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Science 1 September 1995:
Vol. 269. no. 5228, pp. 1278 - 1281
DOI: 10.1126/science.7652576
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Articles

Science, Vol 269, Issue 5228, 1278-1281
Copyright © 1995 by American Association for the Advancement of Science

articles

Commitment of CNS progenitors along the dorsoventral axis of Drosophila neuroectoderm

G Udolph, K Luer, T Bossing, and GM Technau

Institut fur Genetik, Universitat Mainz, Germany.

In the Drosophila embryo, the central nervous system (CNS) develops from a population of neural stem cells (neuroblasts) and midline progenitor cells. Here, the fate and extent of determination of CNS progenitors along the dorsoventral axis was assayed. Dorsal neuroectodermal cells transplanted into the ventral neuroectoderm or into the midline produced CNS lineages consistent with their new position. However, ventral neuroectodermal cells and midline cells transplanted to dorsal sites of the neuroectoderm migrated ventrally and produced CNS lineages consistent with their origin. Thus, inductive signals at the ventral midline and adjacent neuroectoderm may confer ventral identities to CNS progenitors as well as the ability to assume and maintain characteristic positions in the developing CNS. Furthermore, ectopic transplantations of wild-type midline cells into single minded (sim) mutant embryos suggest that the ventral midline is required for correct positioning of the cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Segment-specific requirements for dorsoventral patterning genes during early brain development in Drosophila.
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Molecular markers for identified neuroblasts in the developing brain of Drosophila.
R. Urbach and G. M. Technau (2003)
Development 130, 3621-3637
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Evidence for differential and redundant function of the Sox genes Dichaete and SoxN during CNS development in Drosophila.
P. M. Overton, L. A. Meadows, J. Urban, and S. Russell (2003)
Development 129, 4219-4228
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Cellular diversity in the developing nervous system: a temporal view from Drosophila.
T. Brody and W. F. Odenwald (2003)
Development 129, 3763-3770
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The Sox-domain containing gene Dichaete/fish-hook acts in concert with vnd and ind to regulate cell fate in the Drosophila neuroectoderm.
G. Zhao and J. B. Skeath (2002)
Development 129, 1165-1174
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Differential effects of EGF receptor signalling on neuroblast lineages along the dorsoventral axis of the Drosophila CNS.
G Udolph, J Urban, G Rusing, K Luer, and G. Technau (1998)
Development 125, 3291-3299
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The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo.
J. Skeath (1998)
Development 125, 3301-3312
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Klumpfuss, a putative Drosophila zinc finger transcription factor, acts to differentiate between the identities of two secondary precursor cells within one neuroblast lineage..
X Yang, S Bahri, T Klein, and W Chia (1997)
Genes & Dev. 11, 1396-1408
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CNS midline cells in Drosophila induce the differentiation of lateral neural cells.
T. Menne, K Luer, G. Technau, and C Klambt (1997)
Development 124, 4949-4958
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The differentiation of the serotonergic neurons in the Drosophila ventral nerve cord depends on the combined function of the zinc finger proteins Eagle and Huckebein.
R Dittrich, T Bossing, A. Gould, G. Technau, and J Urban (1997)
Development 124, 2515-2525
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Induction of identified mesodermal cells by CNS midline progenitors in Drosophila.
K Luer, J Urban, C Klambt, and G. Technau (1997)
Development 124, 2681-2690
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Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis.
K. Bhat and P Schedl (1997)
Development 124, 1675-1688
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Regulatory DNA required for vnd/NK-2 homeobox gene expression pattern in neuroblasts.
X. Shao, K. Koizumi, N. Nosworthy, D.-P. Tan, W. Odenwald, and M. Nirenberg (2002)
PNAS 99, 113-117
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