1997)
J. Cell Biol. 136, 1-4
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