Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 7 July 1995:
Vol. 269. no. 5220, pp. 98 - 101
DOI: 10.1126/science.7541558
Prev | Table of Contents | Next

Articles

Science, Vol 269, Issue 5220, 98-101
Copyright © 1995 by American Association for the Advancement of Science

articles

Disruption of retinal axon ingrowth by ablation of embryonic mouse optic chiasm neurons

DW Sretavan, E Pure, MW Siegel, and LF Reichardt

Department of Ophthalmology, University of California, San Francisco 94143, USA.

Mouse retinal ganglion cell axons growing from the eye encounter embryonic neurons at the future site of the optic chiasm. After in vivo ablation of these chiasm neurons with a monoclonal antibody and complement, retinal axons did not cross the midline and stalled at approximately the entry site into the chiasm region. Thus, in the mouse, the presence of early-generated neurons that reside at the site of the future chiasm is required for formation of the optic chiasm by retinal ganglion cell axons.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activity.
N. M. Tian, T. Pratt, and D. J. Price (2008)
Development 135, 4081-4089
   Abstract »    Full Text »    PDF »
Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm..
T. Pratt, C. D. Conway, N. M. M.-L. Tian, D. J. Price, and J. O. Mason (2006)
J. Neurosci. 26, 6911-6923
   Abstract »    Full Text »    PDF »
The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse.
T. Pratt, N. M. M.-L. Tian, T. I. Simpson, J. O. Mason, and D. J. Price (2004)
Development 131, 3773-3784
   Abstract »    Full Text »    PDF »
Architecture of the Optic Chiasm and the Mechanisms That Sculpt Its Development.
G. Jeffery (2001)
Physiol Rev 81, 1393-1414
   Abstract »    Full Text »    PDF »
Early-generated Preplate Neurons in the Developing Telencephalon: Inward Migration into the Developing Striatum.
T. Hamasaki, S. Goto, S. Nishikawa, and Y. Ushio (2001)
Cereb Cortex 11, 474-484
   Abstract »    Full Text »    PDF »
Slit2 Is a Repellent for Retinal Ganglion Cell Axons.
S. P. Niclou, L. Jia, and J. A. Raper (2000)
J. Neurosci. 20, 4962-4974
   Abstract »    Full Text »    PDF »
Retinal Ganglion Cell Axon Guidance in the Mouse Optic Chiasm: Expression and Function of Robos and Slits.
L. Erskine, S. E. Williams, K. Brose, T. Kidd, R. A. Rachel, C. S. Goodman, M. Tessier-Lavigne, and C. A. Mason (2000)
J. Neurosci. 20, 4975-4982
   Abstract »    Full Text »    PDF »
Mutations in the stumpy gene reveal intermediate targets for zebrafish motor axons.
C. Beattie, E Melancon, and J. Eisen (2000)
Development 127, 2653-2662
   Abstract »    PDF »
Axon routing at the optic chiasm after enzymatic removal of chondroitin sulfate in mouse embryos.
K. Chung, J. Taylor, D. Shum, and S. Chan (2000)
Development 127, 2673-2683
   Abstract »    PDF »
GAP-43 mediates retinal axon interaction with lateral diencephalon cells during optic tract formation.
F Zhang, C Lu, C Severin, and D. Sretavan (2000)
Development 127, 969-980
   Abstract »    PDF »
Altered Midline Axon Pathways and Ectopic Neurons in the Developing Hypothalamus of Netrin-1- and DCC-Deficient Mice.
M. S. Deiner and D. W. Sretavan (1999)
J. Neurosci. 19, 9900-9912
   Abstract »    Full Text »    PDF »
A Role for Tectal Midline Glia in the Unilateral Containment of Retinocollicular Axons.
D.-Y. Wu, G. E. Schneider, J. Silver, M. Poston, and S. Jhaveri (1998)
J. Neurosci. 18, 8344-8355
   Abstract »    Full Text »    PDF »
Requirement for Early-Generated Neurons Recognized by Monoclonal Antibody Lot1 in the Formation of Lateral Olfactory Tract.
Y. Sato, T. Hirata, M. Ogawa, and H. Fujisawa (1998)
J. Neurosci. 18, 7800-7810
   Abstract »    Full Text »    PDF »
Retinal Ganglion Cell Axon Progression from the Optic Chiasm to Initiate Optic Tract Development Requires Cell Autonomous Function of GAP-43.
K. Kruger, A. S. Tam, C. Lu, and D. W. Sretavan (1998)
J. Neurosci. 18, 5692-5705
   Abstract »    Full Text »    PDF »
Albinism: modern molecular diagnosis.
S. M CARDEN, R. E BOISSY, P. J SCHOETTKER, and W. V GOOD (1998)
Br J Ophthalmol 82, 189-195
   Full Text »
Pathfinding by Identified Zebrafish Motoneurons in the Absence of Muscle Pioneers.
E. Melancon, D. W. C. Liu, M. Westerfield, and J. S. Eisen (1997)
J. Neurosci. 17, 7796-7804
   Abstract »    Full Text »    PDF »
The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain.
R Macdonald, J Scholes, U Strahle, C Brennan, N Holder, M Brand, and S. Wilson (1997)
Development 124, 2397-2408
   Abstract »    PDF »
Zebrafish mutations affecting retinotectal axon pathfinding.
R. Karlstrom, T Trowe, S Klostermann, H Baier, M Brand, A. Crawford, B Grunewald, P Haffter, H Hoffmann, S. Meyer, et al. (1996)
Development 123, 427-438
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)