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Science 4 August 1995:
Vol. 269. no. 5224, pp. 650 - 656
DOI: 10.1126/science.7624793
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Articles

Science, Vol 269, Issue 5224, 650-656
Copyright © 1995 by American Association for the Advancement of Science

articles

Circuit simulation of genetic networks

HH McAdams and L Shapiro

Department of Developmental Biology, Beckman Center, Stanford University School of Medicine 94305, USA.

Genetic networks with tens to hundreds of genes are difficult to analyze with currently available techniques. Because of the many parallels in the function of these biochemically based genetic circuits and electrical circuits, a hybrid modeling approach is proposed that integrates conventional biochemical kinetic modeling within the framework of a circuit simulation. The circuit diagram of the bacteriophage lambda lysislysogeny decision circuit represents connectivity in signal paths of the biochemical components. A key feature of the lambda genetic circuit is that operons function as active integrated logic components and introduce signal time delays essential for the in vivo behavior of phage lambda.


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