Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 August 1995:
Vol. 269. no. 5224, pp. 679 - 682
DOI: 10.1126/science.7624797
Prev | Table of Contents | Next

Articles

Science, Vol 269, Issue 5224, 679-682
Copyright © 1995 by American Association for the Advancement of Science

articles

Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2

M Hanks, W Wurst, L Anson-Cartwright, AB Auerbach, and AL Joyner

Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Canada.

The related mouse Engrailed genes En-1 and En-2 are expressed from the one- and approximately five-somite stages, respectively, in a similar presumptive mid-hindbrain domain. However, mutations in En-1 and En-2 produce different phenotypes. En-1 mutant mice die at birth with a large mid-hindbrain deletion, whereas En-2 mutants are viable, with cerebellar defects. To determine whether these contrasting phenotypes reflect differences in temporal expression or biochemical activity of the En proteins, En-1 coding sequences were replaced with En-2 sequences by gene targeting. This rescued all En-1 mutant defects, demonstrating that the difference between En-1 and En-2 stems from their divergent expression patterns.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hypoxanthine-guanine phosphoribosyl transferase regulates early developmental programming of dopamine neurons: implications for Lesch-Nyhan disease pathogenesis.
I. Ceballos-Picot, L. Mockel, M.-C. Potier, L. Dauphinot, T. L. Shirley, R. Torero-Ibad, J. Fuchs, and H.A. Jinnah (2009)
Hum. Mol. Genet. 18, 2317-2327
   Abstract »    Full Text »    PDF »
Engrailed Homeobox Genes Determine the Organization of Purkinje Cell Sagittal Stripe Gene Expression in the Adult Cerebellum.
R. V. Sillitoe, D. Stephen, Z. Lao, and A. L. Joyner (2008)
J. Neurosci. 28, 12150-12162
   Abstract »    Full Text »    PDF »
Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5.
C.-A. Mao, S. W. Wang, P. Pan, and W. H. Klein (2008)
Development 135, 3379-3388
   Abstract »    Full Text »    PDF »
MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival.
Y. Kim, P. Zhou, L. Qian, J.-Z. Chuang, J. Lee, C. Li, C. Iadecola, C. Nathan, and A. Ding (2007)
J. Exp. Med. 204, 2063-2074
   Abstract »    Full Text »    PDF »
Genetic subdivision of the tectum and cerebellum into functionally related regions based on differential sensitivity to engrailed proteins.
S. K. Sgaier, Z. Lao, M. P. Villanueva, F. Berenshteyn, D. Stephen, R. K. Turnbull, and A. L. Joyner (2007)
Development 134, 2325-2335
   Abstract »    Full Text »    PDF »
Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R{alpha} mutant mice.
L. C. Osborne, S. Dhanji, J. W. Snow, J. J. Priatel, M. C. Ma, M. J. Miners, H.-S. Teh, M. A. Goldsmith, and N. Abraham (2007)
J. Exp. Med. 204, 619-631
   Abstract »    Full Text »    PDF »
Progressive Loss of Dopaminergic Neurons in the Ventral Midbrain of Adult Mice Heterozygote for Engrailed1.
L. Sonnier, G. Le Pen, A. Hartmann, J.-C. Bizot, F. Trovero, M.-O. Krebs, and A. Prochiantz (2007)
J. Neurosci. 27, 1063-1071
   Abstract »    Full Text »    PDF »
Mutation at the TrkB PLC{gamma}-docking site affects hippocampal LTP and associative learning in conscious mice.
A. Gruart, C. Sciarretta, M. Valenzuela-Harrington, J. M. Delgado-Garcia, and L. Minichiello (2007)
Learn. Mem. 14, 54-62
   Abstract »    Full Text »    PDF »
Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice.
P. Sgado, L. Alberi, D. Gherbassi, S. L. Galasso, G. M. J. Ramakers, K. N. Alavian, M. P. Smidt, R. H. Dyck, and H. H. Simon (2006)
PNAS 103, 15242-15247
   Abstract »    Full Text »    PDF »
Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence.
S. Kellerer, S. Schreiner, C. C. Stolt, S. Scholz, M. R. Bosl, and M. Wegner (2006)
Development 133, 2875-2886
   Abstract »    Full Text »    PDF »
Islet1 and Islet2 have equivalent abilities to promote motoneuron formation and to specify motoneuron subtype identity.
S. A. Hutchinson and J. S. Eisen (2006)
Development 133, 2137-2147
   Abstract »    Full Text »    PDF »
Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons.
J. Kele, N. Simplicio, A. L. M. Ferri, H. Mira, F. Guillemot, E. Arenas, and S.-L. Ang (2006)
Development 133, 495-505
   Abstract »    Full Text »    PDF »
Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function.
P. Lu, G. Minowada, and G. R. Martin (2006)
Development 133, 33-42
   Abstract »    Full Text »    PDF »
The homeoprotein engrailed 1 has pleiotropic functions in calvarial intramembranous bone formation and remodeling.
R. A. Deckelbaum, A. Majithia, T. Booker, J. E. Henderson, and C. A. Loomis (2006)
Development 133, 63-74
   Abstract »    Full Text »    PDF »
Mouse Axin and Axin2/Conductin Proteins Are Functionally Equivalent In Vivo.
I. V. Chia and F. Costantini (2005)
Mol. Cell. Biol. 25, 4371-4376
   Abstract »    Full Text »    PDF »
Otx2 Regulates Subtype Specification and Neurogenesis in the Midbrain.
B. Vernay, M. Koch, F. Vaccarino, J. Briscoe, A. Simeone, R. Kageyama, and S.-L. Ang (2005)
J. Neurosci. 25, 4856-4867
   Abstract »    Full Text »    PDF »
The Exon 8-Containing Prosaposin Gene Splice Variant Is Dispensable for Mouse Development, Lysosomal Function, and Secretion.
T. Cohen, W. Auerbach, L. Ravid, J. Bodennec, A. Fein, A. H. Futerman, A. L. Joyner, and M. Horowitz (2005)
Mol. Cell. Biol. 25, 2431-2440
   Abstract »    Full Text »    PDF »
Deletion of Mouse Rad9 Causes Abnormal Cellular Responses to DNA Damage, Genomic Instability, and Embryonic Lethality.
K. M. Hopkins, W. Auerbach, X. Y. Wang, M. P. Hande, H. Hang, D. J. Wolgemuth, A. L. Joyner, and H. B. Lieberman (2004)
Mol. Cell. Biol. 24, 7235-7248
   Abstract »    Full Text »    PDF »
Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons.
L. Alberi, P. Sgado, and H. H. Simon (2004)
Development 131, 3229-3236
   Abstract »    Full Text »    PDF »
Divergent functions of murine Pax3 and Pax7 in limb muscle development.
F. Relaix, D. Rocancourt, A. Mansouri, and M. Buckingham (2004)
Genes & Dev. 18, 1088-1105
   Abstract »    Full Text »    PDF »
Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3.
M. P. Smidt, S. M. Smits, H. Bouwmeester, F. P. T. Hamers, A. J. A. van der Linden, A. J. C. G. M. Hellemons, J. Graw, and J. P. H. Burbach (2004)
Development 131, 1145-1155
   Abstract »    Full Text »    PDF »
Pax6 and Engrailed 1 Regulate Two Distinct Aspects of Renshaw Cell Development.
T. Sapir, E. J. Geiman, Z. Wang, T. Velasquez, S. Mitsui, Y. Yoshihara, E. Frank, F. J. Alvarez, and M. Goulding (2004)
J. Neurosci. 24, 1255-1264
   Abstract »    Full Text »    PDF »
The isthmic neuroepithelium is essential for cerebellar midline fusion.
A. Louvi, P. Alexandre, C. Metin, W. Wurst, and M. Wassef (2003)
Development 130, 5319-5330
   Abstract »    Full Text »    PDF »
Functions of HNF1 Family Members in Differentiation of the Visceral Endoderm Cell Lineage.
C. Haumaitre, M. Reber, and S. Cereghini (2003)
J. Biol. Chem. 278, 40933-40942
   Abstract »    Full Text »    PDF »
Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon.
S. Scholpp, C. Lohs, and M. Brand (2003)
Development 130, 4881-4893
   Abstract »    Full Text »    PDF »
Differential Roles of Engrailed Paralogs in Determining Sensory Axon Guidance and Synaptic Target Recognition.
B. Marie and J. M. Blagburn (2003)
J. Neurosci. 23, 7854-7862
   Abstract »    Full Text »    PDF »
Factors in the Genetic Background Suppress the Engrailed-1 Cerebellar Phenotype.
N. A. Bilovocky, R. R. Romito-DiGiacomo, C. L. Murcia, S. M. Maricich, and K. Herrup (2003)
J. Neurosci. 23, 5105-5112
   Abstract »    Full Text »    PDF »
The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum.
C. L. Chi, S. Martinez, W. Wurst, and G. R. Martin (2003)
Development 130, 2633-2644
   Abstract »    Full Text »    PDF »
Tools for targeted manipulation of the mouse genome.
L. van der Weyden, D. J. Adams, and A. Bradley (2002)
Physiol Genomics 11, 133-164
   Abstract »    Full Text »    PDF »
Defining the Importance of Phosphatidylserine Synthase 2 in Mice.
M. O. Bergo, B. J. Gavino, R. Steenbergen, B. Sturbois, A. F. Parlow, D. A. Sanan, W. C. Skarnes, J. E. Vance, and S. G. Young (2002)
J. Biol. Chem. 277, 47701-47708
   Abstract »    Full Text »    PDF »
Neuron-Restricted Expression of the Rat Gonadotropin-Releasing Hormone Gene Is Conferred by a Cell-Specific Protein Complex that Binds Repeated CAATT Elements.
C. G. Kelley, M. L. Givens, N. Rave-Harel, S. B. Nelson, S. Anderson, and P. L. Mellon (2002)
Mol. Endocrinol. 16, 2413-2425
   Abstract »    Full Text »    PDF »
Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity.
C. M. Parras, C. Schuurmans, R. Scardigli, J. Kim, D. J. Anderson, and F. Guillemot (2002)
Genes & Dev. 16, 324-338
   Abstract »    Full Text »    PDF »
Differential interactions of eyeless and twin of eyeless with the sine oculis enhancer.
C. Punzo, M. Seimiya, S. Flister, W. J. Gehring, and S. Plaza (2002)
Development 129, 625-634
   Abstract »    Full Text »    PDF »
Absence of the CAAX Endoprotease Rce1: Effects on Cell Growth and Transformation.
M. O. Bergo, P. Ambroziak, C. Gregory, A. George, J. C. Otto, E. Kim, H. Nagase, P. J. Casey, A. Balmain, and S. G. Young (2002)
Mol. Cell. Biol. 22, 171-181
   Abstract »    Full Text »    PDF »
Regulation of the Mitotic and Meiotic Cell Cycles in the Male Germ Line.
D. J. Wolgemuth, E. Laurion, and K. M. Lele (2002)
Recent Prog. Horm. Res. 57, 75-101
   Abstract »    Full Text »    PDF »
Use of Genetically Engineered Mice in Drug Discovery and Development: Wielding Occam's Razor to Prune the Product Portfolio.
B. Bolon and E. Galbreath (2002)
International Journal of Toxicology 21, 55-64
   Abstract »    PDF »
Zic2 Controls Cerebellar Development in Cooperation with Zic1.
J. Aruga, T. Inoue, J. Hoshino, and K. Mikoshiba (2002)
J. Neurosci. 22, 218-225
   Abstract »    Full Text »    PDF »
Gli1 can rescue the in vivo function of Gli2.
C. B. Bai and A. L. Joyner (2001)
Development 128, 5161-5172
   Abstract »    Full Text »    PDF »
The upstream ectoderm enhancer in Pax6 has an important role in lens induction.
P. V. Dimanlig, S. C. Faber, W. Auerbach, H. P. Makarenkova, and R. A. Lang (2001)
Development 128, 4415-4424
   Abstract »    Full Text »    PDF »
Inductive signal and tissue responsiveness defining the tectum and the cerebellum.
T. Sato, I. Araki, and H. Nakamura (2001)
Development 128, 2461-2469
   Abstract »    Full Text »    PDF »
The Neuronal Microtubule-Associated Protein 1B Is under Homeoprotein Transcriptional Control.
M. L. Montesinos, I. Foucher, M. Conradt, G. Mainguy, L. Robel, A. Prochiantz, and M. Volovitch (2001)
J. Neurosci. 21, 3350-3359
   Abstract »    Full Text »    PDF »
Fate of Midbrain Dopaminergic Neurons Controlled by the Engrailed Genes.
H. H. Simon, H. Saueressig, W. Wurst, M. D. Goulding, and D. D. M. O'Leary (2001)
J. Neurosci. 21, 3126-3134
   Abstract »    Full Text »    PDF »
EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region.
A Liu and A. Joyner (2001)
Development 128, 181-191
   Abstract »    PDF »
Fra-1 replaces c-Fos-dependent functions in mice.
A. Fleischmann, F. Hafezi, C. Elliott, C. E. Remé, U. Rüther, and E. F. Wagner (2000)
Genes & Dev. 14, 2695-2700
   Abstract »    Full Text »
GATA factor transgenes under GATA-1 locus control rescue germline GATA-1 mutant deficiencies.
S. Takahashi, R. Shimizu, N. Suwabe, T. Kuroha, K. Yoh, J. Ohta, S. Nishimura, K.-C. Lim, J. D. Engel, and M. Yamamoto (2000)
Blood 96, 910-916
   Abstract »    Full Text »    PDF »
Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation.
R. A. Kimmel, D. H. Turnbull, V. Blanquet, W. Wurst, C. A. Loomis, and A. L. Joyner (2000)
Genes & Dev. 14, 1377-1389
   Abstract »    Full Text »
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.
B. A. Malynn, I. M. de Alboran, R. C. O'Hagan, R. Bronson, L. Davidson, R. A. DePinho, and F. W. Alt (2000)
Genes & Dev. 14, 1390-1399
   Abstract »    Full Text »
The Role of Population Size, Pleiotropy and Fitness Effects of Mutations in the Evolution of Overlapping Gene Functions.
A. Wagner (2000)
Genetics 154, 1389-1401
   Abstract »    Full Text »
Role of the Distal Half of the c-Mpl Intracellular Domain in Control of Platelet Production by Thrombopoietin In Vivo.
S.-M. Luoh, E. Stefanich, G. Solar, H. Steinmetz, T. Lipari, T. I. Pestina, C. W. Jackson, and F. J. de Sauvage (2000)
Mol. Cell. Biol. 20, 507-515
   Abstract »    Full Text »
Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development.
M Bouchard, P Pfeffer, and M Busslinger (2000)
Development 127, 3703-3713
   Abstract »    PDF »
Ectopic engrailed 1 expression in the dorsal midline causes cell death, abnormal differentiation of circumventricular organs and errors in axonal pathfinding.
A Louvi and M Wassef (2000)
Development 127, 4061-4071
   Abstract »    PDF »
Control of chick tectum territory along dorsoventral axis by Sonic hedgehog.
Y Watanabe and H Nakamura (2000)
Development 127, 1131-1140
   Abstract »    PDF »
A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons.
C. Fode, Q. Ma, S. Casarosa, S.-L. Ang, D. J. Anderson, and F. Guillemot (2000)
Genes & Dev. 14, 67-80
   Abstract »    Full Text »
Disruption of the Mouse Rce1 Gene Results in Defective Ras Processing and Mislocalization of Ras within Cells.
E. Kim, P. Ambroziak, J. C. Otto, B. Taylor, M. Ashby, K. Shannon, P. J. Casey, and S. G. Young (1999)
J. Biol. Chem. 274, 8383-8390
   Abstract »    Full Text »    PDF »
Fibroblast Growth Factor-8 Expression Is Regulated by Intronic Engrailed and Pbx1-binding Sites.
J. Gemel, C. Jacobsen, and C. A. MacArthur (1999)
J. Biol. Chem. 274, 6020-6026
   Abstract »    Full Text »    PDF »
Localization of Distant Urogenital System-, Central Nervous System-, and Endocardium-Specific Transcriptional Regulatory Elements in the GATA-3 Locus.
G. Lakshmanan, K. H. Lieuw, K.-C. Lim, Y. Gu, F. Grosveld, J. D. Engel, and A. Karis (1999)
Mol. Cell. Biol. 19, 1558-1568
   Abstract »    Full Text »    PDF »
Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo.
R. Stoffel, S. Ziegler, N. Ghilardi, B. Ledermann, F. J. de Sauvage, and R. C. Skoda (1999)
PNAS 96, 698-702
   Abstract »    Full Text »    PDF »
FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate.
A Liu, K Losos, and A. Joyner (1999)
Development 126, 4827-4838
   Abstract »    PDF »
Engrailed defines the position of dorsal di-mesencephalic boundary by repressing diencephalic fate.
I Araki and H Nakamura (1999)
Development 126, 5127-5135
   Abstract »    PDF »
Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons.
H Saueressig, J Burrill, and M Goulding (1999)
Development 126, 4201-4212
   Abstract »    PDF »
The midbrain-hindbrain boundary genetic cascade is activated ectopically in the diencephalon in response to the widespread expression of one of its components, the medaka gene Ol-eng2.
F Ristoratore, M Carl, K Deschet, L Richard-Parpaillon, D Boujard, J Wittbrodt, D Chourrout, F Bourrat, and J. Joly (1999)
Development 126, 3769-3779
   Abstract »    PDF »
Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation of the midbrain.
H Shamim, R Mahmood, C Logan, P Doherty, A Lumsden, and I Mason (1999)
Development 126, 945-959
   Abstract »    PDF »
Antigen-Induced Eosinophilic Lung Inflammation Develops in Mice Deficient in Chemokine Eotaxin.
Y. Yang, J. Loy, R.-P. Ryseck, D. Carrasco, and R. Bravo (1998)
Blood 92, 3912-3923
   Abstract »    Full Text »    PDF »
Functional Redundancy of the Nuclear Factor kappa B Inhibitors Ikappa Balpha and Ikappa Bbeta.
J. D. Cheng, R.-P. Ryseck, R. M. Attar, D. Dambach, and R. Bravo (1998)
J. Exp. Med. 188, 1055-1062
   Abstract »    Full Text »    PDF »
Detection of Deleterious Genotypes in Multigenerational Studies. I. Disruptions in Individual Arabidopsis Actin Genes.
L. U. Gilliland, E. C. McKinney, M. A. Asmussen, and R. B. Meagher (1998)
Genetics 149, 717-725
   Abstract »    Full Text »    PDF »
Timing Is Everything in Life : Conditional Transgene Expression in the Cardiovascular System.
G. I. Fishman (1998)
Circ. Res. 82, 837-844
   Abstract »    Full Text »    PDF »
Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors.
T. Okuda, Z. Cai, S. Yang, N. Lenny, C.-j. Lyu, J. M.A. van Deursen, H. Harada, and J. R. Downing (1998)
Blood 91, 3134-3143
   Abstract »    Full Text »    PDF »
Knockout and knockin of the beta 1 exon D define distinct roles for integrin splice variants in heart function and embryonic development.
C. Baudoin, M.-J. Goumans, C. Mummery, and A. Sonnenberg (1998)
Genes & Dev. 12, 1202-1216
   Abstract »    Full Text »
Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs.
C. Loomis, R. Kimmel, C. Tong, J Michaud, and A. Joyner (1998)
Development 125, 1137-1148
   Abstract »    PDF »
Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: Evidence from targeted mutations.
M. Schwarz, G. Alvarez-Bolado, P. Urbanek, M. Busslinger, and P. Gruss (1997)
PNAS 94, 14518-14523
   Abstract »    Full Text »    PDF »
Expression Patterns of Developmental Control Genes in Normal and Engrailed-1 Mutant Mouse Spinal Cord Reveal Early Diversity in Developing Interneurons.
M. P. Matise and A. L. Joyner (1997)
J. Neurosci. 17, 7805-7816
   Abstract »    Full Text »    PDF »
The Characterization of the Olf-1/EBF-Like HLH Transcription Factor Family: Implications in Olfactory Gene Regulation and Neuronal Development.
S. S. Wang, R. Y. L. Tsai, and R. R. Reed (1997)
J. Neurosci. 17, 4149-4158
   Abstract »    Full Text »    PDF »
Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules.
C Brakebusch, E Hirsch, A Potocnik, and R Fassler (1997)
J. Cell Sci. 110, 2895-2904
   Abstract »    PDF »
Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function.
K. Wassarman, M Lewandoski, K Campbell, A. Joyner, J. Rubenstein, S Martinez, and G. Martin (1997)
Development 124, 2923-2934
   Abstract »    PDF »
Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development.
F. Porter, J Drago, Y Xu, S. Cheema, C Wassif, S. Huang, E Lee, A Grinberg, J. Massalas, D Bodine, et al. (1997)
Development 124, 2935-2944
   Abstract »    PDF »
The role of Engrailed in establishing the dorsoventral axis of the chick limb.
C Logan, A Hornbruch, I Campbell, and A Lumsden (1997)
Development 124, 2317-2324
   Abstract »    PDF »
Rescue of Drosophila engrailed mutants with a highly divergent mosquito engrailed cDNA using a homing, enhancer-trapping transposon.
M Whiteley and J. Kassis (1997)
Development 124, 1531-1541
   Abstract »    PDF »
Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain.
S. Lee, P. Danielian, B Fritzsch, and A. McMahon (1997)
Development 124, 959-969
   Abstract »    PDF »
Protease nexin-1 is expressed at the mouse met-/mesencephalic junction and FGF signaling regulates its promoter activity in primary met-/mesencephalic cells.
P Kury, N Schaeren-Wiemers, and D Monard (1997)
Development 124, 1251-1262
   Abstract »    PDF »
Analysis of Fgf8 Gene Function in Vertebrate Development.
M. Lewandoski, E.N. Meyers, and G.R. Martin (1997)
Cold Spring Harb Symp Quant Biol 62, 159-168
   Abstract »    PDF »
Cell Interactions in Patterning the Mammalian Midbrain.
D.H. Rowitch, P.S. Danielian, S.M.K. Lee, Y. Echelard, and A.P. McMahon (1997)
Cold Spring Harb Symp Quant Biol 62, 535-544
   Abstract »    PDF »
Conditional Transgene Expression in the Heart.
Z. Yu, C. S. Redfern, and G. I. Fishman (1996)
Circ. Res. 79, 691-697
   Abstract »    Full Text »
Retroviral Misexpression of engrailed Genes in the Chick Optic Tectum Perturbs the Topographic Targeting of Retinal Axons.
G. C. Friedman and D. D. M. O'Leary (1996)
J. Neurosci. 16, 5498-5509
   Abstract »    Full Text »    PDF »
Bone morphogenetic proteins: multifunctional regulators of vertebrate development..
B L Hogan (1996)
Genes & Dev. 10, 1580-1594
   PDF »
Design of a C/EBP-specific, Dominant-negative bZIP Protein with Both Inhibitory and Gain-of-function Properties.
M. Olive, S. C. Williams, C. Dezan, P. F. Johnson, and C. Vinson (1996)
J. Biol. Chem. 271, 2040-2047
   Abstract »    Full Text »    PDF »
Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice.
A Mansouri, A Stoykova, M Torres, and P Gruss (1996)
Development 122, 831-838
   Abstract »    PDF »
Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene.
D. Song, G Chalepakis, P Gruss, and A. Joyner (1996)
Development 122, 627-635
   Abstract »    PDF »
Genetic Approaches to Mammalian Olfaction.
R.R. Reed (1996)
Cold Spring Harb Symp Quant Biol 61, 165-172
   Abstract »    PDF »
Targeted Inactivation of the Isoprenylcysteine Carboxyl Methyltransferase Gene Causes Mislocalization of K-Ras in Mammalian Cells.
M. O. Bergo, G. K. Leung, P. Ambroziak, J. C. Otto, P. J. Casey, and S. G. Young (2000)
J. Biol. Chem. 275, 17605-17610
   Abstract »    Full Text »    PDF »
Biochemical Studies of Zmpste24-deficient Mice.
G. K. Leung, W. K. Schmidt, M. O. Bergo, B. Gavino, D. H. Wong, A. Tam, M. N. Ashby, S. Michaelis, and S. G. Young (2001)
J. Biol. Chem. 276, 29051-29058
   Abstract »    Full Text »    PDF »
Decoupled evolution of coding region and mRNA expression patterns after gene duplication: Implications for the neutralist-selectionist debate.
A. Wagner (2000)
PNAS 97, 6579-6584
   Abstract »    Full Text »    PDF »
Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E.
Y. Terasawa, Z. Ladha, S. W. Leonard, J. D. Morrow, D. Newland, D. Sanan, L. Packer, M. G. Traber, and R. V. Farese Jr. (2000)
PNAS 97, 13830-13834
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)