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Science 28 July 1995:
Vol. 269. no. 5223, pp. 552 - 554
DOI: 10.1126/science.7624780
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Articles

Science, Vol 269, Issue 5223, 552-554
Copyright © 1995 by American Association for the Advancement of Science

articles

Monitoring release of neurotrophic activity in the brains of awake rats

C Humpel, E Lindqvist, S Soderstrom, A Kylberg, T Ebendal, and L Olson

Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.

Intracerebral microdialysis of awake rats was used to monitor the possible release of neurotrophic factors from brain cells in response to injury and excitation. Perfusates were tested with ganglia bioassays and enzyme immunoassay. Trophic activity was released after implantation of the microdialysis probe into the hippocampus but not into the striatum, as assessed by increased nerve fiber outgrowth from Remak's ganglion. Kainic acid treatment significantly increased the release of trophic activity from hippocampal sites. These findings suggest that the brain responds to mechanical injury as well as to certain excitatory stimuli by regional extracellular release of neurotrophic activity that is not identical to the actions of known neurotrophic factors.


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