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Science 14 July 1995:
Vol. 269. no. 5221, pp. 223 - 226
DOI: 10.1126/science.7542403
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Articles

Science, Vol 269, Issue 5221, 223-226
Copyright © 1995 by American Association for the Advancement of Science

articles

Peptide binding and presentation by mouse CD1

AR Castano, S Tangri, JE Miller, HR Holcombe, MR Jackson, WD Huse, M Kronenberg, and PA Peterson

Department of Immunology, La Jolla, CA 92037, USA.

CD1 molecules are distantly related to the major histocompatibility complex (MHC) class I proteins. They are of unknown function. Screening random peptide phage display libraries with soluble empty mouse CD1 (mCD1) identified a peptide binding motif. It consists of three anchor positions occupied by aromatic or bulky hydrophobic amino acids. Equilibrium binding studies demonstrated that mCD1 binds peptides containing the appropriate motif with relatively high affinity. However, in contrast to classical MHC class I molecules, strong binding to mCD1 required relatively long peptides. Peptide-specific, mCD1-restricted T cell responses can be raised, which suggests that the findings are of immunological significance.


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J. Immunol. 160, 3128-3134
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Natural Ligand of Mouse CD1d1: Cellular Glycosylphosphatidylinositol.
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Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo.
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L. Mayer (1998)
Am J Physiol Gastrointest Liver Physiol 274, G7-G9
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Requirements for CD1d Recognition by Human Invariant Valpha 24+ CD4-CD8- T Cells.
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J. Exp. Med. 186, 109-120
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The Recognition of the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule, T10, by the gamma delta T Cell, G8.
M. P. Crowley, Z. Reich, N. Mavaddat, J. D. Altman, and Y.-h. Chien (1997)
J. Exp. Med. 185, 1223-1230
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CD1: presenting unusual antigens to unusual T lymphocytes.
A Bendelac (1995)
Science 269, 185-186
   PDF »
Characterization of CD1e, a Third Type of CD1 Molecule Expressed in Dendritic Cells.
C. Angenieux, J. Salamero, D. Fricker, J.-P. Cazenave, B. Goud, D. Hanau, and H. de la Salle (2000)
J. Biol. Chem. 275, 37757-37764
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Critical contribution of liver natural killer T cells to a murine model of hepatitis.
K. Takeda, Y. Hayakawa, L. Van Kaer, H. Matsuda, H. Yagita, and K. Okumura (2000)
PNAS 97, 5498-5503
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