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Science 30 June 1995:
Vol. 268. no. 5219, pp. 1917 - 1919
DOI: 10.1126/science.7604267
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Articles

Science, Vol 268, Issue 5219, 1917-1919
Copyright © 1995 by American Association for the Advancement of Science

articles

Induction of metaphase arrest in Drosophila oocytes by chiasma-based kinetochore tension

JK Jang, L Messina, MB Erdman, T Arbel, and RS Hawley

Department of Genetics, University of California at Davis 95616, USA.

In normal Drosophila melanogaster oocytes, meiosis arrests at metaphase I and resumes after oocyte passage through the oviduct. Thus, metaphase arrest defines a control point in the meiotic cell cycle. Metaphase arrest only occurs in oocytes that have undergone at least one meiotic exchange. Here it is shown that crossovers between homologs attached to the same centromere do not induce metaphase arrest. Hence, exchanges induce metaphase arrest only when they physically conjoin two separate kinetochores. Thus, the signal that mediates metaphase arrest is not the exchange event per se but the resulting tension on homologous kinetochores.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Spatial and temporal control of mitotic cyclins by the Gnu regulator of embryonic mitosis in Drosophila.
X.-H. Zhang, J. M. Axton, J. Drinjakovic, L. Lorenz, H. White-Cooper, and A. D. Renault (2004)
J. Cell Sci. 117, 3571-3578
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giant nucleiis essential in the cell cycle transition from meiosis to mitosis.
A. D. Renault, X.-H. Zhang, L. S. Alphey, L. M. Frenz, D. M. Glover, R. D. C. Saunders, and J. M. Axton (2003)
Development 130, 2997-3005
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Chromosomal Influence on Meiotic Spindle Assembly: Abnormal Meiosis I in Female Mlh1 Mutant Mice.
L. M. Woods, C. A. Hodges, E. Baart, S. M. Baker, M. Liskay, and P. A. Hunt (1999)
J. Cell Biol. 145, 1395-1406
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Damage Control: The Pleiotropy of DNA Repair Genes in Drosophila melanogaster.
J. J. Sekelsky, K. C. Burtis, and R. S. Hawley (1998)
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Lack of Checkpoint Control at the Metaphase/Anaphase Transition: A Mechanism of Meiotic Nondisjunction in Mammalian Females.
R. LeMaire-Adkins, K. Radke, and P. A. Hunt (1997)
J. Cell Biol. 139, 1611-1619
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The Drosophila genes grauzone and cortex are necessary for proper female meiosis.
A. Page and T. Orr-Weaver (1996)
J. Cell Sci. 109, 1707-1715
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Meiotic spindle organization in fertilized Drosophila oocyte: presence of centrosomal components in the meiotic apparatus.
M. Riparbelli and G Callaini (1996)
J. Cell Sci. 109, 911-918
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Chromosomal Control of Meiotic Cell Division.
K. S. McKim and R. S. Hawley (1995)
Science 270, 1595-1601
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