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Science 14 July 1995: Vol. 269. no. 5221, pp. 230 - 234 DOI: 10.1126/science.7618084
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Articles
Science, Vol 269, Issue 5221, 230-234
Copyright © 1995 by American Association for the Advancement of Science
Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype
DW Threadgill,
AA Dlugosz,
LA Hansen,
T Tennenbaum,
U Lichti,
D Yee,
C LaMantia,
T Mourton,
K Herrup,
RC Harris,
and
al. et
Department of Genetics, Case Western Reserve University, Cleveland, OH 44106-4955, USA.
Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.
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| Full Text »
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| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
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| Abstract »
| Full Text »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- I. V. Yosypiv, M. Schroeder, and S. S. El-Dahr (2006)
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| Abstract »
| Full Text »
| PDF »
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- T. B. El-Abaseri, S. Putta, and L. A. Hansen (2006)
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| Abstract »
| Full Text »
| PDF »
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- X. Wang, D. Bolotin, D. H. Chu, L. Polak, T. Williams, and E. Fuchs (2006)
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172, 409-421
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- D. Tong, J. E. I. Gittens, G. M. Kidder, and D. Bai (2006)
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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25, 8285-8298
| Abstract »
| Full Text »
| PDF »
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- S. Segaert and E. Van Cutsem (2005)
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16, 1425-1433
| Abstract »
| Full Text »
| PDF »
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- M. D. Sternlicht, S. W. Sunnarborg, H. Kouros-Mehr, Y. Yu, D. C. Lee, and Z. Werb (2005)
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| Abstract »
| Full Text »
| PDF »
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- J. R. Peinado, V. Laurent, S.-N. Lee, B. W. Peng, J. E. Pintar, D. F. Steiner, and I. Lindberg (2005)
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- H. Tao, M. Shimizu, R. Kusumoto, K. Ono, S. Noji, and H. Ohuchi (2005)
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| Abstract »
| Full Text »
| PDF »
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280, 24043-24052
| Abstract »
| Full Text »
| PDF »
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- S. Zhuang, Y. Yan, J. Han, and R. G. Schnellmann (2005)
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280, 21036-21042
| Abstract »
| Full Text »
| PDF »
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- E. D. Watson and J. C. Cross (2005)
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20, 180-193
| Abstract »
| Full Text »
| PDF »
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- A. V Badyaev (2005)
Proc R Soc B
272, 877-886
| Abstract »
| Full Text »
| PDF »
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- T. B. El-Abaseri, J. Fuhrman, C. Trempus, I. Shendrik, R. W. Tennant, and L. A. Hansen (2005)
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65, 3958-3965
| Abstract »
| Full Text »
| PDF »
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- M. Jo, K. S. Thomas, N. Marozkina, T. J. Amin, C. M. Silva, S. J. Parsons, and S. L. Gonias (2005)
J. Biol. Chem.
280, 17449-17457
| Abstract »
| Full Text »
| PDF »
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- M. Yoshizawa, T. Kawauchi, M. Sone, Y. V. Nishimura, M. Terao, K. Chihama, Y.-i. Nabeshima, and M. Hoshino (2005)
J. Neurosci.
25, 4406-4419
| Abstract »
| Full Text »
| PDF »
- Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment.
- C. D. Woodworth, E. Michael, D. Marker, S. Allen, L. Smith, and M. Nees (2005)
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4, 650-658
| Abstract »
| Full Text »
| PDF »
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- Y. Shimizu, D. Thumkeo, J. Keel, T. Ishizaki, H. Oshima, M. Oshima, Y. Noda, F. Matsumura, M. M. Taketo, and S. Narumiya (2005)
J. Cell Biol.
168, 941-953
| Abstract »
| Full Text »
| PDF »
- Modeling metastasis in vivo.
- C. Khanna and K. Hunter (2005)
Carcinogenesis
26, 513-523
| Abstract »
| Full Text »
| PDF »
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- L. P. Stabile, J. S. Lyker, C. T. Gubish, W. Zhang, J. R. Grandis, and J. M. Siegfried (2005)
Cancer Res.
65, 1459-1470
| Abstract »
| Full Text »
| PDF »
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- Y. Nakamura, M. Oka, H. Soda, K. Shiozawa, M. Yoshikawa, A. Itoh, Y. Ikegami, J. Tsurutani, K. Nakatomi, T. Kitazaki, et al. (2005)
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65, 1541-1546
| Abstract »
| Full Text »
| PDF »
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- M. Xin, T. Yue, Z. Ma, F.-f. Wu, A. Gow, and Q. R. Lu (2005)
J. Neurosci.
25, 1354-1365
| Abstract »
| Full Text »
| PDF »
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- L. Qin, J. Tamasi, L. Raggatt, X. Li, J. H. M. Feyen, D. C. Lee, E. DiCicco-Bloom, and N. C. Partridge (2005)
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280, 3974-3981
| Abstract »
| Full Text »
| PDF »
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- M. P. Sanderson, S. N. Erickson, P. J. Gough, K. J. Garton, P. T. Wille, E. W. Raines, A. J. Dunbar, and P. J. Dempsey (2005)
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280, 1826-1837
| Abstract »
| Full Text »
| PDF »
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279, 53848-53856
| Abstract »
| Full Text »
| PDF »
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| Abstract »
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- D. Lee, R. S. Pearsall, S. Das, S. K. Dey, V. L. Godfrey, and D. W. Threadgill (2004)
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| Abstract »
| Full Text »
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- J. A. McCormick, Y. Feng, K. Dawson, M. J. Behne, B. Yu, J. Wang, A. W. Wyatt, G. Henke, F. Grahammer, T. M. Mauro, et al. (2004)
Mol. Biol. Cell
15, 4278-4288
| Abstract »
| Full Text »
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- Mechanisms and Limits of Induced Postnatal Lung Growth.
- (2004)
Am. J. Respir. Crit. Care Med.
170, 319-343
| Full Text »
| PDF »
- Phenotypic Variation Resulting From a Deficiency of Epidermal Growth Factor Receptor in Mice Is Caused by Extensive Genetic Heterogeneity That Can Be Genetically and Molecularly Partitioned.
- K. E. Strunk, V. Amann, and D. W. Threadgill (2004)
Genetics
167, 1821-1832
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- Development of the Novel Biologically Targeted Anticancer Agent Gefitinib: Determining the Optimum Dose for Clinical Efficacy.
- M. Wolf, H. Swaisland, and S. Averbuch (2004)
Clin. Cancer Res.
10, 4607-4613
| Abstract »
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- Selective Roles for Tumor Necrosis Factor {alpha}-converting Enzyme/ADAM17 in the Shedding of the Epidermal Growth Factor Receptor Ligand Family: THE JUXTAMEMBRANE STALK DETERMINES CLEAVAGE EFFICIENCY.
- C. L. Hinkle, S. W. Sunnarborg, D. Loiselle, C. E. Parker, M. Stevenson, W. E. Russell, and D. C. Lee (2004)
J. Biol. Chem.
279, 24179-24188
| Abstract »
| Full Text »
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- Molecular Cues to Implantation.
- S. K. Dey, H. Lim, S. K. Das, J. Reese, B. C. Paria, T. Daikoku, and H. Wang (2004)
Endocr. Rev.
25, 341-373
| Abstract »
| Full Text »
| PDF »
- Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib.
- T. J. Lynch, D. W. Bell, R. Sordella, S. Gurubhagavatula, R. A. Okimoto, B. W. Brannigan, P. L. Harris, S. M. Haserlat, J. G. Supko, F. G. Haluska, et al. (2004)
N. Engl. J. Med.
350, 2129-2139
| Abstract »
| Full Text »
| PDF »
- Electroporation of Murine Embryonic Stem Cells: A Step-by-Step Guide.
- D. M. Tompers and P. A. Labosky (2004)
Stem Cells
22, 243-249
| Abstract »
| Full Text »
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- Branching morphogenesis and kidney disease.
- M. M. Shah, R. V. Sampogna, H. Sakurai, K. T. Bush, and S. K. Nigam (2004)
Development
131, 1449-1462
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- Rescue of Female Infertility from the Loss of Cyclooxygenase-2 by Compensatory Up-regulation of Cyclooxygenase-1 Is a Function of Genetic Makeup.
- H. Wang, W.-g. Ma, L. Tejada, H. Zhang, J. D. Morrow, S. K. Das, and S. K. Dey (2004)
J. Biol. Chem.
279, 10649-10658
| Abstract »
| Full Text »
| PDF »
- Centromere protein b-null mice display decreasing reproductive performance through successive generations of breeding due to diminishing endometrial glands.
- K J Fowler, L H Wong, B K Griffiths, M C Sibson, S Reed, and K H A Choo (2004)
Reproduction
127, 367-377
| Abstract »
| Full Text »
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- Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.
- U. Sahin, G. Weskamp, K. Kelly, H.-M. Zhou, S. Higashiyama, J. Peschon, D. Hartmann, P. Saftig, and C. P. Blobel (2004)
J. Cell Biol.
164, 769-779
| Abstract »
| Full Text »
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- Identification of a Second egfr Gene in Xiphophorus Uncovers an Expansion of the Epidermal Growth Factor Receptor Family in Fish.
- A. Gomez, J.-N. Volff, U. Hornung, M. Schartl, and C. Wellbrock (2004)
Mol. Biol. Evol.
21, 266-275
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- Epidermal Growth Factor Receptor Activation Differentially Regulates Claudin Expression and Enhances Transepithelial Resistance in Madin-Darby Canine Kidney Cells.
- A. B. Singh and R. C. Harris (2004)
J. Biol. Chem.
279, 3543-3552
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| Full Text »
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- Velvet, a Dominant Egfr Mutation That Causes Wavy Hair and Defective Eyelid Development in Mice.
- X. Du, K. Tabeta, K. Hoebe, H. Liu, N. Mann, S. Mudd, K. Crozat, S. Sovath, X. Gong, and B. Beutler (2004)
Genetics
166, 331-340
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- Moving forward with chemical mutagenesis in the mouse.
- T. P. O'Brien and W. N. Frankel (2004)
J. Physiol.
554, 13-21
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| Full Text »
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- Application of chromosomal substitution techniques in gene-function discovery.
- A. W. Cowley Jr, R. J. Roman, and H. J. Jacob (2004)
J. Physiol.
554, 46-55
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- Renal expression and activity of the germinal center kinase SK2.
- A. V. Cybulsky, T. Takano, J. Papillon, A. Khadir, K. Bijian, C.-C. Chien, C. E. Alpers, and H. Rabb (2004)
Am J Physiol Renal Physiol
286, F16-F25
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- Importance of Functional EGF Receptors in Recovery from Acute Nephrotoxic Injury.
- Z. Wang, J.-K. Chen, S.-w. Wang, G. Moeckel, and R. C. Harris (2003)
J. Am. Soc. Nephrol.
14, 3147-3154
| Abstract »
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- Small-Molecule Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.
- M. L. Janmaat and G. Giaccone (2003)
Oncologist
8, 576-586
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- Cbl-3-Deficient Mice Exhibit Normal Epithelial Development.
- E. K. Griffiths, O. Sanchez, P. Mill, C. Krawczyk, C. V. Hojilla, E. Rubin, M. M. Nau, R. Khokha, S. Lipkowitz, C.-c. Hui, et al. (2003)
Mol. Cell. Biol.
23, 7708-7718
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- Compromised Reproductive Function in Adult Female Mice Selectively Expressing Mutant ErbB-1 Tyrosine Kinase Receptors in Astroglia.
- B. Li, Z. Yang, J. Hou, A. McCracken, M. A. Jennings, and M. Y. J. Ma (2003)
Mol. Endocrinol.
17, 2365-2376
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- Adrenomedullin Is Decreased in Preeclampsia Because of Failed Response to Epidermal Growth Factor and Impaired Syncytialization.
- H. Li, J. Dakour, S. Kaufman, L. J. Guilbert, B. Winkler-Lowen, and D. W. Morrish (2003)
Hypertension
42, 895-900
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