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Science 28 July 1995:
Vol. 269. no. 5223, pp. 529 - 531
DOI: 10.1126/science.7624774
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Articles

Science, Vol 269, Issue 5223, 529-531
Copyright © 1995 by American Association for the Advancement of Science

articles

Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein

JJ Chen, CE Reid, V Band, and EJ Androphy

Department of Dermatology, New England Medical Center, Boston, MA, USA.

Human papillomaviruses (HPVs) are associated with the majority of cervical cancers and encode a transforming protein, E6, that interacts with the tumor suppressor protein p53. Because E6 has p53-independent transforming activity, the yeast two-hybrid system was used to search for other E6-binding proteins. One such protein, E6BP, interacted with cancer-associated HPV E6 and with bovine papillomavirus type 1 (BPV-1) E6. The transforming activity of BPV-1 E6 mutants correlated with their E6BP-binding ability. E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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J. Virol. 82, 9600-9614
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Binding of Human Papillomavirus Type 16 E6 to E6AP Is Not Required for Activation of hTERT.
P. Sekaric, J. J. Cherry, and E. J. Androphy (2008)
J. Virol. 82, 71-76
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RbAp48 Is a Critical Mediator Controlling the Transforming Activity of Human Papillomavirus Type 16 in Cervical Cancer.
L. Kong, X.-P. Yu, X.-H. Bai, W.-F. Zhang, Y. Zhang, W.-M. Zhao, J.-H. Jia, W. Tang, Y.-B. Zhou, and C.-j. Liu (2007)
J. Biol. Chem. 282, 26381-26391
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Bovine Papillomavirus E7 Oncoprotein Inhibits Anoikis.
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J. Virol. 81, 9419-9425
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The Large and Small Isoforms of Human Papillomavirus Type 16 E6 Bind to and Differentially Affect Procaspase 8 Stability and Activity.
M. Filippova, M. M. Johnson, M. Bautista, V. Filippov, N. Fodor, S. S. Tungteakkhun, K. Williams, and P. J. Duerksen-Hughes (2007)
J. Virol. 81, 4116-4129
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Distribution and Variable Expression of Secretory Pathway Protein Reticulocalbin in Normal Human Organs and Non-neoplastic Pathological Conditions.
T. Fukuda, H. Oyamada, T. Isshiki, M. Maeda, T. Kusakabe, A. Hozumi, T. Yamaguchi, T. Igarashi, H. Hasegawa, T. Seidoh, et al. (2007)
J. Histochem. Cytochem. 55, 335-345
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The Differential Staurosporine-Mediated G1 Arrest in Normal versus Tumor Cells Is Dependent on the Retinoblastoma Protein.
M. McGahren-Murray, N. H.A. Terry, and K. Keyomarsi (2006)
Cancer Res. 66, 9744-9753
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Pitx2a Binds to Human Papillomavirus Type 18 E6 Protein and Inhibits E6-mediated P53 Degradation in HeLa Cells.
Q. Wei (2005)
J. Biol. Chem. 280, 37790-37797
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Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding.
J. DeMasi, K.-W. Huh, Y. Nakatani, K. Munger, and P. M. Howley (2005)
PNAS 102, 11486-11491
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The E6AP Ubiquitin Ligase Is Required for Transactivation of the hTERT Promoter by the Human Papillomavirus E6 Oncoprotein.
X. Liu, H. Yuan, B. Fu, G. L. Disbrow, T. Apolinario, V. Tomaic, M. L. Kelley, C. C. Baker, J. Huibregtse, and R. Schlegel (2005)
J. Biol. Chem. 280, 10807-10816
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The Global Transcriptional Effects of the Human Papillomavirus E6 Protein in Cervical Carcinoma Cell Lines Are Mediated by the E6AP Ubiquitin Ligase.
M. L. Kelley, K. E. Keiger, C. J. Lee, and J. M. Huibregtse (2005)
J. Virol. 79, 3737-3747
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Downregulation of Bax mRNA expression and protein stability by the E6 protein of human papillomavirus 16.
S. S. Magal, A. Jackman, S. Ish-Shalom, L. E. Botzer, P. Gonen, R. Schlegel, and L. Sherman (2005)
J. Gen. Virol. 86, 611-621
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Mechanisms of Human Papillomavirus-Induced Oncogenesis.
K. Munger, A. Baldwin, K. M. Edwards, H. Hayakawa, C. L. Nguyen, M. Owens, M. Grace, and K. Huh (2004)
J. Virol. 78, 11451-11460
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Human Papillomavirus 16 E6 Oncoprotein Interferences with Insulin Signaling Pathway by Binding to Tuberin.
Z. Lu, X. Hu, Y. Li, L. Zheng, Y. Zhou, H. Jiang, T. Ning, Z. Basang, C. Zhang, and Y. Ke (2004)
J. Biol. Chem. 279, 35664-35670
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The Human Papillomavirus 16 E6 Protein Binds to Fas-associated Death Domain and Protects Cells from Fas-triggered Apoptosis.
M. Filippova, L. Parkhurst, and P. J. Duerksen-Hughes (2004)
J. Biol. Chem. 279, 25729-25744
   Abstract »    Full Text »    PDF »
Roles of the E6 and E7 Proteins in the Life Cycle of Low-Risk Human Papillomavirus Type 11.
S. T. Oh, M. S. Longworth, and L. A. Laimins (2004)
J. Virol. 78, 2620-2626
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Signals That Dictate Nuclear Localization of Human Papillomavirus Type 16 Oncoprotein E6 in Living Cells.
M. Tao, M. Kruhlak, S. Xia, E. Androphy, and Z.-M. Zheng (2003)
J. Virol. 77, 13232-13247
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Human Papillomavirus Type 16 E6 Activates TERT Gene Transcription through Induction of c-Myc and Release of USF-Mediated Repression.
H. R. McMurray and D. J. McCance (2003)
J. Virol. 77, 9852-9861
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Association of bovine papillomavirus with the equine sarcoid.
G. Chambers, V. A. Ellsmore, P. M. O'Brien, S. W. J. Reid, S. Love, M. S. Campo, and L. Nasir (2003)
J. Gen. Virol. 84, 1055-1062
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Nuclear Entry of High-Risk Human Papillomavirus Type 16 E6 Oncoprotein Occurs via Several Pathways.
L. G. Le Roux and J. Moroianu (2003)
J. Virol. 77, 2330-2337
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A Mutant of Human Papillomavirus Type 16 E6 Deficient in Binding {alpha}-Helix Partners Displays Reduced Oncogenic Potential In Vivo.
M. Nguyen, S. Song, A. Liem, E. Androphy, Y. Liu, and P. F. Lambert (2002)
J. Virol. 76, 13039-13048
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Genetic Analysis of High-Risk E6 in Episomal Maintenance of Human Papillomavirus Genomes in Primary Human Keratinocytes.
R. B. Park and E. J. Androphy (2002)
J. Virol. 76, 11359-11364
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Human Papillomavirus Oncoprotein E6 Inactivates the Transcriptional Coactivator Human ADA3.
A. Kumar, Y. Zhao, G. Meng, M. Zeng, S. Srinivasan, L. M. Delmolino, Q. Gao, G. Dimri, G. F. Weber, D. E. Wazer, et al. (2002)
Mol. Cell. Biol. 22, 5801-5812
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The Human Papillomavirus 16 E6 Protein Binds to Tumor Necrosis Factor (TNF) R1 and Protects Cells from TNF-induced Apoptosis.
M. Filippova, H. Song, J. L. Connolly, T. S. Dermody, and P. J. Duerksen-Hughes (2002)
J. Biol. Chem. 277, 21730-21739
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Human Papillomavirus E6-induced Degradation of E6TP1 Is Mediated by E6AP Ubiquitin Ligase.
Q. Gao, A. Kumar, L. Singh, J. M. Huibregtse, S. Beaudenon, S. Srinivasan, D. E. Wazer, H. Band, and V. Band (2002)
Cancer Res. 62, 3315-3321
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Mutational analysis of the discs large tumour suppressor identifies domains responsible for human papillomavirus type 18 E6-mediated degradation.
D. Gardiol, S. Galizzi, and L. Banks (2002)
J. Gen. Virol. 83, 283-289
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Interaction of Zyxin, a Focal Adhesion Protein, with the E6 Protein from Human Papillomavirus Type 6 Results in Its Nuclear Translocation.
Y. Y. Degenhardt and S. Silverstein (2001)
J. Virol. 75, 11791-11802
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Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-{{gamma}} Production in Human Peripheral Blood Mononuclear and NK Cells.
S.-J. Lee, Y.-S. Cho, M.-C. Cho, J.-H. Shim, K.-A. Lee, K.-K. Ko, Y. K. Choe, S.-N. Park, T. Hoshino, S. Kim, et al. (2001)
J. Immunol. 167, 497-504
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Human Papillomavirus Type 16 E6-Induced Degradation of E6TP1 Correlates with Its Ability To Immortalize Human Mammary Epithelial Cells.
Q. Gao, L. Singh, A. Kumar, S. Srinivasan, D. E. Wazer, and V. Band (2001)
J. Virol. 75, 4459-4466
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Gps2, a Protein Partner for Human Papillomavirus E6 Proteins.
Y. Y. Degenhardt and S. J. Silverstein (2001)
J. Virol. 75, 151-160
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Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53.
H. Zimmermann, C.-H. Koh, R. Degenkolbe, M. J. O’Connor, A. Müller, G. Steger, J. J. Chen, Y. Lui, E. Androphy, and H.-U. Bernard (2000)
J. Gen. Virol. 81, 2617-2623
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Human Papillomavirus Type 16 E6 and E7 Proteins Inhibit Differentiation-dependent Expression of Transforming Growth Factor-{beta}2 in Cervical Keratinocytes.
M. Nees, J. M. Geoghegan, P. Munson, V. Prabhu, Y. Liu, E. Androphy, and C. D. Woodworth (2000)
Cancer Res. 60, 4289-4298
   Abstract »    Full Text »
PKN Binds and Phosphorylates Human Papillomavirus E6 Oncoprotein.
Q. Gao, A. Kumar, S. Srinivasan, L. Singh, H. Mukai, Y. Ono, D. E. Wazer, and V. Band (2000)
J. Biol. Chem. 275, 14824-14830
   Abstract »    Full Text »    PDF »
Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis.
H. z. Hausen (2000)
J Natl Cancer Inst 92, 690-698
   Abstract »    Full Text »    PDF »
Identification of a Second Transforming Function in Bovine Papillomavirus Type 1 E6 and the Role of E6 Interactions with Paxillin, E6BP, and E6AP.
K. Das, J. Bohl, and S. B. Vande Pol (2000)
J. Virol. 74, 812-816
   Abstract »    Full Text »
Mechanisms of G2 Arrest in Response to Overexpression of p53.
W. R. Taylor, S. E. DePrimo, A. Agarwal, M. L. Agarwal, A. H. Schönthal, K. S. Katula, and G. R. Stark (1999)
Mol. Biol. Cell 10, 3607-3622
   Abstract »    Full Text »
Multiple Functions of Human Papillomavirus Type 16 E6 Contribute to the Immortalization of Mammary Epithelial Cells.
Y. Liu, J. J. Chen, Q. Gao, S. Dalal, Y. Hong, C. P. Mansur, V. Band, and E. J. Androphy (1999)
J. Virol. 73, 7297-7307
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Human Papillomavirus Type 16 E6-enhanced Susceptibility of L929 Cells to Tumor Necrosis Factor alpha Correlates with Increased Accumulation of Reactive Oxygen Species.
Y. Liu, V. Tergaonkar, S. Krishna, and E. J. Androphy (1999)
J. Biol. Chem. 274, 24819-24827
   Abstract »    Full Text »    PDF »
The Human Papillomavirus Type 16 E6 Oncoprotein Can Down-Regulate p53 Activity by Targeting the Transcriptional Coactivator CBP/p300.
H. Zimmermann, R. Degenkolbe, H.-U. Bernard, and M. J. O'Connor (1999)
J. Virol. 73, 6209-6219
   Abstract »    Full Text »
Potential Drugs Against Cervical Cancer: Zinc-Ejecting Inhibitors of the Human Papillomavirus Type 16 E6 Oncoprotein.
W. Beerheide, H.-U. Bernard, Y.-J. Tan, A. Ganesan, W. G. Rice, and A. E. Ting (1999)
J Natl Cancer Inst 91, 1211-1220
   Abstract »    Full Text »    PDF »
Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes.
J. T. Thomas, W. G. Hubert, M. N. Ruesch, and L. A. Laimins (1999)
PNAS 96, 8449-8454
   Abstract »    Full Text »    PDF »
The Human Papillomavirus Type 16 E6 Gene Alone Is Sufficient To Induce Carcinomas in Transgenic Animals.
S. Song, H. C. Pitot, and P. F. Lambert (1999)
J. Virol. 73, 5887-5893
   Abstract »    Full Text »
The E6 Oncoproteins of High-Risk Papillomaviruses Bind to a Novel Putative GAP Protein, E6TP1, and Target It for Degradation.
Q. Gao, S. Srinivasan, S. N. Boyer, D. E. Wazer, and V. Band (1999)
Mol. Cell. Biol. 19, 733-744
   Abstract »    Full Text »    PDF »
DNA Supercoiling Factor Localizes to Puffs on Polytene Chromosomes in Drosophila melanogaster.
M. Kobayashi, N. Aita, S. Hayashi, K. Okada, T. Ohta, and S. Hirose (1998)
Mol. Cell. Biol. 18, 6737-6744
   Abstract »    Full Text »
Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity.
L. V. Ronco, A. Y. Karpova, M. Vidal, and P. M. Howley (1998)
Genes & Dev. 12, 2061-2072
   Abstract »    Full Text »
Identification of an alpha  Helical Motif Sufficient for Association with Papillomavirus E6.
J. J. Chen, Y. Hong, E. Rustamzadeh, J. D. Baleja, and E. J. Androphy (1998)
J. Biol. Chem. 273, 13537-13544
   Abstract »    Full Text »    PDF »
Papillomaviruses and Cervical Cancer: Pathogenesis and Vaccine Development.
D. R. Lowy and J. T. Schiller (1998)
J Natl Cancer Inst Monographs 1998, 27-30
   Abstract »    Full Text »
Interaction of the Bovine Papillomavirus E6 Protein with the Clathrin Adaptor Complex AP-1.
X. Tong, W. Boll, T. Kirchhausen, and P. M. Howley (1998)
J. Virol. 72, 476-482
   Abstract »    Full Text »    PDF »
Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein.
T. Kiyono, A. Hiraiwa, M. Fujita, Y. Hayashi, T. Akiyama, and M. Ishibashi (1997)
PNAS 94, 11612-11616
   Abstract »    Full Text »    PDF »
Neuronal Pentraxin Receptor, a Novel Putative Integral Membrane Pentraxin That Interacts with Neuronal Pentraxin 1 and 2 and Taipoxin-associated Calcium-binding Protein 49.
D'N. C. Dodds, I. A. Omeis, S. J. Cushman, J. A. Helms, and M. S. Perin (1997)
J. Biol. Chem. 272, 21488-21494
   Abstract »    Full Text »    PDF »
Calumenin, a Ca2+-binding Protein Retained in the Endoplasmic Reticulum with a Novel Carboxyl-terminal Sequence, HDEF.
D. Yabe, T. Nakamura, N. Kanazawa, K. Tashiro, and T. Honjo (1997)
J. Biol. Chem. 272, 18232-18239
   Abstract »    Full Text »    PDF »
Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein.
S. S. Lee, R. S. Weiss, and R. T. Javier (1997)
PNAS 94, 6670-6675
   Abstract »    Full Text »    PDF »
The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.
X. Tong and P. M. Howley (1997)
PNAS 94, 4412-4417
   Abstract »    Full Text »    PDF »
Rb-independent Induction of Apoptosis by Bovine Papillomavirus Type 1 E7 in Response to Tumor Necrosis Factor alpha.
Y. Liu, Y. Hong, E. J. Androphy, and J. J. Chen (2000)
J. Biol. Chem. 275, 30894-30900
   Abstract »    Full Text »    PDF »
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells.
A. Hengstermann, L. K. Linares, A. Ciechanover, N. J. Whitaker, and M. Scheffner (2001)
PNAS 98, 1218-1223
   Abstract »    Full Text »    PDF »
Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein.
K. Butz, C. Denk, A. Ullmann, M. Scheffner, and F. Hoppe-Seyler (2000)
PNAS 97, 6693-6697
   Abstract »    Full Text »    PDF »


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