Science 1 September 1995: Vol. 269. no. 5228, pp. 1270 - 1272 DOI: 10.1126/science.7652575

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Articles

MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability.

R. M. Densham, E. O'Neill, J. Munro, I. Konig, K. Anderson, W. Kolch, and M. F. Olson (2009)
Mol. Cell. Biol. 29, 6380-6390
 |  Abstract »  |  Full Text »  |  PDF »

Role of Isoprenylation in Simvastatin-Induced Inhibition of Ovarian Theca-Interstitial Growth in the Rat.

I. J. Rzepczynska, P. C. Piotrowski, D. H. Wong, A. B. Cress, J. Villanueva, and A. J. Duleba (2009)
Biol Reprod 81, 850-855
 |  Abstract »  |  Full Text »  |  PDF »

Rho GTPase Cdc42 is essential for B-lymphocyte development and activation.

F. Guo, C. S. Velu, H. L. Grimes, and Y. Zheng (2009)
Blood 114, 2909-2916
 |  Abstract »  |  Full Text »  |  PDF »

New Insights into How the Rho Guanine Nucleotide Dissociation Inhibitor Regulates the Interaction of Cdc42 with Membranes.

J. L. Johnson, J. W. Erickson, and R. A. Cerione (2009)
J. Biol. Chem. 284, 23860-23871
 |  Abstract »  |  Full Text »  |  PDF »

Enhancement on Primate Corneal Endothelial Cell Survival In Vitro by a ROCK Inhibitor.

N. Okumura, M. Ueno, N. Koizumi, Y. Sakamoto, K. Hirata, J. Hamuro, and S. Kinoshita (2009)
Invest. Ophthalmol. Vis. Sci. 50, 3680-3687
 |  Abstract »  |  Full Text »  |  PDF »

RhoA Regulates G1-S Progression of Gastric Cancer Cells by Modulation of Multiple INK4 Family Tumor Suppressors.

S. Zhang, Q. Tang, F. Xu, Y. Xue, Z. Zhen, Y. Deng, M. Liu, J. Chen, S. Liu, M. Qiu, et al. (2009)
Mol. Cancer Res. 7, 570-580
 |  Abstract »  |  Full Text »  |  PDF »

Rac1 Is a Critical Mediator of Endothelium-Derived Neurotrophic Activity.

N. Sawada, H.-H. Kim, M. A. Moskowitz, and J. K. Liao (2009)
Science Signaling 2, ra10
 |  Abstract »  |  Full Text »  |  PDF »

A novel role of Shc adaptor proteins in steroid hormone-regulated cancers.

S. M. Alam, M. Rajendran, S. Ouyang, S. Veeramani, L. Zhang, and M.-F. Lin (2009)
Endocr. Relat. Cancer 16, 1-16
 |  Abstract »  |  Full Text »  |  PDF »

Morelloflavone, a Biflavonoid, Inhibits Tumor Angiogenesis by Targeting Rho GTPases and Extracellular Signal-Regulated Kinase Signaling Pathways.

X. Pang, T. Yi, Z. Yi, S. G. Cho, W. Qu, D. Pinkaew, K. Fujise, and M. Liu (2009)
Cancer Res. 69, 518-525
 |  Abstract »  |  Full Text »  |  PDF »

Differential Activation of ERK and Rac Mediates the Proliferative and Anti-proliferative Effects of Hyaluronan and CD44.

D. Kothapalli, J. Flowers, T. Xu, E. Pure, and R. K. Assoian (2008)
J. Biol. Chem. 283, 31823-31829
 |  Abstract »  |  Full Text »  |  PDF »

Rho GTPase, Rac1, regulates Skp2 levels, vascular smooth muscle cell proliferation, and intima formation in vitro and in vivo.

M. Bond, Y.-J. Wu, G. B. Sala-Newby, and A. C. Newby (2008)
Cardiovasc Res 80, 290-298
 |  Abstract »  |  Full Text »  |  PDF »

Mechanotransduction - a field pulling together?.

C. S. Chen (2008)
J. Cell Sci. 121, 3285-3292
 |  Abstract »  |  Full Text »  |  PDF »

The Arabidopsis Phosphatidylinositol 3-Kinase Is Important for Pollen Development.

Y. Lee, E.-S. Kim, Y. Choi, I. Hwang, C. J. Staiger, Y.-Y. Chung, and Y. Lee (2008)
Plant Physiology 147, 1886-1897
 |  Abstract »  |  Full Text »  |  PDF »

Increased Rac1b Expression Sustains Colorectal Tumor Cell Survival.

P. Matos and P. Jordan (2008)
Mol. Cancer Res. 6, 1178-1184
 |  Abstract »  |  Full Text »  |  PDF »

Phosphoinositide 3-Kinases p110{alpha} and p110{beta} Regulate Cell Cycle Entry, Exhibiting Distinct Activation Kinetics in G1 Phase.

M. Marques, A. Kumar, I. Cortes, A. Gonzalez-Garcia, C. Hernandez, M. C. Moreno-Ortiz, and A. C. Carrera (2008)
Mol. Cell. Biol. 28, 2803-2814
 |  Abstract »  |  Full Text »  |  PDF »

G1/S Cyclin-dependent Kinase Regulates Small GTPase Rho1p through Phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae.

K. Kono, S. Nogami, M. Abe, M. Nishizawa, S. Morishita, D. Pellman, and Y. Ohya (2008)
Mol. Biol. Cell 19, 1763-1771
 |  Abstract »  |  Full Text »  |  PDF »

Specific Recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 Guanine Nucleotide Exchange Factors.

M. A. Kwofie and J. Skowronski (2008)
J. Biol. Chem. 283, 3088-3096
 |  Abstract »  |  Full Text »  |  PDF »

A Critical Role for Rac1 in Tumor Progression of Human Colorectal Adenocarcinoma Cells.

C. Espina, M. V. Cespedes, M. A. Garcia-Cabezas, M. T. G. del Pulgar, A. Boluda, L. G. Oroz, P. Cejas, M. Nistal, R. Mangues, and J. C. Lacal (2008)
Am. J. Pathol. 172, 156-166
 |  Abstract »  |  Full Text »  |  PDF »

Vasopressin triggers senescence in K-ras transformed cells via RhoA-dependent downregulation of cyclin D1.

F. L Forti and H. A Armelin (2007)
Endocr. Relat. Cancer 14, 1117-1125
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-Increased Prolactin Gene Expression Requires Actin Treadmilling: Potential Role for P21 Activated Kinase.

F. M. Stanley (2007)
Endocrinology 148, 5874-5883
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C{varepsilon} is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation.

S. Citro, S. Malik, E. A. Oestreich, J. Radeff-Huang, G. G. Kelley, A. V. Smrcka, and J. H. Brown (2007)
PNAS 104, 15543-15548
 |  Abstract »  |  Full Text »  |  PDF »

Cadherins, RhoA, and Rac1 Are Differentially Required for Stretch-Mediated Proliferation in Endothelial Versus Smooth Muscle Cells.

W. F. Liu, C. M. Nelson, J. L. Tan, and C. S. Chen (2007)
Circ. Res. 101, e44-e52
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin.

M. Li, Y. Liu, P. Dutt, B. L. Fanburg, and D. Toksoz (2007)
Am J Physiol Lung Cell Mol Physiol 293, L463-L471
 |  Abstract »  |  Full Text »  |  PDF »

Prognostic relevance of increased Rac GTPase expression in prostate carcinomas.

R Engers, S Ziegler, M Mueller, A Walter, R Willers, and H E Gabbert (2007)
Endocr. Relat. Cancer 14, 245-256
 |  Abstract »  |  Full Text »  |  PDF »

G{alpha}12/13 Basally Regulates p53 through Mdm4 Expression.

M.-S. Kim, S. M. Lee, W. D. Kim, S. H. Ki, A. Moon, C. H. Lee, and S. G. Kim (2007)
Mol. Cancer Res. 5, 473-484
 |  Abstract »  |  Full Text »  |  PDF »

The Protective Role of a Small GTPase RhoE against UVB-induced DNA Damage in Keratinocytes.

S. A. Boswell, P. P. Ongusaha, P. Nghiem, and S. W. Lee (2007)
J. Biol. Chem. 282, 4850-4858
 |  Abstract »  |  Full Text »  |  PDF »

Tumor-Suppressive Effect of Retinoid Receptor-Induced Gene-1 (RRIG1) in Esophageal Cancer.

J. Huang, Z. D. Liang, T.-T. Wu, A. Hoque, H. Chen, Y. Jiang, H. Zhang, and X.-c. Xu (2007)
Cancer Res. 67, 1589-1593
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor beta Regulates the Expression of the M2 Muscarinic Receptor in Atrial Myocytes via an Effect on RhoA and p190RhoGAP.

H.-J. Park, S. M. Ward, J. S. Desgrosellier, S. P. Georgescu, A. G. Papageorge, X. Zhuang, J. V. Barnett, and J. B. Galper (2006)
J. Biol. Chem. 281, 19995-20002
 |  Abstract »  |  Full Text »  |  PDF »

RRIG1 Mediates Effects of Retinoic Acid Receptor {beta}2 on Tumor Cell Growth and Gene Expression through Binding to and Inhibition of RhoA..

Z. D. Liang, S. M. Lippman, T.-T. Wu, R. Lotan, and X.-C. Xu (2006)
Cancer Res. 66, 7111-7118
 |  Abstract »  |  Full Text »  |  PDF »

Escherichia coli Cytotoxic Necrotizing Factor 1 Blocks Cell Cycle G2/M Transition in Uroepithelial Cells.

L. Falzano, P. Filippini, S. Travaglione, A. G. Miraglia, A. Fabbri, and C. Fiorentini (2006)
Infect. Immun. 74, 3765-3772
 |  Abstract »  |  Full Text »  |  PDF »

Effect of an epidermal growth factor receptor tyrosine kinase inhibitor on actin remodeling in an in vitro bladder cancer carcinogenesis model..

Y. Jin, K. K. Iwata, A. Belldegrun, R. Figlin, A. Pantuck, Z.-F. Zhang, R. Lieberman, and J. Rao (2006)
Mol. Cancer Ther. 5, 1754-1763
 |  Abstract »  |  Full Text »  |  PDF »

The Rho GTPase Effector ROCK Regulates Cyclin A, Cyclin D1, and p27Kip1 Levels by Distinct Mechanisms.

D. R. Croft and M. F. Olson (2006)
Mol. Cell. Biol. 26, 4612-4627
 |  Abstract »  |  Full Text »  |  PDF »

E-cadherin engagement stimulates proliferation via Rac1.

W. F. Liu, C. M. Nelson, D. M. Pirone, and C. S. Chen (2006)
J. Cell Biol. 173, 431-441
 |  Abstract »  |  Full Text »  |  PDF »

Rac1-null Mouse Embryonic Fibroblasts Are Motile and Respond to Platelet-derived Growth Factor.

L. Vidali, F. Chen, G. Cicchetti, Y. Ohta, and D. J. Kwiatkowski (2006)
Mol. Biol. Cell 17, 2377-2390
 |  Abstract »  |  Full Text »  |  PDF »

Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell motility by decreasing Rac1 activity: essential role of PTP-PEST and p130cas.

A.-C. Ceacareanu, B. Ceacareanu, D. Zhuang, Y. Chang, R. M. Ray, L. Desai, K. E. Chapman, C. M. Waters, and A. Hassid (2006)
Am J Physiol Cell Physiol 290, C1263-C1270
 |  Abstract »  |  Full Text »  |  PDF »

Skeleton crew.

M. Leslie (2006)
J. Cell Biol. 172, 960
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Essential Role for Rac in Heregulin {beta}1 Mitogenic Signaling: a Mechanism That Involves Epidermal Growth Factor Receptor and Is Independent of ErbB4.

C. Yang, Y. Liu, M. A. Lemmon, and M. G. Kazanietz (2006)
Mol. Cell. Biol. 26, 831-842
 |  Abstract »  |  Full Text »  |  PDF »

Abnormal regulation of the cytoskeletal regulator Rho typifies macrophages of the major murine models of spontaneous autoimmunity.

H. Fan, V. A. Patel, A. Longacre, and J. S. Levine (2006)
J. Leukoc. Biol. 79, 155-165
 |  Abstract »  |  Full Text »  |  PDF »

Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment.

L. Wang, L. Yang, M.-D. Filippi, D. A. Williams, and Y. Zheng (2006)
Blood 107, 98-105
 |  Abstract »  |  Full Text »  |  PDF »

ANLN Plays a Critical Role in Human Lung Carcinogenesis through the Activation of RHOA and by Involvement in the Phosphoinositide 3-Kinase/AKT Pathway.

C. Suzuki, Y. Daigo, N. Ishikawa, T. Kato, S. Hayama, T. Ito, E. Tsuchiya, and Y. Nakamura (2005)
Cancer Res. 65, 11314-11325
 |  Abstract »  |  Full Text »  |  PDF »

Differential Involvement of the Actin Cytoskeleton in Differentiation and Mitogenesis of Thyroid Cells: Inactivation of Rho Proteins Contributes to Cyclic Adenosine Monophosphate-Dependent Gene Expression but Prevents Mitogenesis.

N. Fortemaison, S. Blancquaert, J. E. Dumont, C. Maenhaut, K. Aktories, P. P. Roger, and S. Dremier (2005)
Endocrinology 146, 5485-5495
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Urokinase Receptor Expression by Thalidomide Is Associated with Inhibition of Nuclear Factor {kappa}B Activation and Subsequently Suppressed Ovarian Cancer Dissemination.

H. Kobayashi, T. Yagyu, T. Kondo, N. Kurita, K. Inagaki, S. Haruta, R. Kawaguchi, T. Kitanaka, Y. Sakamoto, Y. Yamada, et al. (2005)
Cancer Res. 65, 10464-10471
 |  Abstract »  |  Full Text »  |  PDF »

Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity.

T. H.-Y. Leung, Y.-P. Ching, J. W. P. Yam, C.-M. Wong, T.-O. Yau, D.-Y. Jin, and I. O.-L. Ng (2005)
PNAS 102, 15207-15212
 |  Abstract »  |  Full Text »  |  PDF »

Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth.

L. Wang, L. Yang, K. Burns, C.-Y. Kuan, and Y. Zheng (2005)
PNAS 102, 13484-13489
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Signal-Regulated Kinase 1 Interacts with and Phosphorylates CdGAP at an Important Regulatory Site.

J. Tcherkezian, E. I. Danek, S. Jenna, I. Triki, and N. Lamarche-Vane (2005)
Mol. Cell. Biol. 25, 6314-6329
 |  Abstract »  |  Full Text »  |  PDF »

Integrin Activates Receptor-Like Protein Tyrosine Phosphatase {alpha}, Src, and Rho to Increase Prolactin Gene Expression through a Final Phosphatidylinositol 3-Kinase/Cytoskeletal Pathway that Is Additive with Insulin.

A. I. Vulin, K. K. Jacob, and F. M. Stanley (2005)
Endocrinology 146, 3535-3546
 |  Abstract »  |  Full Text »  |  PDF »

Generation and Characterization of Rac3 Knockout Mice.

S. Corbetta, S. Gualdoni, C. Albertinazzi, S. Paris, L. Croci, G. G. Consalez, and I. de Curtis (2005)
Mol. Cell. Biol. 25, 5763-5776
 |  Abstract »  |  Full Text »  |  PDF »

Generation of rac3 Null Mutant Mice: Role of Rac3 in Bcr/Abl-Caused Lymphoblastic Leukemia.

Y. J. Cho, B. Zhang, V. Kaartinen, L. Haataja, I. de Curtis, J. Groffen, and N. Heisterkamp (2005)
Mol. Cell. Biol. 25, 5777-5785
 |  Abstract »  |  Full Text »  |  PDF »

Rac-GAP-dependent Inhibition of Breast Cancer Cell Proliferation by {beta}2-Chimerin.

C. Yang, Y. Liu, F. C. Leskow, V. M. Weaver, and M. G. Kazanietz (2005)
J. Biol. Chem. 280, 24363-24370
 |  Abstract »  |  Full Text »  |  PDF »

Pituitary Adenylyl Cyclase-activating Polypeptide 38 Reduces Astroglial Proliferation by Inhibiting the GTPase RhoA.

D. K. Meyer, C. Fischer, U. Becker, I. Gottsching, S. Boutillier, C. Baermann, G. Schmidt, N. Klugbauer, and J. Leemhuis (2005)
J. Biol. Chem. 280, 25258-25266
 |  Abstract »  |  Full Text »  |  PDF »

A Rac Homolog Functions Downstream of Ras1 To Control Hyphal Differentiation and High-Temperature Growth in the Pathogenic Fungus Cryptococcus neoformans.

M. A. Vallim, C. B. Nichols, L. Fernandes, K. L. Cramer, and J. A. Alspaugh (2005)
Eukaryot. Cell 4, 1066-1078
 |  Abstract »  |  Full Text »  |  PDF »

A Role of STAT3 in Rho GTPase-regulated Cell Migration and Proliferation.

M. Debidda, L. Wang, H. Zang, V. Poli, and Y. Zheng (2005)
J. Biol. Chem. 280, 17275-17285
 |  Abstract »  |  Full Text »  |  PDF »

Rac2 Regulates Neutrophil Chemotaxis, Superoxide Production, and Myeloid Colony Formation through Multiple Distinct Effector Pathways.

D. Carstanjen, A. Yamauchi, A. Koornneef, H. Zang, M.-D. Filippi, C. Harris, J. Towe, S. Atkinson, Y. Zheng, M. C. Dinauer, et al. (2005)
J. Immunol. 174, 4613-4620
 |  Abstract »  |  Full Text »  |  PDF »

Green Tea Extract Modulates Actin Remodeling via Rho Activity in an In vitro Multistep Carcinogenic Model.

Q.-Y. Lu, Y.-S. Jin, A. Pantuck, Z.-F. Zhang, D. Heber, A. Belldegrun, M. Brooks, R. Figlin, and J. Rao (2005)
Clin. Cancer Res. 11, 1675-1683
 |  Abstract »  |  Full Text »  |  PDF »

Geranylgeranylated Proteins are Involved in the Regulation of Myeloma Cell Growth.

N. W.C.J. van de Donk, H. M. Lokhorst, E. H.J. Nijhuis, M. M.J. Kamphuis, and A. C. Bloem (2005)
Clin. Cancer Res. 11, 429-439
 |  Abstract »  |  Full Text »  |  PDF »

Clostridium difficile Toxin A Induces Expression of the Stress-induced Early Gene Product RhoB.

R. Gerhard, H. Tatge, H. Genth, T. Thum, J. Borlak, G. Fritz, and I. Just (2005)
J. Biol. Chem. 280, 1499-1505
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanisms of Low Intensity Pulsed Ultrasound in Human Skin Fibroblasts.

S. Zhou, A. Schmelz, T. Seufferlein, Y. Li, J. Zhao, and M. G. Bachem (2004)
J. Biol. Chem. 279, 54463-54469
 |  Abstract »  |  Full Text »  |  PDF »

Vav Transformation Requires Activation of Multiple GTPases and Regulation of Gene Expression.

T. R. Palmby, K. Abe, A. E. Karnoub, and C. J. Der (2004)
Mol. Cancer Res. 2, 702-711
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance.

M. Meriane, J. Tcherkezian, C. A. Webber, E. I. Danek, I. Triki, S. McFarlane, E. Bloch-Gallego, and N. Lamarche-Vane (2004)
J. Cell Biol. 167, 687-698
 |  Abstract »  |  Full Text »  |  PDF »

Macrophages from lupus-prone MRL mice are characterized by abnormalities in Rho activity, cytoskeletal organization, and adhesiveness to extracellular matrix proteins.

A. Longacre, J. S. Koh, K. K-H. Hsiao, H. Gilligan, H. Fan, V. A. Patel, and J. S. Levine (2004)
J. Leukoc. Biol. 76, 971-984
 |  Abstract »  |  Full Text »  |  PDF »

Role of the p66Shc Isoform in Insulin-like Growth Factor I Receptor Signaling through MEK/Erk and Regulation of Actin Cytoskeleton in Rat Myoblasts.

A. Natalicchio, L. Laviola, C. De Tullio, L. A. Renna, C. Montrone, S. Perrini, G. Valenti, G. Procino, M. Svelto, and F. Giorgino (2004)
J. Biol. Chem. 279, 43900-43909
 |  Abstract »  |  Full Text »  |  PDF »

Early signaling events involved in the entry of Rickettsia conorii into mammalian cells.

J. J. Martinez and P. Cossart (2004)
J. Cell Sci. 117, 5097-5106
 |  Abstract »  |  Full Text »  |  PDF »

Rho Kinase-Induced Nuclear Translocation of ERK1/ERK2 in Smooth Muscle Cell Mitogenesis Caused by Serotonin.

Y. Liu, Y. J. Suzuki, R. M. Day, and B. L. Fanburg (2004)
Circ. Res. 95, 579-586
 |  Abstract »  |  Full Text »  |  PDF »

RhoE Inhibits Cell Cycle Progression and Ras-Induced Transformation.

P. Villalonga, R. M. Guasch, K. Riento, and A. J. Ridley (2004)
Mol. Cell. Biol. 24, 7829-7840
 |  Abstract »  |  Full Text »  |  PDF »

The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism.

K. Uhlenbrock, A. Eberth, U. Herbrand, N. Daryab, P. Stege, F. Meier, P. Friedl, J. G. Collard, and M. R. Ahmadian (2004)
J. Cell Sci. 117, 4863-4871
 |  Abstract »  |  Full Text »  |  PDF »

Update on Statins: 2003.

C. J. Vaughan and A. M. Gotto Jr (2004)
Circulation 110, 886-892
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Lipid Raft-Associated GTPase Signaling Controls Morphology and CD8+ T Cell Stimulatory Capacity of Human Dendritic Cells.

S. Jaksits, W. Bauer, E. Kriehuber, M. Zeyda, T. M. Stulnig, G. Stingl, E. Fiebiger, and D. Maurer (2004)
J. Immunol. 173, 1628-1639
 |  Abstract »  |  Full Text »  |  PDF »

Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid.

T. Nubel, W. Dippold, B. Kaina, and G. Fritz (2004)
Carcinogenesis 25, 1335-1344
 |  Abstract »  |  Full Text »  |  PDF »

Role of RhoA, mDia, and ROCK in Cell Shape-dependent Control of the Skp2-p27kip1 Pathway and the G1/S Transition.

A. Mammoto, S. Huang, K. Moore, P. Oh, and D. E. Ingber (2004)
J. Biol. Chem. 279, 26323-26330
 |  Abstract »  |  Full Text »  |  PDF »

Elevated Rac1 Activity Changes the M3 Muscarinic Acetylcholine Receptor-Mediated Inhibition of Proliferation to Induction of Cell Death.

S. H. Shafer and C. L. Williams (2004)
Mol. Pharmacol. 65, 1080-1091
 |  Abstract »  |  Full Text »

Nectin-like Molecule-5/Tage4 Enhances Cell Migration in an Integrin-dependent, Nectin-3-independent Manner.

W. Ikeda, S. Kakunaga, K. Takekuni, T. Shingai, K. Satoh, K. Morimoto, M. Takeuchi, T. Imai, and Y. Takai (2004)
J. Biol. Chem. 279, 18015-18025
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Senescence Requires CDK5 Repression of Rac1 Activity.

K. Alexander, H.-S. Yang, and P. W. Hinds (2004)
Mol. Cell. Biol. 24, 2808-2819
 |  Abstract »  |  Full Text »  |  PDF »

Raf and RhoA Cooperate to Transform Intestinal Epithelial Cells and Induce Growth Resistance to Transforming Growth Factor {beta}.

J. Du, B. Jiang, R. J. Coffey, and J. Barnard (2004)
Mol. Cancer Res. 2, 233-241
 |  Abstract »  |  Full Text »  |  PDF »

Deregulation and Mislocalization of the Cytokinesis Regulator ECT2 Activate the Rho Signaling Pathways Leading to Malignant Transformation.

S.'i. Saito, X.-F. Liu, K. Kamijo, R. Raziuddin, T. Tatsumoto, I. Okamoto, X. Chen, C.-C. Lee, M. V. Lorenzi, N. Ohara, et al. (2004)
J. Biol. Chem. 279, 7169-7179
 |  Abstract »  |  Full Text »  |  PDF »

Direct Interaction of p21-Activated Kinase 4 with PDZ-RhoGEF, a G Protein-linked Rho Guanine Exchange Factor.

A. Barac, J. Basile, J. Vazquez-Prado, Y. Gao, Y. Zheng, and J. S. Gutkind (2004)
J. Biol. Chem. 279, 6182-6189
 |  Abstract »  |  Full Text »  |  PDF »

Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase.

D. Fiegen, L.-C. Haeusler, L. Blumenstein, U. Herbrand, R. Dvorsky, I. R. Vetter, and M. R. Ahmadian (2004)
J. Biol. Chem. 279, 4743-4749
 |  Abstract »  |  Full Text »  |  PDF »

Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death.

D. B. Parkinson, A. Bhaskaran, A. Droggiti, S. Dickinson, M. D'Antonio, R. Mirsky, and K. R. Jessen (2004)
J. Cell Biol. 164, 385-394
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Rho Family GTPases in p19Arf- and p53-Mediated Proliferation of Primary Mouse Embryonic Fibroblasts.

F. Guo and Y. Zheng (2004)
Mol. Cell. Biol. 24, 1426-1438
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Guanine Nucleotide Exchange and Rac-mediated Signaling Revealed by a Dominant Negative Trio Mutant.

B. Debreceni, Y. Gao, F. Guo, K. Zhu, B. Jia, and Y. Zheng (2004)
J. Biol. Chem. 279, 3777-3786
 |  Abstract »  |  Full Text »  |  PDF »

Tumor-related Alternatively Spliced Rac1b Is Not Regulated by Rho-GDP Dissociation Inhibitors and Exhibits Selective Downstream Signaling.

P. Matos, J. G. Collard, and P. Jordan (2003)
J. Biol. Chem. 278, 50442-50448
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Dissection of the Interaction between the Small G Proteins Rac1 and RhoA and Protein Kinase C-related Kinase 1 (PRK1).

D. Owen, P. N. Lowe, D. Nietlispach, C. E. Brosnan, D. Y. Chirgadze, P. J. Parker, T. L. Blundell, and H. R. Mott (2003)
J. Biol. Chem. 278, 50578-50587
 |  Abstract »  |  Full Text »  |  PDF »

Rac1 and Rac3 Are Targets for Geranylgeranyltransferase I Inhibitor-Mediated Inhibition of Signaling, Transformation, and Membrane Ruffling.

P. L. Joyce and A. D. Cox (2003)
Cancer Res. 63, 7959-7967
 |  Abstract »  |  Full Text »  |  PDF »

Protein Geranylgeranylation Is Critical for the Regulation of Survival and Proliferation of Lymphoma Tumor Cells.

N. W. C. J. van de Donk, D. Schotte, M. M. J. Kamphuis, A. M. W. van Marion, B. van Kessel, A. C. Bloem, and H. M. Lokhorst (2003)
Clin. Cancer Res. 9, 5735-5748
 |  Abstract »  |  Full Text »  |  PDF »

Fibroblast Growth Factors Regulate Prolactin Transcription via an Atypical Rac-Dependent Signaling Pathway.

T. A. Jackson, D. M. Koterwas, M. A. Morgan, and A. P. Bradford (2003)
Mol. Endocrinol. 17, 1921-1930
 |  Abstract »  |  Full Text »  |  PDF »

Cdc42 Promotes G1 Progression through p70 S6 Kinase-mediated Induction of Cyclin E Expression.

M. M. Chou, J. M. Masuda-Robens, and M. L. Gupta (2003)
J. Biol. Chem. 278, 35241-35247
 |  Abstract »  |  Full Text »  |  PDF »

An Endogenous Inhibitor of Focal Adhesion Kinase Blocks Rac1/JNK but Not Ras/ERK-dependent Signaling in Vascular Smooth Muscle Cells.

L. J. Sundberg, L. M. Galante, H. M. Bill, C. P. Mack, and J. M. Taylor (2003)
J. Biol. Chem. 278, 29783-29791
 |  Abstract »  |  Full Text »  |  PDF »

Gene Expression Profiling of Malignant Mesothelioma.

S. Singhal, R. Wiewrodt, L. D. Malden, K. M. Amin, K. Matzie, J. Friedberg, J. C. Kucharczuk, L. A. Litzky, S. W. Johnson, L. R. Kaiser, et al. (2003)
Clin. Cancer Res. 9, 3080-3097
 |  Abstract »  |  Full Text »  |  PDF »

RacB Regulates Cytoskeletal Function in Dictyostelium spp..

E. Lee, D. J. Seastone, E. Harris, J. A. Cardelli, and D. A. Knecht (2003)
Eukaryot. Cell 2, 474-485
 |  Abstract »  |  Full Text »  |  PDF »

The Small GTP-binding Protein Rac1 Induces Cardiac Myocyte Hypertrophy through the Activation of Apoptosis Signal-regulating Kinase 1 and Nuclear Factor-{kappa}B.

Y. Higuchi, K. Otsu, K. Nishida, S. Hirotani, H. Nakayama, O. Yamaguchi, S. Hikoso, K. Kashiwase, T. Takeda, T. Watanabe, et al. (2003)
J. Biol. Chem. 278, 20770-20777
 |  Abstract »  |  Full Text »  |  PDF »

AIF-1 Is an Actin-Polymerizing and Rac1-Activating Protein That Promotes Vascular Smooth Muscle Cell Migration.

M. V. Autieri, S. E. Kelemen, and K. W. Wendt (2003)
Circ. Res. 92, 1107-1114
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Aggressiveness of Metastatic Mouse Mammary Carcinoma Cells by the {beta}2-Chimaerin GAP Domain.

P. L. Menna, G. Skilton, F. C. Leskow, D. F. Alonso, D. E. Gomez, and M. G. Kazanietz (2003)
Cancer Res. 63, 2284-2291
 |  Abstract »  |  Full Text »  |  PDF »

A Rac/Cdc42-specific Exchange Factor, GEFT, Induces Cell Proliferation, Transformation, and Migration.

X. Guo, L. J. Stafford, B. Bryan, C. Xia, W. Ma, X. Wu, D. Liu, Z. Songyang, and M. Liu (2003)
J. Biol. Chem. 278, 13207-13215
 |  Abstract »  |  Full Text »  |  PDF »

Statin-Associated Myopathy.

P. D. Thompson, P. Clarkson, and R. H. Karas (2003)
JAMA 289, 1681-1690
 |  Abstract »  |  Full Text »  |  PDF »

The TRE17 Oncogene Encodes a Component of a Novel Effector Pathway for Rho GTPases Cdc42 and Rac1 and Stimulates Actin Remodeling.

J. M. Masuda-Robens, S. N. Kutney, H. Qi, and M. M. Chou (2003)
Mol. Cell. Biol. 23, 2151-2161
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomy.

M. D. Wheeler, O. M. Smutney, J. F. Check, I. Rusyn, R. Schulte-Hermann, and R. G. Thurman (2003)
Am J Physiol Gastrointest Liver Physiol 284, G302-G312
 |  Abstract »  |  Full Text »  |  PDF »

trans-Interactions of Nectins Induce Formation of Filopodia and Lamellipodia through the Respective Activation of Cdc42 and Rac Small G Proteins.

T. Kawakatsu, K. Shimizu, T. Honda, T. Fukuhara, T. Hoshino, and Y. Takai (2002)
J. Biol. Chem. 277, 50749-50755
 |  Abstract »  |  Full Text »  |  PDF »

The Cysteine-Rich Sprouty Translocation Domain Targets Mitogen-Activated Protein Kinase Inhibitory Proteins to Phosphatidylinositol 4,5-Bisphosphate in Plasma Membranes.

J. Lim, P. Yusoff, E. S. M. Wong, S. Chandramouli, D.-H. Lao, C. W. Fong, and G. R. Guy (2002)
Mol. Cell. Biol. 22, 7953-7966
 |  Abstract »  |  Full Text »  |  PDF »

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