Science 14 July 1995: Vol. 269. no. 5221, pp. 221 - 223 DOI: 10.1126/science.7618083

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Articles

NADPH Oxidase in Vascular Injury: A New Insight About Its Regulation and Role in T Cells.

J.-i. Abe and C.-H. Woo (2009)
Circ. Res. 104, 147-149
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Filamin A Links Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 1 at Lamellipodia To Orchestrate Cell Migration.

M. Maceyka, S. E. Alvarez, S. Milstien, and S. Spiegel (2008)
Mol. Cell. Biol. 28, 5687-5697
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p21-Activated Kinase Signaling Regulates Oxidant-Dependent NF-{kappa}B Activation by Flow.

A. W. Orr, C. Hahn, B. R. Blackman, and M. A. Schwartz (2008)
Circ. Res. 103, 671-679
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Nox4 Oxidase Overexpression Specifically Decreases Endogenous Nox4 mRNA and Inhibits Angiotensin II-Induced Adventitial Myofibroblast Migration.

M. J. Haurani, M. E. Cifuentes, A. D. Shepard, and P. J. Pagano (2008)
Hypertension 52, 143-149
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Stimulus-dependent Regulation of the Phagocyte NADPH Oxidase by a VAV1, Rac1, and PAK1 Signaling Axis.

K. Roepstorff, I. Rasmussen, M. Sawada, C. Cudre-Maroux, P. Salmon, G. Bokoch, B. van Deurs, and F. Vilhardt (2008)
J. Biol. Chem. 283, 7983-7993
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Regulation of Nox1 Activity via Protein Kinase A-mediated Phosphorylation of NoxA1 and 14-3-3 Binding.

J.-S. Kim, B. A. Diebold, B. M. Babior, U. G. Knaus, and G. M. Bokoch (2007)
J. Biol. Chem. 282, 34787-34800
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16-kDa Prolactin Inhibits Endothelial Cell Migration by Down-Regulating the Ras-Tiam1-Rac1-Pak1 Signaling Pathway.

S.-H. Lee, J. Kunz, S.-H. Lin, and L.-y. Yu-Lee (2007)
Cancer Res. 67, 11045-11053
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p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility.

K. A. Sheehan, Y. Ke, and R. J. Solaro (2007)
Am J Physiol Regulatory Integrative Comp Physiol 293, R963-R973
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Blocking p21-activated Kinase Reduces Lipopolysaccharide-induced Acute Lung Injury by Preventing Polymorphonuclear Leukocyte Infiltration.

J. Reutershan, R. Stockton, A. Zarbock, G. W. Sullivan, D. Chang, D. Scott, M. A. Schwartz, and K. Ley (2007)
Am. J. Respir. Crit. Care Med. 175, 1027-1035
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Phosphorylation of RhoGDI by Src Regulates Rho GTPase Binding and Cytosol-Membrane Cycling.

C. DerMardirossian, G. Rocklin, J.-Y. Seo, and G. M. Bokoch (2006)
Mol. Biol. Cell 17, 4760-4768
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Adventitial delivery of dominant-negative p67phox attenuates neointimal hyperplasia of the rat carotid artery.

M. Weaver, J. Liu, D. Pimentel, D. J. Reddy, P. Harding, E. L. Peterson, and P. J. Pagano (2006)
Am J Physiol Heart Circ Physiol 290, H1933-H1941
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Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events.

G. L. Vilas, M. M. Corvi, G. J. Plummer, A. M. Seime, G. R. Lambkin, and L. G. Berthiaume (2006)
PNAS 103, 6542-6547
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HIV-1 Tat Regulates Endothelial Cell Cycle Progression via Activation of the Ras/ERK MAPK Signaling Pathway.

E. Toschi, I. Bacigalupo, R. Strippoli, C. Chiozzini, A. Cereseto, M. Falchi, F. Nappi, C. Sgadari, G. Barillari, F. Mainiero, et al. (2006)
Mol. Biol. Cell 17, 1985-1994
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p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils.

K. D. Martyn, M.-J. Kim, M. T. Quinn, M. C. Dinauer, and U. G. Knaus (2005)
Blood 106, 3962-3969
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Ligation of Cell Surface-Associated Glucose-Regulated Protein 78 by Receptor-Recognized Forms of {alpha}2-Macroglobulin: Activation of p21-Activated Protein Kinase-2-Dependent Signaling in Murine Peritoneal Macrophages.

U. K. Misra, T. Sharma, and S. V. Pizzo (2005)
J. Immunol. 175, 2525-2533
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Binding of Activated {alpha}2-Macroglobulin to Its Cell Surface Receptor GRP78 in 1-LN Prostate Cancer Cells Regulates PAK-2-dependent Activation of LIMK.

U. K. Misra, R. Deedwania, and S. V. Pizzo (2005)
J. Biol. Chem. 280, 26278-26286
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Protein kinase C{delta} regulates p67phox phosphorylation in human monocytes.

X. Zhao, B. Xu, A. Bhattacharjee, C. M. Oldfield, F. B. Wientjes, G. M. Feldman, and M. K. Cathcart (2005)
J. Leukoc. Biol. 77, 414-420
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NF-{kappa}B- and C/EBP{beta}-driven Interleukin-1{beta} Gene Expression and PAK1-mediated Caspase-1 Activation Play Essential Roles in Interleukin-1{beta} Release from Helicobacter pylori Lipopolysaccharide-stimulated Macrophages.

C. Basak, S. K. Pathak, A. Bhattacharyya, D. Mandal, S. Pathak, and M. Kundu (2005)
J. Biol. Chem. 280, 4279-4288
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Vascular NADPH oxidases: molecular mechanisms of activation.

R. P. Brandes and J. Kreuzer (2005)
Cardiovasc Res 65, 16-27
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Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases.

M. T. Quinn and K. A. Gauss (2004)
J. Leukoc. Biol. 76, 760-781
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Rac2 is critical for neutrophil primary granule exocytosis.

D. Abdel-Latif, M. Steward, D. L. Macdonald, G. A. Francis, M. C. Dinauer, and P. Lacy (2004)
Blood 104, 832-839
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Fungal Metabolite Gliotoxin Inhibits Assembly of the Human Respiratory Burst NADPH Oxidase.

S. Tsunawaki, L. S. Yoshida, S. Nishida, T. Kobayashi, and T. Shimoyama (2004)
Infect. Immun. 72, 3373-3382
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Constitutive p21-activated Kinase (PAK) Activation in Breast Cancer Cells as a Result of Mislocalization of PAK to Focal Adhesions.

M. R. Stofega, L. C. Sanders, E. M. Gardiner, and G. M. Bokoch (2004)
Mol. Biol. Cell 15, 2965-2977
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Tumor Necrosis Factor-{alpha} Promotes Survival of Opossum Kidney Cells via Cdc42-induced Phospholipase C-{gamma}1 Activation and Actin Filament Redistribution.

E. A. Papakonstanti and C. Stournaras (2004)
Mol. Biol. Cell 15, 1273-1286
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Regulation of Microtubule Destabilizing Activity of Op18/Stathmin Downstream of Rac1.

T. Wittmann, G. M. Bokoch, and C. M. Waterman-Storer (2004)
J. Biol. Chem. 279, 6196-6203
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The Mechanism of p21-activated Kinase 2 Autoactivation.

H. Wu and Z.-X. Wang (2003)
J. Biol. Chem. 278, 41768-41778
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Caspase-activated PAK-2 Is Regulated by Subcellular Targeting and Proteasomal Degradation.

R. Jakobi, C. C. McCarthy, M. A. Koeppel, and D. K. Stringer (2003)
J. Biol. Chem. 278, 38675-38685
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Activation of Rac2 and Cdc42 on Fc and complement receptor ligation in human neutrophils.

M. Forsberg, P. Druid, L. Zheng, O. Stendahl, and E. Sarndahl (2003)
J. Leukoc. Biol. 74, 611-619
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p21-Activated Kinase 2 in Neutrophils Can Be Regulated by Phosphorylation at Multiple Sites and by a Variety of Protein Phosphatases.

Q. Zhan, Q. Ge, T. Ohira, T. Van Dyke, and J. A. Badwey (2003)
J. Immunol. 171, 3785-3793
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Vascular Endothelial Growth Factor Causes Translocation of p47phox to Membrane Ruffles through WAVE1.

R. F. Wu, Y. Gu, Y. C. Xu, F. E. Nwariaku, and L. S. Terada (2003)
J. Biol. Chem. 278, 36830-36840
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ERK and RhoA Differentially Regulate Pseudopodia Growth and Retraction during Chemotaxis.

A. A. Brahmbhatt and R. L. Klemke (2003)
J. Biol. Chem. 278, 13016-13025
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p21-activated Kinase 1 (PAK1) Interacts with the Grb2 Adapter Protein to Couple to Growth Factor Signaling.

L. A. Puto, K. Pestonjamasp, C. C. King, and G. M. Bokoch (2003)
J. Biol. Chem. 278, 9388-9393
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Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin.

C. Vidal, B. Geny, J. Melle, M. Jandrot-Perrus, and M. Fontenay-Roupie (2002)
Blood 100, 4462-4469
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The Reactive Adventitia: Fibroblast Oxidase in Vascular Function.

F. E. Rey and P. J. Pagano (2002)
Arterioscler Thromb Vasc Biol 22, 1962-1971
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Synapsin I Is Phosphorylated at Ser603 by p21-activated Kinases (PAKs) in Vitro and in PC12 Cells Stimulated with Bradykinin.

K. Sakurada, H. Kato, H. Nagumo, H. Hiraoka, K. Furuya, T. Ikuhara, Y. Yamakita, K. Fukunaga, E. Miyamoto, F. Matsumura, et al. (2002)
J. Biol. Chem. 277, 45473-45479
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The HIV-1 Nef Protein and Phagocyte NADPH Oxidase Activation.

F. Vilhardt, O. Plastre, M. Sawada, K. Suzuki, M. Wiznerowicz, E. Kiyokawa, D. Trono, and K.-H. Krause (2002)
J. Biol. Chem. 277, 42136-42143
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A p21-Activated Kinase-controlled Metabolic Switch Up-regulates Phagocyte NADPH Oxidase.

T. Shalom-Barak and U. G. Knaus (2002)
J. Biol. Chem. 277, 40659-40665
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Current molecular models for NADPH oxidase regulation by Rac GTPase.

G. M. Bokoch and B. A. Diebold (2002)
Blood 100, 2692-2695
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Inhibitory effects of a dominant-interfering form of the Rho-GTPase Cdc42 in the chemoattractant-elicited signaling pathways leading to NADPH oxidase activation in differentiated HL-60 cells.

M.-J. Rabiet, M. Tardif, L. Braun, and F. Boulay (2002)
Blood 100, 1835-1844
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Association of PI-3 Kinase with PAK1 Leads to Actin Phosphorylation and Cytoskeletal Reorganization.

E. A. Papakonstanti and C. Stournaras (2002)
Mol. Biol. Cell 13, 2946-2962
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The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function.

X. Li, X. Bu, B. Lu, H. Avraham, R. A. Flavell, and B. Lim (2002)
Mol. Cell. Biol. 22, 1158-1171
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Filopodia are conduits for melanosome transfer to keratinocytes.

G. Scott, S. Leopardi, S. Printup, and B. C. Madden (2002)
J. Cell Sci. 115, 1441-1451
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Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines.

M. G. Callow, F. Clairvoyant, S. Zhu, B. Schryver, D. B. Whyte, J. R. Bischoff, B. Jallal, and T. Smeal (2002)
J. Biol. Chem. 277, 550-558
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AR and ER Interaction with a p21-Activated Kinase (PAK6).

S. R. Lee, S. M. Ramos, A. Ko, D. Masiello, K. D. Swanson, M. L. Lu, and S. P. Balk (2002)
Mol. Endocrinol. 16, 85-99
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p21-activated Kinase-1 (PAK1) Inhibition of the Human Scavenger Receptor Class B, Type I Promoter in Macrophages Is Independent of PAK1 Kinase Activity, but Requires the GTPase-binding Domain.

T. G. Hullinger, R. L. Panek, X. Xu, and S. K. Karathanasis (2001)
J. Biol. Chem. 276, 46807-46814
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Association of Fc{gamma}RII with Low-Density Detergent-Resistant Membranes Is Important for Cross-Linking-Dependent Initiation of the Tyrosine Phosphorylation Pathway and Superoxide Generation.

O. Katsumata, M. Hara-Yokoyama, C. Sautes-Fridman, Y. Nagatsuka, T. Katada, Y. Hirabayashi, K. Shimizu, J. Fujita-Yoshigaki, H. Sugiya, and S. Furuyama (2001)
J. Immunol. 167, 5814-5823
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Evidence for a Role of Mixed Lineage Kinases in Neuronal Apoptosis.

M. Mota, M. Reeder, J. Chernoff, and C. E. Bazenet (2001)
J. Neurosci. 21, 4949-4957
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p21-activated kinase 1 participates in tracheal smooth muscle cell migration by signaling to p38 MAPK.

M. A. Dechert, J. M. Holder, and W. T. Gerthoffer (2001)
Am J Physiol Cell Physiol 281, C123-C132
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Phosphorylation of the Activation Loop of {{gamma}} p21-Activated Kinase ({{gamma}}-Pak) and Related Kinases (MSTs) in Normal and Stressed Neutrophils.

J. P. Lian, A. Toker, and J. A. Badwey (2001)
J. Immunol. 166, 6349-6357
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Antagonists of Calcium Fluxes and Calmodulin Block Activation of the p21-Activated Protein Kinases in Neutrophils.

J. P. Lian, L. Crossley, Q. Zhan, R. Huang, P. Coffer, A. Toker, D. Robinson, and J. A. Badwey (2001)
J. Immunol. 166, 2643-2650
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Protein Kinase C {{zeta}} Phosphorylates a Subset of Selective Sites of the NADPH Oxidase Component p47phox and Participates in Formyl Peptide-Mediated Neutrophil Respiratory Burst.

P. M.-C. Dang, A. Fontayne, J. Hakim, J. El Benna, and A. Perianin (2001)
J. Immunol. 166, 1206-1213
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The Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 1/2 Pathway Is Involved in formyl-Methionyl-Leucyl-Phenylalanine-Induced p47phox Phosphorylation in Human Neutrophils.

C. Dewas, M. Fay, M.-A. Gougerot-Pocidalo, and J. El-Benna (2000)
J. Immunol. 165, 5238-5244
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Macropinocytosis by p21-activated Kinase-1.

S. Dharmawardhane, A. Schürmann, M. A. Sells, J. Chernoff, S. L. Schmid, and G. M. Bokoch (2000)
Mol. Biol. Cell 11, 3341-3352
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Ankyrin-Tiam1 Interaction Promotes Rac1 Signaling and Metastatic Breast Tumor Cell Invasion and Migration.

L. Y.W. Bourguignon, H. Zhu, L. Shao, and Y. W. Chen (2000)
J. Cell Biol. 150, 177-192
 |  Abstract »  |  Full Text »  |  PDF »

Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase.

S. Wahl, H. Barth, T. Ciossek, K. Aktories, and B. K. Mueller (2000)
J. Cell Biol. 149, 263-270
 |  Abstract »  |  Full Text »  |  PDF »

The Akt Proto-oncogene Links Ras to Pak and Cell Survival Signals.

Y. Tang, H. Zhou, A. Chen, R. N. Pittman, and J. Field (2000)
J. Biol. Chem. 275, 9106-9109
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Inhibitory Effect of Isoproterenol on NADPH-dependent H2O2 Generation in Human Adipocyte Plasma Membranes Is Mediated by beta gamma -Subunits Derived from Gs.

H. I. Krieger-Brauer, P. K. Medda, B. Sattel, and H. Kather (2000)
J. Biol. Chem. 275, 2486-2490
 |  Abstract »  |  Full Text »  |  PDF »

CD44 Interaction with Tiam1 Promotes Rac1 Signaling and Hyaluronic Acid-mediated Breast Tumor Cell Migration.

L. Y. W. Bourguignon, H. Zhu, L. Shao, and Y. W. Chen (2000)
J. Biol. Chem. 275, 1829-1838
 |  Abstract »  |  Full Text »  |  PDF »

p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis.

A. Schurmann, A. F. Mooney, L. C. Sanders, M. A. Sells, H. G. Wang, J. C. Reed, and G. M. Bokoch (2000)
Mol. Cell. Biol. 20, 453-461
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Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway.

J.-P. Mira, V. Benard, J. Groffen, L. C. Sanders, and U. G. Knaus (2000)
PNAS 97, 185-189
 |  Abstract »  |  Full Text »  |  PDF »

A Phosphatidic Acid-activated Protein Kinase and Conventional Protein Kinase C Isoforms Phosphorylate p22phox, an NADPH Oxidase Component.

D. S. Regier, K. A. Waite, R. Wallin, and L. C. McPhail (1999)
J. Biol. Chem. 274, 36601-36608
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Activation of the PAK-Related Kinase by Human Immunodeficiency Virus Type 1 Nef in Primary Human Peripheral Blood Lymphocytes and Macrophages Leads to Phosphorylation of a PIX-p95 Complex.

A. Brown, X. Wang, E. Sawai, and C. Cheng-Mayer (1999)
J. Virol. 73, 9899-9907
 |  Abstract »  |  Full Text »  |  PDF »

Human JIK, a Novel Member of the STE20 Kinase Family That Inhibits JNK and Is Negatively Regulated by Epidermal Growth Factor.

E. Tassi, Z. Biesova, P. P. Di Fiore, J. S. Gutkind, and W. T. Wong (1999)
J. Biol. Chem. 274, 33287-33295
 |  Abstract »  |  Full Text »  |  PDF »

A Role for P21-Activated Kinase in Endothelial Cell Migration.

W. B. Kiosses, R. H. Daniels, C. Otey, G. M. Bokoch, and M. A. Schwartz (1999)
J. Cell Biol. 147, 831-844
 |  Abstract »  |  Full Text »  |  PDF »

Paka, a Putative Pak Family Member, Is Required for Cytokinesis and the Regulation of the Cytoskeleton in Dictyostelium discoideum Cells during Chemotaxis.

C. Y. Chung and R. A. Firtel (1999)
J. Cell Biol. 147, 559-576
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of p21rac Activation in Human Neutrophils.

N. Geijsen, S. van Delft, J. A.M. Raaijmakers, J.-W. J. Lammers, J. G. Collard, L. Koenderman, and P. J. Coffer (1999)
Blood 94, 1121-1130
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of a Vascular Smooth Muscle Cell NAD(P)H Oxidase by Thrombin. EVIDENCE THAT p47phox MAY PARTICIPATE IN FORMING THIS OXIDASE IN VITRO AND IN VIVO.

C. Patterson, J. Ruef, N. R. Madamanchi, P. Barry-Lane, Z. Hu, C. Horaist, C. A. Ballinger, A. R. Brasier, C. Bode, and M. S. Runge (1999)
J. Biol. Chem. 274, 19814-19822
 |  Abstract »  |  Full Text »  |  PDF »

The Guanine-Nucleotide Exchange Factor Vav Is a Crucial Regulator of B Cell Receptor Activation and B Cell Responses to Nonrepetitive Antigens.

M. F. Bachmann, L. Nitschke, C. Krawczyk, K. Tedford, P. S. Ohashi, K. D. Fischer, and J. M. Penninger (1999)
J. Immunol. 163, 137-142
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-Mediated Proteolysis and Activation of Protein Kinase Cdelta Plays a Central Role in Neutrophil Apoptosis.

A. Khwaja and L. Tatton (1999)
Blood 94, 291-301
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases.

V. Benard, B. P. Bohl, and G. M. Bokoch (1999)
J. Biol. Chem. 274, 13198-13204
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase.

L. C. Sanders, F. Matsumura, G. M. Bokoch, and P. de Lanerolle (1999)
Science 283, 2083-2085
 |  Abstract »  |  Full Text »

Multisite Autophosphorylation of p21-activated Protein Kinase gamma -PAK as a Function of Activation.

A. Gatti, Z. Huang, P. T. Tuazon, and J. A. Traugh (1999)
J. Biol. Chem. 274, 8022-8028
 |  Abstract »  |  Full Text »  |  PDF »

Differential Activation of c-Jun NH2-Terminal Kinase and p38 Pathways During FTY720-Induced Apoptosis of T Lymphocytes That Is Suppressed by the Extracellular Signal-Regulated Kinase Pathway.

S. Matsuda, A. Minowa, S. Suzuki, and S. Koyasu (1999)
J. Immunol. 162, 3321-3326
 |  Abstract »  |  Full Text »  |  PDF »

alpha Pix Stimulates p21-activated Kinase Activity through Exchange Factor-dependent and -independent Mechanisms.

R. H. Daniels, F. T. Zenke, and G. M. Bokoch (1999)
J. Biol. Chem. 274, 6047-6050
 |  Abstract »  |  Full Text »  |  PDF »

Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity.

D. I. Johnson (1999)
Microbiol. Mol. Biol. Rev. 63, 54-105
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human.

C. WIDMANN, S. GIBSON, M. B. JARPE, and G. L. JOHNSON (1999)
Physiol Rev 79, 143-180
 |  Abstract »  |  Full Text »  |  PDF »

Isolation and Characterization of a Variant HL60 Cell Line Defective in the Activation of the NADPH Oxidase by Phorbol Myristate Acetate.

M. Tardif, M.-J. Rabiet, T. Christophe, M.-D. Milcent, and F. Boulay (1998)
J. Immunol. 161, 6885-6895
 |  Abstract »  |  Full Text »  |  PDF »

Vav Regulates Peptide-specific Apoptosis in Thymocytes.

Y.-Y. Kong, K.-D. Fischer, M. F. Bachmann, S. Mariathasan, I. Kozieradzki, M. P. Nghiem, D. Bouchard, A. Bernstein, P. S. Ohashi, and J. M. Penninger (1998)
J. Exp. Med. 188, 2099-2111
 |  Abstract »  |  Full Text »  |  PDF »

Neutrophils Stimulated with a Variety of Chemoattractants Exhibit Rapid Activation of p21-Activated Kinases (Paks): Separate Signals Are Required for Activation and Inactivation of Paks.

R. Huang, J. P. Lian, D. Robinson, and J. A. Badwey (1998)
Mol. Cell. Biol. 18, 7130-7138
 |  Abstract »  |  Full Text »  |  PDF »

Dexamethasone But Not Indomethacin Inhibits Human Phagocyte Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activity by Down-Regulating Expression of Genes Encoding Oxidase Components.

A. Condino-Neto, C. Whitney, and P. E. Newburger (1998)
J. Immunol. 161, 4960-4967
 |  Abstract »  |  Full Text »  |  PDF »

Products of Sphingolipid Catabolism Block Activation of the p21-Activated Protein Kinases in Neutrophils.

J. P. Lian, R. Huang, D. Robinson, and J. A. Badwey (1998)
J. Immunol. 161, 4375-4381
 |  Abstract »  |  Full Text »  |  PDF »

Human T-Cell Leukemia Virus Type 1 Tax Induction of NF-kappa B Involves Activation of the Ikappa B Kinase alpha  (IKKalpha ) and IKKbeta Cellular Kinases.

R. Geleziunas, S. Ferrell, X. Lin, Y. Mu, E. T. Cunningham Jr., M. Grant, M. A. Connelly, J. E. Hambor, K. B. Marcu, and W. C. Greene (1998)
Mol. Cell. Biol. 18, 5157-5165
 |  Abstract »  |  Full Text »  |  PDF »

Structural Requirements for PAK Activation by Rac GTPases.

U. G. Knaus, Y. Wang, A. M. Reilly, D. Warnock, and J. H. Jackson (1998)
J. Biol. Chem. 273, 21512-21518
 |  Abstract »  |  Full Text »  |  PDF »

Angiotensin II Induces p67phox mRNA Expression and NADPH Oxidase Superoxide Generation in Rabbit Aortic Adventitial Fibroblasts.

P. J. Pagano, S. J. Chanock, D. A. Siwik, W. S. Colucci, and J. K. Clark (1998)
Hypertension 32, 331-337
 |  Abstract »  |  Full Text »  |  PDF »

Guanine Nucleotide Exchange Factors Regulate Specificity of Downstream Signaling from Rac and Cdc42.

K. Zhou, Y. Wang, J. L. Gorski, N. Nomura, J. Collard, and G. M. Bokoch (1998)
J. Biol. Chem. 273, 16782-16786
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Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading.

L. S. Price, J. Leng, M. A. Schwartz, and G. M. Bokoch (1998)
Mol. Biol. Cell 9, 1863-1871
 |  Abstract »  |  Full Text »

Cryptic Rac-binding and p21Cdc42HS/Rac-activated Kinase Phosphorylation Sites of NADPH Oxidase Component p67phox.

S. Ahmed, E. Prigmore, S. Govind, C. Veryard, R. Kozma, F. B. Wientjes, A. W. Segal, and L. Lim (1998)
J. Biol. Chem. 273, 15693-15701
 |  Abstract »  |  Full Text »  |  PDF »

Proteases to die for.

V. Cryns and J. Yuan (1998)
Genes & Dev. 12, 1551-1570
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Two Signaling Mechanisms for Activation of alpha Mbeta 2 Avidity in Polymorphonuclear Neutrophils.

S. L. Jones, U. G. Knaus, G. M. Bokoch, and E. J. Brown (1998)
J. Biol. Chem. 273, 10556-10566
 |  Abstract »  |  Full Text »  |  PDF »

A GTPase-independent Mechanism of p21-activated Kinase Activation. REGULATION BY SPHINGOSINE AND OTHER BIOLOGICALLY ACTIVE LIPIDS.

G. M. Bokoch, A. M. Reilly, R. H. Daniels, C. C. King, A. Olivera, S. Spiegel, and U. G. Knaus (1998)
J. Biol. Chem. 273, 8137-8144
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the Thyroid Transcription Factor-1 as a Target for Rat MST2 Kinase.

L. Aurisicchio, R. Di Lauro, and M. Zannini (1998)
J. Biol. Chem. 273, 1477-1482
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: p21-Activated Kinase (PAK) Is Required for Fas-Induced JNK Activation in Jurkat Cells.

T. Rudel, F. T. Zenke, T.-H. Chuang, and G. M. Bokoch (1998)
J. Immunol. 160, 7-11
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Stimulation of CD28 with B7-2 Promotes Focal Adhesion-Like Cell Contacts Where Rho Family Small G Proteins Accumulate in T Cells.

S. Kaga, S. Ragg, K. A. Rogers, and A. Ochi (1998)
J. Immunol. 160, 24-27
 |  Abstract »  |  Full Text »  |  PDF »

Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis.

N. Lee, H. MacDonald, C. Reinhard, R. Halenbeck, A. Roulston, T. Shi, and L. T. Williams (1997)
PNAS 94, 13642-13647
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Ste20-like Oxidant Stress Response Kinase-1 during the Initial Stages of Chemical Anoxia-induced Necrotic Cell Death. REQUIREMENT FOR DUAL INPUTS OF OXIDANT STRESS AND INCREASED CYTOSOLIC [Ca2+].

C. M. Pombo, T. Tsujita, J. M. Kyriakis, J. V. Bonventre, and T. Force (1997)
J. Biol. Chem. 272, 29372-29379
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and Characterization of a Human STE20-like Protein Kinase with Unusual Cofactor Requirements.

K. Schinkmann and J. Blenis (1997)
J. Biol. Chem. 272, 28695-28703
 |  Abstract »  |  Full Text »  |  PDF »

G-Protein-coupled Receptors and Fcgamma -receptors Mediate Activation of Akt/Protein Kinase B in Human Phagocytes.

B. Tilton, M. Andjelkovic, S. A. Didichenko, B. A. Hemmings, and M. Thelen (1997)
J. Biol. Chem. 272, 28096-28101
 |  Abstract »  |  Full Text »  |  PDF »

Localization of p21-Activated Kinase 1 (PAK1) to Pinocytic Vesicles and Cortical Actin Structures in Stimulated Cells.

S. Dharmawardhane, L. C. Sanders, S. S. Martin, R. H. Daniels, and G. M. Bokoch (1997)
J. Cell Biol. 138, 1265-1278
 |  Abstract »  |  Full Text »  |  PDF »

Rho GTPases and signaling networks.

L. Van Aelst and C. D'Souza-Schorey (1997)
Genes & Dev. 11, 2295-2322
 |  Full Text »  |  PDF »

Phosphorylation of the Respiratory Burst Oxidase Subunit p67phox during Human Neutrophil Activation. REGULATION BY PROTEIN KINASE C-DEPENDENT AND INDEPENDENT PATHWAYS.

J. E. Benna, P. M.-C. Dang, M. Gaudry, M. Fay, F. Morel, J. Hakim, and M.-A. Gougerot-Pocidalo (1997)
J. Biol. Chem. 272, 17204-17208
 |  Abstract »  |  Full Text »  |  PDF »

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