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Science 8 September 1995:
Vol. 269. no. 5229, pp. 1427 - 1429
DOI: 10.1126/science.7660125
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Articles

Science, Vol 269, Issue 5229, 1427-1429
Copyright © 1995 by American Association for the Advancement of Science

articles

Inducible gene targeting in mice

R Kuhn, F Schwenk, M Aguet, and K Rajewsky

Institute for Genetics, University of Cologne, Germany.

A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an interferon-responsive promoter to control the expression of Cre recombinase. Here, Cre was used to delete a segment of the DNA polymerase beta gene flanked by IoxP recombinase recognition sites. Deletion was complete in liver and nearly complete in lymphocytes within a few days, whereas partial deletion was obtained in other tissues. This method can be used for the inducible inactivation of any other gene in vivo.


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Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease.
A. M. Wahlstrom, B. A. Cutts, C. Karlsson, K. M. E. Andersson, M. Liu, A.-K. M. Sjogren, B. Swolin, S. G. Young, and M. O. Bergo (2007)
Blood 109, 763-768
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Cbf{beta} Reduces Cbf{beta}-SMMHC-Associated Acute Myeloid Leukemia in Mice.
S. A. Heilman, Y.-H. Kuo, C. S. Goudswaard, P. J. Valk, and L. H. Castilla (2006)
Cancer Res. 66, 11214-11218
   Abstract »    Full Text »    PDF »
Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion.
J. Zhang, X. C. He, W.-G. Tong, T. Johnson, L. M. Wiedemann, Y. Mishina, J. Q. Feng, and L. Li (2006)
Stem Cells 24, 2826-2839
   Abstract »    Full Text »    PDF »
Smad5 is dispensable for adult murine hematopoiesis.
S. Singbrant, J. L. Moody, U. Blank, G. Karlsson, L. Umans, A. Zwijsen, and S. Karlsson (2006)
Blood 108, 3707-3712
   Abstract »    Full Text »    PDF »
STAT3 positively regulates an early step in B-cell development.
W.-C. Chou, D. E. Levy, and C.-K. Lee (2006)
Blood 108, 3005-3011
   Abstract »    Full Text »    PDF »
Normal hematopoiesis after conditional targeting of RXR{alpha} in murine hematopoietic stem/progenitor cells.
M. Ricote, C. S. Snyder, H.-Y. Leung, J. Chen, K. R. Chien, and C. K. Glass (2006)
J. Leukoc. Biol. 80, 850-861
   Abstract »    Full Text »    PDF »
Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication.
E. Lazzerini Denchi, G. Celli, and T. de Lange (2006)
Genes & Dev. 20, 2648-2653
   Abstract »    Full Text »    PDF »
A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis.
M. P. McCormack, M. A. Hall, S. M. Schoenwaelder, Q. Zhao, S. Ellis, J. A. Prentice, A. J. Clarke, N. J. Slater, J. M. Salmon, S. P. Jackson, et al. (2006)
Blood 108, 2248-2256
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