Science 14 July 1995: Vol. 269. no. 5221, pp. 245 - 247 DOI: 10.1126/science.7618088

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Articles

T Cell Responses in the Absence of IFN-{gamma} Exacerbate Uterine Infection with Chlamydia trachomatis.

D. C. Gondek, N. R. Roan, and M. N. Starnbach (2009)
J. Immunol. 183, 1313-1319
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Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse.

R. A. Maldonado, M. A. Soriano, L. C. Perdomo, K. Sigrist, D. J. Irvine, T. Decker, and L. H. Glimcher (2009)
J. Exp. Med. 206, 877-892
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Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver tolerance.

S. Xia, Z. Guo, X. Xu, H. Yi, Q. Wang, and X. Cao (2008)
Blood 112, 3175-3185
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Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells.

R. A. Clark, S. J. Huang, G. F. Murphy, I. G. Mollet, D. Hijnen, M. Muthukuru, C. F. Schanbacher, V. Edwards, D. M. Miller, J. E. Kim, et al. (2008)
J. Exp. Med. 205, 2221-2234
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IFN-{gamma} Mediates the Death of Th1 Cells in a Paracrine Manner.

K. E. Foulds, M. J. Rotte, M. A. Paley, B. Singh, D. C. Douek, B. J. Hill, J. J. O'Shea, W. T. Watford, R. A. Seder, and C.-Y. Wu (2008)
J. Immunol. 180, 842-849
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In the absence of IGF-1 signaling, IFN-{gamma} suppresses human malignant T-cell growth.

L. Conti, G. Regis, A. Longo, P. Bernabei, R. Chiarle, M. Giovarelli, and F. Novelli (2007)
Blood 109, 2496-2504
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Aberrant Contraction of Antigen-Specific CD4 T Cells after Infection in the Absence of Gamma Interferon or Its Receptor.

J. S. Haring and J. T. Harty (2006)
Infect. Immun. 74, 6252-6263
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The Antineoplastic Agent Bryostatin-1 Differentially Regulates IFN-{gamma} Receptor Subunits in Monocytic Cells: Transcriptional and Posttranscriptional Control of IFN-{gamma}R2.

C. S. Garcia, R. E. Curiel, J. M. Mwatibo, S. Pestka, H. Li, and I. Espinoza-Delgado (2006)
J. Immunol. 177, 2707-2716
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Annexin V Associates with the IFN-{gamma} Receptor and Regulates IFN-{gamma} Signaling.

C. Leon, D. Nandan, M. Lopez, A. Moeenrezakhanlou, and N. E. Reiner (2006)
J. Immunol. 176, 5934-5942
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The Vast Majority of CLA+ T Cells Are Resident in Normal Skin.

R. A. Clark, B. Chong, N. Mirchandani, N. K. Brinster, K.-i. Yamanaka, R. K. Dowgiert, and T. S. Kupper (2006)
J. Immunol. 176, 4431-4439
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Self-Limitation of Th1-Mediated Inflammation by IFN-{gamma}..

M. Feuerer, K. Eulenburg, C. Loddenkemper, A. Hamann, and J. Huehn (2006)
J. Immunol. 176, 2857-2863
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Cutting Edge: Early IFN-{gamma} Signaling Directly Enhances Primary Antiviral CD4+ T Cell Responses.

J. K. Whitmire, N. Benning, and J. L. Whitton (2005)
J. Immunol. 175, 5624-5628
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Generation of Pathogen-Specific Th1 Cells in the Absence of the IFN-{gamma} Receptor.

J. S. Haring, V. P. Badovinac, M. R. Olson, S. M. Varga, and J. T. Harty (2005)
J. Immunol. 175, 3117-3122
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Stat1 and Stat2 but Not Stat3 Arbitrate Contradictory Growth Signals Elicited by Alpha/Beta Interferon in T Lymphocytes.

R. Gimeno, C.-K. Lee, C. Schindler, and D. E. Levy (2005)
Mol. Cell. Biol. 25, 5456-5465
 |  Abstract »  |  Full Text »  |  PDF »

Dynamic Regulation of IFN-{gamma} Signaling in Antigen-Specific CD8+ T Cells Responding to Infection.

J. S. Haring, G. A. Corbin, and J. T. Harty (2005)
J. Immunol. 174, 6791-6802
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Iron regulates T-lymphocyte sensitivity to the IFN-{gamma}/STAT1 signaling pathway in vitro and in vivo.

G. Regis, M. Bosticardo, L. Conti, S. De Angelis, D. Boselli, B. Tomaino, P. Bernabei, M. Giovarelli, and F. Novelli (2005)
Blood 105, 3214-3221
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Interferon-{gamma} acts directly on CD8+ T cells to increase their abundance during virus infection.

J. K. Whitmire, J. T. Tan, and J. L. Whitton (2005)
J. Exp. Med. 201, 1053-1059
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The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model.

T. Tamura, H. Ariga, T. Kinashi, S. Uehara, T. Kikuchi, M. Nakada, T. Tokunaga, W. Xu, A. Kariyone, T. Saito, et al. (2004)
Int. Immunol. 16, 1691-1699
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Interferon-{gamma}: an overview of signals, mechanisms and functions.

K. Schroder, P. J. Hertzog, T. Ravasi, and D. A. Hume (2004)
J. Leukoc. Biol. 75, 163-189
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IGF-1 down-regulates IFN-{gamma}R2 chain surface expression and desensitizes IFN-{gamma}/STAT-1 signaling in human T lymphocytes.

P. Bernabei, M. Bosticardo, G. Losana, G. Regis, F. Di Paola, S. De Angelis, M. Giovarelli, and F. Novelli (2003)
Blood 102, 2933-2939
 |  Abstract »  |  Full Text »  |  PDF »

Proliferation of CD30+ T-Helper 2 Lymphoma Cells Can Be Inhibited by CD30 Receptor Cross-Linking with Recombinant CD30 Ligand.

J. Willers, R. Dummer, W. Kempf, T. Kundig, G. Burg, and M. E. Kadin (2003)
Clin. Cancer Res. 9, 2744-2754
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Inhibition of IFN-{gamma} Signaling by Glucocorticoids.

X. Hu, W.-P. Li, C. Meng, and L. B. Ivashkiv (2003)
J. Immunol. 170, 4833-4839
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Paralytic Autoimmune Myositis Develops in Nonobese Diabetic Mice Made Th1 Cytokine-Deficient by Expression of an IFN-{gamma} Receptor {beta}-Chain Transgene.

D. V. Serreze, M. A. Pierce, C. M. Post, H. D. Chapman, H. Savage, R. T. Bronson, P. B. Rothman, and G. A. Cox (2003)
J. Immunol. 170, 2742-2749
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Inhibition of IL-6 signaling by a p38-dependent pathway occurs in the absence of new protein synthesis.

S. T. Ahmed, A. Mayer, J.-D. Ji, and L. B. Ivashkiv (2002)
J. Leukoc. Biol. 72, 154-162
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Stat1-Vitamin D Receptor Interactions Antagonize 1,25-Dihydroxyvitamin D Transcriptional Activity and Enhance Stat1-Mediated Transcription.

M. Vidal, C. V. Ramana, and A. S. Dusso (2002)
Mol. Cell. Biol. 22, 2777-2787
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Interferon-{alpha} as an immunotherapeutic protein.

D. L. Brassard, M. J. Grace, and R. W. Bordens (2002)
J. Leukoc. Biol. 71, 565-581
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Differential IL-10R1 Expression Plays a Critical Role in IL-10-Mediated Immune Regulation.

Y. Ding, L. Qin, D. Zamarin, S. V. Kotenko, S. Pestka, K. W. Moore, and J. S. Bromberg (2001)
J. Immunol. 167, 6884-6892
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Specific Inhibition of Interferon Signal Transduction Pathways by Adenoviral Infection.

T. D. Joseph and D. C. Look (2001)
J. Biol. Chem. 276, 47136-47142
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IFN-{gamma} Affects Homing of Diabetogenic T Cells.

A. Y. Savinov, F. S. Wong, and A. V. Chervonsky (2001)
J. Immunol. 167, 6637-6643
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Regulation of IFN-{gamma} Signaling Is Essential for the Cytotoxic Activity of CD8+ T Cells.

G. Z. Tau, S. N. Cowan, J. Weisburg, N. S. Braunstein, and P. B. Rothman2 (2001)
J. Immunol. 167, 5574-5582
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The Role of IFN-{gamma} in the Production of Th2 Subpopulations: Implications for Variable Th2-Mediated Pathologies in Autoimmunity.

A. Wensky, M. C. Garibaldi Marcondes, and J. J. Lafaille (2001)
J. Immunol. 167, 3074-3081
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Interferon {gamma} Stabilizes the T Helper Cell Type 1 Phenotype.

Y. Zhang, R. Apilado, J. Coleman, S. Ben-Sasson, S. Tsang, J. Hu-Li, W. E. Paul, and H. Huang (2001)
J. Exp. Med. 194, 165-172
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Regulation of TGF-{{beta}} Response During T Cell Activation Is Modulated by IL-10.

F. Cottrez and H. Groux (2001)
J. Immunol. 167, 773-778
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Experimental Autoimmune Myocarditis in A/J mice Is an Interleukin-4-Dependent Disease with a Th2 Phenotype.

M. Afanasyeva, Y. Wang, Z. Kaya, S. Park, M. J. Zilliox, B. H. Schofield, S. L. Hill, and N. R. Rose (2001)
Am. J. Pathol. 159, 193-203
 |  Abstract »  |  Full Text »  |  PDF »

Interferon {gamma} Signaling Alters the Function of T Helper Type 1 Cells.

G. Z. Tau, T. von der Weid, B. Lu, S. Cowan, M. Kvatyuk, A. Pernis, G. Cattoretti, N. S. Braunstein, R. L. Coffman, and P. B. Rothman (2000)
J. Exp. Med. 192, 977-986
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Myeloid differentiation of FdCP1 cells is dependent on Stat5 processing.

F. Piazza, J. Valens, E. Lagasse, and C. Schindler (2000)
Blood 96, 1358-1365
 |  Abstract »  |  Full Text »  |  PDF »

Ligand-Independent Down-Regulation of IFN-{gamma} Receptor 1 Following TCR Engagement.

H. Skrenta, Y. Yang, S. Pestka, and C. G. Fathman (2000)
J. Immunol. 164, 3506-3511
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T Helper Type 2 Cell Differentiation Occurs in the Presence of Interleukin 12 Receptor {beta}2 Chain Expression and Signaling.

R. Nishikomori, R. O. Ehrhardt, and W. Strober (2000)
J. Exp. Med. 191, 847-858
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Protein Tyrosine Phosphatase Activity Is Required for IL-4 Induction of IL-4 Receptor {alpha}-Chain.

H. Huang and W. E. Paul (2000)
J. Immunol. 164, 1211-1215
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Development of Lupus in BXSB Mice Is Independent of IL-4.

D. H. Kono, D. Balomenos, M. S. Park, and A. N. Theofilopoulos (2000)
J. Immunol. 164, 38-42
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Surface Expression of the IFN-{gamma}R2 Chain Is Regulated by Intracellular Trafficking in Human T Lymphocytes.

L. Rigamonti, S. Ariotti, G. Losana, R. Gradini, M. A. Russo, E. Jouanguy, J.-L. Casanova, G. Forni, and F. Novelli (2000)
J. Immunol. 164, 201-207
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Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression.

A. Richter, M. Lohning, and A. Radbruch (1999)
J. Exp. Med. 190, 1439-1450
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Nitric Oxide Suppresses Human T Lymphocyte Proliferation Through IFN-{gamma}-Dependent and IFN-{gamma}-Independent Induction of Apoptosis.

A. Allione, P. Bernabei, M. Bosticardo, S. Ariotti, G. Forni, and F. Novelli (1999)
J. Immunol. 163, 4182-4191
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IFN-{alpha} Activates Stat6 and Leads to the Formation of Stat2:Stat6 Complexes in B Cells.

S. Gupta, M. Jiang, and A. B. Pernis (1999)
J. Immunol. 163, 3834-3841
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Stat5 Protease.

C. Lee, F. Piazza, S. Brutsaert, J. Valens, I. Strehlow, M. Jarosinski, C. Saris, and C. Schindler (1999)
J. Biol. Chem. 274, 26767-26775
 |  Abstract »  |  Full Text »  |  PDF »

T1/ST2 Expression Is Enhanced on CD4+ T Cells from Schistosome Egg-Induced Granulomas: Analysis of Th Cell Cytokine Coexpression Ex Vivo.

M. Lohning, J. L. Grogan, A. J. Coyle, M. Yazdanbakhsh, C. Meisel, J.-C. Gutierrez-Ramos, A. Radbruch, and T. Kamradt (1999)
J. Immunol. 162, 3882-3889
 |  Abstract »  |  Full Text »  |  PDF »

Antibodies to the IL-12 Receptor {beta}2 Chain Mark Human Th1 But Not Th2 Cells In Vitro and In Vivo.

L. Rogge, A. Papi, D. H. Presky, M. Biffi, L. J. Minetti, D. Miotto, C. Agostini, G. Semenzato, L. M. Fabbri, and F. Sinigaglia (1999)
J. Immunol. 162, 3926-3932
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-12 Induces Expression of Interferon Regulatory Factor-1 via Signal Transducer and Activator of Transcription-4 in Human T Helper Type 1 Cells.

E. M. Coccia, N. Passini, A. Battistini, C. Pini, F. Sinigaglia, and L. Rogge (1999)
J. Biol. Chem. 274, 6698-6703
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 Selectively Inhibits IL-2-Triggered Stat5 Activation, But Not Proliferation, in Human T Cells.

A. Castro, T. K. Sengupta, D. C. Ruiz, E. Yang, and L. B. Ivashkiv (1999)
J. Immunol. 162, 1261-1269
 |  Abstract »  |  Full Text »  |  PDF »

Selective Expression of a Novel Surface Molecule by Human Th2 Cells In Vivo.

K. Nagata, K. Tanaka, K. Ogawa, K. Kemmotsu, T. Imai, O. Yoshie, H. Abe, K. Tada, M. Nakamura, K. Sugamura, et al. (1999)
J. Immunol. 162, 1278-1286
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 Signaling Is Regulated through the Recruitment of Phosphatases, Kinases, and SOCS Proteins to the Receptor Complex.

J. LOSMAN, X.P. CHEN, H. JIANG, P.-Y. PAN, M. KASHIWADA, C. GIALLOURAKIS, S. COWAN, K. FOLTENYI, and P. ROTHMAN (1999)
Cold Spring Harb Symp Quant Biol 64, 405-416
 |  Abstract »  |  PDF »

Interferon gamma  Derived from CD4+ T Cells Is Sufficient to Mediate T Helper Cell Type 1 Development.

A. E. Wakil, Z.-E. Wang, J. C. Ryan, D. J. Fowell, and R. M. Locksley (1998)
J. Exp. Med. 188, 1651-1656
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A Signal Transducer and Activator of  Transcription (Stat)4-independent Pathway for the Development of  T Helper Type 1 Cells.

M. H. Kaplan, A. L. Wurster, and M. J. Grusby (1998)
J. Exp. Med. 188, 1191-1196
 |  Abstract »  |  Full Text »  |  PDF »

A Janus Kinase Inhibitor, JAB, Is an Interferon-gamma -Inducible Gene and Confers Resistance to Interferons.

H. Sakamoto, H. Yasukawa, M. Masuhara, S. Tanimura, A. Sasaki, K. Yuge, M. Ohtsubo, A. Ohtsuka, T. Fujita, T. Ohta, et al. (1998)
Blood 92, 1668-1676
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: The Chemokine Receptor CCR8 Is Preferentially Expressed in Th2 But Not Th1 Cells.

A. Zingoni, H. Soto, J. A. Hedrick, A. Stoppacciaro, C. T. Storlazzi, F. Sinigaglia, D. D'Ambrosio, A. O'Garra, D. Robinson, M. Rocchi, et al. (1998)
J. Immunol. 161, 547-551
 |  Abstract »  |  Full Text »  |  PDF »

Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice.

B. Lu, C. Ebensperger, Z. Dembic, Y. Wang, M. Kvatyuk, T. Lu, R. L. Coffman, S. Pestka, and P. B. Rothman (1998)
PNAS 95, 8233-8238
 |  Abstract »  |  Full Text »  |  PDF »

The Prototypic Th2 Autoimmunity Induced by Mercury Is Dependent on IFN-{gamma} and Not Th1/Th2 Imbalance.

D. H. Kono, D. Balomenos, D. L. Pearson, M. S. Park, B. Hildebrandt, P. Hultman, and K. M. Pollard (1998)
J. Immunol. 161, 234-240
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Interleukin 4 Signaling in T Helper Type 1 Cells.

H. Huang and W. E. Paul (1998)
J. Exp. Med. 187, 1305-1313
 |  Abstract »  |  Full Text »  |  PDF »

Natural Killer Cell Depletion Fails to Influence Initial CD4 T Cell Commitment In Vivo in Exogenous Antigen-Stimulated Cytokine and Antibody Responses.

M. Wang, C. A. Ellison, J. G. Gartner, and K. T. HayGlass (1998)
J. Immunol. 160, 1098-1105
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of Human Antigen-Specific Th1 and Th2 Lymphocyte Responses by Isozyme Selective Cyclic Nucleotide Phosphodiesterase Inhibitors.

D. M. Essayan, A. Kagey-Sobotka, L. M. Lichtenstein, and S.-K. Huang (1997)
J. Pharmacol. Exp. Ther. 282, 505-512
 |  Abstract »  |  Full Text »

In differentiated CD4+ T Cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma  production is cytokine-dependent.

J. Hu-Li, H. Huang, J. Ryan, and W. E. Paul (1997)
PNAS 94, 3189-3194
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the Interleukin (IL)-12R beta 2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells.

S. J. Szabo, A. S. Dighe, U. Gubler, and K. M. Murphy (1997)
J. Exp. Med. 185, 817-824
 |  Abstract »  |  Full Text »  |  PDF »

Chimeric Erythropoietin-Interferon gamma Receptors Reveal Differences in Functional Architecture of Intracellular Domains for Signal Transduction.

G. Muthukumaran, S. Kotenko, R. Donnelly, J. N. Ihle, and S. Pestka (1997)
J. Biol. Chem. 272, 4993-4999
 |  Abstract »  |  Full Text »  |  PDF »

The Structure of the Gene for the Second Chain of the Human Interferon-gamma Receptor.

S. Rhee, C. Ebensperger, Z. Dembic, and S. Pestka (1996)
J. Biol. Chem. 271, 28947-28952
 |  Abstract »  |  Full Text »  |  PDF »

Ligand-Induced Autoregulation of IFN-gamma Receptor beta Chain Expression in T Helper Cell Subsets.

E. A. Bach, S. J. Szabo, A. S. Dighe, A. Ashkenazi, M. Aguet, K. M. Murphy, and R. D. Schreiber (1995)
Science 270, 1215-1218
 |  Abstract »  |  PDF »

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