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Science 14 July 1995:
Vol. 269. no. 5221, pp. 245 - 247
DOI: 10.1126/science.7618088
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Articles

Science, Vol 269, Issue 5221, 245-247
Copyright © 1995 by American Association for the Advancement of Science

articles

Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells

A Pernis, S Gupta, KJ Gollob, E Garfein, RL Coffman, C Schindler, and P Rothman

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

The ability of interferon gamma (IFN-gamma) to inhibit the proliferation of type 2 T helper cells (TH2), but not that of type 1 (TH1) cells, suggests that helper cell subsets might differ in their activation of the IFN-gamma signaling pathway. The IFN-gamma-inducible signal transducing factor (STF-IFN gamma) was activated in murine TH2 but not in TH1 cell clones, because in the latter the second chain of the IFN-gamma receptor (accessory factor 1 or IFN-gamma R beta) was absent. Thus, TH1 cells use receptor modification to prevent the activation of STF-IFN gamma and achieve an IFN-gamma-resistant state.


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H. Huang and W. E. Paul (1998)
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   Abstract »    Full Text »    PDF »
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J. Immunol. 160, 1098-1105
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Ligand-Induced Autoregulation of IFN-gamma Receptor beta Chain Expression in T Helper Cell Subsets.
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