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Science 4 August 1995:
Vol. 269. no. 5224, pp. 679 - 682
DOI: 10.1126/science.7624797
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Articles

Science, Vol 269, Issue 5224, 679-682
Copyright © 1995 by American Association for the Advancement of Science

articles

Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2

M Hanks, W Wurst, L Anson-Cartwright, AB Auerbach, and AL Joyner

Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Canada.

The related mouse Engrailed genes En-1 and En-2 are expressed from the one- and approximately five-somite stages, respectively, in a similar presumptive mid-hindbrain domain. However, mutations in En-1 and En-2 produce different phenotypes. En-1 mutant mice die at birth with a large mid-hindbrain deletion, whereas En-2 mutants are viable, with cerebellar defects. To determine whether these contrasting phenotypes reflect differences in temporal expression or biochemical activity of the En proteins, En-1 coding sequences were replaced with En-2 sequences by gene targeting. This rescued all En-1 mutant defects, demonstrating that the difference between En-1 and En-2 stems from their divergent expression patterns.


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