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Science 28 July 1995:
Vol. 269. no. 5223, pp. 532 - 535
DOI: 10.1126/science.7624775
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Articles

Science, Vol 269, Issue 5223, 532-535
Copyright © 1995 by American Association for the Advancement of Science

articles

Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)

SL Lee, RL Wesselschmidt, GP Linette, O Kanagawa, JH Russell, and J Milbrandt

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

T cell hybridomas require the immediate-early gene NGFI-B (nur77) for T cell receptor (TCR)-mediated apoptosis, a model for negative selection of self-reactive T cells. TCR-mediated death was examined in mice bearing an NGFI-B loss-of-function mutation, either by administration of antibodies to CD3 (anti-CD3) or in two well-characterized transgenic models expressing self-reactive TCRs. Both the extent and the rate of thymocyte death were unimpaired. Anti-CD3-induced death was normal in CD4+ peripheral T cells, in which death is mediated predominantly by the Fas signaling pathway. Thus, no unique requirement for NGFI-B is observed for thymic or peripheral T cell death.


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