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Science 8 September 1995:
Vol. 269. no. 5229, pp. 1424 - 1427
DOI: 10.1126/science.7544915
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Articles

Science, Vol 269, Issue 5229, 1424-1427
Copyright © 1995 by American Association for the Advancement of Science

articles

TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

M Rothe, V Sarma, VM Dixit, and DV Goeddel

Molecular Biology Department, Tularik, Inc., South San Francisco, CA 94080, USA.

TNF receptor-associated factor (TRAF) proteins are candidate signal transducers that associate with the cytoplasmic domains of members of the tumor necrosis factor (TNF) receptor superfamily. The role of TRAFs in the TNF-R2 and CD40 signal transduction pathways, which result in the activation of transcription factor NF-kappa B, was investigated. Overexpression of TRAF2, but not TRAF1 or TRAF3, was sufficient to induce NF-kappa B activation. A truncated derivative of TRAF2 lacking an amino-terminal RING finger domain was a dominant-negative inhibitor of NF-kappa B activation mediated by TNF-R2 and CD40. Thus, TRAF2 is a common mediator of TNF-R2 and CD40 signaling.


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J. L. Cannons, E. M. Bertram, and T. H. Watts (2002)
J. Immunol. 169, 2828-2831
   Abstract »    Full Text »    PDF »
Prevention of B cell antigen receptor-induced apoptosis by ligation of CD40 occurs downstream of cell cycle regulation.
W. J. M. Mackus, S. M. A. Lens, R. H. Medema, M. J. Kwakkenbos, L. M. Evers, M. H. J. v. Oers, R. A. W. v. Lier, and E. Eldering (2002)
Int. Immunol. 14, 973-982
   Abstract »    Full Text »    PDF »
2,3,7,8-Tetrachlorodibenzo-p-dioxin Suppresses Tumor Necrosis Factor-alpha and Anti-CD40-Induced Activation of NF-kappa B/Rel in Dendritic Cells: p50 Homodimer Activation Is Not Affected.
C. E. Ruby, M. Leid, and N. I. Kerkvliet (2002)
Mol. Pharmacol. 62, 722-728
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor Induces Apoptosis in Hepatoma Cells by Increasing Ca2+ Release from the Endoplasmic Reticulum and Suppressing Bcl-2 Expression.
B.-C. Kim, H.-T. Kim, M. Mamura, I. S. Ambudkar, K.-S. Choi, and S.-J. Kim (2002)
J. Biol. Chem. 277, 31381-31389
   Abstract »    Full Text »    PDF »
Nuclear Factor {kappa}B-Mediated Induction of Flice-Like Inhibitory Protein Prevents Tumor Necrosis Factor {alpha}-Induced Apoptosis in Rat Granulosa Cells.
C. Wu Xiao, E. Asselin, and B. K. Tsang (2002)
Biol Reprod 67, 436-441
   Abstract »    Full Text »    PDF »
The Death Domain Kinase RIP Protects Thymocytes from Tumor Necrosis Factor Receptor Type 2-induced Cell Death.
N. Cusson, S. Oikemus, E. D. Kilpatrick, L. Cunningham, and M. Kelliher (2002)
J. Exp. Med. 196, 15-26
   Abstract »    Full Text »    PDF »
Regulation of TRAF2 Signaling by Self-induced Degradation.
K. D. Brown, B. S. Hostager, and G. A. Bishop (2002)
J. Biol. Chem. 277, 19433-19438
   Abstract »    Full Text »    PDF »
CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion.
N J Gallagher, A G Eliopoulos, A Agathangelo, J Oates, J Crocker, and L S Young (2002)
Mol. Pathol. 55, 110-120
   Abstract »    Full Text »    PDF »
The Oncogenic Protein Kinase Tpl-2/Cot Contributes to Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1-Induced NF-{kappa}B Signaling Downstream of TRAF2.
A. G. Eliopoulos, C. Davies, S. S. M. Blake, P. Murray, S. Najafipour, P. N. Tsichlis, and L. S. Young (2002)
J. Virol. 76, 4567-4579
   Abstract »    Full Text »    PDF »
African Swine Fever Virus IAP-Like Protein Induces the Activation of Nuclear Factor Kappa B.
C. I. Rodriguez, M. L. Nogal, A. L. Carrascosa, M. L. Salas, M. Fresno, and Y. Revilla (2002)
J. Virol. 76, 3936-3942
   Abstract »    Full Text »    PDF »
Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals.
T. Yasui, M. Muraoka, Y. Takaoka-Shichijo, I. Ishida, N. Takegahara, J. Uchida, A. Kumanogoh, S. Suematsu, M. Suzuki, and H. Kikutani (2002)
Int. Immunol. 14, 319-329
   Abstract »    Full Text »    PDF »
Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-alpha Signaling.
P. Xia, L. Wang, P. A. B. Moretti, N. Albanese, F. Chai, S. M. Pitson, R. J. D'Andrea, J. R. Gamble, and M. A. Vadas (2002)
J. Biol. Chem. 277, 7996-8003
   Abstract »    Full Text »    PDF »
All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction.
J. Y. Chung, Y. C. Park, H. Ye, and H. Wu (2002)
J. Cell Sci. 115, 679-688
   Abstract »    Full Text »    PDF »
Cloning of MASK, a Novel Member of the Mammalian Germinal Center Kinase III Subfamily, with Apoptosis-inducing Properties.
I. Dan, S.-E. Ong, N. M. Watanabe, B. Blagoev, M. M. Nielsen, E. Kajikawa, T. Z. Kristiansen, M. Mann, and A. Pandey (2002)
J. Biol. Chem. 277, 5929-5939
   Abstract »    Full Text »    PDF »
The Yin/Yang of Innate Stress Responses in the Heart.
D.L. MANN (2002)
Cold Spring Harb Symp Quant Biol 67, 363-370
   Abstract »    PDF »
Ceramide-Rich Membrane Rafts Mediate CD40 Clustering.
H. Grassme, V. Jendrossek, J. Bock, A. Riehle, and E. Gulbins (2002)
J. Immunol. 168, 298-307
   Abstract »    Full Text »    PDF »
Differential Effects of HIV-1 Protease Inhibitors on Dendritic Cell Immunophenotype and Function.
A. Gruber, J. C. Wheat, K. L. Kuhen, D. J. Looney, and F. Wong-Staal (2001)
J. Biol. Chem. 276, 47840-47843
   Abstract »    Full Text »    PDF »
Reovirus Infection Activates JNK and the JNK-Dependent Transcription Factor c-Jun.
P. Clarke, S. M. Meintzer, C. Widmann, G. L. Johnson, and K. L. Tyler (2001)
J. Virol. 75, 11275-11283
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Characterization of a CD40-Dominant Inhibitory Receptor Mutant.
A. M. Mehl, M. Jones, M. Rowe, and P. Brennan (2001)
J. Immunol. 167, 6388-6393
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Reactive Oxygen Species Are Downstream Products of TRAF-mediated Signal Transduction.
N. S. Chandel, P. T. Schumacker, and R. H. Arch (2001)
J. Biol. Chem. 276, 42728-42736
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Molecular Characterization of CD40 Signaling Intermediates.
B. G. Werneburg, S. J. Zoog, T. T. A. Dang, M. R. Kehry, and J. J. Crute (2001)
J. Biol. Chem. 276, 43334-43342
   Abstract »    Full Text »    PDF »
IL-4 Influences Apoptosis of Mycobacterium-Reactive Lymphocytes in the Presence of TNF-{alpha}.
G. T. Seah and G. A. W. Rook (2001)
J. Immunol. 167, 1230-1237
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor Receptor-Associated Factor (Traf)2 Represses the T Helper Cell Type 2 Response through Interaction with Nfat-Interacting Protein (Nip45).
R. Lieberson, K. A. Mowen, K. D. McBride, V. Leautaud, X. Zhang, W.-K. Suh, L. Wu, and L. H. Glimcher (2001)
J. Exp. Med. 194, 89-98
   Abstract »    Full Text »    PDF »
The {alpha} and {beta} Subunits of I{kappa}B Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF.
A. Devin, Y. Lin, S. Yamaoka, Z. Li, M. Karin, and Z.-g. Liu (2001)
Mol. Cell. Biol. 21, 3986-3994
   Abstract »    Full Text »


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