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Science 7 July 1995:
Vol. 269. no. 5220, pp. 86 - 89
DOI: 10.1126/science.7604284
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Articles

Science, Vol 269, Issue 5220, 86-89
Copyright © 1995 by American Association for the Advancement of Science

articles

Tissue- and species-specific expression of sp56, a mouse sperm fertilization protein

LH Bookbinder, A Cheng, and JD Bleil

Scripps Research Institute, Department of Molecular Biology, La Jolla, CA 92037, USA.

Mouse sperm recognize and bind to ZP3, one of three glycoproteins in the egg's zona pellucida. A mouse sperm protein, sp56, was identified that has the characteristics expected of the sperm protein responsible for recognition of ZP3. The complementary DNA encoding sp56 was isolated, and its primary sequence indicates that sp56 is a member of a superfamily of protein receptors. It was shown that sp56 expression is restricted to mouse spermatids and that the presence or absence of sp56 on sperm from different species accounts for species specificity of sperm-egg recognition in mice.


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