Science 4 August 1995: Vol. 269. no. 5224, pp. 682 - 685 DOI: 10.1126/science.7624798

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Articles

p27Kip1 Stabilization Is Essential for the Maintenance of Cell Cycle Arrest in Response to DNA Damage.

M. Cuadrado, P. Gutierrez-Martinez, A. Swat, A. R. Nebreda, and O. Fernandez-Capetillo (2009)
Cancer Res. 69, 8726-8732
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitination and Downregulation of BRCA1 by Ubiquitin-Conjugating Enzyme E2T Overexpression in Human Breast Cancer Cells.

T. Ueki, J.-H. Park, T. Nishidate, K. Kijima, K. Hirata, Y. Nakamura, and T. Katagiri (2009)
Cancer Res. 69, 8752-8760
 |  Abstract »  |  Full Text »  |  PDF »

Prognostic significance of S-phase kinase-associated protein 2 and p27kip1 in patients with diffuse large B-cell lymphoma: effects of rituximab.

R. Seki, K. Ohshima, T. Fujisaki, N. Uike, F. Kawano, H. Gondo, S. Makino, T. Eto, Y. Moriuchi, F. Taguchi, et al. (2009)
Ann. Onc.
 |  Abstract »  |  Full Text »  |  PDF »

Mechanoregulation of Proliferation.

X. Jiang, P. F. Austin, R. A. Niederhoff, S. R. Manson, J. J. Riehm, B. L. Cook, G. Pengue, K. Chitaley, K. Nakayama, K. I. Nakayama, et al. (2009)
Mol. Cell. Biol. 29, 5104-5114
 |  Abstract »  |  Full Text »  |  PDF »

Low p27 Expression Predicts Early Relapse and Death in Postmenopausal Hormone Receptor-Positive Breast Cancer Patients Receiving Adjuvant Tamoxifen Therapy.

M. Filipits, M. Rudas, H. Heinzl, R. Jakesz, E. Kubista, S. Lax, W. Schippinger, O. Dietze, R. Greil, W. Stiglbauer, et al. (2009)
Clin. Cancer Res. 15, 5888-5894
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of p27Kip1 by Epstein-Barr Virus Protein Kinase Induces Its Degradation through SCFSkp2 Ubiquitin Ligase Actions during Viral Lytic Replication.

S. Iwahori, T. Murata, A. Kudoh, Y. Sato, S. Nakayama, H. Isomura, T. Kanda, and T. Tsurumi (2009)
J. Biol. Chem. 284, 18923-18931
 |  Abstract »  |  Full Text »  |  PDF »

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.

M. D. Larrea, F. Hong, S. A. Wander, T. G. da Silva, D. Helfman, D. Lannigan, J. A. Smith, and J. M. Slingerland (2009)
PNAS 106, 9268-9273
 |  Abstract »  |  Full Text »  |  PDF »

Thrombin Induces Tumor Cell Cycle Activation and Spontaneous Growth by Down-regulation of p27Kip1, in Association with the Up-regulation of Skp2 and MiR-222.

L. Hu, S. Ibrahim, C. Liu, J. Skaar, M. Pagano, and S. Karpatkin (2009)
Cancer Res. 69, 3374-3381
 |  Abstract »  |  Full Text »  |  PDF »

TP-110, a New Proteasome Inhibitor, Down-regulates IAPs in Human Multiple Myeloma Cells.

M. IIJIMA, I. MOMOSE, and D. IKEDA (2009)
Anticancer Res 29, 977-985
 |  Abstract »  |  Full Text »  |  PDF »

Targeting Ornithine Decarboxylase Impairs Development of MYCN-Amplified Neuroblastoma.

R. J. Rounbehler, W. Li, M. A. Hall, C. Yang, M. Fallahi, and J. L. Cleveland (2009)
Cancer Res. 69, 547-553
 |  Abstract »  |  Full Text »  |  PDF »

Pediatric glioblastomas: A histopathological and molecular genetic study.

V. Suri, P. Das, A. Jain, M. C. Sharma, S. A. Borkar, A. Suri, D. Gupta, and C. Sarkar (2009)
Neuro-oncol 11, 274-280
 |  Abstract »  |  Full Text »  |  PDF »

G0 Function of BCL2 and BCL-xL Requires BAX, BAK, and p27 Phosphorylation by Mirk, Revealing a Novel Role of BAX and BAK in Quiescence Regulation.

Y. Janumyan, Q. Cui, L. Yan, C. G. Sansam, M. Valentin, and E. Yang (2008)
J. Biol. Chem. 283, 34108-34120
 |  Abstract »  |  Full Text »  |  PDF »

A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.

G. A. Miranda-Carboni, S. A. Krum, K. Yee, M. Nava, Q. E. Deng, S. Pervin, A. Collado-Hidalgo, Z. Galic, J. A. Zack, K. Nakayama, et al. (2008)
Genes & Dev. 22, 3121-3134
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Pancreatic Tumor Cell Proliferation and Chemoresistance by the Histone Methyltransferase Enhancer of Zeste Homologue 2.

A. V. Ougolkov, V. N. Bilim, and D. D. Billadeau (2008)
Clin. Cancer Res. 14, 6790-6796
 |  Abstract »  |  Full Text »  |  PDF »

CSIG Inhibits PTEN Translation in Replicative Senescence.

L. Ma, N. Chang, S. Guo, Q. Li, Z. Zhang, W. Wang, and T. Tong (2008)
Mol. Cell. Biol. 28, 6290-6301
 |  Abstract »  |  Full Text »  |  PDF »

A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress.

J. Kimura, S. T. Nguyen, H. Liu, N. Taira, Y. Miki, and K. Yoshida (2008)
Nucleic Acids Res. 36, 5250-5259
 |  Abstract »  |  Full Text »  |  PDF »

Cadmium-induced Activation of Stress Signaling Pathways, Disruption of Ubiquitin-dependent Protein Degradation and Apoptosis in Primary Rat Sertoli Cell-Gonocyte Cocultures.

X. Yu, S. Hong, and E. M. Faustman (2008)
Toxicol. Sci. 104, 385-396
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Modes of Activation of Phosphatidylinositol 3-Kinase in Response to Cyclic Adenosine 3', 5'-Monophosphate or Insulin-Like Growth Factor I Play Different Roles in Regulation of Cyclin D1 and p27Kip1 in FRTL-5 Cells.

T. Fukushima, T. Nedachi, H. Akizawa, M. Akahori, F. Hakuno, and S.-I. Takahashi (2008)
Endocrinology 149, 3729-3742
 |  Abstract »  |  Full Text »  |  PDF »

PDK1 Regulates Cell Proliferation and Cell Cycle Progression through Control of Cyclin D1 and p27Kip1 Expression.

K. Nakamura, H. Sakaue, A. Nishizawa, Y. Matsuki, H. Gomi, E. Watanabe, R. Hiramatsua, M. Tamamori-Adachi, S. Kitajima, T. Noda, et al. (2008)
J. Biol. Chem. 283, 17702-17711
 |  Abstract »  |  Full Text »  |  PDF »

Kruppel-like Factor 4 Induces p27Kip1 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells.

D. Wei, M. Kanai, Z. Jia, X. Le, and K. Xie (2008)
Cancer Res. 68, 4631-4639
 |  Abstract »  |  Full Text »  |  PDF »

Bortezomib (Velcade) Induces p27Kip1 Expression through S-Phase Kinase Protein 2 Degradation in Colorectal Cancer.

S. Uddin, M. Ahmed, P. Bavi, R. El-Sayed, N. Al-Sanea, A. AbdulJabbar, L. H. Ashari, S. Alhomoud, F. Al-Dayel, A. R. Hussain, et al. (2008)
Cancer Res. 68, 3379-3388
 |  Abstract »  |  Full Text »  |  PDF »

Dissection of the APCCdh1-Skp2 Cascade in Breast Cancer.

T. Fujita, W. Liu, H. Doihara, H. Date, and Y. Wan (2008)
Clin. Cancer Res. 14, 1966-1975
 |  Abstract »  |  Full Text »  |  PDF »

Differential Involvement of Cell Cycle Reactivation between Striatal and Cortical Neurons in Cell Death Induced by 3-Nitropropionic Acid.

H. Akashiba, Y. Ikegaya, N. Nishiyama, and N. Matsuki (2008)
J. Biol. Chem. 283, 6594-6606
 |  Abstract »  |  Full Text »  |  PDF »

CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib.

R. Piva, B. Ruggeri, M. Williams, G. Costa, I. Tamagno, D. Ferrero, V. Giai, M. Coscia, S. Peola, M. Massaia, et al. (2008)
Blood 111, 2765-2775
 |  Abstract »  |  Full Text »  |  PDF »

Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-{kappa}B-dependent DNA methyltransferase activity in acute myeloid leukemia.

S. Liu, Z. Liu, Z. Xie, J. Pang, J. Yu, E. Lehmann, L. Huynh, T. Vukosavljevic, M. Takeki, R. B. Klisovic, et al. (2008)
Blood 111, 2364-2373
 |  Abstract »  |  Full Text »  |  PDF »

FoxM1 Regulates Growth Factor-induced Expression of Kinase-interacting Stathmin (KIS) to Promote Cell Cycle Progression.

V. Petrovic, R. H. Costa, L. F. Lau, P. Raychaudhuri, and A. L. Tyner (2008)
J. Biol. Chem. 283, 453-460
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Two Distinct Ubiquitin E3 Ligase Systems for p27 Degradation in Corneal Endothelial Cells.

J. G. Lee and E. P. Kay (2008)
Invest. Ophthalmol. Vis. Sci. 49, 189-196
 |  Abstract »  |  Full Text »  |  PDF »

HMG-CoA Reductase Inhibitor Simvastatin Inhibits Cell Cycle Progression at the G1/S Checkpoint in Immortalized Lymphocytes from Alzheimer's Disease Patients Independently of Cholesterol-Lowering Effects.

S. G. Sala, U. Munoz, F. Bartolome, F. Bermejo, and A. Martin-Requero (2008)
J. Pharmacol. Exp. Ther. 324, 352-359
 |  Abstract »  |  Full Text »  |  PDF »

Cks1 Regulates cdk1 Expression: A Novel Role during Mitotic Entry in Breast Cancer Cells.

L. Westbrook, M. Manuvakhova, F. G. Kern, N. R. Estes II, H. N. Ramanathan, and J. V. Thottassery (2007)
Cancer Res. 67, 11393-11401
 |  Abstract »  |  Full Text »  |  PDF »

Pirh2 Promotes Ubiquitin-Dependent Degradation of the Cyclin-Dependent Kinase Inhibitor p27Kip1.

T. Hattori, T. Isobe, K. Abe, H. Kikuchi, K. Kitagawa, T. Oda, C. Uchida, and M. Kitagawa (2007)
Cancer Res. 67, 10789-10795
 |  Abstract »  |  Full Text »  |  PDF »

Fms-like Tyrosine Kinase 3 Ligand Stimulation Induces MLL-Rearranged Leukemia Cells into Quiescence Resistant to Antileukemic Agents.

Y. Furuichi, K. Goi, T. Inukai, H. Sato, A. Nemoto, K. Takahashi, K. Akahane, K. Hirose, H. Honna, I. Kuroda, et al. (2007)
Cancer Res. 67, 9852-9861
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of the Proteasome Activity by Gallium(III) Complexes Contributes to Their Anti Prostate Tumor Effects.

D. Chen, M. Frezza, R. Shakya, Q. C. Cui, V. Milacic, C. N. Verani, and Q. P. Dou (2007)
Cancer Res. 67, 9258-9265
 |  Abstract »  |  Full Text »  |  PDF »

Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5' UTR.

L. Pavithra, S. Rampalli, S. Sinha, K. Sreenath, R. G. Pestell, and S. Chattopadhyay (2007)
Nucleic Acids Res. 35, 6004-6016
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells.

D. Egozi, M. Shapira, G. Paor, O. Ben-Izhak, K. Skorecki, and D. D. Hershko (2007)
FASEB J 21, 2807-2817
 |  Abstract »  |  Full Text »  |  PDF »

Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas.

T. Lwin, L. A. Hazlehurst, S. Dessureault, R. Lai, W. Bai, E. Sotomayor, L. C. Moscinski, W. S. Dalton, and J. Tao (2007)
Blood 110, 1631-1638
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin D2 Translocates p27 out of the Nucleus and Promotes Its Degradation at the G0-G1 Transition.

E. Susaki, K. Nakayama, and K. I. Nakayama (2007)
Mol. Cell. Biol. 27, 4626-4640
 |  Abstract »  |  Full Text »  |  PDF »

p27Kip1 localization depends on the tumor suppressor protein tuberin.

M. Rosner, A. Freilinger, M. Hanneder, N. Fujita, G. Lubec, T. Tsuruo, and M. Hengstschlager (2007)
Hum. Mol. Genet. 16, 1541-1556
 |  Abstract »  |  Full Text »  |  PDF »

Cell Cycle-dependent Expression of Centrosomal Ninein-like Protein in Human Cells Is Regulated by the Anaphase-promoting Complex.

Y. Wang and Q. Zhan (2007)
J. Biol. Chem. 282, 17712-17719
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer.

G. Chiappetta, C. De Marco, A. Quintiero, D. Califano, S. Gherardi, D. Malanga, M. Scrima, C. Montero-Conde, L. Cito, M. Monaco, et al. (2007)
Endocr. Relat. Cancer 14, 405-420
 |  Abstract »  |  Full Text »  |  PDF »

Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase.

S. Xu, M. Abbasian, P. Patel, K. Jensen-Pergakes, C. R. Lombardo, B. E. Cathers, W. Xie, F. Mercurio, M. Pagano, D. Giegel, et al. (2007)
J. Biol. Chem. 282, 15462-15470
 |  Abstract »  |  Full Text »  |  PDF »

E2A and HEB Are Required to Block Thymocyte Proliferation Prior to Pre-TCR Expression.

J. Wojciechowski, A. Lai, M. Kondo, and Y. Zhuang (2007)
J. Immunol. 178, 5717-5726
 |  Abstract »  |  Full Text »  |  PDF »

Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma.

C. Jakob, K. Egerer, P. Liebisch, S. Turkmen, I. Zavrski, U. Kuckelkorn, U. Heider, M. Kaiser, C. Fleissner, J. Sterz, et al. (2007)
Blood 109, 2100-2105
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor-{beta}, Estrogen, and Progesterone Converge on the Regulation of p27Kip1 in the Normal and Malignant Endometrium.

J. Lecanda, T. V. Parekh, P. Gama, K. Lin, V. Liarski, S. Uretsky, K. Mittal, and L. I. Gold (2007)
Cancer Res. 67, 1007-1018
 |  Abstract »  |  Full Text »  |  PDF »

The Tumor Proteasome Is a Primary Target for the Natural Anticancer Compound Withaferin A Isolated from "Indian Winter Cherry".

H. Yang, G. Shi, and Q. P. Dou (2007)
Mol. Pharmacol. 71, 426-437
 |  Abstract »  |  Full Text »  |  PDF »

BCR ubiquitination controls BCR-mediated antigen processing and presentation.

L. Drake, E. M. McGovern-Brindisi, and J. R. Drake (2006)
Blood 108, 4086-4093
 |  Abstract »  |  Full Text »  |  PDF »

p27Kip1 and Cyclin E Expression and Breast Cancer Survival After Treatment With Adjuvant Chemotherapy.

P. L. Porter, W. E. Barlow, I-T. Yeh, M. G. Lin, X. P. Yuan, E. Donato, G. W. Sledge, C. L. Shapiro, J. N. Ingle, C. M. Haskell, et al. (2006)
J Natl Cancer Inst 98, 1723-1731
 |  Abstract »  |  Full Text »  |  PDF »

Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2-positive breast cancer cells in a synergistic manner.

F. Cardoso, V. Durbecq, J.-F. Laes, B. Badran, L. Lagneaux, F. Bex, C. Desmedt, K. Willard-Gallo, J. S. Ross, A. Burny, et al. (2006)
Mol. Cancer Ther. 5, 3042-3051
 |  Abstract »  |  Full Text »  |  PDF »

Disulfiram, a Clinically Used Anti-Alcoholism Drug and Copper-Binding Agent, Induces Apoptotic Cell Death in Breast Cancer Cultures and Xenografts via Inhibition of the Proteasome Activity.

D. Chen, Q. C. Cui, H. Yang, and Q. P. Dou (2006)
Cancer Res. 66, 10425-10433
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Anticancer Gold(III) Dithiocarbamate Compound Inhibits the Activity of a Purified 20S Proteasome and 26S Proteasome in Human Breast Cancer Cell Cultures and Xenografts.

V. Milacic, D. Chen, L. Ronconi, K. R. Landis-Piwowar, D. Fregona, and Q. P. Dou (2006)
Cancer Res. 66, 10478-10486
 |  Abstract »  |  Full Text »  |  PDF »

p27 Regulates the Transition of {beta}-Cells From Quiescence to Proliferation.

S. Georgia and A. Bhushan (2006)
Diabetes 55, 2950-2956
 |  Abstract »  |  Full Text »  |  PDF »

Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans.

N. S. Pellegata, L. Quintanilla-Martinez, H. Siggelkow, E. Samson, K. Bink, H. Hofler, F. Fend, J. Graw, and M. J. Atkinson (2006)
PNAS 103, 15558-15563
 |  Abstract »  |  Full Text »  |  PDF »

p27Kip1 Repression of ErbB2-Induced Mammary Tumor Growth in Transgenic Mice Involves Skp2 and Wnt/{beta}-Catenin Signaling..

J. Hulit, R. J. Lee, Z. Li, C. Wang, S. Katiyar, J. Yang, A. A. Quong, K. Wu, C. Albanese, R. Russell, et al. (2006)
Cancer Res. 66, 8529-8541
 |  Abstract »  |  Full Text »  |  PDF »

Potential Role of Jun Activation Domain-Binding Protein 1 as a Negative Regulator of p27kip1 in Pancreatic Adenocarcinoma..

M. A. Kouvaraki, A. L. Korapati, G. Z. Rassidakis, L. Tian, Q. Zhang, P. Chiao, L. Ho, D. B. Evans, and F. X. Claret (2006)
Cancer Res. 66, 8581-8589
 |  Abstract »  |  Full Text »  |  PDF »

A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development.

Y.-S. Lee, F. Liu, and N. Segil (2006)
Development 133, 2817-2826
 |  Abstract »  |  Full Text »  |  PDF »

Oncostatin M Induces Growth Arrest by Inhibition of Skp2, Cks1, and Cyclin A Expression and Induced p21 Expression..

H. Halfter, M. Friedrich, A. Resch, M. Kullmann, F. Stogbauer, E. B. Ringelstein, and L. Hengst (2006)
Cancer Res. 66, 6530-6539
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor B1 Stimulated DNA Synthesis in the Granulosa Cells of Preantral Follicles: Negative Interaction with Epidermal Growth Factor.

P. Yang and S. K. Roy (2006)
Biol Reprod 75, 140-148
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells.

E. A. Obeng, L. M. Carlson, D. M. Gutman, W. J. Harrington Jr, K. P. Lee, and L. H. Boise (2006)
Blood 107, 4907-4916
 |  Abstract »  |  Full Text »  |  PDF »

The 19 S Proteasomal Subunit POH1 Contributes to the Regulation of c-Jun Ubiquitination, Stability, and Subcellular Localization.

J. F. Nabhan and P. Ribeiro (2006)
J. Biol. Chem. 281, 16099-16107
 |  Abstract »  |  Full Text »  |  PDF »

Differential expression of cyclin-dependent kinase inhibitors, p27Kip1 and p57Kip2, by corticotropin in rat adrenal cortex..

H. Kobayashi, F. Kambe, T. Imai, Y. Hibi, T. Kikumori, S. Ohmori, A. Nakao, and H. Seo (2006)
J. Endocrinol. 189, 671-679
 |  Abstract »  |  Full Text »  |  PDF »

Focal Adhesion Kinase Controls Cellular Levels of p27/Kip1 and p21/Cip1 through Skp2-Dependent and -Independent Mechanisms..

P. Bryant, Q. Zheng, and K. Pumiglia (2006)
Mol. Cell. Biol. 26, 4201-4213
 |  Abstract »  |  Full Text »  |  PDF »

HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells.

A. Parcellier, M. Brunet, E. Schmitt, E. Col, C. Didelot, A. Hammann, K. Nakayama, K. I. Nakayama, S. Khochbin, E. Solary, et al. (2006)
FASEB J 20, 1179-1181
 |  Abstract »  |  Full Text »  |  PDF »

The nuclear ubiquitin-proteasome system.

A. von Mikecz (2006)
J. Cell Sci. 119, 1977-1984
 |  Abstract »  |  Full Text »  |  PDF »

Celastrol, a Triterpene Extracted from the Chinese "Thunder of God Vine," Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice..

H. Yang, D. Chen, Q. C. Cui, X. Yuan, and Q. P. Dou (2006)
Cancer Res. 66, 4758-4765
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitin-conjugating enzyme 3 delays human lens epithelial cells in metaphase..

Q. Liu, F. Shang, E. Whitcomb, W. Guo, W. Li, and A. Taylor (2006)
Invest. Ophthalmol. Vis. Sci. 47, 1302-1309
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis..

M. Bazzaro, M. K. Lee, A. Zoso, W. L.H. Stirling, A. Santillan, I.-M. Shih, and R. B.S. Roden (2006)
Cancer Res. 66, 3754-3763
 |  Abstract »  |  Full Text »  |  PDF »

IL-7 promotes T cell proliferation through destabilization of p27Kip1.

W. Q. Li, Q. Jiang, E. Aleem, P. Kaldis, A. R. Khaled, and S. K. Durum (2006)
J. Exp. Med. 203, 573-582
 |  Abstract »  |  Full Text »  |  PDF »

Proliferating Human Cells Hypomorphic for Origin Recognition Complex 2 and Pre-replicative Complex Formation Have a Defect in p53 Activation and Cdk2 Kinase Activation.

J. K. Teer, Y. J. Machida, H. Labit, O. Novac, O. Hyrien, K. Marheineke, M. Zannis-Hadjopoulos, and A. Dutta (2006)
J. Biol. Chem. 281, 6253-6260
 |  Abstract »  |  Full Text »  |  PDF »

Significance of Skp2 Expression in Primary Breast Cancer.

H. Sonoda, H. Inoue, K. Ogawa, T. Utsunomiya, T.-a. Masuda, and M. Mori (2006)
Clin. Cancer Res. 12, 1215-1220
 |  Abstract »  |  Full Text »  |  PDF »

In vivo Imaging of Adenovirus Transduction and Enhanced Therapeutic Efficacy of Combination Therapy with Conditionally Replicating Adenovirus and Adenovirus-p27.

C.-T. Lee, Y.-J. Lee, S.-Y. Kwon, J. Lee, K. I. Kim, K.-H. Park, J. H. Kang, C.-G. Yoo, Y. W. Kim, S. K. Han, et al. (2006)
Cancer Res. 66, 372-377
 |  Abstract »  |  Full Text »  |  PDF »

A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression.

A. Besson, M. Gurian-West, X. Chen, K. S. Kelly-Spratt, C. J. Kemp, and J. M. Roberts (2006)
Genes & Dev. 20, 47-64
 |  Abstract »  |  Full Text »  |  PDF »

Biphasic effect of p21Cip1 on smooth muscle cell proliferation: Role of PI 3-kinase and Skp2-mediated degradation.

M. Bond, G. B. Sala-Newby, Y.-J. Wu, and A. C. Newby (2006)
Cardiovasc Res 69, 198-206
 |  Abstract »  |  Full Text »  |  PDF »

Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase.

J. S. Knight, N. Sharma, and E. S. Robertson (2005)
PNAS 102, 18562-18566
 |  Abstract »  |  Full Text »  |  PDF »

Protein gene product 9.5 and ubiquitin are expressed in metabolically active epithelial cells of normal and pathologic human kidney.

F. Diomedi-Camassei, L. Rava, E. Lerut, F. Callea, and B. Van Damme (2005)
Nephrol. Dial. Transplant. 20, 2714-2719
 |  Abstract »  |  Full Text »  |  PDF »

Subcellular Localization and Protein Levels of Cyclin-Dependent Kinase Inhibitor p27 Independently Predict for Survival in Epithelial Ovarian Cancer.

A. Psyrri, A. Bamias, Z. Yu, P. M. Weinberger, M. Kassar, S. Markakis, D. Kowalski, E. Efstathiou, R. L. Camp, D. L. Rimm, et al. (2005)
Clin. Cancer Res. 11, 8384-8390
 |  Abstract »  |  Full Text »  |  PDF »

Role of the UBL-UBA Protein KPC2 in Degradation of p27 at G1 Phase of the Cell Cycle.

T. Hara, T. Kamura, S. Kotoshiba, H. Takahashi, K. Fujiwara, I. Onoyama, M. Shirakawa, N. Mizushima, and K. I. Nakayama (2005)
Mol. Cell. Biol. 25, 9292-9303
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Proliferating Cell Nuclear Antigen Recruits Cyclin-dependent Kinase Inhibitor Xic1 to DNA and Couples Its Proteolysis to DNA Polymerase Switching.

L.-C. Chuang and P. R. Yew (2005)
J. Biol. Chem. 280, 35299-35309
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Involvement of the p97-Ufd1-Npl4 Complex in the Regulated Endoplasmic Reticulum-associated Degradation of Inositol 1,4,5-Trisphosphate Receptors.

K. J. Alzayady, M. M. Panning, G. G. Kelley, and R. J. H. Wojcikiewicz (2005)
J. Biol. Chem. 280, 34530-34537
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Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27Kip1 Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling.

S. Kfir, M. Ehrlich, A. Goldshmid, X. Liu, Y. Kloog, and Y. I. Henis (2005)
Mol. Cell. Biol. 25, 8239-8250
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Targeting Histones and Proteasomes: New Strategies for the Treatment of Lymphoma.

O. A. O'Connor (2005)
J. Clin. Oncol. 23, 6429-6436
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Ubiquitination of p27Kip1 Requires Physical Interaction with Cyclin E and Probable Phosphate Recognition by SKP2.

D. Ungermannova, Y. Gao, and X. Liu (2005)
J. Biol. Chem. 280, 30301-30309
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Myxoma Virus M-T5 Protects Infected Cells from the Stress of Cell Cycle Arrest through Its Interaction with Host Cell Cullin-1.

J. B. Johnston, G. Wang, J. W. Barrett, S. H. Nazarian, K. Colwill, M. Moran, and G. McFadden (2005)
J. Virol. 79, 10750-10763
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The Ubiquitin-Proteasome Pathway and Its Role in Cancer.

A. Mani and E. P. Gelmann (2005)
J. Clin. Oncol. 23, 4776-4789
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Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation.

L. M. Sarmento, H. Huang, A. Limon, W. Gordon, J. Fernandes, M. J. Tavares, L. Miele, A. A. Cardoso, M. Classon, and N. Carlesso (2005)
J. Exp. Med. 202, 157-168
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Proteasome Structures Affected by Ionizing Radiation.

M. Pervan, K. S. Iwamoto, and W. H. McBride (2005)
Mol. Cancer Res. 3, 381-390
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Bowman-Birk inhibitor abates proteasome function and suppresses the proliferation of MCF7 breast cancer cells through accumulation of MAP kinase phosphatase-1.

Y.-W. Chen, S.-C. Huang, S.-Y. Lin-Shiau, and J.-K. Lin (2005)
Carcinogenesis 26, 1296-1306
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EGF stimulates mesangial cell mitogenesis via PI3-kinase-mediated MAPK-dependent and AKT kinase-independent manner: involvement of c-fos and p27Kip1.

L. Mahimainathan, N. Ghosh-Choudhury, B. A. Venkatesan, R. S. Danda, and G. G. Choudhury (2005)
Am J Physiol Renal Physiol 289, F72-F82
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TReP-132 Controls Cell Proliferation by Regulating the Expression of the Cyclin-Dependent Kinase Inhibitors p21WAF1/Cip1 and p27Kip1.

F. Gizard, R. Robillard, O. Barbier, B. Quatannens, A. Faucompre, F. Revillion, J.-P. Peyrat, B. Staels, and D. W. Hum (2005)
Mol. Cell. Biol. 25, 4335-4348
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Reduced E-cadherin expression contributes to the loss of p27kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas.

M. L. Motti, D. Califano, G. Baldassarre, A. Celetti, F. Merolla, F. Forzati, M. Napolitano, B. Tavernise, A. Fusco, and G. Viglietto (2005)
Carcinogenesis 26, 1021-1034
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Hes1 Directly Controls Cell Proliferation through the Transcriptional Repression of p27Kip1.

K. Murata, M. Hattori, N. Hirai, Y. Shinozuka, H. Hirata, R. Kageyama, T. Sakai, and N. Minato (2005)
Mol. Cell. Biol. 25, 4262-4271
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Molecular Dissection of the Interaction between p27 and Kip1 Ubiquitylation-promoting Complex, the Ubiquitin Ligase That Regulates Proteolysis of p27 in G1 Phase.

S. Kotoshiba, T. Kamura, T. Hara, N. Ishida, and K. I. Nakayama (2005)
J. Biol. Chem. 280, 17694-17700
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Cdk2-dependent Phosphorylation of Homeobox Transcription Factor CDX2 Regulates Its Nuclear Translocation and Proteasome-mediated Degradation in Human Intestinal Epithelial Cells.

J. Boulanger, A. Vezina, S. Mongrain, F. Boudreau, N. Perreault, B. A. Auclair, J. Laine, C. Asselin, and N. Rivard (2005)
J. Biol. Chem. 280, 18095-18107
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Molecular Basis of Restenosis and Drug-Eluting Stents.

M. A. Costa and D. I. Simon (2005)
Circulation 111, 2257-2273
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Regulation of Vascular Smooth Muscle Proliferation by Heparin: INHIBITION OF CYCLIN-DEPENDENT KINASE 2 ACTIVITY BY p27kip1.

S. Fasciano, R. C. Patel, I. Handy, and C. V. Patel (2005)
J. Biol. Chem. 280, 15682-15689
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BCR-ABL Induces the Expression of Skp2 through the PI3K Pathway to Promote p27Kip1 Degradation and Proliferation of Chronic Myelogenous Leukemia Cells.

E. J. Andreu, E. Lledo, E. Poch, C. Ivorra, M. P. Albero, J. A. Martinez-Climent, C. Montiel-Duarte, J. Rifon, J. Perez-Calvo, C. Arbona, et al. (2005)
Cancer Res. 65, 3264-3272
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Subcellular Redistribution of Components of the Ubiquitin-Proteasome Pathway during Lens Differentiation and Maturation.

H. Girao, P. Pereira, A. Taylor, and F. Shang (2005)
Invest. Ophthalmol. Vis. Sci. 46, 1386-1392
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SCFSkp2 Complex Targeted by Epstein-Barr Virus Essential Nuclear Antigen.

J. S. Knight, N. Sharma, and E. S. Robertson (2005)
Mol. Cell. Biol. 25, 1749-1763
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Pim-1 Kinase Stability Is Regulated by Heat Shock Proteins and the Ubiquitin-Proteasome Pathway.

K. Petersen Shay, Z. Wang, P.-x. Xing, I. F.C. McKenzie, and N. S. Magnuson (2005)
Mol. Cancer Res. 3, 170-181
 |  Abstract »  |  Full Text »  |  PDF »

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