Science 28 July 1995: Vol. 269. no. 5223, pp. 540 - 543 DOI: 10.1126/science.7624776

Prev | Table of Contents | Next

Articles

Recent advances in understanding leptin signaling and leptin resistance.

D. L. Morris and L. Rui (2009)
Am J Physiol Endocrinol Metab 297, E1247-E1259
 |  Abstract »  |  Full Text »  |  PDF »

PACAP Neurons in the Hypothalamic Ventromedial Nucleus Are Targets of Central Leptin Signaling.

Z. Hawke, T. R. Ivanov, D. A. Bechtold, H. Dhillon, B. B. Lowell, and S. M. Luckman (2009)
J. Neurosci. 29, 14828-14835
 |  Abstract »  |  Full Text »  |  PDF »

Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality.

A. Romero-Corral, V. K. Somers, J. Sierra-Johnson, Y. Korenfeld, S. Boarin, J. Korinek, M. D. Jensen, G. Parati, and F. Lopez-Jimenez (2009)
Eur. Heart J.
 |  Abstract »  |  Full Text »  |  PDF »

Brain imaging studies of appetite in the context of obesity and the menstrual cycle.

D. A. Van Vugt (2009)
Hum. Reprod. Update
 |  Abstract »  |  Full Text »  |  PDF »

The Insulin Effect on Cerebrocortical Theta Activity Is Associated with Serum Concentrations of Saturated Nonesterified Fatty Acids.

O. Tschritter, H. Preissl, A. M. Hennige, T. Sartorius, Y. Grichisch, N. Stefan, M. Guthoff, S. Dusing, J. Machann, E. Schleicher, et al. (2009)
J. Clin. Endocrinol. Metab. 94, 4600-4607
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis.

J. W. Hill, Y. Xu, F. Preitner, M. Fukuda, Y.-R. Cho, J. Luo, N. Balthasar, R. Coppari, L. C. Cantley, B. B. Kahn, et al. (2009)
Endocrinology 150, 4874-4882
 |  Abstract »  |  Full Text »  |  PDF »

Vertebrate sickness behaviors: Adaptive and integrated neuroendocrine immune responses.

J. S. Adelman and L. B. Martin (2009)
Integr. Comp. Biol. 49, 202-214
 |  Abstract »  |  Full Text »  |  PDF »

Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels.

A. Singh, M. Wirtz, N. Parker, M. Hogan, J. Strahler, G. Michailidis, S. Schmidt, A. Vidal-Puig, S. Diano, P. Andrews, et al. (2009)
PNAS 106, 13100-13105
 |  Abstract »  |  Full Text »  |  PDF »

Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages.

S. Hongo, T. Watanabe, S. Arita, T. Kanome, H. Kageyama, S. Shioda, and A. Miyazaki (2009)
Am J Physiol Endocrinol Metab 297, E474-E482
 |  Abstract »  |  Full Text »  |  PDF »

Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status.

S. E. Mitchell, R. Nogueiras, A. Morris, S. Tovar, C. Grant, M. Cruickshank, D. V. Rayner, C. Dieguez, and L. M. Williams (2009)
J. Physiol. 587, 3573-3585
 |  Abstract »  |  Full Text »  |  PDF »

The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling.

G. J. Morton, J. E. Blevins, F. Kim, M. Matsen, and D. P. Figlewicz (2009)
Am J Physiol Endocrinol Metab 297, E202-E210
 |  Abstract »  |  Full Text »  |  PDF »

CNS Regulation of Glucose Homeostasis.

C. K. L. Lam, M. Chari, and T. K. T. Lam (2009)
Physiology 24, 159-170
 |  Abstract »  |  Full Text »  |  PDF »

Leptin Deficiency and Beta-Cell Dysfunction Underlie Type 2 Diabetes in Compound Akt Knockout Mice.

W. S. Chen, X.-D. Peng, Y. Wang, P.-Z. Xu, M.-L. Chen, Y. Luo, S.-M. Jeon, K. Coleman, W. M. Haschek, J. Bass, et al. (2009)
Mol. Cell. Biol. 29, 3151-3162
 |  Abstract »  |  Full Text »  |  PDF »

Simvastatin Suppresses Leptin Expression in 3T3-L1 Adipocytes via Activation of the Cyclic AMP-PKA Pathway Induced by Inhibition of Protein Prenylation.

T. Maeda and N. Horiuchi (2009)
J. Biochem. 145, 771-781
 |  Abstract »  |  Full Text »  |  PDF »

Postnatal early overnutrition changes the leptin signalling pathway in the hypothalamic\#8211;pituitary\#8211;thyroid axis of young and adult rats.

A. L. Rodrigues, E. G. de Moura, M. C. Fonseca Passos, S. C. Potente Dutra, and P. C. Lisboa (2009)
J. Physiol. 587, 2647-2661
 |  Abstract »  |  Full Text »  |  PDF »

Liver-Specific Loss of Lipolysis-Stimulated Lipoprotein Receptor Triggers Systemic Hyperlipidemia in Mice.

P. Narvekar, M. Berriel Diaz, A. Krones-Herzig, U. Hardeland, D. Strzoda, S. Stohr, M. Frohme, and S. Herzig (2009)
Diabetes 58, 1040-1049
 |  Abstract »  |  Full Text »  |  PDF »

Preadipocyte transplantation: an in vivo study of direct leptin signaling on adipocyte morphogenesis and cell size.

K. Guo, J. Mogen, S. Struzzi, and Y. Zhang (2009)
Am J Physiol Regulatory Integrative Comp Physiol 296, R1339-R1347
 |  Abstract »  |  Full Text »  |  PDF »

Nature or nurture?: focus on "Preadipocyte transplantation: an in vivo study of direct leptin signaling on adipocyte morphogenesis and cell size".

R. B. S. Harris (2009)
Am J Physiol Regulatory Integrative Comp Physiol 296, R1336-R1338
 |  Full Text »  |  PDF »

Hindbrain Leptin Stimulation Induces Anorexia and Hyperthermia Mediated by Hindbrain Melanocortin Receptors.

K. P. Skibicka and H. J. Grill (2009)
Endocrinology 150, 1705-1711
 |  Abstract »  |  Full Text »  |  PDF »

Leptin at 14 y of age: an ongoing story.

J. M Friedman (2009)
Am. J. Clinical Nutrition 89, 973S-979S
 |  Abstract »  |  Full Text »  |  PDF »

Leptin: a pivotal regulator of human energy homeostasis.

I S. Farooqi and S. O'Rahilly (2009)
Am. J. Clinical Nutrition 89, 980S-984S
 |  Abstract »  |  Full Text »  |  PDF »

The subfornical organ: a central nervous system site for actions of circulating leptin.

P. M. Smith, A. P. Chambers, C. J. Price, W. Ho, C. Hopf, K. A. Sharkey, and A. V. Ferguson (2009)
Am J Physiol Regulatory Integrative Comp Physiol 296, R512-R520
 |  Abstract »  |  Full Text »  |  PDF »

Resistin-Like Molecule {alpha} Decreases Glucose Tolerance during Intestinal Inflammation.

A. Munitz, L. Seidu, E. T. Cole, R. Ahrens, S. P. Hogan, and M. E. Rothenberg (2009)
J. Immunol. 182, 2357-2363
 |  Abstract »  |  Full Text »  |  PDF »

FoxO1 Inhibits Leptin Regulation of Pro-opiomelanocortin Promoter Activity by Blocking STAT3 Interaction with Specificity Protein 1.

G. Yang, C.-Y. Lim, C. Li, X. Xiao, G. K. Radda, C. Li, X. Cao, and W. Han (2009)
J. Biol. Chem. 284, 3719-3727
 |  Abstract »  |  Full Text »  |  PDF »

Retinol saturase promotes adipogenesis and is downregulated in obesity.

M. Schupp, M. I. Lefterova, J. Janke, K. Leitner, A. G. Cristancho, S. E. Mullican, M. Qatanani, N. Szwergold, D. J. Steger, J. C. Curtin, et al. (2009)
PNAS 106, 1105-1110
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Age and Strain on Yolk Sac Utilization and Leptin Levels in Newly Hatched Broilers.

J. X. Huang, X. G. Luo, L. Lu, and B. Liu (2008)
Poult. Sci. 87, 2647-2652
 |  Abstract »  |  Full Text »  |  PDF »

Amylin-Mediated Restoration of Leptin Responsiveness in Diet-Induced Obesity: Magnitude and Mechanisms.

J. L. Trevaskis, T. Coffey, R. Cole, C. Lei, C. Wittmer, B. Walsh, C. Weyer, J. Koda, A. D. Baron, D. G. Parkes, et al. (2008)
Endocrinology 149, 5679-5687
 |  Abstract »  |  Full Text »  |  PDF »

Selective Inactivation of Socs3 in SF1 Neurons Improves Glucose Homeostasis without Affecting Body Weight.

R. Zhang, H. Dhillon, H. Yin, A. Yoshimura, B. B. Lowell, E. Maratos-Flier, and J. S. Flier (2008)
Endocrinology 149, 5654-5661
 |  Abstract »  |  Full Text »  |  PDF »

Intricacies of Fat.

L. Stehno-Bittel (2008)
Physical Therapy 88, 1265-1278
 |  Abstract »  |  Full Text »  |  PDF »

Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels.

R. Li, K. L. Svenson, L. R. B. Donahue, L. L. Peters, and G. A. Churchill (2008)
Physiol Genomics 33, 26-32
 |  Abstract »  |  Full Text »  |  PDF »

Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Related Cardiovascular Disease.

S. S. Martin, A. Qasim, and M. P. Reilly (2008)
J. Am. Coll. Cardiol. 52, 1201-1210
 |  Abstract »  |  Full Text »  |  PDF »

The contribution of animal models to the study of obesity.

J. Speakman, C. Hambly, S. Mitchell, and E. Krol (2008)
Lab Anim 42, 413-432
 |  Abstract »  |  Full Text »  |  PDF »

Leptin Acts in the Periphery to Protect Thymocytes from Glucocorticoid-Mediated Apoptosis in the Absence of Weight Loss.

R. N. Trotter-Mayo and M. R. Roberts (2008)
Endocrinology 149, 5209-5218
 |  Abstract »  |  Full Text »  |  PDF »

Insulin and leptin relations in obesity: a multimedia approach.

D. K. Yokaichiya, E. Galembeck, B. B. Torres, J. A. Da Silva, and D. R. de Araujo (2008)
Advan Physiol Educ 32, 231-236
 |  Abstract »  |  Full Text »  |  PDF »

Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance.

V. Kus, T. Prazak, P. Brauner, M. Hensler, O. Kuda, P. Flachs, P. Janovska, D. Medrikova, M. Rossmeisl, Z. Jilkova, et al. (2008)
Am J Physiol Endocrinol Metab 295, E356-E367
 |  Abstract »  |  Full Text »  |  PDF »

Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice.

N. S. Singhal, R. T. Patel, Y. Qi, Y.-S. Lee, and R. S. Ahima (2008)
Am J Physiol Endocrinol Metab 295, E331-E338
 |  Abstract »  |  Full Text »  |  PDF »

Effects of leptin deficiency on postnatal lung development in mice.

K. Huang, R. Rabold, E. Abston, B. Schofield, V. Misra, E. Galdzicka, H. Lee, S. Biswal, W. Mitzner, and C. G. Tankersley (2008)
J Appl Physiol 105, 249-259
 |  Abstract »  |  Full Text »  |  PDF »

A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart.

D. M. Purdham, V. Rajapurohitam, A. Zeidan, C. Huang, G. J. Gross, and M. Karmazyn (2008)
Am J Physiol Heart Circ Physiol 295, H441-H446
 |  Abstract »  |  Full Text »  |  PDF »

Leptin Increases Adult Hippocampal Neurogenesis in Vivo and in Vitro.

J. C. Garza, M. Guo, W. Zhang, and X.-Y. Lu (2008)
J. Biol. Chem. 283, 18238-18247
 |  Abstract »  |  Full Text »  |  PDF »

Nescient Helix-Loop-Helix 2 Interacts with Signal Transducer and Activator of Transcription 3 to Regulate Transcription of Prohormone Convertase 1/3.

D. L. Fox and D. J. Good (2008)
Mol. Endocrinol. 22, 1438-1448
 |  Abstract »  |  Full Text »  |  PDF »

Kinin B1 Receptor Deficiency Leads to Leptin Hypersensitivity and Resistance to Obesity.

M. A. Mori, R. C. Araujo, F. C.G. Reis, D. G. Sgai, R. G. Fonseca, C. C. Barros, V. F. Merino, M. Passadore, A. M. Barbosa, B. Ferrari, et al. (2008)
Diabetes 57, 1491-1500
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.

S. Kajimura, P. Seale, T. Tomaru, H. Erdjument-Bromage, M. P. Cooper, J. L. Ruas, S. Chin, P. Tempst, M. A. Lazar, and B. M. Spiegelman (2008)
Genes & Dev. 22, 1397-1409
 |  Abstract »  |  Full Text »  |  PDF »

AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep.

M. J. Zhu, B. Han, J. Tong, C. Ma, J. M. Kimzey, K. R. Underwood, Y. Xiao, B. W. Hess, S. P. Ford, P. W. Nathanielsz, et al. (2008)
J. Physiol. 586, 2651-2664
 |  Abstract »  |  Full Text »  |  PDF »

Chicken leptin receptor is functional in activating JAK-STATpathway in vitro.

H. Adachi, Y. Takemoto, T. Bungo, and T. Ohkubo (2008)
J. Endocrinol. 197, 335-342
 |  Abstract »  |  Full Text »  |  PDF »

Hyperleptinemia without Obesity in Male Mice Lacking Androgen Receptor in Adipose Tissue.

I-C. Yu, H.-Y. Lin, N.-C. Liu, R.-S. Wang, J. D. Sparks, S. Yeh, and C. Chang (2008)
Endocrinology 149, 2361-2368
 |  Abstract »  |  Full Text »  |  PDF »

Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice.

D. L. Allen, A. S. Cleary, K. J. Speaker, S. F. Lindsay, J. Uyenishi, J. M. Reed, M. C. Madden, and R. S. Mehan (2008)
Am J Physiol Endocrinol Metab 294, E918-E927
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Receptor Substrate 4 Couples the Leptin Receptor to Multiple Signaling Pathways.

J. Wauman, A.-S. De Smet, D. Catteeuw, D. Belsham, and J. Tavernier (2008)
Mol. Endocrinol. 22, 965-977
 |  Abstract »  |  Full Text »  |  PDF »

Hypothalamic Phosphatidylinositol 3-Kinase Pathway of Leptin Signaling Is Impaired during the Development of Diet-Induced Obesity in FVB/N Mice.

A. S. Metlakunta, M. Sahu, and A. Sahu (2008)
Endocrinology 149, 1121-1128
 |  Abstract »  |  Full Text »  |  PDF »

Possible entrainment of ghrelin to habitual meal patterns in humans.

J. M. Frecka and R. D. Mattes (2008)
Am J Physiol Gastrointest Liver Physiol 294, G699-G707
 |  Abstract »  |  Full Text »  |  PDF »

Leptin increases endothelin type A receptor levels in vascular smooth muscle cells.

C.-C. Juan, T.-Y. Chuang, C.-C. Lien, Y.-J. Lin, S.-W. Huang, C. F. Kwok, and L.-T. Ho (2008)
Am J Physiol Endocrinol Metab 294, E481-E487
 |  Abstract »  |  Full Text »  |  PDF »

Neuroregulation of nonexercise activity thermogenesis and obesity resistance.

C. M. Kotz, J. A. Teske, and C. J. Billington (2008)
Am J Physiol Regulatory Integrative Comp Physiol 294, R699-R710
 |  Abstract »  |  Full Text »  |  PDF »

Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr.

D. J. Lloyd, J. McCormick, J. Helmering, K. W. Kim, M. Wang, P. Fordstrom, S. A. Kaufman, R. A. Lindberg, and M. M. Veniant (2008)
Am J Physiol Endocrinol Metab 294, E496-E505
 |  Abstract »  |  Full Text »  |  PDF »

Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice.

M. Bjursell, A.-K. Gerdin, C. J. Lelliott, E. Egecioglu, A. Elmgren, J. Tornell, J. Oscarsson, and M. Bohlooly-Y (2008)
Am J Physiol Endocrinol Metab 294, E251-E260
 |  Abstract »  |  Full Text »  |  PDF »

Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice.

A. A. Wendel, A. Purushotham, L.-F. Liu, and M. A. Belury (2008)
J. Lipid Res. 49, 98-106
 |  Abstract »  |  Full Text »  |  PDF »

Counterintuitive Effects of Double-Heterozygous Null Melanocortin-4 Receptor and Leptin Genes on Diet-Induced Obesity and Insulin Resistance in C57BL/6J Mice.

J. L. Trevaskis, E. A. Meyer, J. E. Galgani, and A. A. Butler (2008)
Endocrinology 149, 174-184
 |  Abstract »  |  Full Text »  |  PDF »

A knockin mouse model of the Bardet Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity.

R. E. Davis, R. E. Swiderski, K. Rahmouni, D. Y. Nishimura, R. F. Mullins, K. Agassandian, A. R. Philp, C. C. Searby, M. P. Andrews, S. Thompson, et al. (2007)
PNAS 104, 19422-19427
 |  Abstract »  |  Full Text »  |  PDF »

Fat-specific Protein 27, a Novel Lipid Droplet Protein That Enhances Triglyceride Storage.

V. Puri, S. Konda, S. Ranjit, M. Aouadi, A. Chawla, M. Chouinard, A. Chakladar, and M. P. Czech (2007)
J. Biol. Chem. 282, 34213-34218
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Leptin replacement alters brain response to food cues in genetically leptin-deficient adults.

K. Baicy, E. D. London, J. Monterosso, M.-L. Wong, T. Delibasi, A. Sharma, and J. Licinio (2007)
PNAS 104, 18276-18279
 |  Abstract »  |  Full Text »  |  PDF »

Modified activity-stress paradigm in an animal model of the female athlete triad.

N. M. DiMarco, L. Dart, and C. Sanborn (2007)
J Appl Physiol 103, 1469-1478
 |  Abstract »  |  Full Text »  |  PDF »

Effects of photoperiod history on body mass and energy metabolism in Brandt's voles (Lasiopodomys brandtii).

Q. Lu, W.-Q. Zhong, and D.-H. Wang (2007)
J. Exp. Biol. 210, 3838-3847
 |  Abstract »  |  Full Text »  |  PDF »

Long-Term Effect of Leptin on H+-Coupled Peptide Cotransporter 1 Activity and Expression in Vivo: Evidence in Leptin-Deficient Mice.

P. Hindlet, A. Bado, R. Farinotti, and M. Buyse (2007)
J. Pharmacol. Exp. Ther. 323, 192-201
 |  Abstract »  |  Full Text »  |  PDF »

Leptin Responsiveness in Chronically Decerebrate Rats.

R. B. S. Harris, T. J. Bartness, and H. J. Grill (2007)
Endocrinology 148, 4623-4633
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Prohormone Convertases in Hypothalamic Neurons: Implications for ProThyrotropin-Releasing Hormone and Proopiomelanocortin.

E. A. Nillni (2007)
Endocrinology 148, 4191-4200
 |  Abstract »  |  Full Text »  |  PDF »

Adipocyte-Derived Serum Amyloid A3 and Hyaluronan Play a Role in Monocyte Recruitment and Adhesion.

C. Y. Han, S. Subramanian, C. K. Chan, M. Omer, T. Chiba, T. N. Wight, and A. Chait (2007)
Diabetes 56, 2260-2273
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Intranasal Administration of a Leptin-Secreting Lactococcus lactis Recombinant on Food Intake, Body Weight, and Immune Response of Mice.

L. G. Bermudez-Humaran, S. Nouaille, V. Zilberfarb, G. Corthier, A. Gruss, P. Langella, and T. Issad (2007)
Appl. Envir. Microbiol. 73, 5300-5307
 |  Abstract »  |  Full Text »  |  PDF »

Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients.

A. Campo, G. Fruhbeck, J. J. Zulueta, J. Iriarte, L. M. Seijo, A. B. Alcaide, J. B. Galdiz, and J. Salvador (2007)
Eur. Respir. J. 30, 223-231
 |  Abstract »  |  Full Text »  |  PDF »

Leptin-Induced IL-6 Production Is Mediated by Leptin Receptor, Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, Akt, NF-{kappa}B, and p300 Pathway in Microglia.

C.-H. Tang, D.-Y. Lu, R.-S. Yang, H.-Y. Tsai, M.-C. Kao, W.-M. Fu, and Y.-F. Chen (2007)
J. Immunol. 179, 1292-1302
 |  Abstract »  |  Full Text »  |  PDF »

S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury.

A. Dey, A. A. Caro, and A. I. Cederbaum (2007)
Am J Physiol Gastrointest Liver Physiol 293, G91-G103
 |  Abstract »  |  Full Text »  |  PDF »

Changes in environmental temperature influence leptin responsiveness in low- and high-fat-fed mice.

R. B. S. Harris, T. D. Mitchell, E. W. Kelso, and W. P. Flatt (2007)
Am J Physiol Regulatory Integrative Comp Physiol 293, R106-R115
 |  Abstract »  |  Full Text »  |  PDF »

Decreased Vesicular Somatodendritic Dopamine Stores in Leptin-Deficient Mice.

A. G. Roseberry, T. Painter, G. P. Mark, and J. T. Williams (2007)
J. Neurosci. 27, 7021-7027
 |  Abstract »  |  Full Text »  |  PDF »

Adipokines and Coronary Vasomotor Dysfunction.

J. D. Knudson, G. M. Dick, and J. D. Tune (2007)
Experimental Biology and Medicine 232, 727-736
 |  Abstract »  |  Full Text »  |  PDF »

Hepatic steatosis and plasma dyslipidemia induced by a high-sucrose diet are corrected by an acute leptin infusion.

W. Huang, N. Dedousis, and R. M. O'Doherty (2007)
J Appl Physiol 102, 2260-2265
 |  Abstract »  |  Full Text »  |  PDF »

Leptin receptors in human skeletal muscle.

B. Guerra, A. Santana, T. Fuentes, S. Delgado-Guerra, A. Cabrera-Socorro, C. Dorado, and J. A. L. Calbet (2007)
J Appl Physiol 102, 1786-1792
 |  Abstract »  |  Full Text »  |  PDF »

Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independently of adiposity.

P. W. Franks, R. J. F. Loos, S. Brage, S. O'Rahilly, N. J. Wareham, and U. Ekelund (2007)
J Appl Physiol 102, 1921-1926
 |  Abstract »  |  Full Text »  |  PDF »

Leptin-Mediated Decrease of Cyclin A2 and Increase of Cyclin D1 Expression: Relevance for the Control of Prepubertal Rat Leydig Cell Division and Differentiation.

J. Fombonne, C. Charrier, I. Goddard, E. Moyse, and S. Krantic (2007)
Endocrinology 148, 2126-2137
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic overexpression of protein targeting to glycogen markedly increases adipocytic glycogen storage in mice.

M. J. Jurczak, A. M. Danos, V. R. Rehrmann, M. B. Allison, C. C. Greenberg, and M. J. Brady (2007)
Am J Physiol Endocrinol Metab 292, E952-E963
 |  Abstract »  |  Full Text »  |  PDF »

Obesity and asthma: lessons from animal models.

S. A. Shore (2007)
J Appl Physiol 102, 516-528
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Human Body Weight Changes on Circulating Levels of Peptide YY and Peptide YY3-36.

P. T. Pfluger, J. Kampe, T. R. Castaneda, T. Vahl, D. A. D'Alessio, T. Kruthaupt, S. C. Benoit, U. Cuntz, H. J. Rochlitz, M. Moehlig, et al. (2007)
J. Clin. Endocrinol. Metab. 92, 583-588
 |  Abstract »  |  Full Text »  |  PDF »

Leptin Transcriptionally Enhances Peptide Transporter (hPepT1) Expression and Activity via the cAMP-response Element-binding Protein and Cdx2 Transcription Factors.

V. Nduati, Y. Yan, G. Dalmasso, A. Driss, S. Sitaraman, and D. Merlin (2007)
J. Biol. Chem. 282, 1359-1373
 |  Abstract »  |  Full Text »  |  PDF »

Pulmonary responses to acute ozone exposure in fasted mice: effect of leptin administration.

R. A. Johnston, T. A. Theman, R. D. Terry, E. S. Williams, and S. A. Shore (2007)
J Appl Physiol 102, 149-156
 |  Abstract »  |  Full Text »  |  PDF »

Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release.

A. Reaux-Le Goazigo, R. Alvear-Perez, P. Zizzari, J. Epelbaum, M.-T. Bluet-Pajot, and C. Llorens-Cortes (2007)
Am J Physiol Endocrinol Metab 292, E7-E15
 |  Abstract »  |  Full Text »  |  PDF »

The dorsomedial hypothalamus: a new player in thermoregulation.

J. A. DiMicco and D. V. Zaretsky (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R47-R63
 |  Abstract »  |  Full Text »  |  PDF »

Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: Endorsed by the American Academy of Pediatrics.

R.-E. W. Kavey, V. Allada, S. R. Daniels, L. L. Hayman, B. W. McCrindle, J. W. Newburger, R. S. Parekh, and J. Steinberger (2006)
Circulation 114, 2710-2738
 |  Abstract »  |  Full Text »  |  PDF »

A possible role for melanocortin peptides in longitudinal growth.

J. K Yeh, J. F Evans, Q.-T. Niu, and J. F Aloia (2006)
J. Endocrinol. 191, 677-686
 |  Abstract »  |  Full Text »  |  PDF »

Passive immunization of lactating mice with stanniocalcin-1 antiserum reduces mammary gland development, milk fat content, and postnatal pup growth.

D. Zaidi, K. A. James, and G. F. Wagner (2006)
Am J Physiol Endocrinol Metab 291, E974-E981
 |  Abstract »  |  Full Text »  |  PDF »

Metabolic decompensation in children with type 1 diabetes mellitus associated with increased serum levels of the soluble leptin receptor..

J Kratzsch, I Knerr, A Galler, T Kapellen, K Raile, A Korner, J Thiery, J Dotsch, and W Kiess (2006)
Eur. J. Endocrinol. 155, 609-614
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of corticotropin-releasing factor and its types 1 and 2 receptors by leptin in rats subjected to treadmill running-induced stress..

Q. Huang, E. Timofeeva, and D. Richard (2006)
J. Endocrinol. 191, 179-188
 |  Abstract »  |  Full Text »  |  PDF »

Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator-Activated Receptor {gamma} Function (P465L PPAR{gamma}) in Mice..

S. L. Gray, E. D. Nora, J. Grosse, M. Manieri, T. Stoeger, G. Medina-Gomez, K. Burling, S. Wattler, A. Russ, G. S.H. Yeo, et al. (2006)
Diabetes 55, 2669-2677
 |  Abstract »  |  Full Text »  |  PDF »

Influence of porcine genotype on the abundance of thyroid hormones and leptin in sow milk and its impact on growth, metabolism and expression of key adipose tissue genes in offspring..

A. Mostyn, S. Sebert, J. C Litten, K. S Perkins, J. Laws, M. E Symonds, and L. Clarke (2006)
J. Endocrinol. 190, 631-639
 |  Abstract »  |  Full Text »  |  PDF »

Obesity and the role of gut and adipose hormones in female reproduction.

G. G. Gosman, H. I. Katcher, and R. S. Legro (2006)
Hum. Reprod. Update 12, 585-601
 |  Abstract »  |  Full Text »  |  PDF »

Meal size and feeding frequency influence serum leptin concentration in yearling horses.

S. M. Steelman, E. M. Michael-Eller, P. G. Gibbs, and G. D. Potter (2006)
J Anim Sci 84, 2391-2398
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes.

P. F. Pilch and N. Bergenhem (2006)
Mol. Pharmacol. 70, 779-785
 |  Abstract »  |  Full Text »  |  PDF »

Individual differences in physical activity are closely associated with changes in body weight in adult female rhesus monkeys (Macaca mulatta).

E. L. Sullivan, F. H. Koegler, and J. L. Cameron (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R633-R642
 |  Abstract »  |  Full Text »  |  PDF »

Behavioral, physiological, and molecular differences in response to dietary restriction in three inbred mouse strains.

C. Gelegen, D. A. Collier, I. C. Campbell, H. Oppelaar, and M. J. H. Kas (2006)
Am J Physiol Endocrinol Metab 291, E574-E581
 |  Abstract »  |  Full Text »  |  PDF »

Aging-related sex-dependent loss of the circulating leptin 24-h rhythm in the rhesus monkey..

J. L Downs and H. F Urbanski (2006)
J. Endocrinol. 190, 117-127
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of metabolic responses by adipocyte/ macrophage Fatty Acid-binding proteins in leptin-deficient mice..

H. Cao, K. Maeda, C. Z. Gorgun, H.-J. Kim, S.-Y. Park, G. I. Shulman, J. K. Kim, and G. S. Hotamisligil (2006)
Diabetes 55, 1915-1922
 |  Abstract »  |  Full Text »  |  PDF »

Leptin Selectively Augments Thymopoiesis in Leptin Deficiency and Lipopolysaccharide-Induced Thymic Atrophy.

R. W. Hick, A. L. Gruver, M. S. Ventevogel, B. F. Haynes, and G. D. Sempowski (2006)
J. Immunol. 177, 169-176
 |  Abstract »  |  Full Text »  |  PDF »

Leptin (ob gene) of the South African clawed frog Xenopus laevis.

E. J. Crespi and R. J. Denver (2006)
PNAS 103, 10092-10097
 |  Abstract »  |  Full Text »  |  PDF »

Stimulatory effect of PYY-(3-36) on gonadotropin secretion is potentiated in fasted rats.

L. Pinilla, R. Fernandez-Fernandez, E. Vigo, V. M. Navarro, J. Roa, J. M. Castellano, R. Pineda, M. Tena-Sempere, and E. Aguilar (2006)
Am J Physiol Endocrinol Metab 290, E1162-E1171
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products