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Science 8 September 1995:
Vol. 269. no. 5229, pp. 1435 - 1439
DOI: 10.1126/science.7660128
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Articles

Science, Vol 269, Issue 5229, 1435-1439
Copyright © 1995 by American Association for the Advancement of Science

articles

Separation of caveolae from associated microdomains of GPI-anchored proteins

JE Schnitzer, DP McIntosh, AM Dvorak, J Liu, and P Oh

Department of Pathology, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA.

In situ coating of the surface of endothelial cells in rat lung with cationic colloidal silica particles was used to separate caveolae from detergent-insoluble membranes rich in glycosyl phosphatidylinositol (GPI)-anchored proteins but devoid of caveolin. Immunogold electron microscopy showed that ganglioside GM1-enriched caveolae associated with an annular plasmalemmal domain enriched in GPI-anchored proteins. The purified caveolae contained molecular components required for regulated transport, including various lipid-anchored signaling molecules. Such specialized distinct microdomains may exist separately or together in the plasma membrane to organize signaling molecules and to process surface-bound ligands differentially.


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R. R. Fortna, H. A. Watson, and S. E. Nyquist (1999)
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Translocation of tyrosine-phosphorylated TCR{zeta} chain to glycolipid-enriched membrane domains upon T cell activation.
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Plant Physiology 118, 315-322
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Angiotensin II Type 1 Receptor : Relationship With Caveolae and Caveolin After Initial Agonist Stimulation.
N. Ishizaka, K. K. Griendling, B. Lassegue, and R. W. Alexander (1998)
Hypertension 32, 459-466
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Distribution of a Glycosylphosphatidylinositol-anchored Protein at the Apical Surface of MDCK Cells Examined at a Resolution of <100 A Using Imaging Fluorescence Resonance Energy Transfer.
A.K. Kenworthy and M. Edidin (1998)
J. Cell Biol. 142, 69-84
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Phosphatidylinositol 4-Phosphate Synthesis in Immunoisolated Caveolae-like Vesicles and Low Buoyant Density Non-caveolar Membranes.
M. G. Waugh, D. Lawson, S. K. Tan, and J. J. Hsuan (1998)
J. Biol. Chem. 273, 17115-17121
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