Science 18 August 1995: Vol. 269. no. 5226, pp. 970 - 973 DOI: 10.1126/science.7638621

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Articles

Effects of Family History and Apolipoprotein E {varepsilon}4 Status on Cognitive Decline in the Absence of Alzheimer Dementia: The Cache County Study.

K. M. Hayden, P. P. Zandi, N. A. West, J. T. Tschanz, M. C. Norton, C. Corcoran, J. C. S. Breitner, K. A. Welsh-Bohmer, and for the Cache County Study Group (2009)
Arch Neurol 66, 1378-1383
 |  Abstract »  |  Full Text »  |  PDF »

Interplay of the Ca2+-binding Protein DREAM with Presenilin in Neuronal Ca2+ Signaling.

L. Fedrizzi, D. Lim, E. Carafoli, and M. Brini (2008)
J. Biol. Chem. 283, 27494-27503
 |  Abstract »  |  Full Text »  |  PDF »

A novel PSEN2 mutation associated with a peculiar phenotype.

P. Piscopo, G. Marcon, M. R. Piras, A. Crestini, L. M. Campeggi, E. Deiana, R. Cherchi, F. Tanda, A. Deplano, N. Vanacore, et al. (2008)
Neurology 70, 1549-1554
 |  Abstract »  |  Full Text »  |  PDF »

Identification of {gamma}-Secretase Inhibitor Potency Determinants on Presenilin.

B. Zhao, M. Yu, M. Neitzel, J. Marugg, J. Jagodzinski, M. Lee, K. Hu, D. Schenk, T. Yednock, and G. Basi (2008)
J. Biol. Chem. 283, 2927-2938
 |  Abstract »  |  Full Text »  |  PDF »

Presenilin-1 C410Y Alzheimer Disease Plaques Contain Synaptic Proteins.

K. Haleem, C. F. Lippa, T. W. Smith, H. Kowa, Jianlin Wu, and T. Iwatsubo (2007)
American Journal of Alzheimer's Disease and Other Dementias 22, 137-144
 |  Abstract »  |  PDF »

Fuzzy p-values in latent variable problems.

E. A. Thompson and C. J. Geyer (2007)
Biometrika 94, 49-60
 |  Abstract »  |  Full Text »  |  PDF »

Intra- or Intercomplex Binding to the {gamma}-Secretase Enzyme: A MODEL TO DIFFERENTIATE INHIBITOR CLASSES.

E. E. Clarke, I. Churcher, S. Ellis, J. D. J. Wrigley, H. D. Lewis, T. Harrison, M. S. Shearman, and D. Beher (2006)
J. Biol. Chem. 281, 31279-31289
 |  Abstract »  |  Full Text »  |  PDF »

Familial risk for Alzheimer's disease alters fMRI activation patterns.

S. S. Bassett, D. M. Yousem, C. Cristinzio, I. Kusevic, M. A. Yassa, B. S. Caffo, and S. L. Zeger (2006)
Brain 129, 1229-1239
 |  Abstract »  |  Full Text »  |  PDF »

Lewy Body Pathology in Familial Alzheimer Disease: Evidence for Disease- and Mutation-Specific Pathologic Phenotype..

J. B. Leverenz, M. A. Fishel, E. R. Peskind, T. J. Montine, D. Nochlin, E. Steinbart, M. A. Raskind, G. D. Schellenberg, T. D. Bird, and D. Tsuang (2006)
Arch Neurol 63, 370-376
 |  Abstract »  |  Full Text »  |  PDF »

An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures.

N. N. Dewji, D. Mukhopadhyay, and S. J. Singer (2006)
PNAS 103, 1540-1545
 |  Abstract »  |  Full Text »  |  PDF »

The unfolded protein response: A stress signaling pathway critical for health and disease.

K. Zhang and R. J. Kaufman (2006)
Neurology 66, S102-S109
 |  Abstract »  |  Full Text »  |  PDF »

Hyperphosphorylation of JNK-interacting Protein 1, a Protein Associated with Alzheimer Disease.

C. D'Ambrosio, S. Arena, G. Fulcoli, M. H. Scheinfeld, D. Zhou, L. D'Adamio, and A. Scaloni (2006)
Mol. Cell. Proteomics 5, 97-113
 |  Abstract »  |  Full Text »  |  PDF »

The Familial Dementia BRI2 Gene Binds the Alzheimer Gene Amyloid-{beta} Precursor Protein and Inhibits Amyloid-{beta} Production.

S. Matsuda, L. Giliberto, Y. Matsuda, P. Davies, E. McGowan, F. Pickford, J. Ghiso, B. Frangione, and L. D'Adamio (2005)
J. Biol. Chem. 280, 28912-28916
 |  Abstract »  |  Full Text »  |  PDF »

Functional Overexpression of {gamma}-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity.

J. D. J. Wrigley, I. Schurov, E. J. Nunn, A. C. L. Martin, E. E. Clarke, S. Ellis, T. P. Bonnert, M. S. Shearman, and D. Beher (2005)
J. Biol. Chem. 280, 12523-12535
 |  Abstract »  |  Full Text »  |  PDF »

Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities.

A. K. Bauer, A. M. Malkinson, and S. R. Kleeberger (2004)
Am J Physiol Lung Cell Mol Physiol 287, L685-L703
 |  Abstract »  |  Full Text »  |  PDF »

The Presenilin Proteins Are Components of Multiple Membrane-bound Complexes That Have Different Biological Activities.

Y. Gu, N. Sanjo, F. Chen, H. Hasegawa, A. Petit, X. Ruan, W. Li, C. Shier, T. Kawarai, G. Schmitt-Ulms, et al. (2004)
J. Biol. Chem. 279, 31329-31336
 |  Abstract »  |  Full Text »  |  PDF »

Intramembrane proteolysis by presenilin and presenilin-like proteases.

W. Xia and M. S. Wolfe (2003)
J. Cell Sci. 116, 2839-2844
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer Disease: Current Concepts and Emerging Diagnostic and Therapeutic Strategies.

C. M. Clark and J. H.T. Karlawish (2003)
Ann Intern Med 138, 400-410
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Precursor Protein, Presenilins, and alpha -Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer's Disease.

Y.-H. Suh and F. Checler (2002)
Pharmacol. Rev. 54, 469-525
 |  Abstract »  |  Full Text »  |  PDF »

Explaining the Cause of the Amyloid Burden in Alzheimer Disease.

R. N. Rosenberg (2002)
Arch Neurol 59, 1367-1368
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Disturbed Activation of Endoplasmic Reticulum Stress Transducers by Familial Alzheimer's Disease-linked Presenilin-1 Mutations.

T. Katayama, K. Imaizumi, A. Honda, T. Yoneda, T. Kudo, M. Takeda, K. Mori, R. Rozmahel, P. Fraser, P. St. George-Hyslop, et al. (2001)
J. Biol. Chem. 276, 43446-43454
 |  Abstract »  |  Full Text »  |  PDF »

TAU as a Susceptibility Gene for Amyotropic Lateral Sclerosis-Parkinsonism Dementia Complex of Guam.

P. Poorkaj, D. Tsuang, E. Wijsman, E. Steinbart, R. M. Garruto, U.-K. Craig, N. H. Chapman, L. Anderson, T. D. Bird, C. C. Plato, et al. (2001)
Arch Neurol 58, 1871-1878
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{gamma}-Secretase: A Catalyst of Alzheimer Disease and Signal Transduction.

Y.-M. Li (2001)
Mol. Interv. 1, 198-207
 |  Abstract »  |  Full Text »  |  PDF »

Psychological features in persons at risk for familial Alzheimer's disease.

J. M. Swearer, B. F. O'Donnell, M. Parker, K. J. Kane, and D. A. Drachman (2001)
American Journal of Alzheimer's Disease and Other Dementias 16, 157-162
 |  Abstract »  |  PDF »

Genetic linkage methods for quantitative traits.

C. I Amos and M. de Andrade (2001)
Statistical Methods in Medical Research 10, 3-25
 |  Abstract »  |  PDF »

Presenilin-1 Mutations Reduce Cytoskeletal Association, Deregulate Neurite Growth, and Potentiate Neuronal Dystrophy and Tau Phosphorylation.

G. Pigino, A. Pelsman, H. Mori, and J. Busciglio (2001)
J. Neurosci. 21, 834-842
 |  Abstract »  |  Full Text »  |  PDF »

Age-Dependent Changes in Brain, CSF, and Plasma Amyloid {beta} Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease.

T. Kawarabayashi, L. H. Younkin, T. C. Saido, M. Shoji, K. H. Ashe, and S. G. Younkin (2001)
J. Neurosci. 21, 372-381
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility.

J. Theuns and C. Van Broeckhoven (2000)
Hum. Mol. Genet. 9, 2383-2394
 |  Abstract »  |  Full Text »  |  PDF »

The molecular and genetic basis of AD: The end of the beginning: The 2000 Wartenberg lecture.

R. N. Rosenberg (2000)
Neurology 54, 2045-2054
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Familial Aggregation of Alzheimer Disease Among Whites, African Americans, and Caribbean Hispanics in Northern Manhattan.

G. Devi, R. Ottman, M.-X. Tang, K. Marder, Y. Stern, and R. Mayeux (2000)
Arch Neurol 57, 72-77
 |  Abstract »  |  Full Text »  |  PDF »

The Influence of Endoproteolytic Processing of Familial Alzheimer's Disease Presenilin 2 on Abeta 42 Amyloid Peptide Formation.

H. Jacobsen, D. Reinhardt, M. Brockhaus, D. Bur, C. Kocyba, H. Kurt, M. G. Grim, R. Baumeister, and H. Loetscher (1999)
J. Biol. Chem. 274, 35233-35239
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The genetic basis of cognition.

J. Flint (1999)
Brain 122, 2015-2032
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid beta -Protein Fibrillogenesis. STRUCTURE AND BIOLOGICAL ACTIVITY OF PROTOFIBRILLAR INTERMEDIATES.

D. M. Walsh, D. M. Hartley, Y. Kusumoto, Y. Fezoui, M. M. Condron, A. Lomakin, G. B. Benedek, D. J. Selkoe, and D. B. Teplow (1999)
J. Biol. Chem. 274, 25945-25952
 |  Abstract »  |  Full Text »  |  PDF »

Membrane Topology of Alzheimer's Disease-related Presenilin 1. EVIDENCE FOR THE EXISTENCE OF A MOLECULAR SPECIES WITH A SEVEN MEMBRANE-SPANNING AND ONE MEMBRANE-EMBEDDED STRUCTURE.

T. Nakai, A. Yamasaki, M. Sakaguchi, K. Kosaka, K. Mihara, Y. Amaya, and S. Miura (1999)
J. Biol. Chem. 274, 23647-23658
 |  Abstract »  |  Full Text »  |  PDF »

Microvessels from Alzheimer's Disease Brains Kill Neurons in Vitro.

P. Grammas, P. Moore, and P. H. Weigel (1999)
Am. J. Pathol. 154, 337-342
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Prospective Study of Risk Factors for Alzheimer's Disease: Results at 7.5 Years.

G. S. Zubenko, E. Winwood, B. Jacobs, I. Teply, J. S. Stiffler, H. B. Hughes III, F. J. Huff, T. Sunderland, and A. J. Martinez (1999)
Am J Psychiatry 156, 50-57
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Specific intercellular binding of the beta -amyloid precursor protein to the presenilins induces intercellular signaling: Its significance for Alzheimer's disease.

N. N. Dewji and S. J. Singer (1998)
PNAS 95, 15055-15060
 |  Abstract »  |  Full Text »  |  PDF »

Lewy Bodies Contain Altered {alpha}-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes.

C. F. Lippa, H. Fujiwara, D. M.A. Mann, B. Giasson, M. Baba, M. L. Schmidt, L. E. Nee, B. O'Connell, D. A. Pollen, P. St. George-Hyslop, et al. (1998)
Am. J. Pathol. 153, 1365-1370
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of the apolipoprotein E and CI loci in predisposing to late-onset Alzheimer's disease.

E. Drigalenko, S. Poduslo, and R. Elston (1998)
Neurology 51, 131-135
 |  Abstract »  |  Full Text »  |  PDF »

The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains beta -Catenin.

G. Yu, F. Chen, G. Levesque, M. Nishimura, D.-M. Zhang, L. Levesque, E. Rogaeva, D. Xu, Y. Liang, M. Duthie, et al. (1998)
J. Biol. Chem. 273, 16470-16475
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Syndrome and not Alzheimer's disease: The historical struggle to define the disease.

J. R. Shua-Haim and J. S. Ross (1998)
American Journal of Alzheimer's Disease and Other Dementias 13, 92-95
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Prevalence of Alzheimer's Disease and Apolipoprotein E Allele Frequencies in the Old Order Amish.

J. Holder and A. C. Warren (1998)
J Neuropsychiatry Clin Neurosci 10, 100-102
 |  Abstract »  |  Full Text »

Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.

D Levitan and I Greenwald (1998)
Development 125, 3599-3606
 |  Abstract »  |  PDF »

The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells.

N. N. Dewji and S. J. Singer (1997)
PNAS 94, 14025-14030
 |  Abstract »  |  Full Text »  |  PDF »

On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues.

N. N. Dewji, C. Do, and S. J. Singer (1997)
PNAS 94, 14031-14036
 |  Abstract »  |  Full Text »  |  PDF »

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.

X. Li and I. Greenwald (1997)
PNAS 94, 12204-12209
 |  Abstract »  |  Full Text »  |  PDF »

Increased Apoptosis Arising from Increased Expression of the Alzheimer's Disease-associated Presenilin-2 Mutation (N141I).

S. Janicki and M. J. Monteiro (1997)
J. Cell Biol. 139, 485-495
 |  Abstract »  |  Full Text »  |  PDF »

Prevention of Amyloid-Like Deposition by a Selective Prolyl Endopeptidase Inhibitor, Y-29794, in Senescence-Accelerated Mouse.

A. Kato, A. Fukunari, Y. Sakai, and T. Nakajima (1997)
J. Pharmacol. Exp. Ther. 283, 328-335
 |  Abstract »  |  Full Text »

Cell surface expression of the Alzheimer disease-related presenilin proteins.

N. N. Dewji and S. J. Singer (1997)
PNAS 94, 9926-9931
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

M. Seeger, C. Nordstedt, S. Petanceska, D. M. Kovacs, G. K. Gouras, S. Hahne, P. Fraser, L. Levesque, A. J. Czernik, P. S. George-Hyslop, et al. (1997)
PNAS 94, 5090-5094
 |  Abstract »  |  Full Text »  |  PDF »

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

J. Walter, J. Grunberg, A. Capell, B. Pesold, A. Schindzielorz, M. Citron, K. Mendla, P. S. George-Hyslop, G. Multhaup, D. J. Selkoe, et al. (1997)
PNAS 94, 5349-5354
 |  Abstract »  |  Full Text »  |  PDF »

Controlling Amyloid beta -Peptide Fibril Formation with Protease-stable Ligands.

L. O. Tjernberg, C. Lilliehook, D. J. E. Callaway, J. Naslund, S. Hahne, J. Thyberg, L. Terenius, and C. Nordstedt (1997)
J. Biol. Chem. 272, 12601-12605
 |  Abstract »  |  Full Text »  |  PDF »

Exploring the Etiology of Alzheimer Disease Using Molecular Genetics.

C. L. Lendon, F. Ashall, and A. M. Goate (1997)
JAMA 277, 825-831
 |  Abstract »  |  PDF »

The Clinical Introduction of Genetic Testing for Alzheimer Disease: An Ethical Perspective.

S. G. Post, P. J. Whitehouse, R. H. Binstock, T. D. Bird, S. K. Eckert, L. A. Farrer, L. M. Fleck, A. D. Gaines, E. T. Juengst, H. Karlinsky, et al. (1997)
JAMA 277, 832-836
 |  Abstract »  |  PDF »

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta  protein ending at the 42nd (or 43rd) residue.

T. Tomita, K. Maruyama, T. C. Saido, H. Kume, K. Shinozaki, S. Tokuhiro, A. Capell, J. Walter, J. Grunberg, C. Haass, et al. (1997)
PNAS 94, 2025-2030
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues.

M. K. Lee, H. H. Slunt, L. J. Martin, G. Thinakaran, G. Kim, S. E. Gandy, M. Seeger, E. Koo, D. L. Price, and S. S. Sisodia (1996)
J. Neurosci. 16, 7513-7525
 |  Abstract »  |  Full Text »  |  PDF »

Damage, Repair, and Mutagenesis in Nuclear Genes after Mouse Forebrain Ischemia-Reperfusion.

P. K. Liu, C. Y. Hsu, M. Dizdaroglu, R. A. Floyd, Y. W. Kow, A. Karakaya, L. E. Rabow, and J.-K. Cui (1996)
J. Neurosci. 16, 6795-6806
 |  Abstract »  |  Full Text »  |  PDF »

Membrane Disruption by Alzheimer beta -Amyloid Peptides Mediated through Specific Binding to Either Phospholipids or Gangliosides. IMPLICATIONS FOR NEUROTOXICITY.

J. McLaurin and A. Chakrabartty (1996)
J. Biol. Chem. 271, 26482-26489
 |  Abstract »  |  Full Text »  |  PDF »

Geriatric Medicine.

W. B. Applegate and R. Burns (1996)
JAMA 275, 1812-1813
 |  Abstract »  |  PDF »

Neurology.

R. J. Joynt (1996)
JAMA 275, 1826-1827
 |  Abstract »  |  PDF »

Molecular Biology and Genetics of Prion Diseases.

S.B. Prusiner (1996)
Cold Spring Harb Symp Quant Biol 61, 473-493
 |  Abstract »  |  PDF »

The Role of Presenilin 1 in the Genetics of Alzheimer's Disease.

R.F. Clark, M. Hutton, C. Talbot, M. Wragg, C. Lendon, F. Busfield, S.W. Han, J. Perez-Tur, M. Adams, R. Fuldner, et al. (1996)
Cold Spring Harb Symp Quant Biol 61, 551-558
 |  Abstract »  |  PDF »

Two Homologous Genes Causing Early-onset Familial Alzheimer's Disease.

P.H. St. George-Hyslop, G. Levesque, L. Levesque, J. Rommens, D. Westaway, and P.E. Fraser (1996)
Cold Spring Harb Symp Quant Biol 61, 559-564
 |  Abstract »  |  PDF »

Neurodegenerative Diseases and Model Systems.

D.L. Price, D.R. Borchelt, P.C. Wong, C.A. Pardo, G. Thinakaran, M.K. Lee, D.W. Cleveland, and S.S. Sisodia (1996)
Cold Spring Harb Symp Quant Biol 61, 725-738
 |  Abstract »  |  PDF »

Cross-Cultural Research on Alzheimer's Disease: A Critical Review.

A. Smith (1996)
Transcultural Psychiatry 33, 247-276
 |  Abstract »  |  PDF »

Candidate gene for the chromosome 1 familial Alzheimer's disease locus.

E Levy-Lahad, W Wasco, P Poorkaj, D. Romano, J Oshima, W. Pettingell, C. Yu, P. Jondro, S. Schmidt, K Wang, et al. (1995)
Science 269, 973-977
 |  Abstract »  |  PDF »

Mutation of Conserved Aspartates Affects Maturation of Both Aspartate Mutant and Endogenous Presenilin 1 and Presenilin 2 Complexes.

G. Yu, F. Chen, M. Nishimura, H. Steiner, A. Tandon, T. Kawarai, S. Arawaka, A. Supala, Y.-Q. Song, E. Rogaeva, et al. (2000)
J. Biol. Chem. 275, 27348-27353
 |  Abstract »  |  Full Text »  |  PDF »

Mutant Presenilin 2 Transgenic Mice. A LARGE INCREASE IN THE LEVELS OF Abeta 42 IS PRESUMABLY ASSOCIATED WITH THE LOW DENSITY MEMBRANE DOMAIN THAT CONTAINS DECREASED LEVELS OF GLYCEROPHOSPHOLIPIDS AND SPHINGOMYELIN.

N. Sawamura, M. Morishima-Kawashima, H. Waki, K. Kobayashi, T. Kuramochi, M. P. Frosch, K. Ding, M. Ito, T.-W. Kim, R. E. Tanzi, et al. (2000)
J. Biol. Chem. 275, 27901-27908
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E4 Stimulates cAMP Response Element-binding Protein Transcriptional Activity through the Extracellular Signal-regulated Kinase Pathway.

N. Ohkubo, N. Mitsuda, M. Tamatani, A. Yamaguchi, Y.-D. Lee, T. Ogihara, M. P. Vitek, and M. Tohyama (2001)
J. Biol. Chem. 276, 3046-3053
 |  Abstract »  |  Full Text »  |  PDF »

Activated cAMP-response Element-binding Protein Regulates Neuronal Expression of Presenilin-1.

N. Mitsuda, N. Ohkubo, M. Tamatani, Y.-D. Lee, M. Taniguchi, K. Namikawa, H. Kiyama, A. Yamaguchi, N. Sato, K. Sakata, et al. (2001)
J. Biol. Chem. 276, 9688-9698
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacological Knock-down of the Presenilin 1 Heterodimer by a Novel gamma -Secretase Inhibitor. IMPLICATIONS FOR PRESENILIN BIOLOGY.

D. Beher, J. D. J. Wrigley, A. Nadin, G. Evin, C. L. Masters, T. Harrison, J. L. Castro, and M. S. Shearman (2001)
J. Biol. Chem. 276, 45394-45402
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Presenilin 1 is linked with gamma -secretase activity in the detergent solubilized state.

Y.-M. Li, M.-T. Lai, M. Xu, Q. Huang, J. DiMuzio-Mower, M. K. Sardana, X.-P. Shi, K.-C. Yin, J. A. Shafer, and S. J. Gardell (2000)
PNAS 97, 6138-6143
 |  Abstract »  |  Full Text »  |  PDF »

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