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Science 4 August 1995:
Vol. 269. no. 5224, pp. 671 - 674
DOI: 10.1126/science.7624796
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Articles

Science, Vol 269, Issue 5224, 671-674
Copyright © 1995 by American Association for the Advancement of Science

articles

Detection of creatinine by a designed receptor

TW Bell, Z Hou, Y Luo, MG Drew, E Chapoteau, BP Czech, and A Kumar

Department of Chemistry, State University of New York, Stony Brook 11794-3400, USA.

An artificial receptor has been designed to bind creatinine with a color change (chromogenic response) caused by proton transfer from one end of the receptor to the other. The receptor was synthesized and found to extract creatinine from water into chlorocarbon solvents. The color change in the organic layer is specific for creatinine relative to other organic solutes, and it is selective for creatinine relative to sodium, potassium, and ammonium ions. The chromogenic mechanism is revealed by x-ray crystal structures of creatinine, the free receptor, and the complex, showing "induced fit" binding resulting from electronic complementarity between host and guest.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fluorescent, Sequence-Selective Peptide Detection by Synthetic Small Molecules.
C. Chen, H. Wagner, and W. C. Still (1998)
Science 279, 851-853
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