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Science 4 August 1995:
Vol. 269. no. 5224, pp. 688 - 690
DOI: 10.1126/science.7542803
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Articles

Science, Vol 269, Issue 5224, 688-690
Copyright © 1995 by American Association for the Advancement of Science

articles

Molecular identification of an IgE-dependent histamine-releasing factor

SM MacDonald, T Rafnar, J Langdon, and LM Lichtenstein

Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.

An immunoglobulin E (IgE)-dependent histamine-releasing factor (HRF) produced by lymphocytes of atopic children and present in biological fluids of allergic patients has been identified and purified. Amino-terminal sequencing revealed extensive homology to a mouse protein, p21, and its human homolog, p23. Both recombinant proteins caused histamine release from the human basophils of a subpopulation of donors, and this release was dependent on IgE. Polyclonal antibodies recognized and removed the biological activity of recombinant and native HRF. HRF identifies a heterogeneity of IgE and is believed to play a prominent role in chronic allergic disease processes.


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