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Science 4 August 1995:
Vol. 269. no. 5224, pp. 690 - 693
DOI: 10.1126/science.7624799
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Articles

Science, Vol 269, Issue 5224, 690-693
Copyright © 1995 by American Association for the Advancement of Science

articles

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

B Stoyanov, S Volinia, T Hanck, I Rubio, M Loubtchenkov, D Malek, S Stoyanova, B Vanhaesebroeck, R Dhand, B Nurnberg, and al. et

Max Planck Research Unit in Growth Factor Signal Transduction, Medical Faculty, University of Jena, Germany.

Phosphoinositide-3 kinase activity is implicated in diverse cellular responses triggered by mammalian cell surface receptors and in the regulation of protein sorting in yeast. Receptors with intrinsic and associated tyrosine kinase activity recruit heterodimeric phosphoinositide-3 kinases that consist of p110 catalytic subunits and p85 adaptor molecules containing Src homology 2 (SH2) domains. A phosphoinositide-3 kinase isotype, p110 gamma, was cloned and characterized. The p110 gamma enzyme was activated in vitro by both the alpha and beta gamma subunits of heterotrimeric guanosine triphosphate (GTP)-binding proteins (G proteins) and did not interact with p85. A potential pleckstrin homology domain is located near its amino terminus. The p110 gamma isotype may link signaling through G protein-coupled receptors to the generation of phosphoinositide second messengers phosphorylated in the D-3 position.


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J. Biol. Chem. 275, 4803-4809
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Function of PI3K in Thymocyte Development, T Cell Activation, and Neutrophil Migration.
T. Sasaki, J. Irie-Sasaki, R. G. Jones, A. J. Oliveira-dos-Santos, W. L. Stanford, B. Bolon, A. Wakeham, A. Itie, D. Bouchard, I. Kozieradzki, et al. (2000)
Science 287, 1040-1046
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Roles of PLC-2 and -3 and PI3K in Chemoattractant-Mediated Signal Transduction.
Z. Li, H. Jiang, W. Xie, Z. Zhang, A. V. Smrcka, and D. Wu (2000)
Science 287, 1046-1049
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Distinct Classes of Phosphatidylinositol 3'-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells.
A. Petiot, E. Ogier-Denis, E. F. C. Blommaart, A. J. Meijer, and P. Codogno (2000)
J. Biol. Chem. 275, 992-998
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The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling.
R Hooshmand-Rad, L Hajkova, P Klint, R Karlsson, B Vanhaesebroeck, L Claesson-Welsh, and C. Heldin (2000)
J. Cell Sci. 113, 207-214
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fMet-Leu-Phe Stimulates Proinflammatory Cytokine Gene Expression in Human Peripheral Blood Monocytes: The Role of Phosphatidylinositol 3-Kinase.
Z. K. Pan, L.-Y. Chen, C. G. Cochrane, and B. L. Zuraw (2000)
J. Immunol. 164, 404-411
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The CXC Chemokine Stromal Cell-Derived Factor Activates a Gi-Coupled Phosphoinositide 3-Kinase in T Lymphocytes.
Y. Sotsios, G. C. Whittaker, J. Westwick, and S. G. Ward (1999)
J. Immunol. 163, 5954-5963
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Endothelin-1-induced GLUT4 Translocation Is Mediated via Galpha q/11 Protein and Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes.
T. Imamura, K.-i. Ishibashi, S. Dalle, S. Ugi, and J. M. Olefsky (1999)
J. Biol. Chem. 274, 33691-33695
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An Epidermal Growth Factor Receptor/Gab1 Signaling Pathway Is Required for Activation of Phosphoinositide 3-Kinase by Lysophosphatidic Acid.
M. Laffargue, P. Raynal, A. Yart, C. Peres, R. Wetzker, S. Roche, B. Payrastre, and H. Chap (1999)
J. Biol. Chem. 274, 32835-32841
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Roles of Non-catalytic Subunits in Gbeta gamma -induced Activation of Class I Phosphoinositide 3-Kinase Isoforms beta and gamma.
U. Maier, A. Babich, and B. Nurnberg (1999)
J. Biol. Chem. 274, 29311-29317
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Differential regulation of MAP kinase by contraction and insulin in skeletal muscle: metabolic implications.
J. F. P. Wojtaszewski, J. Lynge, A. B. Jakobsen, L. J. Goodyear, and E. A. Richter (1999)
Am J Physiol Endocrinol Metab 277, E724-E732
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Involvement of Phosphatidylinositol 3-Kinase in Stromal Cell-Derived Factor-1{alpha}-Induced Lymphocyte Polarization and Chemotaxis.
M. Vicente-Manzanares, M. Rey, D. R. Jones, D. Sancho, M. Mellado, J. M. Rodriguez-Frade, M. A. del Pozo, M. Yanez-Mo, A. M. de Ana, C. Martinez-A., et al. (1999)
J. Immunol. 163, 4001-4012
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Agonists Cause Nuclear Translocation of Phosphatidylinositol 3-Kinase gamma . A Gbeta gamma -DEPENDENT PATHWAY THAT REQUIRES THE p110gamma AMINO TERMINUS.
A. Metjian, R. L. Roll, A. D. Ma, and C. S. Abrams (1999)
J. Biol. Chem. 274, 27943-27947
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Intracellular Movement of Green Fluorescent Protein-Tagged Phosphatidylinositol 3-Kinase in Response to Growth Factor Receptor Signaling.
H. Gillham, M. C.H.M. Golding, R. Pepperkok, and W. J. Gullick (1999)
J. Cell Biol. 146, 869-880
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Src-family Tyrosine Kinases in Activation of ERK-1 and p85/p110-phosphatidylinositol 3-Kinase by G/CCKB Receptors.
L. Daulhac, A. Kowalski-Chauvel, L. Pradayrol, N. Vaysse, and C. Seva (1999)
J. Biol. Chem. 274, 20657-20663
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Gi Proteins Use a Novel beta gamma - and Ras-independent Pathway to Activate Extracellular Signal-regulated Kinase and Mobilize AP-1 Transcription Factors in Jurkat T Lymphocytes.
K. E. Hedin, M. P. Bell, C. J. Huntoon, L. M. Karnitz, and D. J. McKean (1999)
J. Biol. Chem. 274, 19992-20001
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Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation.
V. P. Krymskaya, R. B. Penn, M. J. Orsini, P. H. Scott, R. J. Plevin, T. R. Walker, A. J. Eszterhas, Y. Amrani, E. R. Chilvers, and R. A. Panettieri Jr. (1999)
Am J Physiol Lung Cell Mol Physiol 277, L65-L78
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