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Science 4 August 1995:
Vol. 269. no. 5224, pp. 693 - 695
DOI: 10.1126/science.7624800
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Articles

Science, Vol 269, Issue 5224, 693-695
Copyright © 1995 by American Association for the Advancement of Science

articles

A gene outside the human MHC related to classical HLA class I genes

K Hashimoto, M Hirai, and Y Kurosawa

Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan.

By presenting antigenic peptides to T lymphocytes, major histocompatibility complex (MHC) class I molecules play important roles in the human immune system. Knowledge is limited on the evolutionary history of human MHC class I-related molecules. An expressed class I gene, MR1, has now been identified on human chromosome 1q25, outside the MHC. In contrast to other known human divergent class I genes, MR1 encodes peptide-binding domains similar to those encoded by human leukocyte antigen (HLA) class I genes on chromosome 6 and by nonmammalian classical MHC class I genes. This gene may thus contribute to understanding the evolution of the MHC.


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