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Science 7 July 1995:
Vol. 269. no. 5220, pp. 81 - 83
DOI: 10.1126/science.7541555
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Articles

Science, Vol 269, Issue 5220, 81-83
Copyright © 1995 by American Association for the Advancement of Science

articles

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

CL Yu, DJ Meyer, GS Campbell, AC Larner, C Carter-Su, J Schwartz, and R Jove

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109, USA.

Cytokines and growth factors induce tyrosine phosphorylation of signal transducers and activators of transcription (STATs) that directly activate gene expression. Cells stably transformed by the Src oncogene tyrosine kinase were examined for STAT protein activation. Assays of electrophoretic mobility, DNA-binding specificity, and antigenicity indicated that Stat3 or a closely related STAT family member was constitutively activated by the Src oncoprotein. Induction of this DNA-binding activity was accompanied by tyrosine phosphorylation of Stat3 and correlated with Src transformation. These findings demonstrate that Src can activate STAT signaling pathways and raise the possibility that Stat3 contributes to oncogenesis by Src.


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Pyk2 Amplifies Epidermal Growth Factor and c-Src-induced Stat3 Activation.
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J. Biol. Chem. 279, 17224-17231
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J. Savell, Y. Ma, K. S. Morrow, R. Jove, N. Olashaw, P. L. Moseley, W. D. Cress, and W. Wharton (2004)
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J. Immunol. 171, 3919-3927
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Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells.
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J. Virol. 77, 7635-7644
   Abstract »    Full Text »    PDF »
STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation.
W. Xu, S. A. A. Comhair, S. Zheng, S. C. Chu, J. Marks-Konczalik, J. Moss, S. J. Haque, and S. C. Erzurum (2003)
Am J Physiol Lung Cell Mol Physiol 285, L137-L148
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STAT3 Ubiquitylation and Degradation by Mumps Virus Suppress Cytokine and Oncogene Signaling.
C. M. Ulane, J. J. Rodriguez, J.-P. Parisien, and C. M. Horvath (2003)
J. Virol. 77, 6385-6393
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Activation of Signal Transducer and Activator of Transcription 3 by Oncogenic RET/PTC (Rearranged in Transformation/Papillary Thyroid Carcinoma) Tyrosine Kinase: Roles in Specific Gene Regulation and Cellular Transformation.
J. H. Hwang, D. W. Kim, J. M. Suh, H. Kim, J. H. Song, E. S. Hwang, K. C. Park, H. K. Chung, J. M. Kim, T.-H. Lee, et al. (2003)
Mol. Endocrinol. 17, 1155-1166
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Matrix-independent Activation of Phosphatidylinositol 3-Kinase, Stat3, and Cyclin A-associated Cdk2 Is Essential for Anchorage-independent Growth of v-Ros-transformed Chicken Embryo Fibroblasts.
S. Uttamsingh, C. S. Zong, and L.-H. Wang (2003)
J. Biol. Chem. 278, 18798-18810
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Kaposi sarcoma-associated viral cyclin K overrides cell growth inhibition mediated by oncostatin M through STAT3 inhibition.
A. Lundquist, B. Barre, F. Bienvenu, J. Hermann, S. Avril, and O. Coqueret (2003)
Blood 101, 4070-4077
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Fes Tyrosine Kinase Promotes Survival and Terminal Granulocyte Differentiation of Factor-dependent Myeloid Progenitors (32D) and Activates Lineage-specific Transcription Factors.
J. Kim, Y. Ogata, and R. A. Feldman (2003)
J. Biol. Chem. 278, 14978-14984
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Signal transducer and activator of transcription proteins in leukemias.
M. Benekli, M. R. Baer, H. Baumann, and M. Wetzler (2003)
Blood 101, 2940-2954
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